Cardiology and cardiovascular medicine最新文献

{"title":"False Atrial Fibrillation Alerts from Smartwatches are Associated with Decreased Perceived Physical Well-being and Confidence in Chronic Symptoms Management.","authors":"Khanh-Van Tran, Andreas Filippaios, Kamran Noorishirazi, Eric Ding, Dong Han, Fahimeh Mohagheghian, Qiying Dai, Jordy Mehawej, Ziyue Wang, Darleen Lessard, Edith Mensah Otabil, Alex Hamel, Tenes Paul, Matthew F Gottbrecht, Timothy P Fitzgibbons, Jane Saczynski, Ki H Chon, David D McManus","doi":"10.26502/fccm.92920314","DOIUrl":"10.26502/fccm.92920314","url":null,"abstract":"<p><p>Wrist-based wearables have been FDA approved for AF detection. However, the health behavior impact of false AF alerts from wearables on older patients at high risk for AF are not known. In this work, we analyzed data from the Pulsewatch (NCT03761394) study, which randomized patients (≥50 years) with history of stroke or transient ischemic attack to wear a patch monitor and a smartwatch linked to a smartphone running the Pulsewatch application vs to only the cardiac patch monitor over 14 days. At baseline and 14 days, participants completed validated instruments to assess for anxiety, patient activation, perceived mental and physical health, chronic symptom management self-efficacy, and medicine adherence. We employed linear regression to examine associations between false AF alerts with change in patient-reported outcomes. Receipt of false AF alerts was related to a dose-dependent decline in self-perceived physical health and levels of disease self-management. We developed a novel convolutional denoising autoencoder (CDA) to remove motion and noise artifacts in photoplethysmography (PPG) segments to optimize AF detection, which substantially reduced the number of false alerts. A promising approach to avoid negative impact of false alerts is to employ artificial intelligence driven algorithms to improve accuracy.</p>","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"7 2","pages":"97-107"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Analysis of CYP2C19 Alleles and Clopidogrel Resistance Among Bangladeshi Patients with Acute Coronary Syndrome","authors":"Mohsin Ahmed, Sayeedur Rahman Khan, Aminur Razzaque, M. Arifur Rahman, S. Islam, Mainul Islam, Monwarul Islam AKM, Mohammad Ullah Firoze, Md. Matiur Rahman, T. Ahmad, Kudrat-E-Khuda Cm, Shiblee Sa","doi":"10.26502/fccm.92920321","DOIUrl":"https://doi.org/10.26502/fccm.92920321","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Post-Operative Electrocardiographic (ECG) Changes Indicate any Underlying Graft Problem after CABG? Correlation of Early Post-Operative ECG Changes with CT Coronary Angiography (CTCA)","authors":"Abhishek Rajendra Potnis, S. Potwar, B. Aironi, Dwarkanath Vivekanand Kulkarni, U. E. Jadhav, Gaurish Omprakash Sawant","doi":"10.26502/fccm.92920323","DOIUrl":"https://doi.org/10.26502/fccm.92920323","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Coronary Sinus Flutter: A Unique Form of an Atypical Atrial Flutter. A Case Report","authors":"A. Ziakos, H. Greiss, Angelis Sezenias, A. Sause","doi":"10.26502/fccm.92920307","DOIUrl":"https://doi.org/10.26502/fccm.92920307","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocarditis in COVID-19 Patients: A Cross-Sectional Study","authors":"","doi":"10.26502/fccm.92920316","DOIUrl":"https://doi.org/10.26502/fccm.92920316","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapagliflozin and Sitagliptin Combination Therapy: An Overview of Clinical Utility in Type 2 Diabetes Mellitus with Multiple Cardiovascular Risk Factors","authors":"L. Ravikumar, Ravindra S Kiwalkar, R. H. S., Beerakayala Lokesh, Dhammdeep C. Dabhade","doi":"10.26502/fccm.92920319","DOIUrl":"https://doi.org/10.26502/fccm.92920319","url":null,"abstract":"Cardiovascular disease remains the leading cause of mortality in patients with diabetes. Control of multiple cardiovascular risk factors in patients with type 2 diabetes mellitus often leads to substantial reduction in adverse cardiovascular events. Newer antihyperglycemic agents at several randomized controlled trials have demonstrated their cardiovascular safety along with reduction in cardiovascular outcomes in type 2 diabetes mellitus with or without heart failure. Sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors reported to have positive CV outcomes; especially, combination therapy with dapagliflozin and sitagliptin seem to be suitable therapeutic option. However, data upon the fixed-dose combination of these agents is limited. This review discusses the rationale and clinical utility of combination therapy with dapagliflozin and sitagliptin in improving glycemic control and reducing cardiovascular events in patients with type 2 diabetes mellitus with multiple cardiovascular risk factors.