Cardiology and cardiovascular medicine最新文献_第4页

The Safety of Heparin-Free Strategy in Patients Supported by Venoarterial Extracorporeal Membrane Oxygenation 静脉体外膜氧合支持患者无肝素策略的安全性

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920339

Dong Jung Kim, J. H. Lee, J. S. Kim, C. Lim, Kay-Hyun Park, H. Chang

{"title":"The Safety of Heparin-Free Strategy in Patients Supported by Venoarterial Extracorporeal Membrane Oxygenation","authors":"Dong Jung Kim, J. H. Lee, J. S. Kim, C. Lim, Kay-Hyun Park, H. Chang","doi":"10.26502/fccm.92920339","DOIUrl":"https://doi.org/10.26502/fccm.92920339","url":null,"abstract":"Background: The necessity of heparinization during venoarterial extracorporeal membrane oxygenation (VA-ECMO) is well documented. However, heparinization can increase the risk of bleeding in certain situations. The aim of this study was to investigate the safety of a heparin-free strategy in patients on VA-ECMO. Methods: Data for 90 adult patients on VA-ECMO, wherein cannulation and maintenance were performed by cardiothoracic surgeons and support was provided for >24 h (2018–2021), were retrospectively reviewed. Patients were divided into two groups: heparin-free group, without heparinization for ≥ 24 h during VA-ECMO support (n = 66), and control group (n = 24). Clinical outcomes including hemorrhagic and thromboembolic complications were compared between the two groups. Results: The reasons for VA-ECMO support included post-cardiotomy cardiogenic shock in 37 patients (41.1%), and extracorporeal cardiopulmonary resuscitation in 44 patients (48.9%). The total duration of VA-ECMO was not significantly different between the two groups (132.3±106.1 vs. 141.6±117.9 h, P=0.734). In the heparin-free group, the duration of VA-ECMO without heparinization was 79.8±60.7 h, and 26 patients (39.4%) were completely heparin-free during the support period. No significant difference was found in the frequency of oxygenator changes due to thrombosis between the two groups (8.3 vs. 10.6%, P>0.999). Pump malfunction was not observed in any group. The overall incidence of thromboembolic complications was not significantly different between the two groups. Conclusion: No additional risk of thromboembolic complications was observed with the use of a heparin-free strategy during VA-ECMO support. Appropriate discontinuation of heparinization could be a safe strategy for VA-ECMO patients with active bleeding or a high hemorrhagic risk.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metadichol Treatment of Fibroblasts and Embryonic Stem Cells Regulates Key Cardiac Progenitors 成纤维细胞和胚胎干细胞的二元醇处理调节关键的心脏祖细胞

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920340

Palayakotai R. Raghavan

引用次数: 0

Prevalence and Associated Predictors of Hypertension in Adult Patients with Thyroid Nodules at the Royal Commission Hospital, Kingdom of Saudi Arabia. 沙特阿拉伯王国皇家委员会医院成年甲状腺结节患者高血压患病率及相关预测因素

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.9220303

Ahmed M Khair, Mona A Sid Ahmed, Faisal H Alharbi, Soha Hassan, Nusaiba M Elbadwi, Sami Naji Almutairi, Imad R Musa

{"title":"Prevalence and Associated Predictors of Hypertension in Adult Patients with Thyroid Nodules at the Royal Commission Hospital, Kingdom of Saudi Arabia.","authors":"Ahmed M Khair, Mona A Sid Ahmed, Faisal H Alharbi, Soha Hassan, Nusaiba M Elbadwi, Sami Naji Almutairi, Imad R Musa","doi":"10.26502/fccm.9220303","DOIUrl":"https://doi.org/10.26502/fccm.9220303","url":null,"abstract":"Background: Hypertension and thyroid nodules (TNs) are common medical problems that are increasing in prevalence globally. Hence, we conducted this study to assess the prevalence and associated predictors of hypertension in adult patients with TNs at the Royal Commission Hospital, Kingdom of Saudi Arabia (KSA).Methods: A retrospective study was conducted between 1 January 2015 and 31 December 2021. Patients with documented TNs based on the Thyroid Imaging Reporting and Data System (TI-RADS) were recruited to assess the prevalence and associated risk factors for hypertension.Result: Three hundred ninety-one patients with TNs were recruited for this study. The median (interquartile range, IQR) age was 46.00 (20.0) years, and 332 (84.9%) of the patients were females. The median (IQR) body mass index (BMI) was 30.26 (7.71) kg/m2. There was a high prevalence of hypertension (22.5%) in adult patients with TNs. In the univariate analysis, there were significant associations between diagnosed hypertension in patients with TNs and age, sex, diabetes mellitus (DM), bronchial asthma, triiodothyronine (FT3), total cholesterol and high-density lipoprotein (HDL). In the multivariate analysis, age (OR = 1.076 [95% CI 1.048 - 1.105]), sex (OR = 2.28 [95% CI 1.132 - 4.591]), DM (OR = 0.316 [95% CI 0.175 - 0.573]) and total cholesterol levels (OR = 0.820 [95% CI 0.694 - 0.969]) were significantly associated with hypertension.Conclusion: There is a high prevalence of hypertension in patients with TNs. Age, female sex, DM and elevated total cholesterol are significant predictors of hypertension in adult patients with TNs.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"17-24"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10848880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Sodium-Glucose Cotransporter Inhibitors in the Management of Heart Failure: A Position Statement 钠-葡萄糖共转运蛋白抑制剂在心力衰竭治疗中的作用:立场声明

