ChemSystemsChem最新文献

Front Cover: Can Molecular Systems Learn? (ChemSystemsChem 2/2025)

IF 3.1

ChemSystemsChem Pub Date : 2025-03-14 DOI: 10.1002/syst.202580201

Kübra Kaygisiz, Rein V. Ulijn

引用次数: 0

Can Molecular Systems Learn?

IF 3.1

ChemSystemsChem Pub Date : 2025-01-24 DOI: 10.1002/syst.202400075

Kübra Kaygisiz, Rein V. Ulijn

{"title":"Can Molecular Systems Learn?","authors":"Kübra Kaygisiz, Rein V. Ulijn","doi":"10.1002/syst.202400075","DOIUrl":"https://doi.org/10.1002/syst.202400075","url":null,"abstract":"Research across various disciplines shows the benefits of learning and memory for gaining functionality and improving performance. It is increasingly clear that learning and memory can be found in both physical and virtual systems, from intelligent life forms to machines, simple organisms, and even designed chemical systems. We are interested in understanding to what extent physical embodiments of these processes can be synthesized and engineered from the bottom up by using molecular components. In this perspective, we raise and attempt to answer conceptual questions about supramolecular systems as the smallest units capable of learning. We define learning as a process where a complex system of interacting components modifies itself in response to an applied stress or stimulus, resulting in structural changes and information gain. We highlight the potential of systems chemistry and molecular networks to design systems that meet this definition by encoding, decoding, and storing information as memory within the system′s composition. Understanding the physical basis of molecular memory and learning could inform the development of materials and chemical systems that autonomously acquire new properties in response to their environment. This could also provide insights for next-generation computing and physical, rather than virtual, learning systems.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review (ChemSystemsChem 1/2025)

IF 3.1

ChemSystemsChem Pub Date : 2025-01-17 DOI: 10.1002/syst.202580101

Prof. Hiroshi Noguchi

引用次数: 0

Investigating Impacts of Amino Acids on the Structural Stability of Anionic Biomembranes

IF 3.1

ChemSystemsChem Pub Date : 2025-01-08 DOI: 10.1002/syst.202400065

Arslan Siddique, Lauren A. Lowe, Soumya Kanti De, Daniel W. K. Loo, Anton P. Le Brun, Andrew R. J. Nelson, Anna Wang

{"title":"Investigating Impacts of Amino Acids on the Structural Stability of Anionic Biomembranes","authors":"Arslan Siddique, Lauren A. Lowe, Soumya Kanti De, Daniel W. K. Loo, Anton P. Le Brun, Andrew R. J. Nelson, Anna Wang","doi":"10.1002/syst.202400065","DOIUrl":"https://doi.org/10.1002/syst.202400065","url":null,"abstract":"Anionic biomembranes are vital features of all living cells and were perhaps key components of the earliest cell-like structures – protocells. In the absence of evolved protein machinery, any protocell membranes would have had their properties heavily influenced by the ambient environment, posing a systems chemistry challenge to understanding how such membranes functioned. Here we use a range of techniques to examine the effect of glycine and lysine, representative neutral and cationic amino acids, on the properties of model anionic membranes composed of equimolar POPC and POPG. Using QCM−D and neutron reflectometry, we find that unlike glycine, lysine strongly binds to the membrane, resulting in significant lipid loss and changes in the scattering length density and volume fraction of the lipids in the bilayer. Interestingly, we also find that even though lysine causes substantial changes in the physicochemical and structural properties of the anionic membrane, permeability studies show that lysine cannot permeate while glycine can, highlighting a disconnect between the structural changes observed for low curvature systems and the permeability trends observed in high curvature systems. This research provides mechanistic insights into single amino acid-anionic biomembrane interactions, and how they could have impacted evolving protocell membrane functions and stability.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Photostimuli Reach a Selective Intermediate in a Microflow: One-Shot Transformation from a Supramolecular Co-Polymer to a Micro-Disk Structure (ChemSystemsChem 6/2024) 封面光刺激到达微流中的选择性中间体：从超分子共聚物到微盘结构的一次性转化（ChemSystemsChem 6/2024）

IF 3.1

ChemSystemsChem Pub Date : 2024-11-16 DOI: 10.1002/syst.202480601

Akira Kaneyoshi, Shota Nomura, Takato Maeda, Dr. Takahiro Kusukawa, Dr. Yoshihiro Kikkawa, Dr. Munenori Numata

