ChemSystemsChem最新文献

Photoacid-Mediated Controllable Gelation in a Chemical Reaction Cycle 化学反应循环中光酸介导的可控凝胶化

IF 3.1

ChemSystemsChem Pub Date : 2026-04-06 DOI: 10.1002/syst.70037

Alvaro Lopez-Acosta, Jorge S. Valera, Rafal Klajn, Thomas M. Hermans

引用次数: 0

Self-Replicating Fuels via Autocatalytic Molecular Bond Fission 通过自催化分子键裂变的自我复制燃料

IF 3.1

ChemSystemsChem Pub Date : 2026-04-01 DOI: 10.1002/syst.202500060

Peter Agbo

{"title":"Self-Replicating Fuels via Autocatalytic Molecular Bond Fission","authors":"Peter Agbo","doi":"10.1002/syst.202500060","DOIUrl":"https://doi.org/10.1002/syst.202500060","url":null,"abstract":"<div>\u0000 \u0000 This computational study introduces a conceptual framework for practical, electrochemical fuel generation schemes that display exponential product yields as functions of time. Exponential reaction scaling for formate replication is simulated through an autocatalytic cycle that emulates the process of DNA replication facilitated by the polymerase chain reaction (PCR). Here, an initial buildup of formate into a two-carbon chain through CO2 carboxylation forms oxalate. A subsequent two-electron reduction yields glyoxylate, with base-mediated hydrolysis driving C─C bond breakage of glyoxylate into two formate equivalents. These products are then recycled to serve as reactants. This recursive process chemistry drives formate evolution that scales as 2n, where n is the cycle number. Each step of the proposed fuel cycle is analogized to the steps of DNA annealing, nucleotide polymerization and hybridized strand fission that are responsible for the exponential product yields observed in PCR-mediated DNA synthesis. As a consequence of this replication behavior, rapid rates of fuel production become accessible even when the individual rate constants for the cycle's constituent reactions are slow. Practical barriers to realizing this system are discussed, particularly the difficulty of formate carboxylation and the energy demands of chemical amplification.\u0000 </div>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147714944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmembrane Condensation in Albumin-Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein 内在无序蛋白诱导白蛋白巨泡的跨膜凝结

IF 3.1

ChemSystemsChem Pub Date : 2026-03-26 DOI: 10.1002/syst.202500076

Paula De Dios Andres, Ankush Garg, Ramy Alam, Isabella N. Westensee, Magnus Kjaergaard, Brigitte Städler

{"title":"Transmembrane Condensation in Albumin-Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein","authors":"Paula De Dios Andres, Ankush Garg, Ramy Alam, Isabella N. Westensee, Magnus Kjaergaard, Brigitte Städler","doi":"10.1002/syst.202500076","DOIUrl":"https://doi.org/10.1002/syst.202500076","url":null,"abstract":"The interplay between biomolecular condensates and cellular membranes is central to understanding dynamic intracellular organization and membrane repair. Here, we present a minimal synthetic system to examine how membrane composition and curvature govern condensate–membrane interactions within this model platform. We demonstrate that the exposure of either lipid or polymer–lipid hybrid giant vesicles with encapsulated bovine serum albumin to a resilin-inspired intrinsically disordered protein (IDP), which undergoes liquid–liquid phase separation, results in in situ formation of transmembrane condensates. This observation of cargo-triggered condensation across giant vesicle membranes directly links encapsulated protein crowding to condensate nucleation and insertion. The condensation morphology was tunable by vesicle size and membrane elasticity where smaller vesicles and stiffer hybrid membranes favored transmembrane condensation, whereas larger or softer membranes promoted membrane wetting and deformation. Condensate formation locally reorganized lipids and facilitated leaflet coupling without compromising overall membrane integrity or cargo retention. This mechanistic understanding offers a unique opportunity to gain insight into the complex cell biological process of membrane repair using a minimal system.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202500076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal Control Over Complex, Simple, and Multiphase Coacervates Using Ureolysis and Ammonium Carbonate Decomposition 利用尿素分解和碳酸铵分解对复杂、简单和多相凝聚物的时间控制

IF 3.1

ChemSystemsChem Pub Date : 2026-03-14 DOI: 10.1002/syst.202500081

Shana Shirin Valapra, Malak Jaber, Tsvetomir Ivanov, Lucas Caire da Silva, Guillermo Monreal Santiago

