Actas espanolas de psiquiatria最新文献

{"title":"The Chain Mediating Effect of Sleep Quality and Family Resilience Between Depressive Mood and Treatment Compliance in Continuous Blood Purification Patients.","authors":"Wei Dong, Xin Zhao, Qiuxia Gao","doi":"10.62641/aep.v54i4.2183","DOIUrl":"10.62641/aep.v54i4.2183","url":null,"abstract":"<p><strong>Background: </strong>Patients undergoing continuous blood purification (CBP) face considerable physical and psychological burdens, and the prevalence of depressive mood is high, which adversely affects treatment compliance. This study aimed to investigate the chain mediating roles of sleep quality and family resilience in the relationship between depressive mood and treatment compliance among patients with CBP.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 195 patients with CBP from May 2024 to May 2025. Assessment included the Self-Rating Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI), Family Resilience Assessment Scale-Chinese version (FRAS-C), and Dialysis Treatment Adherence Scale (DTAS). We performed Pearson correlation, multiple linear regression, and bootstrap mediation analyses (PROCESS Macro Model 6) to test the hypothesized chain mediation model.</p><p><strong>Results: </strong>The mean scores were SDS 52.64 ± 5.82, PSQI 10.55 ± 4.08, FRAS-C 87.09 ± 11.24, and DTAS 70.95 ± 13.25. Depressive mood was significantly associated of poorer sleep quality (β = 0.521, <i>p</i> < 0.01) with lower family resilience (β = -0.391, <i>p</i> < 0.01), which in turn were associated with lower treatment adherence (β = -0.253 and β = 0.192, respectively, both <i>p</i> < 0.01). The total indirect effect accounted for 41.74% of the total effect, with the chain path (depression → sleep → resilience → adherence) contributing 5.06%. After adjusting for age, the model remained significant.</p><p><strong>Conclusions: </strong>Improving sleep quality and enhancing family resilience may be potential strategies to mitigate the adverse effects of depressive mood on self-reported treatment compliance in patients with CBP, though these findings require confirmation using adherence measures validated specifically for the CBP population.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1110-1119"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Emotion-Focused Therapy on Weight Restoration and Emotion Regulation in Adolescents With Anorexia Nervosa.","authors":"Linfeng Liu, Nongmei Cheng, Qing Feng","doi":"10.62641/aep.v54i4.2290","DOIUrl":"10.62641/aep.v54i4.2290","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effects of emotion-focused therapy (EFT) on weight restoration and emotion regulation in adolescents with anorexia nervosa (AN).</p><p><strong>Methods: </strong>This retrospective study included 188 adolescents with AN treated at Chongqing Mental Health Center between January 2023 and December 2025. According to treatment methods, patients were divided into a control group and an EFT group. After screening based on inclusion and exclusion criteria, 60 patients in each group were included in the final analysis. The control group received routine nutritional support, cognitive behavioral therapy, and medication when necessary, while the EFT group additionally received EFT. Both groups were treated for 12 weeks. Body mass index (BMI), nutritional indicators, Eating Attitudes Test-26 (EAT-26), Trait Meta-Mood Scale (TMMS), Generalized Anxiety Disorder-7 (GAD-7), and Children's Depression Inventory-2 (CDI-2) scores were compared between the two groups. Safety outcomes were retrospectively collected from electronic medical records. Multiple linear regression analysis was performed to evaluate the independent association between EFT and BMI improvement.</p><p><strong>Results: </strong>After 12 weeks of treatment, BMI and nutritional indicators in the EFT group were higher than those in the control group, while the EAT-26 scores were significantly lower (all <i>p</i> < 0.05). At weeks 4, 8, and 12, TMMS scores in the EFT group were significantly higher, while GAD-7 and CDI-2 scores were significantly lower than those in the control group (all <i>p</i> < 0.05). No significant between-group differences were observed in refeeding syndrome or readmission rates (all <i>p</i> > 0.05). Multiple linear regression analysis showed that EFT remained independently associated with higher BMI at week 12 after adjustment for baseline BMI, age, sex, and olanzapine use (β = 0.382, <i>p</i> < 0.05). Moderate-to-large effect sizes were observed for major outcome measures (Cohen's d = 0.77-1.23).