Cardiology and cardiovascular medicine最新文献

{"title":"Indexing of Left Atrial Volume by Body Surface Area and Height in a Brazilian Population without Previous Heart Disease and with a Normal Heart on Echocardiography. Behavior in Obese and Overweight Patients.","authors":"Edmundo J Nassri Camara,&nbsp;Flávia R do Prado Valladares,&nbsp;Ng Kin Key,&nbsp;Paloma Fonseca Santana,&nbsp;Jun Ramos Kawaoka,&nbsp;Thais Harada Campos,&nbsp;Marcus Ribeiro de O Santana,&nbsp;Alex Costa Cunha,&nbsp;Danilo Sousa Sampaio,&nbsp;Gustavo Pinheiro Santana,&nbsp;Luis Gustavo S Brito,&nbsp;Narjara de O Cardoso Dourado,&nbsp;Saulo Jende Nascimento,&nbsp;Alice Povoa A L Lira,&nbsp;Naily N do Nascimento,&nbsp;Romeu Pacheco F Dos Santos,&nbsp;Sérgio Rodrigo F Rocha,&nbsp;Thaise Gordiano Machado","doi":"10.26502/fccm.92920304","DOIUrl":"https://doi.org/10.26502/fccm.92920304","url":null,"abstract":"<p><strong>Background: </strong>Left atrial (LA) volume indexing for body surface area (BSA) may underestimate LA size in obese and overweight people. Since LA volume is a risk marker for some cardiovascular events, it is suggested that indexing for height would be an alternative more appropriate method. The aims of this study were to find normal and the best cutoff values for LA volume indexed for height in our population.</p><p><strong>Methods: </strong>Echocardiograms from 2018 to 2021 were reviewed and patients without known cardiac disease and completely normal echocardiograms that had the left atrial volume (LAvol) measured by biplane Simpson's method were included. LAvol was indexed by BSA (ml/m²), by height (LAvol/m), by height raised to exponent 2.7 (ml/ m^2.7) and by height squared (ml/h²).</p><p><strong>Results: </strong>A total of 545 patients, 50.5 ± 13.4 y., 335 females (61,5%) were analyzed. There were 145 normal weight (26.6%), 215 overweight (39.4%), 154 obese (28.3%) and 31 low weight (5.7%) patients. To establish normal values we included only the normal weight group and considered normal values from 2SD below to 2SD above the mean. Mean and normal values were: LAvol/h 26.0 ±4.5, 17 - 35 ml/m, LAvol/ht² 16 ± 2.8, 10.4 - 21.6 ml/ ht² and LAvol/ht^2.7 11.4 ± 2.2, 7.0 - 15.8 ml/m^2.7. The normal LAvol/ht^2.7 differed between male and female (11.4 ± 2.4 and 12.8 ± 2.6, p < 0.001). LA diameter, LAvol, LAvol/h, LAvol/h² and LAvol/ht^2.7 increased progressively from low-weight, normal weight, overweight and obese patients (p< 0.0001), but not LAvol/BSA. When indexing LAvol for height, for height² and for height^2.7 20.8%, 22.7% and 21.4% of the obese patients, respectively, were reclassified as enlarged LA, and 7.4%, 8.8% and 8.4% of the overweight patients as well. Using ROC curve analysis, LAvol/h² had the highest AUC ant the best predictive value to identify LA enlargement and LAvol/BSA the worst one.</p><p><strong>Conclusions: </strong>Normal values for LAvol indexed for height by three different methods are described in normal individuals. We reinforce that LAvol indexation for BSA underestimates LA size in obese and overweight patients and in these groups, specially, indexing for height² is probably the best method to evaluate LAvol.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"25-31"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9163079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Analysis of Neutrophil/Albumin Ratio and Leukocyte Count/Albumin Ratio with Ischemic Stroke Severity.","authors":"Sanying Mao, Yuanhong Hu, Xingwu Zheng, Chengmin Yang, Meiling Yang, Xianghong Li, Jingwei Shang, Koji Abe","doi":"10.26502/fccm.92920305","DOIUrl":"10.26502/fccm.92920305","url":null,"abstract":"<p><p>Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END) occurrence remain elusive in acute IS. A total of 299 patients with acute IS and 56 healthy controls were enrolled. According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in five indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. Furthermore, explore the correlation between the above indicators and the severity of IS and END occurrence. The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albumin levels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. NAR and LAR were positively and albumin was negatively correlated with the severity of IS. Meanwhile, NAR and LAR showed a good predictive value in identifying patients with END after acute IS. NAR and LAR may be predictors of the severity of IS and END occurrence after acute IS.