{"title":"Temporal Control Over Complex, Simple, and Multiphase Coacervates Using Ureolysis and Ammonium Carbonate Decomposition","authors":"Shana Shirin Valapra, Malak Jaber, Tsvetomir Ivanov, Lucas Caire da Silva, Guillermo Monreal Santiago","doi":"10.1002/syst.202500081","DOIUrl":"https://doi.org/10.1002/syst.202500081","url":null,"abstract":"Active compartmentalization is a fundamental property of life, as well as a key element in cell regulation. In order to build synthetic systems with emergent cell-like properties, we need to develop active compartments that form, disappear, and change properties autonomously over time. Here, we report a new strategy to induce temporal changes in coacervates using the urea-urease reaction. This reaction triggers the dissolution of complex coacervates after a controllable delay, as it increases ionic strength through the production of ammonium carbonate. This delayed dissolution can be directly used for a broad range of complex coacervates without any synthetic effort. Furthermore, ammonium carbonate can also decompose over time, evaporating from the solution. This combination of enzymatic synthesis and spontaneous decomposition of salt leads to transient coacervate dissolution, which can be used for the controlled release of cargo and for the modulation of a compartmentalized reaction. Cycles of dissolution/reformation can be repeated multiple times without any waste generation, although the number of cycles is limited by the denaturation of urease. Finally, by combining polyelectrolytes with a protected dipeptide, ureolysis can trigger the formation of multiphase coacervates, as well as the sequential formation, dissolution, and aggregation of simple and complex coacervates.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202500081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147565807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-based Photoswitches: From Natural Systems to Engineered Materials 基于蛋白质的光开关：从自然系统到工程材料

IF 3.1

ChemSystemsChem Pub Date : 2026-03-03 DOI: 10.1002/syst.202500072

Olivia J. Armendarez, Wei-Ting Chang, Leila F. Deravi

引用次数: 0

Front Cover: Surface-Driven Protocell Formation in Geologically Relevant Early Earth Environment (ChemSystemsChem 2/2026) 封面：地质相关的早期地球环境中表面驱动的原始细胞形成（chemsystemscheme 2/2026）

IF 3.1

ChemSystemsChem Pub Date : 2026-02-28 DOI: 10.1002/syst.70033

Pamela Knoll, Silvia Holler

引用次数: 0

Synthetic Cells on Demand: From Molecular Stimuli to Cellular Functions 按需合成细胞：从分子刺激到细胞功能

IF 3.1

ChemSystemsChem Pub Date : 2026-02-28 DOI: 10.1002/syst.202500071

Masato Suzuki, Koki Kamiya

{"title":"Synthetic Cells on Demand: From Molecular Stimuli to Cellular Functions","authors":"Masato Suzuki, Koki Kamiya","doi":"10.1002/syst.202500071","DOIUrl":"https://doi.org/10.1002/syst.202500071","url":null,"abstract":"Synthetic cells constructed via bottom-up approaches using lipid or polymer vesicles have become essential tools for mimicking cellular functions and studying synthetic biological systems. These vesicles can undergo morphological changes and trigger internal reactions in response to external stimuli, such as osmotic pressure, temperature, pH, light, and chemical signals. This review highlights recent advances in the design of stimulus-responsive artificial cells, with a focus on lipid or polymer vesicle deformation, division, and signal-triggered biochemical activity. Special emphasis is placed on multivesicular vesicle systems that emulate organelle-level compartmentalization and allow precise control of internal functions. Additionally, artificial cell−cell communication systems have been developed using DNA-based adhesion, nanopores, and cell-penetrating peptides to facilitate molecular exchange between lipid or polymer vesicles. These developments have paved the way for the construction of autonomous artificial cells capable of sensing their environment and performing programmable functions. Such systems hold great promise for applications in synthetic biology, including therapeutic delivery, biosensing, and biomolecular robot development.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202500071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147569810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of the Interlocked Rings in a Water-Soluble Radial [7]Catenane 水溶性径向[7]链烷互锁环动力学

IF 3.1

ChemSystemsChem Pub Date : 2026-02-18 DOI: 10.1002/syst.202500075

Antony Wing Hung Ng, Yu Hin Leung, Ho Yu Au-Yeung

引用次数: 0

Enhanced Ribose-Forming Pathways in the Formose Reaction by Oxometalate Catalysts 金属酸氧催化Formose反应增强核糖形成途径