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiographic Findings in Unstable Angina and Prediction of 1-Year Risk of Recurrent Acute Coronary Syndrome or Death: A Nationwide Machine Learning Study","authors":"T. Råmunddal, A. Rawshani, B. Redfors, P. Pétursson, O. Angerås, G. Hirlekar, D. Ioanes, J. Odenstedt, C. Dworeck, S. Völz, A. Myredal","doi":"10.26502/fccm.92920330","DOIUrl":"https://doi.org/10.26502/fccm.92920330","url":null,"abstract":"Background: We studied whether machine learning could predict survival, risk of future acute coronary syndrome (ACS) and coronary angiographic (CAG) findings in patients with unstable angina (UA). We also studied whether high-sensitivity troponin levels within normal range can predict the presence of obstructive coronary lesions, risk of future ACS and death. Methods: We used the SWEDEHEART registry to include patients admitted to the coronary care unit due to chest pain, with normal high-sensitivity cardiac troponin T or I (hs-cTnI, hs-cTnT), who underwent CAG and did not receive a final diagnosis of acute myocardial infarction (AMI). We studied CAG findings on segmental level, developed machine learning models predicting the risk of ACS or death within 1-year, and angiographic findings. The latter model predicted CAG resulting in interventions (any) or eliciting further assessments after CAG. Models for ACS and death included 130 candidate predictors and models for angiographic findings included 110 predictors. Results: We included 9’314 patients; 1-year rate of death was 0.9% (n=78) and ACS was 2.7% (n=251). A total of 5455 (61.5%) of CAG resulted in no intervention and no further assessment afterwards, with 40% without significant stenosis. There was a strong association between hs-cTnI (within normal range) and severity of coronary atherosclerosis; e.g 32.4% in patients with hs-cTnI 26-35 ng/L had >50% stenosis in segment 6, as compared with 12.6% in those with hs-cTnI 0-5 ng/L. All segments displayed similar associations with troponin levels. Among 17 predictors for atherosclerosis, hs-cTnI was the strongest predictor of having >50% stenosis in the left anterior descending artery (LAD). Mortality increased at hs-cTnI levels above 10 ng/L for men, but not women. Age and sex adjusted hazard ratio for hs-cTnI 25-35 vs hs-TnI 0-5 was 5.73 (2.14-15.35) for 1-year mortality. No association was noted for hs-cTnT. The strongest predictors of 1-year mortality were C-reactive protein, body mass index, estimated glomerular filtration rate.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergy among Genes and Genes-Environment on Coronary Artery Disease Risk and Prognosis","authors":"M. Mendonça, M. Santos, M. Temtem, Débora Sá, F. Sousa, E. Henriques, S. Freitas, S. Borges, M. Rodrigues, G. Guerra, A. Drumond, A. C. Sousa, R. Palma Reis","doi":"10.26502/fccm.92920332","DOIUrl":"https://doi.org/10.26502/fccm.92920332","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety of Heparin-Free Strategy in Patients Supported by Venoarterial Extracorporeal Membrane Oxygenation","authors":"Dong Jung Kim, J. H. Lee, J. S. Kim, C. Lim, Kay-Hyun Park, H. Chang","doi":"10.26502/fccm.92920339","DOIUrl":"https://doi.org/10.26502/fccm.92920339","url":null,"abstract":"Background: The necessity of heparinization during venoarterial extracorporeal membrane oxygenation (VA-ECMO) is well documented. However, heparinization can increase the risk of bleeding in certain situations. The aim of this study was to investigate the safety of a heparin-free strategy in patients on VA-ECMO. Methods: Data for 90 adult patients on VA-ECMO, wherein cannulation and maintenance were performed by cardiothoracic surgeons and support was provided for >24 h (2018–2021), were retrospectively reviewed. Patients were divided into two groups: heparin-free group, without heparinization for ≥ 24 h during VA-ECMO support (n = 66), and control group (n = 24). Clinical outcomes including hemorrhagic and thromboembolic complications were compared between the two groups. Results: The reasons for VA-ECMO support included post-cardiotomy cardiogenic shock in 37 patients (41.1%), and extracorporeal cardiopulmonary resuscitation in 44 patients (48.9%). The total duration of VA-ECMO was not significantly different between the two groups (132.3±106.1 vs. 141.6±117.9 h, P=0.734). In the heparin-free group, the duration of VA-ECMO without heparinization was 79.8±60.7 h, and 26 patients (39.4%) were completely heparin-free during the support period. No significant difference was found in the frequency of oxygenator changes due to thrombosis between the two groups (8.3 vs. 10.6%, P>0.999). Pump malfunction was not observed in any group. The overall incidence of thromboembolic complications was not significantly different between the two groups. Conclusion: No additional risk of thromboembolic complications was observed with the use of a heparin-free strategy during VA-ECMO support. Appropriate discontinuation of heparinization could be a safe strategy for VA-ECMO patients with active bleeding or a high hemorrhagic risk.","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metadichol Treatment of Fibroblasts and Embryonic Stem Cells Regulates Key Cardiac Progenitors","authors":"Palayakotai R. Raghavan","doi":"10.26502/fccm.92920340","DOIUrl":"https://doi.org/10.26502/fccm.92920340","url":null,"abstract":"","PeriodicalId":72523,"journal":{"name":"Cardiology and cardiovascular medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}