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9567343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration.","authors":"Drishtant Singh,&nbsp;Vikrant Rai,&nbsp;Devendra K Agrawal","doi":"10.26502/fccm.92920302","DOIUrl":"https://doi.org/10.26502/fccm.92920302","url":null,"abstract":"<p><p>The structure of connective tissues including cartilage, tendons, and ligaments as well as many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on collagen. The bulk of the network of structural proteins that make up the extracellular matrix of the heart is composed of collagen type I and type III, which provide structural support for the muscle cells and are crucial for cardiac function. The prognosis and progression of a disease or diseased state may be significantly impacted by the upregulation or downregulation of the collagen types, particularly Col I and Col III. For example, increasing Col I protein levels may impose increasing myocardial stiffness, impairing the diastolic and systolic function of the myocardium. Collagen I is a stiff fibrillar protein that gives tensile strength, whereas Col III produces an elastic network that stores kinetic energy as an elastic rebound. These two collagen proteins have distinct physical properties in nature. Therefore, the control of Col I and Col III as well as the potential relevance of the Col I/Col III ratio in many biological processes serve as the foundation for this comprehensive review article.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 1","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Faciliated Endovascular Fibrinolysis for Acute Bilateral Pulmonary Embolism in a Patient with SARS-CoV-2 Infection: Case Report","authors":"Hani Al-Terki, T. Paulus, M. Gotzmann, Andreas Mügge","doi":"10.26502/fccm.92920312","DOIUrl":"https://doi.org/10.26502/fccm.92920312","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between ECG Changes and Coronary Angiographic Findings in Patient with Inferior Myocardial Infarction in a Tertiary Care Hospital","authors":"Shaikh Md. Shahidul Haque, Mohammad Morshedul Ahsan, Alok Chandra Sarker, Md, Shahadat Hossain, Md, Abu Baqar Md, Jamil Shahriar Kabir","doi":"10.26502/fccm.92920313","DOIUrl":"https://doi.org/10.26502/fccm.92920313","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Diagnosis through Diastolic Hyperemia-Free Ratio (DFR) over Fractional Flow Reserve (FFR) in Intermediate Coronary Lesions.","authors":"Muralidharan Thoddi Ramamurthy,&nbsp;Vinod Kumar Balakrishnan,&nbsp;Mano Vikash Vallivedu,&nbsp;Nagendra Boopathy Senguttuvan,&nbsp;Panchanatham Manokar,&nbsp;Ramesh Sankaran,&nbsp;Shanmugasundaram Sadhanandham,&nbsp;Jayanthi Venkata Balasubramaniyan,&nbsp;Jebaraj Rathinasamy,&nbsp;Preetam Krishnamurthy,&nbsp;Sandhya Sundaram,&nbsp;Jayanthi Sri Sathiyanarayana Murthy,&nbsp;Sadagopan Thanikachalam,&nbsp;Steven Pogwizd,&nbsp;John R Hoidal,&nbsp;Rajasekaran Namakkal-Soorappan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the fractional flow reserve (FFR) and diastolic hyperemia-free ratio (DFR) measurements in a population with intermediate coronary artery stenosis and improve the diagnosis.</p><p><strong>Background: </strong>Visual assessment of coronary artery stenosis severity, particularly in intermediate lesions, is prone to errors in decision-making. FFR provides a reliable assessment of functional severity in these cases but requires hyperemia induction by adenosine, which has side effects and increased cost. DFR is a novel hyperemia-independent index, which could be used as an alternative to adenosine-based hyperemia induction.</p><p><strong>Methods and results: </strong>Between September 2019 to March 2020, 25 patients with 38 intermediate coronary stenotic lesions were included in the study. All patients underwent assessment of whole cycle Pd/Pa (ratio of distal coronary pressure to proximal aortic pressure), DFR and FFR. Mean whole cycle Pd/Pa, DFR and FFR were 0.93±0.06, 0.88±0.09, and 0.85±0.08, respectively. A significant positive correlation between DFR and FFR [r = 0.74; p<0.001] was observed. Receiver operating characteristic analysis showed an area under the curve of 0.90. DFR-only strategy with a treatment cut-off of ≤0.89 showed a diagnostic agreement with the FFR-only strategy in 74% of lesions, with a sensitivity of 54%, specificity of 82%, a positive predictive value of 60%, and a negative predictive value of 79%.