Brazilian journal of cardiovascular surgery最新文献

{"title":"Papillary Fibroelastomas: 16-Year Single-Center Experience.","authors":"Strahinja Mrvic, Ranko Zdravkovic, Andrej Preveden, Novica Kalinic, Ilija Bjeljac, Aleksandar M Milosavljevic, Mirko Todic","doi":"10.21470/1678-9741-2023-0431","DOIUrl":"10.21470/1678-9741-2023-0431","url":null,"abstract":"<p><strong>Introduction: </strong>Papillary fibroelastoma is a rare primary benign cardiac tumor. The majority of patients are asymptomatic. Complications may result in embolic events, syncope, ventricular arrhythmias, and sudden death. In this study, we report on a series of papillary fibroelastomas documented in our institution.</p><p><strong>Methods: </strong>Medical history records from period between 2007 and 2022 were reviewed for all the patients diagnosed with cardiac papillary fibroelastomas treated surgically and confirmed histologically. Clinical, tumor, and demographic characteristics, echocardiography findings, and treatment modalities were analyzed.</p><p><strong>Results: </strong>In a sixteen-year period, 12 cases of papillary fibroelastomas were documented. The percentage of female patients was 83.3%. The average age was 59.0 ± 11.2 years. Average diameter of tumor was 1.2 cm. The aortic valve was the most common origin site, with six cases (50%). In two cases (17%), the mitral valve was involved. There were single cases of tumor (8% each) found on the tricuspid valve, in the left atrium, in the left ventricle, and in the right ventricle. All patients were treated successfully by complete resection.</p><p><strong>Conclusion: </strong>PFEs are generally small and single tumors. Complete surgical resection of the tumor has a good prognosis and is a safe, efficient, and definitive treatment.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230431"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of TGFBR1 Gene Variants in Two Chinese Pedigrees with Loeys-Dietz Syndrome.","authors":"Jiehua Qiu, Wei Chen, Xixi Min, Yang Shen, Xianhua Zhu, Jiacong Qiu, Xiande Zeng, Xiong Zeng, Yanchun Ji, Weimin Zhou","doi":"10.21470/1678-9741-2023-0495","DOIUrl":"10.21470/1678-9741-2023-0495","url":null,"abstract":"<p><strong>Objective: </strong>To investigate a precise treatment and related gene variants in some Loeys-Dietz syndrome (LDS) patients with vascular disease.</p><p><strong>Methods: </strong>Two probands (JX001-II1 and JX002-II1) diagnosed with LDS and their families were recruited. Routine blood test, antiphospholipid antibodies, immune globulins, nuclear antibodies (ANAs) and biochemical tests, and computed tomography angiography (CTA) were performed for probands. Deoxyribonucleic acid was collected from the two families and was sequenced by the next-generation sequencing employing the Ion Torrent platform (Life Technologies); the variants were confirmed by Sanger sequencing.</p><p><strong>Results: </strong>Two probands' antiphospholipid antibodies, immune globulins, and ANAs were near normal. CTA showed that both probands had an LDS patient typical arterial change: aortic aneurysm. Genetic testing of the 10 LDS-associated genes in the two probands showed that c.605C>T (JX001-II1) and c.679G>A (JX002-II1) variants were both positioned in exon 1 of TGFBR1 and it results in the substitution of highly conserved 202 alanine (Ala) for valine (Val) ( P. Ala 202Val, JX001-II1) and 227 glutamic acids (Glu) for lysine (Lys) ( P. Glu 227Lys, JX002-II1). However, the parents of both patients did not have similar symptoms and did not carry such gene variants. Proband 1 (JX001-II1) died unexpectedly during the operation preparations, whereas proband 2 (JX002-II1) underwent two operations, and the patient is currently in excellent health.</p><p><strong>Conclusion: </strong>The two TGFBR1 gene variants may be a primary genetic cause of LDS. The results expand the TGFBR1 variant spectrum. Endovascular surgery can be a feasible option for LDS patients.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230495"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Arch Replacement is Safe as Hemiarch Repair in Acute Type A Aortic Dissection in a Middle-Income Country Setting.","authors":"Juan David Niño-Calvera, Julian Senosiain, Nicolas Nuñez-Ordonez, Ivonne Pineda, Lina Ramírez, Carlos Villa, Carlos Obando, Tomas Chalela, Nestor Sandoval, Juan P Umaña, Jaime Camacho","doi":"10.21470/1678-9741-2024-0088","DOIUrl":"10.21470/1678-9741-2024-0088","url":null,"abstract":"<p><strong>Objectiver: </strong>The aim of this study was to determine the clinical outcomes of patients with acute type A aortic dissection comparing proximal aortic repair vs. total arch replacement.</p><p><strong>Methods: </strong>This was a retrospective cohort study. We included all acute type A aortic dissection procedures from January 2002 to November 2022. Groups were defined according to the extent of aortic replacement (hemiarch repair vs. total arch replacement). We collected data from pre, intra, and postoperative variables. Our main endpoints were stroke rate, spinal cord injury, and in-hospital mortality. We performed a statistical analysis for between-group comparisons according to the nature and distribution of variables. Bivariate analyses were done using the Mann-Whitney U test and for categorical variables, the Chi-square test or Fisher's exact test. Significance was established at alpha level of 0.05.