Maria Suely Bezerra Diogenes, Acrísio Sales Valente, Hermano Alexandre Lima Rocha
{"title":"Adult Congenital Heart Disease: Report from a Public Reference Hospital in Northeastern Brazil.","authors":"Maria Suely Bezerra Diogenes, Acrísio Sales Valente, Hermano Alexandre Lima Rocha","doi":"10.21470/1678-9741-2023-0039","DOIUrl":"10.21470/1678-9741-2023-0039","url":null,"abstract":"<p><strong>Introduction: </strong>The increasing worldwide number of adults with congenital heart disease (CHD) demands greater attention from health professionals. The purpose of this report is to describe the clinical demographic profile, frequency, and invasive treatment status of adults with CHD in a public reference hospital in northeastern Brazil.</p><p><strong>Methods: </strong>This is a retrospective cross-sectional study including 704 patients attended between August 2016 and August 2020. Data were collected from virtual database.</p><p><strong>Results: </strong>Patients' age varied from 17 to 81 years (mean 32±14; median 27 years); 294 (41.8%) patients were male, and 410 (58,2%) were female; 230 (32,7%) had diagnosis from age 18 and up. Cardiac complexity categories were \"simple defects\" (134 [19%] patients), \"moderate complexity\" (503 [71.5%]), and \"great complexity\" (67 [9.5%]). Atrial septal defect (ASD) was diagnosed in 216 (30.7%) patients, ventricular septal defect (VSD) in 101 (14.3%), tetralogy of Fallot in 93 (13.2%), and other CHD in 294 (41.8%). New York Heart Association (NYHA) functional classes were I (401 [57%]), II (203 [28.8%]), III (76 [10.8%]), and IV (24 [3.4%]). Complications were arrhythmias (173 [24%]) and severe pulmonary hypertension (69 [9.8%]). Invasive treatments were corrective surgery (364 (51.6%]), reoperation (28 [4.0%]), palliation (11 [1.6%]), interventional catheterization (12 [1.7%]), surgery plus interventional catheterization (5 [0.7%]), and preoperation (91 [12.9%]). Treatment was not required in 102 (14,5%) patients, and 91 (12.9%) were inoperable.</p><p><strong>Conclusion: </strong>The leading diagnosis was ASD. Frequency of unrepaired patients was high, mainly ASD, due to late diagnosis, which favored complications and denotes a matter of great concern.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Razuk, Samuel Lucas Dos Santos, Flavio Pola Dos Reis, Luis Gustavo Abdalla, Lucas Matos Fernades, Paulo Manuel Pêgo-Fernandes
{"title":"Use of Octopus™ Tissue Stabilizer for Minimal Manipulation Approach of Bronchial Anastomosis in Lung Transplant.","authors":"Mauro Razuk, Samuel Lucas Dos Santos, Flavio Pola Dos Reis, Luis Gustavo Abdalla, Lucas Matos Fernades, Paulo Manuel Pêgo-Fernandes","doi":"10.21470/1678-9741-2022-0413","DOIUrl":"10.21470/1678-9741-2022-0413","url":null,"abstract":"<p><p>Bronchial anastomotic complications are a cause of grave concern for surgeons that perform lung transplantations. There are several risk factors that may lead to this complication, being inadequate surgical technique one of them, specifically regarding adequate exposure and manipulation of the bronchial stump and anastomosis. Here we report the use of Octopus™ Tissue Stabilizer as a mean to allow for a better exposure of the stump and facilitate a \"no-touch\" approach towards anastomosis. Systematic application of devices that facilitate the employment of the correct surgical techniques can have an effect in reducing the incidence of bronchial anastomotic complications.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Senning Procedure: Conceptualization in the Wet Lab.","authors":"César Castillo Romero, Iris Pamela Flores Sarria, Gabriella Ricciardi, Jorge Luis Cervantes Salazar","doi":"10.21470/1678-9741-2023-0025","DOIUrl":"10.21470/1678-9741-2023-0025","url":null,"abstract":"<p><p>Training congenital heart surgeons today is challenging for themselves and their mentors. The situation becomes even more complicated while teaching complex surgical procedures. Senning operation is one of the most ingenious intracardiac techniques. We consider this surgical technique a worthy example to stand out the potential advantage of wet lab training. This article demonstrates the simulation of the Senning procedure in an explanted porcine model.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Livia Rocha do Valle, Cristiane Nunes Martins, Roberto Max Lopes, Fernando Antonio Fantini, Erika Correa Vrandecic, Fernando Amaral
