Cardiology and cardiovascular medicine最新文献

{"title":"Modified Shock Index to Predict In-Hospital Outcome among Patients Presenting with ST-Segment Elevation Myocardial Infarction","authors":"M. Asifudduza, N. Ahmed, Md. Owashak Faysal, Rahatul Quadir, Sharmin Ali, Md Rakibul Hasan, Nurul Islam, S. Sultana","doi":"10.26502/fccm.92920333","DOIUrl":"https://doi.org/10.26502/fccm.92920333","url":null,"abstract":"Background: Prompt identification of higher-risk patients presenting with ST-segment elevation myocardial infarction (STEMI) is crucial to pursue a more aggressive approach. Objective: To evaluate the Modified Shock Index (MSI), as a predictor of in-hospital outcome among patients with STEMI. Methods: This cross sectional observational study was carried out in the Department of Cardiology, National Heart Foundation Hospital and Research Institute, Mirpur, Dhaka from January 2020 to December 2020. A total of 100 patients were selected with acute STEMI admitted in the department of Cardiology, NHFH&RI, within the study period, who fulfilled the inclusion and exclusion criteria. Results: The mean age 55.6±10.2 years in Group I and 56.1±12.0 years in Group II. Male patients were predominant in both the groups. Regarding MSI 40(40.0%) patients had high admission MSI (≥0.91) and 60(60.0%) patients had normal admission MSI (<0.91). Regarding risk factors, hypertension, diabetes mellitus, smoking, dyslipidemia and family H/O CAD were not statistically significant (p>0.05) between the two groups. There was a significant (p<0.05) difference observed for NT-pro-BNP which was higher in group I than group II (77.5% vs 40.0%), but other investigations were not statistically significant (p>0.05) between the two groups. LVEF was found lower in Group I than group II (38.0±4.7 percent vs 42.6±5.2 percent), which was statistically significant (p<0.05) between the two groups. Regarding ECG findings 72.5% of patients were found with anterior MI in group I and 33.3% in group II, which was statistically significant (p<0.05) between the two groups. During the period of hospitalization patients in group I developed heart failure more than group II patients (67.5% vs 26.7%, p value=0.001). Development of cardiogenic shock was also significant in group I patients compared to group II patients (57.5% vs","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Dobutamine to Facilitate Induction of Supraventricular Tachycardia Compared to Isoproterenol","authors":"Joseph Donnelly, Ali Seyar Rahyab, Haisam Ismail, Laurence Epstein, Bruce Goldner","doi":"10.26502/fccm.92920344","DOIUrl":"https://doi.org/10.26502/fccm.92920344","url":null,"abstract":"Background: Isoproterenol has been utilized for the induction of supraventricular and ventricular arrhythmias during electrophysiological (EP) testing. However, with the increasing number of catheter ablations performed and the significant increase in the price of isoproterenol in 2015, the cost implications led us to explore alternatives, although the price of isoproterenol has decreased since 2015. Dobutamine is a synthetic compound which was developed from isoproterenol with a similar ability to enhance conduction and shorten refractoriness of the AV node, thus making it an ideal choice given its lower cost. The effectiveness of dobutamine to facilitate induction of arrhythmias has not been extensively studied. Objective: To evaluate the ability of dobutamine to reproduce the properties of isoproterenol to help facilitate induction of arrhythmias. This study also evaluated the safety of dobutamine. Methods: From January 2014 to January 2017, 174 non-consecutive patients, with a diagnosis of confirmed or suspected supraventricular tachycardia (SVT) were enrolled. Dobutamine was used to induce SVT if patients were non-inducible at baseline using programmed electrical stimulation (PES). Post procedure, dobutamine was","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136003747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncostatin M, Serpins, and Oxidative Stress in Extracellular Matrix Remodeling and Arteriovenous Fistula Maturation.","authors":"Nathaniel DeMarco,&nbsp;Vikrant Rai,&nbsp;Daniel R Wilson,&nbsp;Devendra K Agrawal","doi":"10.26502/fccm.92920318","DOIUrl":"https://doi.org/10.26502/fccm.92920318","url":null,"abstract":"<p><p>End-stage renal disease is a crippling diagnosis that generally requires dialysis to prolong life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous fistula (AVF) is commonly performed. Maturation of the AVF is required to allow for successful dialysis. However, AVFs commonly fail to