Acta tropica最新文献

{"title":"Transcriptome analysis reveals significant discrepancies between two in vitro models of host-trematode interaction","authors":"Ekaterina A. Lishai ,&nbsp;Dmitry V. Ponomarev ,&nbsp;Oxana G. Zaparina ,&nbsp;Maria Y. Pakharukova","doi":"10.1016/j.actatropica.2025.107534","DOIUrl":"10.1016/j.actatropica.2025.107534","url":null,"abstract":"<div><div>Cell models emulating an <em>in vitro</em> parasitic infection can greatly improve our understanding of helminthiases. Nonetheless, it remains challenging to select an appropriate <em>in vitro</em> model to study molecular pathogenesis of infections by trematodes having a complex life cycle. Therefore, adequate models are in high demand. The epidemiologically important foodborne trematode <em>Opisthorchis felineus</em> parasitizes bile ducts of fish-eating mammals, including humans. The human infection leads to chronic inflammation and biliary intraepithelial neoplasia, which is considered precancerous. This study was aimed at evaluating two useful <em>in vitro</em> research tools based on human cholangiocytes’ (H69 cells’) response to the trematode: coculture with live worms or incubation with parasite-derived excretory–secretory products (ESPs). We assessed H69 cells’ proliferation, migration rate, cell cycle shift, and cytokine production. We also conducted genome-wide transcriptome analysis to identify affected cascades of regulatory signaling events. We demonstrated significant discrepancies between the two <em>in vitro</em> models of host–parasite interactions. Although differences between the two models in cell proliferation and cell migration rate were weak, there were substantial differences in the production and release of cytokines IL-6, IL-4, and TNF. A total of 144 genes in H69 cells were found to be differentially expressed after coculture with live worms, whereas 537 genes were differentially expressed after exposure to ESPs. Transcriptomic analysis revealed only 11 common upregulated genes and six common downregulated genes. Functional enrichment analysis of the gene sets also revealed some striking differences between the <em>in vitro</em> models. Our data will contribute to a deeper understanding of biliary neoplasia associated with liver fluke infection. This study underscores the importance of choosing an appropriate <em>in vitro</em> model to accurately emulate host–parasite interactions. The data also highlight the need for further investigation into the pathogenesis of the precancerous biliary lesions associated with liver fluke infection.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107534"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of encephalitis in children with scrub typhus-associated acute febrile illness","authors":"Neha Srivastava ,&nbsp;Shahnawaz Jamal ,&nbsp;Kamran Zaman ,&nbsp;Hirawati Deval ,&nbsp;Rohit Beniwal ,&nbsp;Bhoopendra Sharma ,&nbsp;Urmila Gupta ,&nbsp;Rajni Kant ,&nbsp;Aman Agarwal ,&nbsp;Umaer Alam ,&nbsp;Manoj Murhekar ,&nbsp;Mahima Mittal","doi":"10.1016/j.actatropica.2025.107525","DOIUrl":"10.1016/j.actatropica.2025.107525","url":null,"abstract":"<div><div>Scrub typhus (ST) is an emerging public health concern in India. Despite being treatable, 20–30 % of acute febrile illnesses (AFI) progress to encephalitis in endemic regions. This study aimed to identify early markers for encephalitis development in children hospitalized with AFI and positive <em>Orientia tsutsugamushi</em> (Ots) serology. This prospective cohort study was conducted during January-December 2018, involved AFI patients (age ≤ 16 years) tested positive for IgM antibodies against Ots. These patients were followed up prospectively to monitor the development of encephalitis. The clinical and biochemical data from ST-AFI cases developed encephalitis were compared with ST-AFI cases did not develop encephalitis. Univariate and multivariate logistic regression analysis were used to determine predictors of encephalitis. Total 41 out of 190 (21.6 %) ST-AFI patients progressed to encephalitis. The multivariate regression analysis identified initiation of antibiotic therapy after more than 5 days from illness onset (OR 4; 95 % CI [1.4–11.6]), vomiting (&gt;3 episodes) (OR: 10.9; 95 % CI [2.3–51.4]), Glasgow Coma Scale (9–12) (OR 6; 95 %CI [1.9–19]), calcium level (≤8 mg/dL) (OR 6.1 95 % CI [1.1–32.6]), serum creatinine (&gt;1 mg/dL) (OR 16.8, 95 % CI [1.5–191.9]), and oxygen support requirement (OR 19.5, 95 % CI[6.4–59.3]) at admission as predictor of encephalitis in ST-AFI cases. The sensitivity and specificity of model was 67.50 % and 93.96 % respectively, Hosmer-Lemeshow test (χ2 = 8.82, <em>P</em> = 0.3584), and an area under the ROC curve of 0.9514. Study found initiation of antibiotic more than 5 days after illness onset, multiple vomiting episodes, low GCS, hypocalcaemia, high creatinine, and oxygen need as predictors of encephalitis in ST-AFI patients.