</p><p><strong>Conclusions: </strong>EFT combined with routine nutritional support and psychotherapy may be associated with improved weight restoration, emotional regulation, nutritional status, and reduced anxiety and depressive symptoms in adolescents with AN. However, due to the retrospective single-center design and limited sample size, further prospective studies are warranted to confirm these findings.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1018-1027"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of the Remote Primary Care and Psychiatry Model (MAP-PSI) for Depression in Youth Living in Rural and Indigenous Communities.","authors":"Héctor Cabello-Rangel, Héctor Guillermo García-De Los Santos, Jorge Luis López-Jiménez, Marco Antonio Vázque-Rosales, Mauricio Israel Velázquez-Posada, Lina Díaz-Castro","doi":"10.62641/aep.v54i4.2180","DOIUrl":"10.62641/aep.v54i4.2180","url":null,"abstract":"<p><strong>Background: </strong>Community- and school-based interventions focused on mental health promotion and early detection of depressive symptoms have proven to be cost-effective. Our objective was estimated the cost-effectiveness ratio of the remote and pilot Primary Care and Psychiatry Model (MAP-PSI) compared with community usual care (CUC) in a rural municipality in Mexico.</p><p><strong>Methods: </strong>We analyzed all adolescents and young adults aged 15-25 years who received care between November 2023 and November 2024. Effectiveness measures included care-seeking behavior, school absenteeism prevented, suicide attempts avoided and suicides prevented. Direct and indirect costs including lost workdays, were considered. Incremental Costs-Effectiveness Ratios (ICERs) and deterministic sensitivity analyses were performed.</p><p><strong>Results: </strong>Of 1057 recruited participants, 932 completed screening (88.2%); mean age was 16.63 years ± standard deviation (SD) 1.53, and 60.51% were female. MAP-PSI delivered mental health care to 932 youths compared with 16 under CUC and was associated with the prevention of 12,195 school absenteeism days, at an incremental cost of $7.84 USD per absenteeism day avoided. Based on model projections, the intervention reduced expected suicide attempts from 13 to four cases; corresponding to nine suicide attempts avoided at an estimated incremental cost of $10,622.10 USD per suicide attempt avoided. Sensitivity analyses suggested that lower intervention effectiveness substantially increased ICERs under conservative scenarios.</p><p><strong>Conclusions: </strong>The MAP-PSI is a cost-effective strategy for reducing suicidal behavior and school absenteeism in young people with depressive symptoms living in rural and Indigenous communities.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1168-1178"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized Medication Selection and Outcome Prediction for Patients With Dementia and BPSD Based on Systemic Immune-Inflammation Index (SII): A Retrospective Case-Control Study.","authors":"Jiawen Liu, Haoshui Hua, Qicheng Zhang, Yuming Jiang, Mengting Li","doi":"10.62641/aep.v54i4.2229","DOIUrl":"10.62641/aep.v54i4.2229","url":null,"abstract":"<p><strong>Background: </strong>Behavioural and psychological symptoms of dementia (BPSD) are often treated with atypical antipsychotics, but heterogeneous treatment responses remain a clinical challenge. A systemic inflammatory state may contribute to this heterogeneity, but it is unclear whether the baseline systemic immune-inflammation index (SII) is associated with differential short-term responses among BPSD patients treated with risperidone, olanzapine, and quetiapine. Therefore, this study aimed to investigate whether baseline SII was associated with differential short-term responses among antipsychotic treatment groups.