Actas espanolas de psiquiatria最新文献

{"title":"Integrating Dialectical Behaviour Therapy Into the Treatment of Adolescent Depression: A Retrospective Study.","authors":"Caiqin Xi, Xiaomei Jiang, Yanyan He, Yinping Liu, Huahua An, Keyi Shang, Xiaojing Ma, Dong Ren","doi":"10.62641/aep.v53i4.1963","DOIUrl":"10.62641/aep.v53i4.1963","url":null,"abstract":"<p><strong>Background: </strong>Globally, the prevalence of depression among adolescents is on the rise, posing serious societal problems. Dialectical behaviour therapy (DBT) and selective serotonin reuptake inhibitors (SSRIs), such as sertraline, are two commonly employed therapeutic approaches that have shown good clinical outcomes. This study aims to investigate the therapeutic effects of DBT with or without sertraline on adolescent depression.</p><p><strong>Methods: </strong>This retrospective analysis reviewed 88 cases of adolescent depression treated at our hospital and compared them with 60 healthy adolescents. The patients with depression were divided into three groups: sertraline alone, DBT alone, and combined DBT and sertraline (DBT+sertraline) treatment. In the Sertraline-only and DBT+sertraline groups, sertraline was administered orally for a continuous period of 24 weeks. In the DBT-only and the DBT+sertraline groups, DBT treatment lasted for 13 weeks, followed by an observation period of another 11 weeks. DBT treatment efficacy was evaluated using the Hamilton Depression Rating Scale (HAMD) and the Cognitive Emotion Regulation Questionnaire (CERQ) at baseline and after 5, 9, 13 and 24 weeks of treatment.</p><p><strong>Results: </strong>Results showed that all three treatment modalities significantly reduced HAMD scores (p < 0.001, η = 0.749). The combined treatment group achieved the fastest reduction in HAMD score at the initial treatment stage. Whilst the Sertraline group showed a pronounced reduction by Week 13, it later exhibited a rebound in scores at 24 weeks, unlike the DBT-containing groups. In terms of emotional regulation strategies, CERQ scores indicated that DBT+sertraline significantly increased positive emotional regulation strategy scores, followed by DBT alone (DBT+sertraline vs DBT, p < 0.001), whilst the sertraline-alone group had the smallest increase (DBT+sertraline vs sertraline, p < 0.001) This pattern was particularly pronounced in the Positive Reappraisal subscale. Negative emotional regulation strategy scores were significantly reduced across all treatment groups, especially for the Self-blame item, with the largest reduction observed in the DBT+sertraline group, followed by the DBT alone (DBT+sertraline vs DBT, no significance) and sertraline-alone (DBT+sertraline vs sertraline, p < 0.001) groups.</p><p><strong>Conclusions: </strong>This study's findings demonstrate that DBT and sertraline can improve emotional regulation abilities and effectively alleviate symptoms of depression in adolescents. In particular, superior outcomes were observed in the combined treatment group compared to the individual treatment groups. These findings aim to provide guidance and reference for clinicians, mental health professionals, policymakers and families of patients.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 4","pages":"701-714"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sources of Stigma and its Relation to Internalized Stigma in Women with Borderline Personality Disorder.","authors":"Elia Solís-Villegas, María Yoldi-Negrete, Iván Arango de Montis, Ilyamín Merlín-García, Carlos-Alfonso Tovilla-Zárate, Ana Fresán","doi":"10.62641/aep.v53i4.1926","DOIUrl":"10.62641/aep.v53i4.1926","url":null,"abstract":"<p><strong>Background: </strong>Borderline personality disorder (BPD) has a high prevalence, presenting with self-injurious behaviors, suicide attempts and other psychiatric comorbidities. This condition is accompanied by high levels of stigma and self-stigma, driving to deleterious effects on prognosis. The present study aimed to compare demographic and clinical characteristics of women diagnosed with BPD with low and high internalized stigma and to address internalized stigma dimensions severity (disclosure, positive aspects, and discrimination) between the source of perceived stigma.</p><p><strong>Methods: </strong>A total of 106 women with a diagnosis of BPD were evaluated for sociodemographic data, sources of stigma, the severity of the symptomatology and internalized stigma, evaluated with the Borderline Evaluation of Severity Over Time (BEST) and the Spanish version of King's Internalized Stigma Scale (ISS), respectively.</p><p><strong>Results: </strong>Participants with high internalized stigma reported greater symptom severity. Regarding the reported sources of stigma, in almost all sources of stigma, discrimination was perceived as greater (p < 0.05) (friends, co-workers, doctors, psychiatrists and nurses) as well as the perceived global internalized stigma (p < 0.05) for friends, co-workers and nursing staff.