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107525"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling a new focus of spotted fever rickettsioses as causative agents of acute undifferentiated febrile illness in Odisha, a state in eastern coastal India","authors":"Dr CS Premnath ,&nbsp;Shriya Goel ,&nbsp;Prof Bijayini Behera ,&nbsp;Prof Manisha Biswal ,&nbsp;Prof Baijayantimala Mishra ,&nbsp;Prof Rashmi Ranjan Mohanty ,&nbsp;Prof Rashmi Ranjan Das","doi":"10.1016/j.actatropica.2025.107522","DOIUrl":"10.1016/j.actatropica.2025.107522","url":null,"abstract":"<div><div>Spotted fever group <em>Rickettsia</em> (SFGR) infections remain largely under-investigated as causative agents of acute undifferentiated febrile illness (AUFI) in resource-limited settings. Few studies are available on the prevalence of SFGR infections in India, especially in eastern India. In a cross-sectional study conducted in 192 hospitalized adult and paediatric patients with AUFI, the frequency of SFGR using sequential PCR targeting genes encoding citrate synthase (<em>gltA</em>), <em>17 kDa</em> lipoprotein precursor antigen (<em>17kDa</em>), outer membrane proteins A and B (<em>omp A</em> &amp; <em>omp B</em>) was 6.2% (12/192) including 7.4% (8/108) in adults and 4.7% (4/84) in paediatric patients with AUFI. Phylogenetic analysis of SFGR based on the concatenated sequences of <em>omp A-gltA-17kDa-omp B</em> showed that the patients' isolates obtained in the study clustered with <em>Rickettsia conorii</em> str. Malish 7 (AE006914.1). The SFGR cases described here, to the best of our knowledge, are the first human cases diagnosed in Odisha, eastern coastal India that were laboratory-confirmed by molecular detection and sequencing. The findings of this study will be beneficial for designing systematic future studies covering more geographical locations for continued surveillance of SFGR human infections along with vector surveillance.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107522"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular detection and diversity of Bartonella spp. in non-hematophagous bats from the Peruvian Amazon","authors":"Luis A. Gomez-Puerta ,&nbsp;Juana Ampuero-Riega ,&nbsp;Noelia Medrano-Uchuya ,&nbsp;Siever Morales-Cauti","doi":"10.1016/j.actatropica.2025.107539","DOIUrl":"10.1016/j.actatropica.2025.107539","url":null,"abstract":"<div><div>The <em>Bartonella</em> genus comprises a variety of species capable of infecting a wide range of mammals through hematophagous arthropods, such as fleas, ticks, flies, and lice. Domestic (dogs and cats) and wild (rodents and bats) reservoirs harbor species with zoonotic potential. This molecular study identified the diversity of <em>Bartonella</em> spp. in bats from the Peruvian Amazon. Blood samples from 62 bats were molecularly analyzed for the detection of <em>Bartonella</em> spp. by amplification of the 16S–23S internal transcribed spacer (ITS) region and the citrate synthase (<em>gltA</em>) gene. The ITS region amplification revealed the presence of <em>Bartonella</em> spp. DNA in 12 bats (19.4 %). These bats were four <em>Carollia perspicillata</em>, three <em>Uroderma bilobatum</em>, two <em>Phyllostomus hastatus</em>, a <em>Platyrrhinus infuscus</em>, and a <em>Noctilio albiventris</em>. Partial analysis of the <em>gltA</em> gene successfully assessed <em>Bartonella</em> genetic variants in 11 of the ITS-positive samples. Eleven genetic variants were identified, with differences ranging from 0.3 % to 18.0 % among them. Both a bat N<em>. albiventris</em> and a specimen of <em>C. perspicillata</em> exhibited two variants previously detected in N<em>. albiventris</em> from French Guiana and the bat fly <em>Strebla guajiro</em> collected from <em>C. perspicillata</em> in Brazil. The remaining nine variants correspond to newly identified <em>Bartonella</em> variants in bats. The results revealed a remarkable diversity of <em>Bartonella</em> spp. among bats in the Americas. These findings expand knowledge on the genetic variability of <em>Bartonella</em> infection in these mammals and provide new insights into the ecology of bat-borne <em>Bartonella</em> species.