</p><p><strong>Methods: </strong>This was a retrospective cohort study. We reviewed the electronic medical records of hospitalised patients with dementia and BPSD from January 2020 to December 2024 and divided the patients into a risperidone group, an olanzapine group and a quetiapine group according to the antipsychotic treatment in the medical records. Using the risperidone group as the reference, 1:1 nearestneighbour matching without replacement was performed to obtain three balanced groups of 77 patients each (n = 231 in total). Normally distributed continuous data were analysed using t-tests, analysis of variance (ANOVA) and paired t-tests; non-normally distributed continuous data were analyzed using Wilcoxon rank-sum tests, Kruskal-Wallis tests and Wilcoxon signed-rank tests; categorical data were analysed using chi-square tests. Correlation analysis, multivariate linear regression and restricted cubic splines(RCS) were used for additional analyses.</p><p><strong>Results: </strong>Spearman's rank correlation test revealed divergent therapeutic trajectories. Baseline SII was positively correlated with the reduction rate of the Scale for the Assessment of Positive Symptoms (SAPS) in the risperidone group (r = 0.863, p < 0.001), and negatively correlated with the reduction rate of the SAPS in the olanzapine group (r = - 0.513, p < 0.001) and the quetiapine group (r = -0.368, p < 0.001). RCS analysis further revealed a non-linear relationship between SII and SAPS reduction rate (non-linear test p = 0.001). A significant interaction between medication type and SII was confirmed by the multivariable regression model (interaction p < 0.001).</p><p><strong>Conclusions: </strong>Baseline systemic inflammatory status is differentially associated with short-term antipsychotic response in hospitalised patients with dementia and BPSD. These findings suggest that inflammatory burden may be clinically relevant to the heterogeneous short-term response patterns across antipsychotic groups. However, prospective validation is required before any implications for treatment stratification can be drawn.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"992-1004"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence and Lethality in a Cohort of Minors With Suicidal Behaviour: 2010-2024.","authors":"Marina Adrados-Pérez, Vicent Llorca-Bofí, Eugènia Nicolau-Subires, Laura Arenas-Pijoan, Teresa Jové-Miró, Andrea Jiménez-Mayoral, Diego de la Vega-Sánchez, María Mur-Laín, María Irigoyen-Otiñano","doi":"10.62641/aep.v54i4.2219","DOIUrl":"10.62641/aep.v54i4.2219","url":null,"abstract":"<p><strong>Background: </strong>Suicidal behaviour in children and adolescents has increased significantly over the last decade, generating growing concern among healthcare professionals. However, clinical and evolutionary differences between minors and adults after a suicide attempt are not sufficiently defined. This study analyses the differential profile of minors treated for suicide attempts in a large provincial cohort to identify specific vulnerabilities and risk patterns.</p><p><strong>Methods: </strong>Retrospective cohort study (MCOSUL Cohort) that included all suicide attempts treated in provincial psychiatric emergency services between 2010 and 2024. Sociodemographic variables, psychiatric diagnoses, substance use, method and lethality of the index attempt, recurrence, and mortality were collected. High lethality was defined according to Beautrais criteria. χ², Fisher, Student's t, Kruskal-Wallis tests, and survival analyses for recurrence were applied.</p><p><strong>Results: </strong>Minors represented 8% of the cohort, with a female predominance (83%). They presented a higher prevalence of neurodevelopmental disorders and eating disorders (EDs), as well as a differential consumption pattern dominated by tetrahydrocannabinol (THC). They used more violent methods, especially cutting, without an increase in lethality. The Cox model shows that being a minor is significantly associated with earlier recurrence of suicidal behaviour (HR = 1.36), even after adjusting the analysis for sex, neurodevelopmental disorders, THC use, and the method employed. Adults showed higher lethality, mortality, and more frequent use of sedative medications as a suicide method. Recurrence of subsequent suicidal behaviour was similar but occurred earlier in minors.</p><p><strong>Conclusions: </strong>Adolescent suicidal behaviour appears to present a distinct clinical phenotype, characterized by a predominance of female adolescents, frequent neurodevelopmental vulnerabilities, THC use, low-lethality violent methods, and relatively rapid recurrence, highlighting the need for tailored prevention strategies.