</p><p><strong>Conclusion: </strong>It is necessary to address stigmatizing behaviors by health personnel and the support network close to the patient in addition to improving awareness about associated internalized stigma which is related to worse outcomes.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 4","pages":"683-692"},"PeriodicalIF":1.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Prevalence of Mild Cognitive Impairment and its Influencing Factors in the Elderly Population in Huzhou City.","authors":"Weiliang He, Zheli Chen, Liang Xu, Fei Fang, Xin Zu, Xilong Jin, Jing Chen","doi":"10.62641/aep.v53i3.1722","DOIUrl":"10.62641/aep.v53i3.1722","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) is a critical stage in the development of Alzheimer's disease, and early intervention in patients during this stage may reverse or delay their disease progression. As one of the regions with severe aging in China, it is necessary to understand the prevalence of MCI in Huzhou and adopt effective intervention measures. The study was aimed to investigate the prevalence rate and influencing factors of MCI in the elderly population in Huzhou city.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 800 elderly residents of Huzhou city. The Montreal Cognitive Assessment (MoCA) and the activity of daily living (ADL) were used to assess the occurrence of MCI in the elderly. The influencing factors of MCI were investigated by univariate analysis and multi-factor analysis.</p><p><strong>Results: </strong>A total of 800 questionnaires were sent out in this survey, and 778 were effectively collected, with an effective recovery rate of 97.25%. Among 778 elderly people in Huzhou city, 668 had normal cognitive function, 82 had MCI, and 28 had dementia, the prevalence rate of MCI was 10.54% (82/778). According to the presence or absence of MCI, the patients were divided into an MCI group (n = 82) and a non-MCI group (n = 668). Female (p = 0.026), high age (p = 0.009), low Community Screening Instrument for Dementia (CSI-D) score (p = 0.007), high Dementia Screening Questionnaire (AD8) score (p < 0.001), high Patient Health Questionnaire Depression Scale (PHQ-9) score (p = 0.037) were all risk factors for MCI in the urban elderly population of Huzhou City.</p><p><strong>Conclusion: </strong>The prevalence of MCI in the elderly population in Huzhou City is high, and its occurrence is closely related to many factors. It is necessary to increase attention to the high-risk population of MCI and implement targeted intervention measures to improve their cognitive function and improve the quality of life of the elderly population.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"526-534"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of the Oxytocin System in the Hypothalamic Paraventricular Nucleus Improves Stress-Induced Postpartum Depression-Like Behavior in Rats.","authors":"Jingjing Dang, Huihui Kuai, Siqi Zhou, Shanshan Guo, Jingyi Sheng, Zhiping Wang","doi":"10.62641/aep.v53i3.1773","DOIUrl":"10.62641/aep.v53i3.1773","url":null,"abstract":"<p><strong>Background: </strong>Oxytocin (OT) is a key molecule that not only acts as a uterine-contracting hormone during delivery but is also a critical maternal hormone that enables the social transmission of maternal behavior. Postpartum depression (PPD) is a series of depression-like symptoms that occur especially in women in the perinatal period and is accompanied by the failure to adapt to motherhood as well as impaired parent-infant bonding. However, the mechanism by which OT regulates PPD is still unclear. This study aimed to investigate the correlation between OT levels in the paraventricular nucleus (PVN) and PPD and to explore the potential mechanism underlying the involvement of the OT system in the regulation of PPD.</p><p><strong>Methods: </strong>We induced perinatal chronic stress in pregnant rats to establish a PPD model. OT levels in the cerebrospinal fluid (CSF) and PVN were measured throughout the perinatal period. We administered the chemogenetic virus hM3Dq into the PVN, intraperitoneally injected N-oxyclozapine to activate OT-secreting neurons, and observed the effects of OT treatment on behaviors related to PPD. Finally, we investigated the potential mechanism underlying PPD regulation by the OT system via transmission electron microscopy, immunofluorescence (IF), and quantitative real-time PCR (qRT-PCR).