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920326

P. Mohanan, V. Chopra, R. Yadav, J. Dalal, Mrinal Kanti Das, S. Ray, H. P, P. Kerkar

引用次数: 0

Modified Shock Index to Predict In-Hospital Outcome among Patients Presenting with ST-Segment Elevation Myocardial Infarction 改良休克指数预测st段抬高型心肌梗死患者的住院预后

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920333

M. Asifudduza, N. Ahmed, Md. Owashak Faysal, Rahatul Quadir, Sharmin Ali, Md Rakibul Hasan, Nurul Islam, S. Sultana

{"title":"Modified Shock Index to Predict In-Hospital Outcome among Patients Presenting with ST-Segment Elevation Myocardial Infarction","authors":"M. Asifudduza, N. Ahmed, Md. Owashak Faysal, Rahatul Quadir, Sharmin Ali, Md Rakibul Hasan, Nurul Islam, S. Sultana","doi":"10.26502/fccm.92920333","DOIUrl":"https://doi.org/10.26502/fccm.92920333","url":null,"abstract":"Background: Prompt identification of higher-risk patients presenting with ST-segment elevation myocardial infarction (STEMI) is crucial to pursue a more aggressive approach. Objective: To evaluate the Modified Shock Index (MSI), as a predictor of in-hospital outcome among patients with STEMI. Methods: This cross sectional observational study was carried out in the Department of Cardiology, National Heart Foundation Hospital and Research Institute, Mirpur, Dhaka from January 2020 to December 2020. A total of 100 patients were selected with acute STEMI admitted in the department of Cardiology, NHFH&RI, within the study period, who fulfilled the inclusion and exclusion criteria. Results: The mean age 55.6±10.2 years in Group I and 56.1±12.0 years in Group II. Male patients were predominant in both the groups. Regarding MSI 40(40.0%) patients had high admission MSI (≥0.91) and 60(60.0%) patients had normal admission MSI (<0.91). Regarding risk factors, hypertension, diabetes mellitus, smoking, dyslipidemia and family H/O CAD were not statistically significant (p>0.05) between the two groups. There was a significant (p<0.05) difference observed for NT-pro-BNP which was higher in group I than group II (77.5% vs 40.0%), but other investigations were not statistically significant (p>0.05) between the two groups. LVEF was found lower in Group I than group II (38.0±4.7 percent vs 42.6±5.2 percent), which was statistically significant (p<0.05) between the two groups. Regarding ECG findings 72.5% of patients were found with anterior MI in group I and 33.3% in group II, which was statistically significant (p<0.05) between the two groups. During the period of hospitalization patients in group I developed heart failure more than group II patients (67.5% vs 26.7%, p value=0.001). Development of cardiogenic shock was also significant in group I patients compared to group II patients (57.5% vs","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Dobutamine to Facilitate Induction of Supraventricular Tachycardia Compared to Isoproterenol 与异丙肾上腺素相比，多巴酚丁胺促进诱发室上性心动过速的有效性

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920344

Joseph Donnelly, Ali Seyar Rahyab, Haisam Ismail, Laurence Epstein, Bruce Goldner

