Biomolecules & biomedicine最新文献_第8页

PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway. PF4通过CXCR3/PI3K/AKT/Nrf2途径调控脑出血中神经元的铁凋亡

Biomolecules & biomedicine Pub Date : 2025-04-26 DOI: 10.17305/bb.2024.11415

Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu

{"title":"PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway.","authors":"Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu","doi":"10.17305/bb.2024.11415","DOIUrl":"10.17305/bb.2024.11415","url":null,"abstract":"Inhibiting ferroptosis represents a promising strategy for managing neuronal injury caused by intracerebral hemorrhage (ICH). Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ferroptosis. To investigate this, a hemin-induced injury model was established in PC12 cells in vitro, and an ICH model was created in vivo using IV collagenase injection. Hemin-treated PC12 cells were co-cultured with recombinant mouse PF4 (Rm-PF4) protein to examine the effects of PF4 on ferroptosis. Additionally, Rm-PF4 was administered intraperitoneally to ICH mice, and its influence on neurological dysfunction, brain edema, and neuronal ferroptosis was evaluated. Western blot analysis was employed to assess PF4 levels, CXCR3/phosphatidylinositol 3-kinase (PI3K)/AKT/nuclear factor erythroid-2-related factor 2 (Nrf2) pathway activation, and ferroptosis-related protein expression. PF4 levels were found to be reduced in both perihematomal brain tissues of ICH mice and hemin-treated PC12 cells. Treatment with Rm-PF4 decreased ferrous ion, malondialdehyde (MDA), and reactive oxygen species (ROS) levels, effectively inhibiting ferroptosis in PC12 cells. Furthermore, Rm-PF4 administration alleviated neurological dysfunction, neuronal damage, and brain edema while suppressing neuronal ferroptosis in ICH mice. Mechanistically, Rm-PF4 activated the CXCR3/PI3K/AKT/Nrf2 pathway, and this protective effect was diminished by a CXCR3 antagonist in both ICH mice and hemin-treated PC12 cells. In conclusion, PF4 mitigates ICH-induced neuronal ferroptosis in mouse models and PC12 cells by activating the CXCR3/PI3K/AKT/Nrf2 pathway.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":"1322-1334"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of elevated CEA levels on the outcome of colorectal cancer patients with different histopathologic types:A SEER population-based study. CEA水平升高对不同组织病理学类型结直肠癌患者预后的影响：一项基于 SEER 群体的研究。

Biomolecules & biomedicine Pub Date : 2025-04-26 DOI: 10.17305/bb.2024.11265

Siqi Sheng, Xiaoming Bai, Yiting Wang, Haimei Feng, Jie Chen, Yitian Chen, Mengxi Huang, Zengjie Lei, Xiaoyuan Chu

{"title":"Effect of elevated CEA levels on the outcome of colorectal cancer patients with different histopathologic types:A SEER population-based study.","authors":"Siqi Sheng, Xiaoming Bai, Yiting Wang, Haimei Feng, Jie Chen, Yitian Chen, Mengxi Huang, Zengjie Lei, Xiaoyuan Chu","doi":"10.17305/bb.2024.11265","DOIUrl":"10.17305/bb.2024.11265","url":null,"abstract":"Limited and contradictory evidence has been reported regarding the prognostic effects of carcinoembryonic antigen (CEA) on the prognosis and metastasis of classical adenocarcinoma (CA), mucinous adenocarcinoma (MA), and signet-ring cell carcinoma (SRCC) in colorectal cancer (CRC) patients. We investigated the associations between histological subtypes and preoperative serum CEA levels in determining the oncologic outcomes of CRC patients. A total of 47,692 patients with clearly diagnosed CRC were selected from the Surveillance, Epidemiology, and End Results (SEER) database and divided into two cohorts based on serum CEA levels: CEA-normal (C0) and CEA-elevated (C1). Chi-square analysis revealed a correlation between CEA levels and histological classification. We then included a newly defined interaction variable (H&CEA) in the Cox regression analysis, which demonstrated that this variable could serve as an independent prognostic factor (P < 0.001). CA, in the context of elevated serum CEA levels, differed from the other two histopathological types, showing unexpectedly higher risks for both overall survival (OS) (HR = 1.70, 95% CI = 1.65-1.75, P < 0.001) and cancer-specific survival (CSS) (HR = 1.78, 95% CI = 1.72-1.85, P < 0.001). Furthermore, elevated CEA levels significantly increased the proportion of liver metastases in the CA group (25.43% vs 3.95%, P < 0.001). The interaction variable H&CEA can be used as an independent prognostic factor for CRC and should be considered in the diagnosis of CRC and the development of personalized treatment plans. Additionally, in the context of elevated CEA levels, CA is associated with poor prognosis and increased liver metastases. This CRC subgroup warrants special clinical attention from oncologists.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":"1396-1407"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent intra-aortic balloon pump and veno-arterial extracorporeal membrane oxygenation for acute coronary syndrome-related cardiogenic shock: A meta-analysis of multivariate studies. 同时使用主动脉内球囊泵和静脉-动脉体外膜肺氧合治疗急性冠状动脉综合征相关心源性休克：一项多变量研究的荟萃分析。