</p><p><strong>Results: </strong>Compared with those in the normal group, CSF oxytocin levels in the postpartum depression group decreased from late pregnancy to lactation (p < 0.001). Chemogenetic activation-induced endogenous OT release in the PVN not only alleviated PPD-like symptoms in rats but also enhanced the intracellular production of OT. Transmission electron microscopy revealed an increase in the size of the Golgi apparatus, endoplasmic reticulum, and dense vesicles within OT neurons. IF and qRT-PCR revealed elevated OT levels and increased oxytocin expression within the PVN following chemogenetic activation (p < 0.01).</p><p><strong>Conclusion: </strong>Lower OT levels are strongly associated with the occurrence of PPD. The release of activated OT has been shown to improve PPD-like behaviors in rats and promote intracellular OT synthesis.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"504-515"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duloxetine: The Next Gold Standard for Treating Depression and Motor Symptoms in Parkinson's Disease?","authors":"Guilherme Nobre Nogueira","doi":"10.62641/aep.v53i3.1864","DOIUrl":"10.62641/aep.v53i3.1864","url":null,"abstract":"<p><p>No abstract present.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"638-639"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Omicron-related Stress on Mental Health in the General Population of China.","authors":"WenYan Zhao, YuLiang Zhou, YingYing Hu, Jing Wang, Hong Zhu, YaHong Li, ZhiPeng Xu","doi":"10.62641/aep.v53i3.1831","DOIUrl":"10.62641/aep.v53i3.1831","url":null,"abstract":"<p><strong>Background: </strong>Outbreaks of infectious disease represent unique stressors for the general population. In this study, we investigated the prevalence of mental health symptoms and associated risk factors in the general population of China during the Omicron wave.</p><p><strong>Methods: </strong>We conducted a cross-sectional and large sample online survey during the surge of Omicron cases between 17 December 2022 and 8 January 2023 among Chinese citizens. Then we assessed the prevalence of symptoms of anxiety, depression, insomnia, acute stress disorder, and resilience levels, in the general population of China during the Omicron pandemic by utilizing the coronavirus disease 2019 (COVID-19) anxiety scale (CAS), the Center for Epidemiologic Studies Depression Scale (CES-D), the Insomnia Severity Index scale (ISI), the Stanford Acute Stress Reaction Questionnaire (SASRQ), and the Connor-Davidson Resilience Scale (CD-RISC). Multivariate logistic regression analyses were used to identify demographic and Omicron-related risk factors.</p><p><strong>Results: </strong>In total, 2800 respondents across 32 provinces and autonomous regions on the Chinese mainland participated in this survey; 1133 (40.5%) were male, and 1860 (66.4%) were 40 years-of-age or younger. The prevalence of anxiety, depression, insomnia, and acute stress disorder was 52%, 58.3%, 45.2%, and 34.8%, respectively. After adjustment for covariates, female gender, a younger age, being unmarried, low income, and a non-medical post were all associated with mental health problems. During the course of infection, participants had a higher risk of developing symptoms of anxiety (odds ratio [OR]: 1.27; 95% confidence interval [CI]: 1.03-1.57; p = 0.028), depression (OR: 1.76; 95% CI: 1.44-2.16; p < 0.001), insomnia (OR: 1.95; 95% CI: 1.57-2.42, p < 0.001) and acute stress disorder (OR: 1.56; 95% CI: 1.25-1.93, p = 0.001). In addition, we found that a lower resilience among participants was associated with a higher risk of anxiety, depression, insomnia, and acute stress disorder (p < 0.001).</p><p><strong>Conclusion: </strong>Omicron-related stress had a profound effect on the mental health of the general population of China, especially among those infected during the course of coronavirus disease 2019 (COVID-19) and with lower resilience. Our findings suggest that mental health can be improved during a pandemic by increasing resilience.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"464-475"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol Use Disorder Following Bariatric Surgery: A Narrative Review.","authors":"Farhana Nazmin, Sasidhar Gunturu, Sanobar Jaka, Saidur Rahman","doi":"10.62641/aep.v53i3.1830","DOIUrl":"10.62641/aep.v53i3.1830","url":null,"abstract":"<p><strong>Objective: </strong>To explore the incidence of alcohol use disorder (AUD) after bariatric surgery and the associated risk factors and specific manifestations of increased AUD risk, such as increased alcohol sensitivity and earlier symptom onset.</p><p><strong>Methods: </strong>This review adhered to PRISMA guidelines. Data were sourced from PubMed, Google Scholar, Cochrane, and Science.gov using search terms related to alcohol, bariatric surgery, and nutrition. Articles were screened based on inclusion and exclusion criteria: Inclusion criteria were English language articles published from 2013-present, availability in full text or open access, and adult patients (≥18 years) who had bariatric surgery. Exclusion criteria were non-English articles, articles written before 2013, unavailable full text or open access, articles that featured pediatric patients or patients who did not use alcohol or had bariatric surgery, and abstracts or opinion pieces. A final total of 11 studies were found.