</p><p><strong>Results: </strong>We identified 107 acute type A aortic dissection procedures (69 hemiarch repairs vs. 38 total arch replacements). There were no differences in postoperative outcomes such as surgical site infection or acute kidney injury. Bleeding reoperation was more frequent in the hemiarch group (30% vs. 11 %). We did not find statistically significant differences in stroke rate, spinal cord injury, or in-hospital mortality.</p><p><strong>Conclusion: </strong>Acute type A aortic dissection treatment is still a challenge. Total arch replacement does not increase the risk of major early postoperative complications in comparison to hemiarch repair. The extended repair seems to provide benefits such as a lower risk of reoperation. Total arch replacement should be performed in selected patients, as it may improve long-term outcomes.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20240088"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Mechanical Ventilation and Extubation Failure in Children and Adolescents Undergoing Cardiac Surgery.","authors":"Alessandra Muniz Pereira da Costa, Luziene Alencar Bonates Dos Santos, Edinely Michely de Alencar Nelo, Lívia Barboza de Andrade","doi":"10.21470/1678-9741-2023-0281","DOIUrl":"10.21470/1678-9741-2023-0281","url":null,"abstract":"<p><strong>Introduction: </strong>Mechanical ventilation (MV) is one of the factors that may be associated with postoperative complications of cardiac surgeries. This study aimed to verify the clinical and biological factors related to prolonged MV and extubation failure in children and adolescents submitted to cardiac surgeries.</p><p><strong>Method: </strong>This retrospective cohort included all patients aged between 0 and 15 years at the Unidade de Recuperação Cardio-Torácica Pediátrica who were submitted to the first extubation after cardiac surgery. Those tracheostomized and under MV before the surgery or who suffered accidental extubation were excluded. The following data was collected - age, weight, and sex; body mass index (BMI); heart disease; surgical severity (Risk Adjustment for Congenital Heart Surgery-1); hospitalization period and length of stay at intensive care unit; MV, cardiopulmonary bypass, and anoxia duration; use of continuous sedation (midazolam and/or fentanyl); pulmonary hypertension; nitric oxide use; Down syndrome, extubation site, and failure. The outcomes were prolonged MV and extubation failure.</p><p><strong>Results: </strong>A total of 233 patients were included - 79 (33.9%) aged below 12 months, 47 (20.2%) had Down syndrome, and 215 (92.3%) presented low BMI. Down syndrome patients and those under continuous sedation in the immediate postoperative period presented a higher risk of prolonged MV (P<0.001). Moreover, patients aged below 12 months (P=0.048) and those under prolonged MV (P=0.006) presented the highest risk of extubation failure.</p><p><strong>Conclusion: </strong>Patients with continuous sedation or Down syndrome required longer MV. In addition, children younger than 12 months or under prolonged MV presented a high extubation failure rate.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230281"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Konno-Rastan Procedure in the Current Era: Still A Feasible Option?","authors":"Safak Alpat, Timucin Sabuncu, Ahmet Aydin, Murat Guvener, Riza Dogan, Mustafa Yilmaz","doi":"10.21470/1678-9741-2024-0002","DOIUrl":"10.21470/1678-9741-2024-0002","url":null,"abstract":"<p><strong>Introduction: </strong>The Konno-Rastan procedure is a commonly used surgical technique to address complicated subaortic stenosis and to enlarge the aorta via an anterior route. The objective of this report is to describe the experience of our unit with this procedure.</p><p><strong>Methods: </strong>Between 2002 and 2022, we identified pediatric patients who underwent the Konno-Rastan procedure. Relevant information was retrospectively collected.</p><p><strong>Results: </strong>There were 16 patients who underwent the Konno-Rastan procedure. The median follow-up was nine years (4 - 16 years), and there was no operative mortality. All patients had a straightforward recovery, and five patients required reoperation at follow-up, none of which was related to the left ventricular outflow tract. The median echocardiographic indices at the most recent follow-up were not significantly different from the preoperative values, with a median peak gradient across the left ventricular outflow tract of 25 mmHg. In their most recent follow-up, 81% of the patients were New York Heart Association class 1. No bleeding, thromboembolic, or infective complications were encountered.