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107539"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological evidence of Crimean-Congo haemorrhagic fever in domestic animals from eight regions of Namibia","authors":"Lourens de Villiers ,&nbsp;Umberto Molini ,&nbsp;Leandra van Zyl ,&nbsp;Siegfried Khaiseb ,&nbsp;Frank Busch ,&nbsp;Klaas Dietze ,&nbsp;Sascha Knauf ,&nbsp;Giovanni Franzo","doi":"10.1016/j.actatropica.2025.107524","DOIUrl":"10.1016/j.actatropica.2025.107524","url":null,"abstract":"<div><div>Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonotic disease endemic to regions of Africa, the Balkans, the Middle East, and Asia, with increasing reports of cases in southern Europe. Human transmission occurs primarily through the bite of infected ticks and by body fluids from infected human. Crimean-Congo haemorrhagic fever virus (CCHFV) affects a broad host range, including both domestic and wild vertebrates. Recent studies have suggested a potential susceptibility of companion animals, posing an additional threat to public health. In the present study, the presence of CCHFV antibodies was evaluated by screening 374 dog and 238 cat serum samples collected from eight Namibian regions using a commercial enzyme-linked immunosorbent assay. Overall, dogs (11.50 %) showed significantly higher odds of seropositivity (OR = 7.60; 95 % CI = 3.02 - 25.51; <em>p</em>-value &lt; 0.001) compared to cats (1.68 %). Most of the positive dogs and all positive cats originated from the Kunene and Hardap regions. No other factors were found to affect seroprevalence. The limited development of farming systems in these regions, combined with the higher roaming activity of dogs, may suggest a greater exposure risk to wild animals or infected ticks. Tick species of the genus <em>Hyalomma</em> are not commonly reported to infest dogs in Namibia, and other tick species may also be involved in transmission. The detection of CCHFV antibodies in dogs and cats in Namibia should be considered by public health authorities as a potential threat, warranting further investigation to identify infection sources and risk factors. While the level and duration of viremia in companion animals, as well as their actual infectivity, remain unknown, efforts should focus on reducing contact between domestic pets, livestock, and wild animals, as well as regular prophylactic tick treatment of pets to prevent or minimise tick infestations.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107524"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraspecific genetic variation in the lymphatic filariasis vector Mansonia dives (Diptera: Culicidae) in Thailand: Hidden species or genetically divergent populations?","authors":"Sedthapong Laojun ,&nbsp;Tanasak Changbunjong ,&nbsp;Tanawat Chaiphongpachara","doi":"10.1016/j.actatropica.2025.107526","DOIUrl":"10.1016/j.actatropica.2025.107526","url":null,"abstract":"<div><div><em>Mansonia dives</em> is recognized as a vector for brugian filariasis in Thailand. A recent study analyzing the cytochrome <em>c</em> oxidase subunit I (<em>COI</em>) gene revealed two distinct clades within the <em>Ma. dives</em> population in Thailand. This study aimed to examine the genetic diversity and structure of <em>Ma. dives</em> using the <em>COI</em> gene and the internal transcribed spacer 2 (ITS2) region to determine the presence of distinct species or genetically divergent populations. We analyzed 60 <em>COI</em> and 60 ITS2 sequences from <em>Ma. dives</em> populations in Narathiwat, Ranong, Tak, and Trat. The results showed a nucleotide diversity of 0.019 and a haplotype diversity of 0.979 for the <em>COI</em> gene, while the ITS2 region displayed a nucleotide diversity of 0.005 and a haplotype diversity of 0.545. Phylogenetic and haplotype