</p><p><strong>Data extraction: </strong>Studies published from 2013 to the present that involved adult bariatric surgery patients with a history of alcohol consumption.</p><p><strong>Results: </strong>Findings suggest an elevated risk of AUD post-bariatric surgery, particularly following sleeve gastrectomy or Roux-en-Y gastric bypass surgery. There was strong evidence of increased alcohol sensitivity and AUD symptoms post-surgery, causing potential health effects.</p><p><strong>Conclusions: </strong>These results underscore the importance of comprehensive preoperative assessments and tailored interventions for bariatric surgery patients with AUD.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"605-615"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combined Effects of EEG Biofeedback and Olanzapine on Glucose and Lipid Metabolism, Cardiac Function, and Cognitive Function in Patients With Schizophrenia.","authors":"Weiwen Xu, Yaping Chen, Weifang Yang","doi":"10.62641/aep.v53i3.1823","DOIUrl":"10.62641/aep.v53i3.1823","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SCZ) is a chronic mental disorder characterized by severe impairments in the daily functioning and social interactions of the patient. Compared to conventional pharmacological interventions, electroencephalogram (EEG) biofeedback offers stable and sustained effects and reduces susceptibility to relapse. This study aimed to investigate the impact of EEG biofeedback combined with olanzapine (OLZ) on glucose and lipid metabolism, cardiac function, and cognitive ability in SCZ patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical records of 66 SCZ patients who received treatment at Taizhou Second Peoples' Hospital between June 2023 and March 2024. The patients were categorized into groups based on their treatment regimens: a single group (n = 30) and a combined therapy group (EEG biofeedback + OLZ, n = 36). Treatment efficacy and adverse reactions were compared between the groups. Key parameters assessed included glucose and lipid metabolism [total cholesterol (TC), triglyceride (TG), and fasting plasma glucose (FPG)], electrocardiographic (ECG) findings [T-wave changes, ST-segment changes, sinus bradycardia, sinus tachycardia, and other abnormalities], symptom severity [Positive and Negative Syndrome Scale (PANSS)], and cognitive function [Insight and Treatment Attitudes Questionnaire (ITAQ)] before and after treatment.</p><p><strong>Results: </strong>The total effective rate in the combined therapy group (91.67%) was significantly higher than in the single group (73.33%) (p < 0.05). Post-treatment, both groups exhibited significantly lower TC and FPG levels and higher TG levels compared to pre-treatment values (p < 0.05). However, no significant differences were observed between groups in these metabolic indices (p > 0.05). Similarly, no significant differences in ECG abnormalities were detected between groups, either pre- or post-treatment (p > 0.05). The combined therapy group demonstrated significantly greater improvements in general psychopathological symptoms, positive symptoms, negative symptoms, and PANSS scores, as well as significantly higher ITAQ scores compared to the single group (p < 0.05). The incidence of adverse reactions did not significantly differ between the single group (6.67%) and the combined therapy group (13.89%) (p > 0.05).</p><p><strong>Conclusion: </strong>EEG biofeedback combined with OLZ improves psychiatric symptoms and cognitive function of SCZ patients compared to OLZ monotherapy. Notably, the combined therapy does not exacerbate ECG abnormalities, metabolic indices, or adverse reactions, indicating a favorable safety profile.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"570-577"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of the Adjunctive Therapeutic Value of Mindfulness-Based Stress Reduction Therapy for Patients With Nasopharyngeal Carcinoma Induced Moderate Depression.","authors":"Zeyu Zheng, Jing Han","doi":"10.62641/aep.v53i3.1749","DOIUrl":"10.62641/aep.v53i3.1749","url":null,"abstract":"<p><strong>Background: </strong>Nasopharyngeal carcinoma (NPC) presents a substantial challenge for patients, impacting their physical and psychological well-being. Patients may experience moderate depression, anxiety, and reduced quality of life due to the disease and its treatments. Therefore, we retrospectively analyzed the adjunctive therapeutic potential of mindfulness-based stress reduction (MBSR) therapy for NPC patients with moderate depression.