ChemSystemsChem最新文献

Front Cover: Micrometer-Sized Liposome-Based Systems: A Hierarchical Breakdown (ChemSystemsChem 3/2025) 封面：微米级脂质体系统：分层分解（chemsystemscheme 3/2025）

IF 3.1

ChemSystemsChem Pub Date : 2025-05-19 DOI: 10.1002/syst.202580301

Prof. Dr. Shogo Hamada, Dr. Hironori Sugiyama, Prof. Dr. Yiting Zhang, Prof. Dr. Shoji Iwabuchi, Soichiro Hiroi, Toshiki Maruyama, Yuktesh Balaji, Sota Kumagai, Prof. Dr. Satoshi Murata, Prof. Dr. Taro Toyota

引用次数: 0

Front Cover: Can Molecular Systems Learn? (ChemSystemsChem 2/2025) 封面：分子系统能学习吗？(ChemSystemsChem 2/2025)

IF 3.1

ChemSystemsChem Pub Date : 2025-03-14 DOI: 10.1002/syst.202580201

Kübra Kaygisiz, Rein V. Ulijn

引用次数: 0

Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models 生命出现的有机反应性：动态障碍和分子多样性被认为是新兴自主系统模型的关键因素

IF 3.1

ChemSystemsChem Pub Date : 2025-03-13 DOI: 10.1002/syst.202400096

Dr. Robert Pascal

{"title":"Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models","authors":"Dr. Robert Pascal","doi":"10.1002/syst.202400096","DOIUrl":"https://doi.org/10.1002/syst.202400096","url":null,"abstract":"The idea that organic chemistry can gradually self-organize towards the emergence of life has been challenged by views considering that the most important driver should be the existence of a crucial thermodynamic disequilibrium. In this work, past views are critically addressed and a mechanism through which disequilibrium can promote the emergence and development of organized systems is suggested. This analysis is based on the propensity of carbon to form covalent bonds with other elements, which usually corresponds to deep energy wells generating high kinetic barriers hindering reactions. Potential energy wells and the associated kinetic barriers are considered as storing a prepaid entropy loss within a potential energy surface and therefore constitute a potential giving room for subsequent self-organization processes. This potential associated with the notion of Kinetically Stable Thermodynamically Activated (KSTA) compounds gives rise to the possibility of alternative pathways based on non-linear autocatalytic processes. As other systems working in a far-from-equilibrium context, like molecular machines, kinetic parameters are crucial for determining how they proceed and how they change, which suggests that interactions between the fields of molecular machines and of the emergence of life could be mutually beneficial.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 4","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Memory in a Three-Reaction Dynamic System 三反应动力学系统中的化学记忆

IF 3.1

ChemSystemsChem Pub Date : 2025-03-10 DOI: 10.1002/syst.202500002

Micaela B. Riera, Dr. Mario O. Salazar, Dr. Ruben M. Maggio, Dr. Ricardo L. E. Furlan

{"title":"Chemical Memory in a Three-Reaction Dynamic System","authors":"Micaela B. Riera, Dr. Mario O. Salazar, Dr. Ruben M. Maggio, Dr. Ricardo L. E. Furlan","doi":"10.1002/syst.202500002","DOIUrl":"https://doi.org/10.1002/syst.202500002","url":null,"abstract":"In systems chemistry, a key goal is to design molecular networks that exhibit emergent behaviors beyond those of their individual components. Dynamic combinatorial libraries (DCLs), which consist of molecular species interconverting through reversible reactions, provide a powerful platform to achieve this. This study introduces a DCL constructed using reversible exchange reactions involving thiols, dithioacetals, thioesters, and disulfides. The library is organized into two distinct yet interconnected layers: one activated under acidic conditions via thiol/dithioacetal exchange, and the other responsive to basic conditions through thiol/thioester/disulfide exchange, with temperature further modulating these processes. The layers operate independently but share thiol intermediates, enabling redistribution of molecular components in response to environmental changes. Transient variations in pH or temperature alter the system's connectivity, driving shifts in its final steady-state composition. Notably, the system encodes information about the nature and timing of these disturbances, which persists even after the external stimuli are removed. This “chemical memory” is reflected in the equilibrium state reached after 24 hours, offering new insights into how dynamic systems can retain environmental information.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 4","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Propulsion of a Benzoic Acid Disk Reflecting the Mesoscopic State of an Amphiphilic Molecular Layer 反映两亲分子层介观状态的苯甲酸圆盘的自推进

IF 3.1

ChemSystemsChem Pub Date : 2025-02-20 DOI: 10.1002/syst.202400088

Risa Fujita, Prof. Dr. Muneyuki Matsuo, Dr. Taizo Mori, Prof. Dr. Takeshi Hasegawa, Prof. Dr. Satoshi Nakata