{"title":"Reversed Potts Shunt as a Palliative Option for EndStage Idiopathic Pulmonary Arterial Hypertension in Childhood.","authors":"Livia Rocha do Valle, Cristiane Nunes Martins, Roberto Max Lopes, Fernando Antonio Fantini, Erika Correa Vrandecic, Fernando Amaral","doi":"10.21470/1678-9741-2022-0034","DOIUrl":"10.21470/1678-9741-2022-0034","url":null,"abstract":"","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Breah Lynn Paciotti, Pankaj Garg, Charles A Ritchie, Kevin Landolfo, Basar Sareyyupoglu
{"title":"Aggressive Management of a Bilateral Chylothorax Complicating an Orthotopic Heart-Kidney Transplantation.","authors":"Breah Lynn Paciotti, Pankaj Garg, Charles A Ritchie, Kevin Landolfo, Basar Sareyyupoglu","doi":"10.21470/1678-9741-2023-0041","DOIUrl":"10.21470/1678-9741-2023-0041","url":null,"abstract":"<p><p>Chylothorax after an orthotopic heart transplant is a rare but potentially detrimental occurrence. This is the first reported case of bilateral chylothorax complicating a heart-kidney transplant patient. No universally accepted protocol exists for the management of chylothorax in general population, let alone the immunocompromised transplant patient. This case presents unique challenges to the management of postoperative chylothorax given heart-kidney transplant's effect on the patient's volume status and immunocompromised state. We make the argument for aggressive treatment of chylothorax in an immunocompromised heart-kidney transplant patient to limit complications in a patient population predisposed to infection.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zihni Mert Duman, Ersin Kadiroğulları, Mustafa Can Kaplan, Barış Timur, Aylin Başgöze, Emre Yaşar, Muhammed Bayram, Ünal Aydın, Burak Onan
{"title":"Central vs. Peripheral Cannulation During Reoperations: A Propensity Score Matching Analysis.","authors":"Zihni Mert Duman, Ersin Kadiroğulları, Mustafa Can Kaplan, Barış Timur, Aylin Başgöze, Emre Yaşar, Muhammed Bayram, Ünal Aydın, Burak Onan","doi":"10.21470/1678-9741-2022-0463","DOIUrl":"10.21470/1678-9741-2022-0463","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to compare the postoperative outcomes and early mortality of peripheral and central cannulation techniques in cardiac reoperations using propensity score matching analysis.</p><p><strong>Methods: </strong>In this retrospective cohort, patients who underwent cardiac reoperations with median resternotomy were analyzed in terms of propensity score matching. Between November 2010 and September 2020, 257 patients underwent cardiac reoperations via central (Group 1) or peripheral (Group 2) cannulation. A 1:1 propensity score matching was performed to balance the influence of potential confounding factors to compare postoperative data and mortality rate.</p><p><strong>Results: </strong>There were no significant differences when comparing the matched groups regarding early mortality (P=0.51), major cardiac injury (P=0.99), prolonged ventilation (P=0.16), and postoperative stroke (P=0.99). The development of acute renal failure (P=0.02) was statistically less frequent in Group 1.</p><p><strong>Conclusions: </strong>Performing cardiopulmonary bypass via peripheral cannulation increases acute renal failure in cardiac reoperations. In contrast, peripheral or central cannulation have similar early mortality rate in cardiac reoperations.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypothermic Circulatory Arrest in Median Sternotomy Hemorrhage During Redo Aortic Surgery.","authors":"Tiansheng Tang, Changjuan Wu, Jianshi Liu, Kaitao Jian, Wei Liu, Weiyong Sheng","doi":"10.21470/1678-9741-2022-0164","DOIUrl":"10.21470/1678-9741-2022-0164","url":null,"abstract":"<p><strong>Introduction: </strong>This study summarizes the clinical data of patients who developed sternotomy hemorrhage during redo aortic surgery and analyzes the clinical experience of using hypothermic circulatory arrest.