mature, leading to the fistula closure, the necessity for another fistula site, and markedly increased morbidity and mortality. The current literature concerning molecular mechanisms associated with AVF maturation failure supports the role of inflammatory mediators involving immune cells and inflammatory cytokines. However, the role of oncostatin M (OSM), an inflammatory cytokine, and its downstream targets are not well investigated. Through inflammation, oxidative stress, and hypoxic conditions, the vascular tissue surrounding the AVF undergoes fibrosis, stenosis, and wall thickening, leading to complete occlusion and nonfunctional. In this report, first we critically review the existing literature on the role of OSM in the most common causes of early AVF failure - vascular inflammation, thrombosis, and stenosis. We next consider the potential of using OSM as a therapeutic target, and finally discuss therapeutic agents targeting inflammatory mediators involved in OSM signaling to potentiate successful maturation of the AVF.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 2","pages":"129-140"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361734/pdf/nihms-1895006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9861519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Right Ventricular Systolic Dysfunction Using 2D STE to Predict Short Term Outcome in Patients with Heart Failure with Reduced Ejection Fraction","authors":"Md Rakibul Hasan, T. Haque, Nurul Islam, M. Asifudduza, Md. Owashak Faysal, Rahatul Quadir, Sharmin Ali, Hosne Ara Sonia","doi":"10.26502/fccm.92920336","DOIUrl":"https://doi.org/10.26502/fccm.92920336","url":null,"abstract":"Dysfunction Using 2D STE to Predict","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treat to Target ASCVD Risk with Oral Non-statins and Bempedoic Acid: DELPHI Statement","authors":"J. Sawhney, S. Ray, Prakash C Hazra, S. Sathe, B. Srinivas, V. Pathak, J. Shah, Kamal Sharma, Ashutosh Kakkad, K. K.","doi":"10.26502/fccm.92920337","DOIUrl":"https://doi.org/10.26502/fccm.92920337","url":null,"abstract":"Background: In Asian countries, the high endemicity of Coronary Artery Disease (CAD) has been associated with an increase in premature deaths requiring a multi-interventional or multidisciplinary approach to control the cardiovascular risk traits associated with most of these cases. Objective: ESC recommendations on lipid goals of ≤55 mg/dl in Atherosclerotic cardiovascular disease (ASCVD)","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Risk Factors and Angiographic Profile of Patients Undergoing Coronary Angiography in A Tertiary Care Hospital","authors":"Dr. Mohammad Morshedul Ahsan, Dr. Shahidul Haque SM, Dr. Surovi Sultana, Dr. Alok Chandra Sarker, Dr. Md. Shahadat Hossain, Dr. Mohammad Khalilur Rahman Siddiqui, Dr. Abu Baqar Md. Jamil, Dr. Md. Fysal Faruq","doi":"10.26502/fccm.92920301","DOIUrl":"https://doi.org/10.26502/fccm.92920301","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"182 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indexing of Left Atrial Volume by Body Surface Area and Height in a Brazilian Population without Previous Heart Disease and with a Normal Heart on Echocardiography. Behavior in Obese and Overweight Patients.","authors":"Edmundo J Nassri Camara,&nbsp;Flávia R do Prado Valladares,&nbsp;Ng Kin Key,&nbsp;Paloma Fonseca Santana,&nbsp;Jun Ramos Kawaoka,&nbsp;Thais Harada Campos,&nbsp;Marcus Ribeiro de O Santana,&nbsp;Alex Costa Cunha,&nbsp;Danilo Sousa Sampaio,&nbsp;Gustavo Pinheiro Santana,&nbsp;Luis Gustavo S Brito,&nbsp;Narjara de O Cardoso Dourado,&nbsp;Saulo Jende Nascimento,&nbsp;Alice Povoa A L Lira,&nbsp;Naily N do Nascimento,&nbsp;Romeu Pacheco F Dos Santos,&nbsp;Sérgio Rodrigo F Rocha,&nbsp;Thaise Gordiano Machado","doi":"10.26502/fccm.92920304","DOIUrl":"https://doi.org/10.26502/fccm.92920304","url":null,"abstract":"<p><strong>Background: </strong>Left atrial (LA) volume indexing for body surface area (BSA) may underestimate LA size in obese and overweight people. Since LA volume is a risk marker for some cardiovascular events, it is suggested that indexing for height would be an alternative more appropriate method. The aims of this study were to find normal and the best cutoff values for LA volume indexed for height in our population.</p><p><strong>Methods: </strong>Echocardiograms from 2018 to 2021 were reviewed and patients without known cardiac disease and completely normal echocardiograms that had the left atrial volume (LAvol) measured by biplane Simpson's method were included. LAvol was indexed by BSA (ml/m²), by height (LAvol/m), by height raised to exponent 2.7 (ml/ m^2.7) and by height squared (ml/h²).