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1055-1065"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Social Media Use Duration and Depressive and Anxiety Symptoms in Adolescents: A Retrospective Study.","authors":"Lanlan Feng, Zhaojun Tan","doi":"10.62641/aep.v54i4.2228","DOIUrl":"10.62641/aep.v54i4.2228","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship between the duration of social media use and the prevalence and severity of depressive and anxiety symptoms among adolescents in the real-world settings, thereby providing data support to inform mental health support and guide appropriate social media use.</p><p><strong>Methods: </strong>This retrospective study analysed clinical data from 156 adolescents admitted to the Mental Health Service Centre of The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province) between January 2022 and December 2023. Data were extracted from electronic medical record system and structured survey forms. Baseline demographic characteristics, social media use related data, and mental health assessment results were collected. Pearson correlation analysis was used to examine relationship between social media use duration and scores on the 9-item Patient Health Questionnaire (PHQ-9) and 7-item Generalized Anxiety Disorder scale (GAD-7). Multivariate logistic regression was performed to identify factors independently associated with depression and anxiety symptoms.</p><p><strong>Results: </strong>Univariate analysis revealed statistically significant differences in parenting style, academic performance, weekly exercise frequency, and depression and anxiety symptoms across different durations of social media use (p < 0.05). Correlation analysis demonstrated significant positive correlations between average daily social media use duration and PHQ-9 score (r = 0.352, p < 0.001) and GAD-7 score (r = 0.308, p < 0.001). Multivariate logistic regression identified longer social media use as an independent risk factor for positive depressive symptoms (odds ratio (OR) = 1.794, 95% confidence interval (CI): 1.261-2.547), along with authoritative parenting (OR = 2.485, 95% CI: 1.253-4.922), permissive parenting (OR = 3.427, 95% CI: 1.503-7.816), medium academic performance (OR = 2.867, 95% CI: 1.286-6.396), and poor academic performance (OR = 6.118, 95% CI: 2.534-14.779). For positive anxiety symptoms, independent risk factors included longer social media use (OR = 1.624, 95% CI: 1.169-2.267), authoritative parenting (OR = 2.278, 95% CI: 1.171-4.425), permissive parenting (OR = 2.863, 95% CI: 1.317-6.256), medium academic performance (OR = 2.564, 95% CI: 1.176-5.614), poor academic performance (OR = 4.575, 95% CI: 1.975-10.614), and reduced weekly exercise frequency (1-2 times/week: OR = 1.927, 95% CI: 1.027-3.608; <1 time/week: OR = 3.825, 95% CI: 1.896-7.736).</p><p><strong>Conclusions: </strong>Social media use duration is significantly associated with depressive and anxiety symptoms in adolescents. These findings underscore the importance of monitoring adolescent social media use and implementing targeted health guidance to reduce mental health risks.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1141-1149"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Association Between Antidepressant Use and Thyroid Disease Risk: A Two-Sample Mendelian Randomization Study.","authors":"Yingxian Ling, Qisong Chen","doi":"10.62641/aep.v54i4.2313","DOIUrl":"10.62641/aep.v54i4.2313","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have reported associations between antidepressant use and thyroid dysfunction; however, confounding precludes firm causal inference. This study aimed to evaluate the potential causal association between genetically predicted antidepressant use and the risks of Hashimoto's thyroiditis, hypothyroidism and thyroid cancer using Mendelian randomisation (MR).</p><p><strong>Methods: </strong>Publicly available genome-wide association study (GWAS) summary statistics were used, with genetically predicted antidepressant use as the exposure and Hashimoto's thyroiditis, hypothyroidism and thyroid cancer as the outcomes. Following data harmonisation, 13 single nucleotide polymorphisms (SNPs) meeting the prespecified significance threshold were selected as instrumental variables. The mean F statistic was 24.12 (range, 20.96-29.98), indicating that weak-instrument bias was unlikely. Inverse variance weighted (IVW) was used for the primary analysis, with MR-Egger regression, weighted-median and mode-based methods used in sensitivity analyses. Cochran's Q test was used to assess heterogeneity, and the MREgger intercept was used to assess directional horizontal pleiotropy.