</p><p><strong>Methods: </strong>We retrospectively analyzed the medical records of patients who developed sternotomy hemorrhage during redo aortic surgery from May 2018 to August 2021. General anesthesia with single-lumen tracheal intubation was used. Femoral artery, vein, and superior vena cava cannulation were used if cardiopulmonary bypass was required according to the situation, and right superior vein or apical cannulation was selected for left heart drainage.</p><p><strong>Results: </strong>A total of 11 patients were enrolled in this study, comprising nine males and two females, with an average age of 44.3±16.7 years. All cases were successfully completed without cerebrovascular complications or paraplegia. Two patients died during hospitalization, two patients died during the follow-up after discharge, and the remaining patients are recovering well.</p><p><strong>Conclusion: </strong>The femoral-femoral bypass with hypothermic circulatory arrest technique is a safe and reliable method to use in cases of sternotomy hemorrhage during redo aortic surgery.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Single-Dose Cardioplegia in Valvular Heart Surgery: Lactated Ringer's-Based del Nido vs. Histidine-Tryptophan-Ketoglutarate Cardioplegia Solution.","authors":"Narongrit Kantathut, Kasisak Luangpatom-Aram, Siam Khajarern, Parinya Leelayana, Piya Cherntanomwong","doi":"10.21470/1678-9741-2022-0447","DOIUrl":"10.21470/1678-9741-2022-0447","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated myocardial protection and clinical outcomes when using lactated Ringer's solution as the base solution for del Nido cardioplegia compared with histidine-tryptophan-ketoglutarate (HTK) solution in valvular surgery.</p><p><strong>Methods: </strong>From January 2017 to May 2018, 71 adult patients who underwent valvular surgery with del Nido cardioplegia (n=37) or HTK cardioplegia (n=34) were retrospectively analyzed.</p><p><strong>Results: </strong>Patients' characteristics were comparable between groups. Postoperative peak troponin T levels were similar. The del Nido group had a decreased incidence of ventricular fibrillation after aortic cross-clamp removal (13.51 vs. 55.88%; P<0.001), lower total volume of cardioplegia administered (1,000 [1,000, 1,250] vs. 1,800 [1,500, 2,000] mL; P<0.001), shorter hospital stay (6 [5, 8] vs. 7 [6, 10] days; P=0.03), and less postoperative red cell transfusion (34.29 vs. 61.11%; P=0.024). There is no difference in aortic cross-clamping time, postoperative change in left ventricular ejection fraction, intensive care unit stay, duration of inotropic support, new onset of atrial fibrillation, in-hospital mortality, complications, and three-year overall survival rate.</p><p><strong>Conclusion: </strong>Lactated Ringer's-based del Nido cardioplegia can be safely used for valvular surgery with acceptable clinical outcomes compared to HTK cardioplegia.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julio Kevin Matos Flores, Lizeth Jackelin Cabrera Ipurre
{"title":"Measurement of Changes in the Emotional State of Patients with Cardiac Diseases and Use of Cardiac Devices.","authors":"Julio Kevin Matos Flores, Lizeth Jackelin Cabrera Ipurre","doi":"10.21470/1678-9741-2022-0460","DOIUrl":"10.21470/1678-9741-2022-0460","url":null,"abstract":"Dessotte et al.[1] recently presented, in the Brazilian Journal of Cardiovascular Surgery, an interesting parallel between the emotional changes that take place in patients with coronary conditions who use different cardiac devices for their treatment, and other variables in consideration. Pérez et al.