network analyses of the <em>COI</em> gene identified two genetic lineages: one confined to Trat and another encompassing the other sites. However, species delimitation methods suggested that these genetic differences were insufficient to classify the lineages as distinct species. In contrast, the ITS2 analysis indicated a uniform genetic pattern across all populations. We conducted neutrality tests and mismatch distribution to examine the demographic history. For the <em>COI</em> gene, Tajima's <em>D</em> was slightly positive and non-significant (0.014), while Fu's <em>Fs</em> was negative (−9.750), indicating a potential expansion phase. Conversely, for the ITS2 region, Tajima's <em>D</em> and Fu's <em>Fs</em> were positive and non-significant, suggesting that the population might be in equilibrium or undergoing contraction. Moreover, the mismatch distribution analysis for the ITS2 region was inconclusive. The apparent discrepancies between these markers indicate the presence of genetically divergent populations, rather than distinct species.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107526"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odor masking to decrease the attraction of Triatoma infestans (Hemiptera: Reduviidae, Triatominae), a Chagas disease vector, towards a host","authors":"Andrea Martínez Beningaza ,&nbsp;I.M. Desiree Di Benedetto ,&nbsp;Lucía Babino ,&nbsp;Pablo G Guerenstein","doi":"10.1016/j.actatropica.2024.107520","DOIUrl":"10.1016/j.actatropica.2024.107520","url":null,"abstract":"<div><div>Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However, insecticide resistance, and environmental and health issues, stress the need for new, environmentally-friendly methods for reducing vector-host contacts. Kissing bugs use the odor blend emitted by hosts to locate them. The proportions of the constituents of that blend are important to determine the attraction evoked by it. We aimed at assessing whether artificial alterations of those proportions could render an attractive host, unattractive for the kissing bug <em>Triatoma infestans</em>. Thus, the behavior of the bugs after adding a source of nonanal, a component of vertebrate odor detected by the bugs, to an attractive mouse was studied. For this, nymphs were tested using a dual-choice trap-olfactometer and different doses of nonanal. Addition of nonanal resulted in a dose- dependent reduction in the attraction of the bugs towards the mouse although it did not prevent the bugs from leaving their release zone nor it affected their (reduced) host preference near the host. Nonanal <em>per se</em> did not evoke any behavior at the doses tested. We suggest that the increase in the proportion of nonanal resulted in masking of the mouse odor. This approach could help reach a “push” effect within an effective push- pull strategy for kissing bugs. That strategy would help diminish the vector-host contacts and, therefore, Chagas disease incidence, in an environmentally-friendly manner. It remains to be established whether this strategy proves effective in the field when adequate odor dispensers and socially acceptable odors are used.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107520"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular and serological investigation of Brucella species in kennel and farm dogs in Iran","authors":"Baharak Akhtardanesh ,&nbsp;Elham Mohammadi ,&nbsp;Soheil Sadr ,&nbsp;Asma Askari ,&nbsp;Zeinab Manzari Tavakoli ,&nbsp;Rozhin Ahmadi ,&nbsp;Shakiba Nazemian ,&nbsp;Hossein Rashidi ,&nbsp;Morteza Aghamiri ,&nbsp;Mehdi Golchin ,&nbsp;Masoud Imani","doi":"10.1016/j.actatropica.2025.107521","DOIUrl":"10.1016/j.actatropica.2025.107521","url":null,"abstract":"<div><h3>Introduction</h3><div>Brucellosis is still a significant emerging threat to public health, as it can infect humans, wild, domestic animals, and livestock. Hence, the current study aims to determine the frequency of canine brucellosis (CB), its relationship with clinical findings and reproductive disorders in kennel and farm dogs, and its importance on public health.