</p><p><strong>Conclusions: </strong>Real-time DFR measurements show a clinically reliable correlation with FFR. Hence, using DFR is likely to avoid adenosine administration as well as reduce the cost and procedural time. Further studies with a larger sample size would be ideal to evaluate specific cut-off values and endpoints.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 2","pages":"108-116"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409495/pdf/nihms-1890200.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10344169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety and Efficacy of Ultrasound-Accelerated-Catheter-Directedthrombolysis with Urokinase in Patients with Intermediate-High Risk Pulmonary Embolism","authors":"Hani Al-Terki, T. Paulus, M. Gotzmann, Andreas Mügge","doi":"10.26502/fccm.92920311","DOIUrl":"https://doi.org/10.26502/fccm.92920311","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Thresholds for Emerging Cardiometabolic Risk Markers of Elevated Carotid Intima – Media Thickness (Cimt) in Uncontrolled Hypertensive Patients in A Hospital Setting in Kinshasa, Dr Congo","authors":"Yanda Tongo Stéphane, Longo-Mbenza Benjamin, Lelo Tshikwela Michel, Mawalala Malengele Héritier, Tshimpi Wola Antoine, Makulo Risasi Jean Robert, Kisoka Lusunsi Christian, Monkondjimobe Etienne","doi":"10.26502/fccm.92920342","DOIUrl":"https://doi.org/10.26502/fccm.92920342","url":null,"abstract":"Background: Acute rheumatic fever (ARF) is an important public health problem in developing countries. Subclinical carditis (SCC) that is detected only by echocardiogram without audible heart murmurs is relatively common in ARF. The aim of this study was to determine the pattern of SCC in patients of ARF in a specialized center in Bangladesh.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"242 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135441054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the Trendelenburg Maneuver on Right Ventricular Pressure- Volume Relationship","authors":"Tjörvi E Perry, A. Shaffer, G. Hiremath","doi":"10.26502/fccm.92920308","DOIUrl":"https://doi.org/10.26502/fccm.92920308","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Metabolic Syndrome on Coronary Microvascular Dysfunction: A Single Center Experience","authors":"V. Sucato, C. Madaudo, Luca Di Fazio, G. Manno, G. Vadalà, S. Novo, S. Evola, G. Novo, Alfredo Ruggero Galassi","doi":"10.26502/fccm.92920320","DOIUrl":"https://doi.org/10.26502/fccm.92920320","url":null,"abstract":"Coronary microvascular dysfunction (CMD) represents a widespread condition and a prevalent cause of ischemic heart disease. Total TIMI frame count (TTFC) can be a good indicator of CMD in different populations. The aim of our study was to evaluate the incidence of CMD in different populations such as METS patients compared with diabetic and hypertensive patients. The study was carried out on patients with chest pain and/or positive stress test and angiographically undamaged coronary arteries. Our CMD population was divided into three subgroups; patients with arterial hypertension, patients with type II diabetes mellitus and patients with metabolic syndrome. TIMI Frame Count (TFC) and Myocardial Blush Grade (MBG) are indices used to evaluate the degree of microcirculatory dysfunction, in particular the TIMI frame count and the Myocardial Blush degree. Patients with Mets had worse coronary perfusion indices with a higher TFC than the hypertensive population (LAD TFC 33.1 ± 5.6 vs 28.4 ± 5.6 p = 0.018), (TFC RCA 27.2 ± 5.2 vs 23.1 ± 5.2 p = 0.014) (TFC CX 27.9 ± 5.4 vs 26.9 ± 5.4 p = 0.03). However, no differences were found in the three coronary vessels in terms of MBG which, however, was reduced in both groups (7.1 ± 0.49 versus 7.1 ± 0.6 p-value = 0.04). According to the TTFC patients with Mets had worse coronary perfusion than patients with type II diabetes (LAD TFC 33.1 ± 5.6 vs 30.6 ± 6.2 p = 0.04), (TFC RCA 27, 2 ± 5.2 vs 25 ± 5.3 p = 0.02), (TFC CX 27.9 ± 5.4 vs 27.2 ± 5.6 p = 0.05) while MBG was lower in patients with diabetes. In our study, we observed that patients with MetS had slower coronary blood flow using TFC imaging technique analysis than diabetic or hypertensive patients. These indices could help in the diagnosis and management of CMD.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}