{"title":"Effectiveness of Dobutamine to Facilitate Induction of Supraventricular Tachycardia Compared to Isoproterenol","authors":"Joseph Donnelly, Ali Seyar Rahyab, Haisam Ismail, Laurence Epstein, Bruce Goldner","doi":"10.26502/fccm.92920344","DOIUrl":"https://doi.org/10.26502/fccm.92920344","url":null,"abstract":"Background: Isoproterenol has been utilized for the induction of supraventricular and ventricular arrhythmias during electrophysiological (EP) testing. However, with the increasing number of catheter ablations performed and the significant increase in the price of isoproterenol in 2015, the cost implications led us to explore alternatives, although the price of isoproterenol has decreased since 2015. Dobutamine is a synthetic compound which was developed from isoproterenol with a similar ability to enhance conduction and shorten refractoriness of the AV node, thus making it an ideal choice given its lower cost. The effectiveness of dobutamine to facilitate induction of arrhythmias has not been extensively studied. Objective: To evaluate the ability of dobutamine to reproduce the properties of isoproterenol to help facilitate induction of arrhythmias. This study also evaluated the safety of dobutamine. Methods: From January 2014 to January 2017, 174 non-consecutive patients, with a diagnosis of confirmed or suspected supraventricular tachycardia (SVT) were enrolled. Dobutamine was used to induce SVT if patients were non-inducible at baseline using programmed electrical stimulation (PES). Post procedure, dobutamine was","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136003747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncostatin M, Serpins, and Oxidative Stress in Extracellular Matrix Remodeling and Arteriovenous Fistula Maturation. 细胞外基质重塑和动静脉瘘成熟中的抑癌素M、蛇形蛋白和氧化应激。

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920318

Nathaniel DeMarco, Vikrant Rai, Daniel R Wilson, Devendra K Agrawal

{"title":"Oncostatin M, Serpins, and Oxidative Stress in Extracellular Matrix Remodeling and Arteriovenous Fistula Maturation.","authors":"Nathaniel DeMarco, Vikrant Rai, Daniel R Wilson, Devendra K Agrawal","doi":"10.26502/fccm.92920318","DOIUrl":"https://doi.org/10.26502/fccm.92920318","url":null,"abstract":"End-stage renal disease is a crippling diagnosis that generally requires dialysis to prolong life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous fistula (AVF) is commonly performed. Maturation of the AVF is required to allow for successful dialysis. However, AVFs commonly fail to mature, leading to the fistula closure, the necessity for another fistula site, and markedly increased morbidity and mortality. The current literature concerning molecular mechanisms associated with AVF maturation failure supports the role of inflammatory mediators involving immune cells and inflammatory cytokines. However, the role of oncostatin M (OSM), an inflammatory cytokine, and its downstream targets are not well investigated. Through inflammation, oxidative stress, and hypoxic conditions, the vascular tissue surrounding the AVF undergoes fibrosis, stenosis, and wall thickening, leading to complete occlusion and nonfunctional. In this report, first we critically review the existing literature on the role of OSM in the most common causes of early AVF failure - vascular inflammation, thrombosis, and stenosis. We next consider the potential of using OSM as a therapeutic target, and finally discuss therapeutic agents targeting inflammatory mediators involved in OSM signaling to potentiate successful maturation of the AVF.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 2","pages":"129-140"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361734/pdf/nihms-1895006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9861519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Right Ventricular Systolic Dysfunction Using 2D STE to Predict Short Term Outcome in Patients with Heart Failure with Reduced Ejection Fraction 用2D STE评估右心室收缩功能障碍预测心力衰竭伴射血分数降低患者的短期预后

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920336

Md Rakibul Hasan, T. Haque, Nurul Islam, M. Asifudduza, Md. Owashak Faysal, Rahatul Quadir, Sharmin Ali, Hosne Ara Sonia

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Treat to Target ASCVD Risk with Oral Non-statins and Bempedoic Acid: DELPHI Statement 口服非他汀类药物和苯培多酸治疗ASCVD风险:DELPHI声明

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920337

J. Sawhney, S. Ray, Prakash C Hazra, S. Sathe, B. Srinivas, V. Pathak, J. Shah, Kamal Sharma, Ashutosh Kakkad, K. K.

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Clinical Characteristics, Risk Factors and Angiographic Profile of Patients Undergoing Coronary Angiography in A Tertiary Care Hospital 某三级医院冠状动脉造影患者的临床特点、危险因素及血管造影特征

Cardiology and cardiovascular medicine Pub Date : 2023-01-01 DOI: 10.26502/fccm.92920301

Dr. Mohammad Morshedul Ahsan, Dr. Shahidul Haque SM, Dr. Surovi Sultana, Dr. Alok Chandra Sarker, Dr. Md. Shahadat Hossain, Dr. Mohammad Khalilur Rahman Siddiqui, Dr. Abu Baqar Md. Jamil, Dr. Md. Fysal Faruq

引用次数: 0