</div></div><div><h3>Materials and methods</h3><div>From January 2022 to December 2023, a total of 150 blood samples were taken from 100 adult dogs in breeding kennels and 50 shepherd dogs in breeding farms in Kerman, Iran. Rose Bengal test (RBT) and Wright tests were used for the primary screening of <em>Brucella abortus</em> (<em>B. abortus</em>) and <em>Brucella melitensis</em> (<em>B. melitensis</em>) species, and conventional IS711-based PCR and real-time polymerase chain reaction (RT-PCR) were performed to determine the <em>Brucella</em> genus and species in all samples.</div></div><div><h3>Findings</h3><div>In kennel dogs, 34 % (34/100) had a history of breeding disorders, and 30 % (30/100) were RBT-positive. Moreover, <em>B. canis</em> and <em>B. abortus</em> species were detected in kennel dogs. Among farm dogs, 16 % (8/50) had a history of breeding disorders, and 28 % (14/50) were RBT positive. Additionally, <em>B. canis, B. abortus</em>, and <em>B. melitensis</em> species were detected in farm dogs. Feeding with unpasteurized milk was significantly related to a positive RBT in kennel dogs (<em>p</em> = 0.009), and there was a significant correlation between breeding disorders and seropositivity in kennel (<em>p</em> = 0.045) and farm dogs (<em>p</em> = 0.03).</div></div><div><h3>Conclusion</h3><div>The current study represents a significant advancement in understanding CB in Iran by the first molecular detection of <em>B. canis</em>, revealing <em>B. melitensis</em> and <em>B. abortus</em> as important pathogens in kennel and farm dogs and highlighting the public health significance of disease in Iran.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107521"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In search of pathogenic Leptospira species in Myotis and other vesper bats, Russia","authors":"Alex Lintu Viskontene ,&nbsp;Ekaterina V. Radyuk ,&nbsp;Oleg A. Shapkin ,&nbsp;Evgeniy A. Khizhkin ,&nbsp;Victoria P. Bulanenko ,&nbsp;Yana A. Voytsekhovskaya ,&nbsp;Sergey G. Medvedev ,&nbsp;Lyudmila S. Karan","doi":"10.1016/j.actatropica.2024.107506","DOIUrl":"10.1016/j.actatropica.2024.107506","url":null,"abstract":"<div><div>Various bat species worldwide have been identified as <em>Leptospira</em> carriers, especially in tropical regions. In this study, we investigated the infection of Vespertilionidae bats by pathogenic <em>Leptospira</em> in north-west Russia. Out of 264 bats from 13 species, the urine of 24 specimens tested positive according to a polymerase chain reaction test. The infected species were exclusively <em>Myotis</em> bats: <em>M. brandtii</em> (1/56; 1.8 %); <em>M. dasycneme</em> (9/40; 22.5 %); and <em>M. daubentonii</em> (14/47; 29.8 %). The detected <em>Leptospira</em> strains were similar to <em>L. kirschneri</em> and <em>L. borgpetersenii</em>.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107506"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wolbachia-based mosquito control: Environmental perspectives on population suppression and replacement strategies","authors":"Joydeb Bhattacharyya ,&nbsp;Daniel L. Roelke","doi":"10.1016/j.actatropica.2024.107517","DOIUrl":"10.1016/j.actatropica.2024.107517","url":null,"abstract":"<div><div>Mosquito-borne diseases pose a significant threat to global health, and traditional mosquito control methods often fall short of effectiveness. A promising alternative is the biological control strategy of transinfecting mosquitoes with <em>Wolbachia</em>, a bacterium capable of outcompeting harmful pathogens and reducing the ability of mosquitoes to transmit diseases. However, <em>Wolbachia</em> infections are sensitive to abiotic environmental factors such as temperature and humidity, which can affect their densities in mosquitoes and, consequently, their ability to block pathogens. This review evaluates the effectiveness of different <em>Wolbachia</em> strains transinfected into mosquitoes in reducing mosquito-borne diseases. It explores how <em>Wolbachia</em> contributes to mosquito population control and pathogen interference, highlighting the importance of mathematical models in understanding <em>Wolbachia</em> transmission dynamics. Additionally, the review addresses the potential impact on arboviral transmission and the challenges posed by environmental fluctuations in mosquito control programs.</div></div>","PeriodicalId":7240,"journal":{"name":"Acta tropica","volume":"262 ","pages":"Article 107517"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}