ChemSystemsChem最新文献

Front Cover: How Activated Carboxylic Acids Can Drive Dissipative Systems (ChemSystemsChem 5/2025) 封面：活化羧酸如何驱动耗散系统（chemsystemscheme 5/2025）

IF 3.1

ChemSystemsChem Pub Date : 2025-09-15 DOI: 10.1002/syst.70008

Matteo Valentini, Gianfranco Ercolani, Stefano Di Stefano

引用次数: 0

How Activated Carboxylic Acids Can Drive Dissipative Systems 活化羧酸如何驱动耗散系统

IF 3.1

ChemSystemsChem Pub Date : 2025-07-04 DOI: 10.1002/syst.202500021

Dr. Matteo Valentini, Prof. Dr. Gianfranco Ercolani, Prof. Dr. Stefano Di Stefano

{"title":"How Activated Carboxylic Acids Can Drive Dissipative Systems","authors":"Dr. Matteo Valentini, Prof. Dr. Gianfranco Ercolani, Prof. Dr. Stefano Di Stefano","doi":"10.1002/syst.202500021","DOIUrl":"10.1002/syst.202500021","url":null,"abstract":"Dissipative (non-equilibrium) chemical systems whose properties are transitorily changed by light or chemical stimuli are increasingly investigated. Among chemical stimuli, activated carboxylic acids (ACAs) are used to drive acid–base-based dissipative systems. Here, we give a comprehensive description of the operation mechanisms of such systems. Three types of systems are identified: systems under dissipative conditions (Type 1), energy ratchets (Type 2), and non-equilibrium steady state (NESS) systems (Type 3). Type 1 systems are driven from an equilibrium state to another via protonation by the ACA. However, this new equilibrium is transient because decarboxylation of the ACA conjugate base and back proton transfer rapidly restore the initial state. In Type 2 systems, after ACA consumption, the system is brought into an out-of-equilibrium state. Consequently, part of the free energy change due to the ACA decarboxylation is transferred to the system. Differently from Types 1 and 2, in Type 3 systems, ACA decarboxylation is part of the cyclic network; when fuel and waste species are chemostatted, a NESS can be reached displaying kinetic asymmetry.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202500021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steady Out-of-Equilibrium Chemistry: What? Why? How? 稳定非平衡化学：什么？为什么?如何?

IF 3.1

ChemSystemsChem Pub Date : 2025-05-30 DOI: 10.1002/syst.202500011

Dr. Raphaël Plasson, Prof. Dr. Ludovic Jullien

引用次数: 0

Front Cover: Micrometer-Sized Liposome-Based Systems: A Hierarchical Breakdown (ChemSystemsChem 3/2025) 封面：微米级脂质体系统：分层分解（chemsystemscheme 3/2025）

IF 3.1

ChemSystemsChem Pub Date : 2025-05-19 DOI: 10.1002/syst.202580301

Prof. Dr. Shogo Hamada, Dr. Hironori Sugiyama, Prof. Dr. Yiting Zhang, Prof. Dr. Shoji Iwabuchi, Soichiro Hiroi, Toshiki Maruyama, Yuktesh Balaji, Sota Kumagai, Prof. Dr. Satoshi Murata, Prof. Dr. Taro Toyota

引用次数: 0

Response of Giant Unilamellar Vesicles (GUVs) in Acoustic Field 巨型单层囊泡（GUVs）在声场中的响应

IF 3.1

ChemSystemsChem Pub Date : 2025-05-08 DOI: 10.1002/syst.202500014

Xuejing Wang, Liangfei Tian, Xiaojun Han

引用次数: 0

Autonomous Artificial Molecular Motors and Pumps 自主人工分子马达和泵

IF 3.1

ChemSystemsChem Pub Date : 2025-04-28 DOI: 10.1002/syst.202400101

Dr. Chiara Taticchi, Dr. Massimiliano Curcio, Dr. Stefano Corra

引用次数: 0

Transient Changes in Conductivity of a Water Solution by Means of an Activated Carboxylic Acid (ACA) 活化羧酸（ACA）对水溶液电导率的瞬态变化

IF 3.1

ChemSystemsChem Pub Date : 2025-04-28 DOI: 10.1002/syst.202500008

Dr. Federico Frateloreto, Dr. Giorgio Capocasa, Aurora D'Arrigo, Dr. Martina De Angelis, Prof. Osvaldo Lanzalunga, Prof. Stefano Di Stefano