[2] refer that the heart is the most affected organ in chronic Chagas disease, and this eventually induces dilated cardiomyopathy with systolic-diastolic dysfunction, arrhythmias, and sudden cardiac death. The diagnosis of this disease was evaluated in the Dessotte’s study. However, neither the context nor the results justify the reason for including this illness. We consider it would have been better to take a general view of cardiac disorders, as evidenced in other similar investigations[3-5]. In this sense, we suggest that the title should have been “Comparison of anxiety and depression symptoms in individuals with heart disease according to sex and type of cardiac device”. Further on, Dessotte et al. indicate that the Hospital Anxiety and Depression Scale (HADS) is used to evaluate anxiety and stress symptoms, justifying their choice. However, in one of the works cited by the authors to recommend the use of HADS[6], this tool is not used, but rather two others: the Short Form 36 Health Survey (or SF-36) and the Assessment of QUAlity of Life and RELated Events (or AQUAREL). This is obviously a contradiction. On the other hand, the Methodology does not mention the test used to evaluate the mean implantation time of implantable cardioverter defibrillators and pacemakers, although the results show that these variables were evaluated[1], which casts doubt on the accuracy of these data. Likewise, providing the information in the form of averages is useful, but it would have been more interesting to know the ranges in which these measurements were taken in order to better understand the results and to allow them to be used as a reference for future studies. Julio Kevin Matos Flores1, MD https://orcid.org/0000-0002-5078-1947 1Professional School of Human Medicine, Faculty of Human Medicine, San Juan Bautista Private University, campus Chincha, Peru. E-mail: julio.matos@upsjb.edu.pe","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin Yang, Zhiqiang Gong, Junjie Dong, Haotian Li, Bing Wang, Kaili Du, Chunqiang Zhang, Lingqiang Chen
{"title":"Transcriptomics Provides Novel Insights into the Regulatory Mechanism of IncRNA HIF1 A-AS1 on Vascular Smooth Muscle Cells.","authors":"Jin Yang, Zhiqiang Gong, Junjie Dong, Haotian Li, Bing Wang, Kaili Du, Chunqiang Zhang, Lingqiang Chen","doi":"10.21470/1678-9741-2022-0260","DOIUrl":"10.21470/1678-9741-2022-0260","url":null,"abstract":"<p><strong>Introduction: </strong>Thoracic aortic aneurysm is a potentially fatal disease with a strong genetic contribution. The dysfunction of vascular smooth muscle cells (VSMCs) contributes to the formation of this aneurysm. Although previous studies suggested that long non-coding ribonucleic acid (RNA) hypoxia inducible factor 1 α-antisense RNA 1 (HIF1A-AS1) exerted a vital role in the progression and pathogenesis of thoracic aortic aneurysm, we managed to find a new regulatory mechanism of HIF1A-AS1 in VSMCs via transcriptomics.</p><p><strong>Methods: </strong>Cell viability was detected by the cell counting kit-8 assay. Cell apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide double staining. Transwell migration assay and wound healing assay were performed to check the migration ability of HIF1A-AS1 on VSMCs. The NextSeq XTen system (Illumina) was used to collect RNA sequencing data. Lastly, reverse transcription-quantitative polymerase chain reaction confirmed the veracity and reliability of RNA-sequencing results.</p><p><strong>Results: </strong>We observed that overexpressing HIF1A-AS1 successfully promoted apoptosis, significantly altered cell cycle distribution, and greatly attenuated migration in VSMCs, further highlighting the robust promoting effects of HIF1A-AS1 to thoracic aortic aneurysm. Moreover, transcriptomics was implemented to uncover its underlying mechanism. A total of 175 differently expressed genes were identified, with some of them enriched in apoptosis, migration, and cell cycle-related pathways. Intriguingly, some differently expressed genes were noted in vascular development or coagulation function pathways.</p><p><strong>Conclusion: </strong>We suggest that HIF1A-AS1 mediated the progression of thoracic aortic aneurysm by not only regulating the function of VSMCs, but also altering vascular development or coagulation function.</p>","PeriodicalId":72457,"journal":{"name":"Brazilian journal of cardiovascular surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}