IF 3.1

ChemSystemsChem Pub Date : 2026-02-18 DOI: 10.1002/syst.202500077

Hiroaki Nishijima, Taizo Ikuta, Hiro Tabata, Takashi Harada, Rika Miyake, Shuji Nakanishi, Yoko Hase

{"title":"Enhanced Ribose-Forming Pathways in the Formose Reaction by Oxometalate Catalysts","authors":"Hiroaki Nishijima, Taizo Ikuta, Hiro Tabata, Takashi Harada, Rika Miyake, Shuji Nakanishi, Yoko Hase","doi":"10.1002/syst.202500077","DOIUrl":"https://doi.org/10.1002/syst.202500077","url":null,"abstract":"<div>\u0000 \u0000 Controlling product selectivity in complex chemical reaction networks (CRNs) remains a major challenge in rational catalyst design, as multiple competing pathways often yield diverse products. The formose reaction, an autocatalytic process that converts formaldehyde (HCHO) into monosaccharides, represents a prototypical nonenzymatic CRN. It has long been investigated in the context of prebiotic chemistry and, more recently, as a system that transforms a C1 compound into higher-carbon species. In this study, we examined the influence of catalysts on pathway selectivity within this reaction network. Sodium tungstate (Na2WO4), which we have previously investigated, produces a product distribution distinct from that obtained with conventional strong base catalysts. Analysis of the aldopentose (C5a) formation pathway revealed that xylose formation predominates under NaOH catalysis, whereas Na2WO4 selectively promotes ribose production. Mechanistic experimental studies and density functional theory (DFT) calculations indicate that WO42− preferentially stabilizes the transition state leading to ribose. These findings demonstrate that understanding catalyst–substrate interactions and identifying the reaction pathways they govern in the formose reaction network enables the prediction of product distributions in complex CRNs.\u0000 </div>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic Cofactors in the Electron Transport Chain: Properties and Connection to the Prebiotic World 电子传递链中的有机辅因子：性质及其与益生元世界的联系

IF 3.1

ChemSystemsChem Pub Date : 2026-02-11 DOI: 10.1002/syst.202500037

Sophia Riazi-Sekowski, Kamilah Bundang, Jordan L. Chastain, Nancy Carman, Seneca J. Velling, John Aguilera, Matt Luna, Cathy Trejo, Osama Alian, Bronwyn L. Teece, Katherine A. Dzurilla, Laura M. Barge, Jessica M. Weber

{"title":"Organic Cofactors in the Electron Transport Chain: Properties and Connection to the Prebiotic World","authors":"Sophia Riazi-Sekowski, Kamilah Bundang, Jordan L. Chastain, Nancy Carman, Seneca J. Velling, John Aguilera, Matt Luna, Cathy Trejo, Osama Alian, Bronwyn L. Teece, Katherine A. Dzurilla, Laura M. Barge, Jessica M. Weber","doi":"10.1002/syst.202500037","DOIUrl":"https://doi.org/10.1002/syst.202500037","url":null,"abstract":"<div>\u0000 \u0000 Metabolism is a critical process for biology and is of great interest to those researching geobiological processes and the origins of life. A metabolism comprises a network of chemical reactions for molecular synthesis, energy conversion pathways, and cellular function. Understanding the mechanisms underlying metabolic processes provides insight into the evolution of electrochemical processes in complex systems and informs the possible pathways by which abiotic chemistry transitioned to biochemistry. Modern enzymes utilize cofactors to mediate chemical reactions and overcome energetic limitations. While enzymes are specific, large, and complex biological proteins, cofactors are simpler ions and molecules incorporated within the larger protein complex. Cofactors play a fundamental role in supplementing an enzyme's catalytic role and may represent a convergence between abiotic and biotic chemistry, allowing studies of cofactors to reveal potential prebiotic processes. Here, we review some of the organic / nucleotide cofactors participating in the electron transport chain (ETC): their structures, capacity for energy conversion, and their putative role in the origins of life. We choose to focus on four specific organic cofactors that have evolved to be key in extant mitochondrial ETCs—adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NADH), flavins (FAD, FMN), and quinones (ubiquinone)—to conceptually bridge the gap between the earliest inorganic cofactors and the protein complexes of modern biochemistry. We then make recommendations for future research topics and avenues.\u0000 </div>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"8 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147268906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0