引用次数: 0

Computational Evaluation of the Binding of Activated Ribonucleotides in Nonenzymatic RNA Template Copying 非酶促RNA模板复制中活化核糖核苷酸结合的计算评价

IF 3.1

ChemSystemsChem Pub Date : 2025-04-28 DOI: 10.1002/syst.202400086

Barbara K. Lech, Boluwatife B. Ogunnaiya, Elizaveta F. Petrusevich, Rafał Szabla

{"title":"Computational Evaluation of the Binding of Activated Ribonucleotides in Nonenzymatic RNA Template Copying","authors":"Barbara K. Lech, Boluwatife B. Ogunnaiya, Elizaveta F. Petrusevich, Rafał Szabla","doi":"10.1002/syst.202400086","DOIUrl":"10.1002/syst.202400086","url":null,"abstract":"Nonenzymatic self-replication is considered as one of the most primordial functions of RNA, which likely preceded the emergence of more complex ribozymes. Among different possible scenarios, nucleotide activation with imidazole derivatives attracted substantial attention over the last years. However, despite the progress in proposing plausible variants of nonenzymatic RNA template copying with phosphoroimidazolides, mechanistic aspects of this process still remain obscure. Furthermore, efficient RNA self-replication involving activated uridine and adenosine still remains a challenge. Here, we employed classical molecular dynamics simulations to evaluate the binding specificity of different imidazolium-bridged dinucleotide intermediates, which was suggested to control the yield and fidelity of the reaction. In particular, RMSD-based clustering of the MD trajectories revealed previously unknown structural arrangements of activated dinucleotide intermediates that may play a critical role in nonenzymatic primer extension. Most importantly, our results indicate that yield and fidelity of nonenzymatic RNA template copying cannot be simply associated with the number of Watson–Crick hydrogen bonds between the activated dinucleotides and the templating strand. Instead, the efficiency of the reaction correlates with the preference for the formation of the canonically stacked form of the activated dinucleotide intermediate, which can then selectively bind to the template and participate in the primer extension reaction.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple Hydroxybenzene Molecules as Thermally Stable Catalysts 简单羟基苯分子作为热稳定催化剂的研究

IF 3.1

ChemSystemsChem Pub Date : 2025-04-28 DOI: 10.1002/syst.202500006

Omer Agazani, Daniel Boas, Vinay Shankar Tiwari, Or Cohen, Deborah E. Shalev, Meital Reches

{"title":"Simple Hydroxybenzene Molecules as Thermally Stable Catalysts","authors":"Omer Agazani, Daniel Boas, Vinay Shankar Tiwari, Or Cohen, Deborah E. Shalev, Meital Reches","doi":"10.1002/syst.202500006","DOIUrl":"10.1002/syst.202500006","url":null,"abstract":"Catalysis plays a central role in the creation of life and is vital for living systems. How catalysts have evolved over the years remains a mystery. The answer to this question is central for understanding enzyme evolution and developing new catalytic entities. Enzymes are folded sequences of coded amino acids. These building blocks may have been present under prebiotic conditions. However, how simple amino acids evolved to create complicated and functional macromolecules such as enzymes is still unknown. Previous reports have shown that coded amino acids, their assemblies, and complexes with metals can have catalytic activity. We have recently demonstrated that even a noncoded amino acid, l-3,4-dihydroxyphenylalanine (DOPA), can catalyze two hydrolysis reactions mediated by its hydroxybenzene moiety. DOPA is found in marine mussels' foot proteins. These proteins function in an environment characterized by high salt concentrations and UV radiation similar to suggested prebiotic conditions. Here, we show that other hydroxybenzene molecules, such as pyrogallol, can also catalyze hydrolysis reactions. The catalytic activity of the hydrolysis reactions of p-nitrophenylacetate and thioacetylcholine depended on the number of hydroxyl groups and their relative position on the benzene rings. The catalytic activity of pyrogallol and tannic acid is stable even at high temperatures, close to the boiling point of water, suggesting they can function as stable artificial catalysts.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 5","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202500006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145057858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Can Molecular Systems Learn? (ChemSystemsChem 2/2025) 封面：分子系统能学习吗？(ChemSystemsChem 2/2025)

IF 3.1

ChemSystemsChem Pub Date : 2025-03-14 DOI: 10.1002/syst.202580201

Kübra Kaygisiz, Rein V. Ulijn

引用次数: 0