</p><p><strong>Conclusion: </strong>We concluded that the Konno-Rastan procedure can be regarded as a definitive alternative to other surgical interventions for left ventricular outflow tract obstructions. Although reoperations are still necessary, particularly in patients with additional mitral valve disease, the Konno-Rastan procedure is still a viable option in patients with complex left ventricular disease.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20240002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial Prognosis Scale for Coronary Artery Bypass Grafting - Brazilian Version: Adaptation and Content Validity.","authors":"Elisabete Silvana de Oliveira Sene, Renata Eloah de Lucena Ferretti-Rebustini, Meena Hariharan, Marlyn Thomas Savio, Vinicius Batista Santos, Camila Takáo Lopes","doi":"10.21470/1678-9741-2023-0371","DOIUrl":"10.21470/1678-9741-2023-0371","url":null,"abstract":"<p><strong>Introduction: </strong>The Biopsychosocial Prognosis Scale for Coronary Artery Bypass Grafting (BIPROSCAB) assesses biophysical symptoms and psychosocial experiences following coronary artery bypass grafting (CABG), thereby enabling the targeting of interventions to improve post-procedure biopsychosocial prognosis. The aim of this study was to adapt the BIPROSCAB for use in Brazil and assess the content validity of the adapted version.</p><p><strong>Methods: </strong>For the cross-cultural adaptation, English-Portuguese translations, synthesis of translations, back-translations, assessment of back-translations for conceptual consistency by the authors of the original instrument, and evaluation of semantic, idiomatic, cultural, and conceptual equivalences by 11 expert judges were performed. Modifications were made based on suggestions until consensus > 80% was achieved. For the content validity assessment, experts assessed the clarity, theoretical relevance, and practical pertinence of the items, which were considered adequate when the content validity ratio (CVR) > 0.635. Post-CABG patients completed the questionnaire and evaluated understandability of the items.</p><p><strong>Results: </strong>Three rounds were required to achieve the desired agreement in the cross-cultural adaptation process. In the content evaluation by experts, only one round was needed, with CVR > 0.635. Following content evaluation by patients, it was decided to reverse the order of the response scale to an ascending order.</p><p><strong>Conclusion: </strong>The Brazilian version, BIPROSCAB-Br, is equivalent to the original instrument and has satisfactory evidence of content validity. Additional psychometric assessments are needed for use in Brazil.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230371"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hearing Loss After Open-Heart Surgery: A Systematic Review.","authors":"Khashayar Rezvani Emamzadehashemi, Ezzat Paryad, Arsalan Salari, Marzieh Jahani Sayad Noveiri","doi":"10.21470/1678-9741-2023-0197","DOIUrl":"10.21470/1678-9741-2023-0197","url":null,"abstract":"<p><strong>Introduction: </strong>Today, due to the increase in the incidence of heart problems in people, we see an increase in the number of heart surgeries worldwide. Hearing disorders in the form of hearing loss have been reported as one of the side effects of this kind of surgery in some studies. Considering the evidence of the effect of open-heart surgery on patients' hearing loss, this systematic review study was conducted to determine the frequency of hearing loss after open-heart surgery.</p><p><strong>Methods: </strong>To carry out this systematic review, studies that investigated hearing loss after open-heart surgery in Iran and the rest of world, published in Persian or English, and various international electronic databases including PubMed®, Web of Science, Scopus®, and authentic Persian sources (e.g., Irandoc and Scientific Information Database) until the end of 2021 have been indexed.</p><p><strong>Results: </strong>In the initial review, 46 of the 2230 initially searched articles had the conditions for further review. After checking the articles' title and abstract and the working method of the studies and removing duplicates and incomplete articles, a total of 16 articles were included in the study. Then, their results were analyzed as the frequency of hearing loss after open-heart surgery by age and sex.</p><p><strong>Conclusion: </strong>The review of various studies confirms the fact that after open-heart surgery, the existence of evidence of hearing changes is not far from expected.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230197"},"PeriodicalIF":1.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Acute Aortic Dissection After Coronary Artery Bypass Grafting.","authors":"Živojin S Jonjev, Adam Adam, Novica Kalinić, Tamaš Vaštag, Ilija Bjeljac","doi":"10.21470/1678-9741-2023-0342","DOIUrl":"10.21470/1678-9741-2023-0342","url":null,"abstract":"<p><p>Patients having Stanford type A acute dissection soon after cardiac surgery have a high risk of rupture and death. The presentation, management, and outcome of primary dissection of the ascending aorta (Stanford type A or De Bakey type I or II) are well described. However, patients with Stanford type A acute aortic dissection soon (3-4 weeks) after primary cardiac surgery have distinctly different presentation, management, and postoperative outcome. In this report, we describe the clinical and surgical findings of a patient with early Stanford type A acute aortic dissection four weeks after primary coronary artery bypass grafting.