{"title":"Self-Propulsion of a Benzoic Acid Disk Reflecting the Mesoscopic State of an Amphiphilic Molecular Layer","authors":"Risa Fujita, Prof. Dr. Muneyuki Matsuo, Dr. Taizo Mori, Prof. Dr. Takeshi Hasegawa, Prof. Dr. Satoshi Nakata","doi":"10.1002/syst.202400088","DOIUrl":"https://doi.org/10.1002/syst.202400088","url":null,"abstract":"In this study, we developed a novel self-propulsion system using the mesoscopic state of an amphiphilic molecular layer. A benzoic acid (BA) disk and 4-stearoyl amidobenzoic acid (SABA) were used as the self-propelled object and amphiphile, respectively. The BA disk was driven by the difference in surface tension around it on the aqueous surface, and its motion was influenced by the intermolecular interactions between BA and SABA. Simultaneous Brewster angle microscopy and surface pressure versus area isotherm measurements were performed to evaluate the meso- and macroscopic states of the SABA molecular layer at different temperatures (T) in the aqueous phase. At T = 293 K and 10 ≤ A ≤ 16.8 Å2 molecule−1, the BA disk exhibited linear reciprocating motion due to the homogeneously distributed SABA molecular layer. Conversely, the heterogeneous distribution of SABA domains at T = 303 K and 10 ≤ A ≤ 12.6 Å2 molecule−1 led to ring-shaped reciprocating motion. The SABA molecular layer, which was irreversibly compressed via BA disk motion, acted as a boundary for the BA disk motion. The findings of this study should advance the programming of self-propulsion at the molecular level via the mesoscopic state.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 4","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomous Changes in Polymer Materials Driven by Chemical Fuels 化学燃料驱动下高分子材料的自主变化

IF 3.1

ChemSystemsChem Pub Date : 2025-02-04 DOI: 10.1002/syst.202400090

Chamoni W. H. Rajawasam, Dominik Konkolewicz, C. Scott Hartley

引用次数: 0

Influence of Chemo-Hydrodynamical Oscillations in Bimolecular Reactions on Mixing 双分子反应中化学-流体动力学振荡对混合的影响

IF 3.1

ChemSystemsChem Pub Date : 2025-01-31 DOI: 10.1002/syst.202400099

Adam Bigaj, Dr. Marcello A. Budroni, Prof. Laurence Rongy

引用次数: 0

Can Molecular Systems Learn? 分子系统能学习吗？

IF 3.1

ChemSystemsChem Pub Date : 2025-01-24 DOI: 10.1002/syst.202400075

Kübra Kaygisiz, Rein V. Ulijn

{"title":"Can Molecular Systems Learn?","authors":"Kübra Kaygisiz, Rein V. Ulijn","doi":"10.1002/syst.202400075","DOIUrl":"https://doi.org/10.1002/syst.202400075","url":null,"abstract":"Research across various disciplines shows the benefits of learning and memory for gaining functionality and improving performance. It is increasingly clear that learning and memory can be found in both physical and virtual systems, from intelligent life forms to machines, simple organisms, and even designed chemical systems. We are interested in understanding to what extent physical embodiments of these processes can be synthesized and engineered from the bottom up by using molecular components. In this perspective, we raise and attempt to answer conceptual questions about supramolecular systems as the smallest units capable of learning. We define learning as a process where a complex system of interacting components modifies itself in response to an applied stress or stimulus, resulting in structural changes and information gain. We highlight the potential of systems chemistry and molecular networks to design systems that meet this definition by encoding, decoding, and storing information as memory within the system′s composition. Understanding the physical basis of molecular memory and learning could inform the development of materials and chemical systems that autonomously acquire new properties in response to their environment. This could also provide insights for next-generation computing and physical, rather than virtual, learning systems.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review (ChemSystemsChem 1/2025) 封面：活性蛋白相互作用和化学反应诱导的非平衡膜动力学：综述（chemsystemscheme 1/2025）

IF 3.1

ChemSystemsChem Pub Date : 2025-01-17 DOI: 10.1002/syst.202580101

Prof. Hiroshi Noguchi

引用次数: 0

Micrometer-Sized Liposome-Based Systems: A Hierarchical Breakdown 微米级脂质体系统：分层分解

IF 3.1

ChemSystemsChem Pub Date : 2025-01-13 DOI: 10.1002/syst.202400074

Prof. Dr. Shogo Hamada, Dr. Hironori Sugiyama, Prof. Dr. Yiting Zhang, Prof. Dr. Shoji Iwabuchi, Soichiro Hiroi, Toshiki Maruyama, Yuktesh Balaji, Sota Kumagai, Prof. Dr. Satoshi Murata, Prof. Dr. Taro Toyota

{"title":"Micrometer-Sized Liposome-Based Systems: A Hierarchical Breakdown","authors":"Prof. Dr. Shogo Hamada, Dr. Hironori Sugiyama, Prof. Dr. Yiting Zhang, Prof. Dr. Shoji Iwabuchi, Soichiro Hiroi, Toshiki Maruyama, Yuktesh Balaji, Sota Kumagai, Prof. Dr. Satoshi Murata, Prof. Dr. Taro Toyota","doi":"10.1002/syst.202400074","DOIUrl":"https://doi.org/10.1002/syst.202400074","url":null,"abstract":"Liposomes have attracted attention as a compartment for various synthetic biomolecular systems, including artificial cells and drug delivery carriers. Notably, micrometer-sized liposomes (MSLs) have emerged as a key platform for engineering de novo biomolecular systems, extending beyond their role as model compartments in scientific research. However, there is still a lack of reviews on MSLs from the perspective of artificial systems across various disciplines from basic sciences to applied sciences and to engineering. In this review, we aim to fill this gap by providing a hierarchical breakdown that offers a systematic overview of MSL design and experimental methods. Primarily targeted at readers new to the field, our review presents a unified description of MSL-based functional systems and guidance on experimental details such as lipid composition and preparation methods. Our approach seeks to present a consolidated perspective of functionalized liposomes as an artificial system, contributing to advancements across various disciplines.","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":"7 3","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202400074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0