</p><p><strong>Results: </strong>Genetically predicted antidepressant use was positively associated with the risk of Hashimoto's thyroiditis (IVW: odds ratio [OR] = 1.483, 95% confidence interval [CI]: 1.176-1.871; p = 0.001). A weak but statistically significant positive association was also observed for hypothyroidism (IVW: OR = 1.012, 95% CI: 1.002-1.023; p = 0.025). The directions of effect were generally consistent across sensitivity analyses. No evidence of an association with thyroid cancer was identified (IVW: p = 0.407). No evidence of bias was found in the heterogeneity test and the horizontal pleiotropy (p > 0.05), and the leave-one-out analysis confirmed the robustness of the results.</p><p><strong>Conclusions: </strong>This study provides genetic evidence of potential associations between antidepressant use and increased risks of Hashimoto's thyroiditis and hypothyroidism. These findings support consideration of thyroidfunction monitoring in patients receiving antidepressant treatment, particularly those with pre-existing thyroid risk factors.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1257-1268"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive Symptoms Mediate the Association Between Family Functioning and Non-Suicidal Self-Injury in Adolescent Psychiatric Patients: A Cross-Sectional Study.","authors":"Yushan Zhang, Li Luo, Rui Tang, Xiaoqing Luo, Qi Liu","doi":"10.62641/aep.v54i4.2208","DOIUrl":"10.62641/aep.v54i4.2208","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is highly prevalent among adolescent psychiatric patients, yet the pathways linking family functioning to NSSI have not been fully elucidated. This study aimed to investigate whether depressive symptoms function as a mediator in the association between family functioning and NSSI among adolescent psychiatric inpatients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 180 adolescent patients admitted to a psychiatric department between June 2023 and June 2025. Family functioning, depressive symptoms, and NSSI-related frequency (encompassing both NSSI ideation and actual NSSI behaviours) were assessed using validated Chinese versions of the Family Adaptability and Cohesion Evaluation Scale II, Patient Health Questionnaire-9 (PHQ-9), and Ottawa Self-Injury Inventory. To avoid measurement overlap between the mediator and outcome, the PHQ-8 total score (PHQ-9 excluding the self-harm/suicide item) was employed as the mediator in the primary analysis. Mediation analysis was performed using the PROCESS macro with bootstrap methods, controlling for demographic and clinical covariates including age, sex, only-child status, parental marital status, family monthly income, duration of illness, history of suicide attempts, and primary diagnosis.</p><p><strong>Results: </strong>NSSI was identified in 60.56% of participants. Family functioning was negatively correlated with depressive symptoms (r = -0.463, <i>p</i> < 0.001) and NSSI-related frequency score (r = -0.387, <i>p</i> < 0.001). Depressive symptoms partially mediated the association between family functioning and NSSI-related frequency (indirect effect = -0.058, 95% CI [-0.092, -0.029], accounting for 34.52% of the total effect. Sensitivity analyses including comparison with the original PHQ-9 as mediator (proportion mediated = 40.48%) and a most conservative model utilising only NSSI behavioural items as the outcome (proportion mediated = 35.16%) confirmed the robustness of these findings.</p><p><strong>Conclusions: </strong>Among adolescents with mental disorders, depressive symptoms may partially mediate the negative association between family functioning and nonsuicidal self-injury. Interventions may benefit from integrating family-based approaches with depression-targeted therapies to address NSSI in this vulnerable population.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1028-1041"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk of Mild Cognitive Impairment Among Chinese Adults Aged 60 Years and Above: A Cross-Sectional Study Based on National Data.","authors":"Qingpan Wen, Xinli Zhou, Changyi Xie, Hongying Pan, Huan Zhou, Marcin Bialas, Bifen Dai, Jiepeng Lei","doi":"10.62641/aep.v54i4.2096","DOIUrl":"10.62641/aep.v54i4.2096","url":null,"abstract":"<p><strong>Background: </strong>This study conducted a cross-sectional analysis to assess the prevalence of mild cognitive impairment (MCI) among older adults in China and to identify its associated risk factors, with the aim of informing the development of early intervention strategies.