</p><p><strong>Methods: </strong>Psychological parameters were assessed using standardized scales, including the Hamilton Depression Scale-17 (HAMD-17), Self-Rating Depression Scale (SDS), Perceived Social Support Scale (PSSS), the Short-From-12 Health Survey (SF-12), and Mindfulness Attention Awareness Scale (MAAS). Statistical analyses were performed to compare the two groups.</p><p><strong>Results: </strong>A total of 131 patients including 67 patients with control group and 64 patients with Mindfulness-Based Stress Reduction therapy group were included. After 8 weeks of treatment, the MBSR therapy group showed significant improvements in psychological parameters, including depression, anxiety, perceived stress, quality of life, and mindfulness attention awareness (p < 0.05), compared to the control group. Additionally, the MBSR therapy group reported significantly higher overall satisfaction with treatment, willingness to recommend treatment, and perceived benefit from treatment (p < 0.05).</p><p><strong>Conclusion: </strong>The study findings support the adjunctive therapeutic value of MBSR therapy in improving psychological outcomes and patient satisfaction among individuals with NPC-induced moderate depression.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"516-525"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Impact of rTMS in Combination With Antidepressant Medications on Residual Symptoms in Acute Depression.","authors":"Hong Dai, Conghao Sun, Jinfeng Fei, Baohua Song","doi":"10.62641/aep.v53i3.1860","DOIUrl":"10.62641/aep.v53i3.1860","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;After several rounds of optimized pharmacotherapy, approximately one-third of patients with depression still exhibit residual symptoms (RS). While repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive treatment for depression, its effectiveness in treating RS associated with depression remains unclear. This study investigated the effectiveness of different frequencies of repetitive transcranial magnetic stimulatio rTMS combined with antidepressant drugs in treating RS of acute depression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study included 110 acute depression patients hospitalized in the Huzhou Third Municipal Hospital between April 2020 and April 2022. The clinical data were analyzed, and patients were divided into a control group (n = 31 cases), a low-frequency rTMS (LF-rTMS) group (n = 37 cases), and a high-frequency rTMS (HF-rTMS) group (n = 42 cases). The control group received antidepressant medicines, the LF-rTMS group was treated with LF-rTMS stimulation of the right dorsolateral prefrontal cortex (DLPFC) in addition to standard antidepressant medication, and the HF-rTMS group was given HF-rTMS stimulation of the left DLPFC. These treatment modalities were continued for four weeks. Additionally, the 16-item Quick Inventory of Depressive Symptomatology (QIDS-16), the 24-item Hamilton Depression Rating Scale (HAMD-24), and the number of RS were observed before and after treatment in the three groups, and the clinical effectiveness rates were monitored across these three experimental groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After treatment, the total QIDS-16 score, the number of RS, and the total HAMD-24 score were significantly decreased among the three groups compared to the before-treatment levels (p &lt; 0.05). Both the LF-rTMS and HF-rTMS groups exhibited lower QIDS-16 scores, fewer RS, and lower HAMD-24 total scores than the control group (p &lt; 0.05). Following treatment, all three groups demonstrated a significant decrease in the QIDS-16 sleep scores for sleep onset, nighttime sleep, early morning awakening, and sleep duration compared to pre-treatment levels (p &lt; 0.05). Furthermore, the LF-rTMS group had lower post-treatment scores for sleep onset and nighttime sleep than the HF-rTMS group (p &lt; 0.05). Conversely, the HF-rTMS group exhibited lower scores for early morning awakening and sleep duration than the LF-rTMS group (p &lt; 0.05). Additionally, both the LF-rTMS and HF-rTMS groups showed higher clinical effectiveness rates than the control group (p &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings showed that HF-rTMS targeting left DLPFC and LF-rTMS targeting right DLPFC could effectively alleviate clinical symptoms in patients with RS of acute depression, thereby increasing the efficacy rate of treatment. However, regarding the sleep disorder factors evaluated by the QIDS-16, there were differences in the emphasis of improvements between HF-rTMS targetin","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"53 3","pages":"456-463"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}