引用次数: 0

Interfacing Complex Coacervates with Natural Cells

IF 3.1

ChemSystemsChem Pub Date : 2024-11-15 DOI: 10.1002/syst.202400071

He Meng, Yanglimin Ji, Yan Qiao

{"title":"Interfacing Complex Coacervates with Natural Cells","authors":"He Meng, Yanglimin Ji, Yan Qiao","doi":"10.1002/syst.202400071","DOIUrl":"https://doi.org/10.1002/syst.202400071","url":null,"abstract":"Coacervates have been investigated as protocells or synthetic cells, as well as subcellular compartments for the creation of new materials, thus bridging the gap between living and non-living systems in materials science, synthetic biology, and bioengineering. Given the design flexibility and simplicity of coacervates, along with the functionality and complexity of natural cells, the interfacing of complex coacervates with natural cells is considered significant for various biotechnological and biomedical applications. In this review, the fundamental mechanisms and underlying theories of coacervate systems are introduced. Recent efforts to interface coacervates with natural cells are summarized in three key scenarios: (i) the integration of coacervates with natural cell components for the living material assembly into protocells; (ii) communication between therapeutic synthetic cells and natural cells for drug delivery and cell repair; and (iii) the formation of intracellular condensates for metabolic regulation, followed by the regulation of their phase transitions for pathological elucidation. Finally, the potential of coacervate-natural cell interfaces is discussed in the context of developing living/synthetic cell constructs, creating precise disease therapy strategies, and advancing programmable metabolic engineering networks.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing and Controlling Transient Supramolecular Gels

IF 3.1

ChemSystemsChem Pub Date : 2024-11-05 DOI: 10.1002/syst.202400073

Emma L. Bowley, Simona Bianco, Fin Hallam Stewart, Chloe M. Wallace, Rebecca E. Ginesi, Alex S. Loch, Martin Rosenthal, Andrew J. Smith, Dave J. Adams

引用次数: 0

Supramolecular Systems Chemistry Based on the Interplay Between Peptides and Porphyrins

IF 3.1

ChemSystemsChem Pub Date : 2024-10-23 DOI: 10.1002/syst.202400068

Yue Fu, Lian Zhang, Xuehai Yan, Kai Liu

引用次数: 0

Shape Analysis of Biomimetic and Plasma Membrane Vesicles

IF 3.1

ChemSystemsChem Pub Date : 2024-10-23 DOI: 10.1002/syst.202400052

Rajni Kudawla, Harshmeet Kaur, Tanmay Pandey, Tripta Bhatia

{"title":"Shape Analysis of Biomimetic and Plasma Membrane Vesicles","authors":"Rajni Kudawla, Harshmeet Kaur, Tanmay Pandey, Tripta Bhatia","doi":"10.1002/syst.202400052","DOIUrl":"https://doi.org/10.1002/syst.202400052","url":null,"abstract":"Giant membrane vesicles (GUVs) and Giant plasma membrane vesicles (GPMVs) are used as models to study membrane properties. We conducted a comparative study to examine how reducing the volume of vesicles with different lipid compositions, solution symmetries, solution asymmetries, and membrane charges affects their morphology. We used three-dimensional visualization techniques to study the shape of the vesicles. Although the vesicles may not be perfectly spherical, they exhibit some fluctuations in their shape. To understand these variations, we used confocal image stacks for visualization. Our experimental observations show that the membrane′s charge influences the deflation of the GUVs in the presence of trans-bilayer sugar asymmetries. The lipid bilayers of our GUVs have a uniform distribution of lipids in both leaflets, indicating no asymmetry in lipid composition. We induce trans-bilayer asymmetries by exposing each leaflet of the bilayer to different solution compositions. We also estimated and compared the deformation of GPMV extracted from HEK-293 cells with trans-bilayer buffer asymmetries and inherent leaflet compositional asymmetry with biomimetic membranes.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially Coded Transformations in Gradient-Dependent Protocell Morphogenesis

IF 3.1

ChemSystemsChem Pub Date : 2024-10-22 DOI: 10.1002/syst.202400064

Shuqi Wu, Wei Ji, Mei Li, Stephen Mann, Liangfei Tian

{"title":"Spatially Coded Transformations in Gradient-Dependent Protocell Morphogenesis","authors":"Shuqi Wu, Wei Ji, Mei Li, Stephen Mann, Liangfei Tian","doi":"10.1002/syst.202400064","DOIUrl":"https://doi.org/10.1002/syst.202400064","url":null,"abstract":"Chemical gradients provide spatiotemporal signaling fields in various cellular processes, driving complex dynamic behaviours such as differentiation and spatial organization. Here we employ opposing gradients of two artificial morphogens (sodium dodecyl sulfate (SDS) and sodium phosphotungstate (polyoxometalate; POM)) to systematically investigate morphological differentiation in organized populations of coacervate microdroplet-based protocells. Using a matrix of 16 sets of counter-diffusive gradients, we classify the differentiated protocells into five phenotypes and encode their spontaneous organization into different spatially patterned protocell consortia using a 3-bit binary information system. We show that a predominant SDS gradient produces a diversity of differentiated phenotypes to generate complex spatially coded 2D protocell organizations. In contrast, a prevailing POM gradient decreases morphological differentiation, resulting in population homogenization. Our results improve our understanding of gradient concentration-dependent collective responses in synthetic microscale agents and provide a step to a new spatially resolved information encoding method with 3-bit binary outputs.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0