</p><p><strong>Methods: </strong>This cross-sectional study used data collected in 2018 (Wave 4). The initial survey sample comprised 19,744 individuals, of whom 4773 formed the valid sample for analysis. After screening, the study ultimately selected 694 individuals who met all the inclusion criteria. MCI was defined according to the criteria for ageassociated cognitive decline (AACD). Sociodemographic information, past comorbidities, and lifestyle were assessed.</p><p><strong>Results: </strong>The prevalence of MCI was 14.54%, with 694 individuals diagnosed with MCI. An elevated Center for Epidemiologic Studies Depression (CESD) score was identified as a significant risk factor for MCI (OR = 1.6, 95% CI: 1.3-1.9; <i>p</i> < 0.001). Living in rural areas (odds ratios (OR) = 2.0, 95% confidence interval (CI): 1.6-2.6; <i>p</i> < 0.001) and napping (OR = 1.3, 95% CI: 1.1-1.6; <i>p</i> = 0.002) were also significant risk factors for MCI. Additionally, gender, memory level, and nighttime sleep were each associated with a 1.2-fold increase in MCI risk (OR = 1.2 for all; <i>p</i> range: 0.001-0.047). Correlation analysis indicated that both age and the current CESD score were significantly negatively correlated with the total cognitive score (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Among Chinese older adults living in the community, CESD score, napping, nighttime sleep, being female, and memory level were identified as independent risk factorsfor MCI. These findings underscore the importance of implementing screening and preventive strategies to mitigate MCI risk in this demographic.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"971-981"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy Analysis of Evidence-Based Nursing Combined With Computer-Assisted Cognitive Correction Therapy on Cognitive Function and Quality of Life in Patients With Schizophrenia.","authors":"Yinai Zhao, Xiulong Liu","doi":"10.62641/aep.v54i4.2325","DOIUrl":"10.62641/aep.v54i4.2325","url":null,"abstract":"<p><strong>Background: </strong>To investigate the effects of evidence-based nursing combined with computer-assisted cognitive remediation on cognitive function and quality of life in patients with schizophrenia.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 120 patients with schizophrenia admitted between March 2023 and March 2025. Patients were divided into an observation group (n = 60, receiving evidencebased nursing combined with computer-assisted cognitive remediation) and a control group (n = 60, receiving routine nursing combined with routine cognitive training) according to their treatment and nursing protocols. Continuous treatment included in-hospital and post-discharge 12 weeks. Cognitive function, including the Wisconsin Card Sorting Test (WCST), Digit Symbol Substitution Test (DSST), Semantic Verbal Fluency (sVF) task, and the Schizophrenia Patient Quality of Life Scale (SQLS), was compared between the two groups before and 12 weeks after treatment.</p><p><strong>Results: </strong>Before treatment, there were no statistically significant differences in the scores of WCST, DSST, sVF, and SQLS dimensions between the two groups (p > 0.05). After 12 weeks of treatment, all cognitive indices showed significant within-group improvements for both groups (all p < 0.001), while each SQLS dimension and total score were significantly reduced within each group (observation group: all p < 0.01; control group: all p < 0.05). After Bonferroni correction for multiple comparisons, all cognitive and SQLS outcomes showed significantly larger improvements in the observation group relative to the control group (all corrected between-group p < 0.001).</p><p><strong>Conclusions: </strong>Evidence-based nursing combined with computer-assisted cognitive correction therapy is associated with better cognitive performance and higher quality of life in patients with schizophrenia, showing promising clinical application value.</p>","PeriodicalId":7251,"journal":{"name":"Actas espanolas de psiquiatria","volume":"54 4","pages":"1066-1076"},"PeriodicalIF":2.1,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}