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20230342"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Two Coronary Anastomosis Techniques in Terms of Flow Rate in Porcine Hearts.","authors":"Safa Gode, Mucahit Polat, Elif Guneysu, Timucin Aksu, Olgar Bayserke, Muhammed Bayram, Ulku Kafa Kulacoglu, Taner Iyigun, Zihni Mert Duman, Oznur Inan","doi":"10.21470/1678-9741-2024-0073","DOIUrl":"10.21470/1678-9741-2024-0073","url":null,"abstract":"<p><strong>Introduction: </strong>The quality of coronary anastomoses is one of the important parameters that may affect graft patency in coronary artery bypass grafting patients. Therefore, we compared two different anastomotic techniques to improve graft flow and patency rates.</p><p><strong>Methods: </strong>This study was conducted by performing two different fashions of anastomosis with a human saphenous vein graft on 24 various coronary segments of five postmortem porcine hearts. Each arteriotomy was used for both anastomotic techniques. In the first method, epicardial fat tissue around the coronary artery was involved to the saphenous vein anastomosis line (coronary wall and epicardial fat tissue [CWE] technique). In the second method, the saphenous vein graft was sutured to the coronary wall only, without involving epicardial fat tissue (only coronary wall [OCW] technique).The time it tookfor 30 cc of 0.9% isotonic saline solution to pass through the anastomosis in a free-flow fashion by gravity was measured following each technique. Additionally, the anastomotic areas in mm2 were measured and compared between the two techniques.</p><p><strong>Results: </strong>The mean flow time for the CWE technique was 77.5 ± 21.4 seconds, whereas for the OCW technique, it was 87.2 ± 19.5 seconds (P<0.001). The flow rates were 23.2 ml/min and 20.6 ml/min, respectively. The anastomotic area was 3.947 mm2 for the CWE technique and 1.430 mm2 for the OCW technique.</p><p><strong>Conclusion: </strong>When the sutures penetrate both the epicardial fat tissue and the coronary artery wall simultaneously, a larger anastomosis area can be created. Consequently, potentially better graft flow and hemodynamic performance could be achieved.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20240073"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Concentration of Papaverine for the Inhibition of Internal Thoracic Artery Vasospasm during Coronary Artery Bypass Graft Surgery.","authors":"Naoko Tanaka-Totoribe, Eisaku Nakamura, Masachika Kuwabara, Shin Onizuka, Ryuichi Yamamoto","doi":"10.21470/1678-9741-2024-0058","DOIUrl":"10.21470/1678-9741-2024-0058","url":null,"abstract":"<p><strong>Introduction: </strong>The internal thoracic artery is commonly used as a graft in coronary artery bypass grafting. In this study, we aimed to investigate whether papaverine prevents vasoconstriction caused by various vasospasm inducers, including 5-hydroxytriptamine or serotonin, in endothelium-denuded internal thoracic artery at concentrations as low as 1.25 mM used for radial arteries.</p><p><strong>Methods: </strong>Human internal thoracic artery tissue was obtained from patients (n=6) undergoing coronary artery bypass grafting. The organ bath technique was used to determine the inhibitory effects of papaverine on vasoconstriction induced by ergonovine, adenosine diphosphate, 5-hydroxytriptamine, noradrenaline, and angiotensin II in isolated endothelium-denuded internal thoracic artery. Moreover, the inhibitory effect of papaverine on collagen-stimulated human platelet aggregation was examined at the same concentration.</p><p><strong>Results: </strong>Papaverine inhibited ergonovine-induced vasoconstriction in a concentration-dependent manner. Papaverine at concentrations > 30 μM not only blocked ergonovine-induced vasoconstriction but also induced vasodilation. Papaverine at 30 μM significantly suppressed the vasoconstriction induced by 5-hydroxytriptamine or noradrenaline and completely blocked that induced by adenosine diphosphate or angiotensin II. However, 100 μM papaverine completely blocked the vasoconstriction induced by adenosine diphosphate, 5-hydroxytriptamine, noradrenaline, and angiotensin II. Additionally, papaverine significantly inhibited collagen-stimulated human platelet aggregation in a concentration-dependent manner.</p><p><strong>Conclusion: </strong>Overall, 100 μM papaverine prevented vasoconstriction by various vasospasm inducers, such as 5-hydroxytriptamine, and significantly suppressed collagen-stimulated platelet aggregation. These results suggest that papaverine at 100 μM, which is 1/10th the concentration used for radial artery, is sufficient to prevent vasospasm in internal thoracic artery during coronary artery bypass grafting.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":"40 1","pages":"e20240058"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}