</p><p><strong>Results: </strong>A total of 545 patients, 50.5 ± 13.4 y., 335 females (61,5%) were analyzed. There were 145 normal weight (26.6%), 215 overweight (39.4%), 154 obese (28.3%) and 31 low weight (5.7%) patients. To establish normal values we included only the normal weight group and considered normal values from 2SD below to 2SD above the mean. Mean and normal values were: LAvol/h 26.0 ±4.5, 17 - 35 ml/m, LAvol/ht² 16 ± 2.8, 10.4 - 21.6 ml/ ht² and LAvol/ht^2.7 11.4 ± 2.2, 7.0 - 15.8 ml/m^2.7. The normal LAvol/ht^2.7 differed between male and female (11.4 ± 2.4 and 12.8 ± 2.6, p < 0.001). LA diameter, LAvol, LAvol/h, LAvol/h² and LAvol/ht^2.7 increased progressively from low-weight, normal weight, overweight and obese patients (p< 0.0001), but not LAvol/BSA. When indexing LAvol for height, for height² and for height^2.7 20.8%, 22.7% and 21.4% of the obese patients, respectively, were reclassified as enlarged LA, and 7.4%, 8.8% and 8.4% of the overweight patients as well. Using ROC curve analysis, LAvol/h² had the highest AUC ant the best predictive value to identify LA enlargement and LAvol/BSA the worst one.</p><p><strong>Conclusions: </strong>Normal values for LAvol indexed for height by three different methods are described in normal individuals. We reinforce that LAvol indexation for BSA underestimates LA size in obese and overweight patients and in these groups, specially, indexing for height² is probably the best method to evaluate LAvol.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9163079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Neutrophil/Albumin Ratio and Leukocyte Count/Albumin Ratio with Ischemic Stroke Severity.","authors":"Sanying Mao, Yuanhong Hu, Xingwu Zheng, Chengmin Yang, Meiling Yang, Xianghong Li, Jingwei Shang, Koji Abe","doi":"10.26502/fccm.92920305","DOIUrl":"10.26502/fccm.92920305","url":null,"abstract":"<p><p>Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END) occurrence remain elusive in acute IS. A total of 299 patients with acute IS and 56 healthy controls were enrolled. According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in five indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. Furthermore, explore the correlation between the above indicators and the severity of IS and END occurrence. The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albumin levels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. NAR and LAR were positively and albumin was negatively correlated with the severity of IS. Meanwhile, NAR and LAR showed a good predictive value in identifying patients with END after acute IS. NAR and LAR may be predictors of the severity of IS and END occurrence after acute IS.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9567343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration.","authors":"Drishtant Singh,&nbsp;Vikrant Rai,&nbsp;Devendra K Agrawal","doi":"10.26502/fccm.92920302","DOIUrl":"https://doi.org/10.26502/fccm.92920302","url":null,"abstract":"<p><p>The structure of connective tissues including cartilage, tendons, and ligaments as well as many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on collagen. The bulk of the network of structural proteins that make up the extracellular matrix of the heart is composed of collagen type I and type III, which provide structural support for the muscle cells and are crucial for cardiac function. The prognosis and progression of a disease or diseased state may be significantly impacted by the upregulation or downregulation of the collagen types, particularly Col I and Col III. For example, increasing Col I protein levels may impose increasing myocardial stiffness, impairing the diastolic and systolic function of the myocardium. Collagen I is a stiff fibrillar protein that gives tensile strength, whereas Col III produces an elastic network that stores kinetic energy as an elastic rebound. These two collagen proteins have distinct physical properties in nature. Therefore, the control of Col I and Col III as well as the potential relevance of the Col I/Col III ratio in many biological processes serve as the foundation for this comprehensive review article.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Faciliated Endovascular Fibrinolysis for Acute Bilateral Pulmonary Embolism in a Patient with SARS-CoV-2 Infection: Case Report","authors":"Hani Al-Terki, T. Paulus, M. Gotzmann, Andreas Mügge","doi":"10.26502/fccm.92920312","DOIUrl":"https://doi.org/10.26502/fccm.92920312","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}