Biomolecules & biomedicine Pub Date : 2025-04-26 DOI: 10.17305/bb.2024.11011

Xin Huang, Di Huang, Weiye Wan, Hongling Zhang, Zhengdong Liu

{"title":"Concurrent intra-aortic balloon pump and veno-arterial extracorporeal membrane oxygenation for acute coronary syndrome-related cardiogenic shock: A meta-analysis of multivariate studies.","authors":"Xin Huang, Di Huang, Weiye Wan, Hongling Zhang, Zhengdong Liu","doi":"10.17305/bb.2024.11011","DOIUrl":"10.17305/bb.2024.11011","url":null,"abstract":"Concurrent intra-aortic balloon pump (IABP) use has been suggested to reduce mortality in patients with acute coronary syndrome (ACS)-related cardiogenic shock (CS) on veno-arterial extracorporeal membrane oxygenation (ECMO). However, this observation is primarily based on small-scale univariate studies. The aim of this meta-analysis was to evaluate whether concurrent IABP and ECMO were independently associated with reduced mortality in patients with ACS-related CS. We searched Medline, Web of Science, and Embase for studies published up to May 28, 2024. The inclusion criteria were longitudinal observational studies comparing concurrent IABP and ECMO to ECMO alone in ACS-related CS patients, reporting all-cause mortality with multivariate adjustments. The primary outcome was the risk ratio (RR) of short-term mortality. A random-effects model incorporating heterogeneity was used to pool the results. Seven cohort studies, involving 5467 patients, were included. Concurrent IABP and ECMO were associated with a significant reduction in short-term mortality (adjusted RR: 0.64; 95% CI: 0.48-0.87, P = 0.005; I² = 83%). Sensitivity analyses confirmed the robustness of these results. Meta-regression indicated that the proportion of men in each study significantly influenced the outcomes, fully explaining the heterogeneity (I² residual = 0%). Subgroup analyses showed consistent results across various study designs, patient ages, observational durations, and study quality scores. In conclusion, concurrent IABP and ECMO are independently associated with reduced short-term mortality in ACS-related CS patients, particularly in studies with higher proportions of men. These findings support the potential benefits of combined mechanical support in this high-risk population.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":"1233-1244"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity. 黄花蒿倍半萜类化合物的体外抗sars - cov -2活性研究

Biomolecules & biomedicine Pub Date : 2025-04-25 DOI: 10.17305/bb.2025.12052

Irma Gušić, Ilma Terzić, Toni Eterović, Adis Softić, Šejla Goletić, Teufik Goletić, Dejan Nikolić, Emina Korić, Katarina Bijelić, Haris Nikšić, Senka Vidović, Kemal Durić

{"title":"Profiling of sesquiterpenoid fractions from Artemisia annua L. and testing their in vitro anti-SARS-CoV-2 activity.","authors":"Irma Gušić, Ilma Terzić, Toni Eterović, Adis Softić, Šejla Goletić, Teufik Goletić, Dejan Nikolić, Emina Korić, Katarina Bijelić, Haris Nikšić, Senka Vidović, Kemal Durić","doi":"10.17305/bb.2025.12052","DOIUrl":"https://doi.org/10.17305/bb.2025.12052","url":null,"abstract":"The current state of research on the anti‑SARS‑CoV‑2 potential of artemisinin‑related compounds has identified arteannuin B as a potent inhibitor of the nCoV‑2019BetaCov/Wuhan/WiV04/2019 and BetaCov/Italy/CDG1/2020 strains of the virus. The aim of this work was to fractionate the targeted sesquiterpenoid compounds, arteannuin B and artemisinin, from the complex matrix of the crude ethanolic leaf extract of Artemisia annua L. using high‑speed countercurrent chromatography (HSCCC) and to test the simplified or purified fractions against the genomically characterized Alpha SARS‑CoV‑2 variant in vitro. This is the first detailed in vitro anti‑SARS‑CoV‑2 study using an analytically characterized supercritical fluid extract of A. annua L. The preparative HSCCC method enabled the isolation of purified arteannuin B in a single chromatographic step, which was confirmed by LC‑ESI‑QTOF‑MS/MS. The MS data confirmed the selectivity of the HSCCC method for the targeted fractionation of artemisinin from the complex matrix, as it was successfully separated from the EtOH crude extract without co‑elution with arteannuin B. Antiviral activity determined by quantitative real‑time PCR (qRT‑PCR) yielded half‑maximal effective concentrations (EC₅₀) of 93.7 µg/mL (SC‑CO₂ extract), 173.5 µg/mL (EtOH extract), 187.3 µg/mL (artemisinin knockout fraction), 38.1 µg/mL (arteannuin B fraction), and >100 µg/mL (artemisinin). The arteannuin B fraction was highly active at 50 µg/mL (p < 0.0001) and 100 µg/mL (p < 0.0001), and inhibited the amplification of the SARS‑CoV‑2 N and RdRp genes by 84% and 100%, respectively. An important contribution of this study is the demonstration of the antiviral activity of arteannuin B against the Alpha variant of SARS‑CoV‑2, which is known to have increased infectivity and transmissibility.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Synthesis, characterization, and in vitro-in ovo toxicological screening of silibinin fatty acids conjugates as prodrugs with potential biomedical applications. 修正：水飞蓟宾脂肪酸缀合物作为具有潜在生物医学应用的前药的合成、表征和卵外毒理学筛选。

Biomolecules & biomedicine Pub Date : 2025-04-25 DOI: 10.17305/bb.2025.12570

Cristina Dehelean, Simona Cinta Pinzaru, Adrian Pirnau, Vasile Chis, Andrea Simion, Geza Lazar, Andrada Iftode, Iasmina Marcovici, Ersilia Alexa, Estera Boeriu

引用次数: 0

Correction: LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis. 更正：LKB1抑制通过LKB1- ampk - yap轴促进心肌细胞再生。

Biomolecules & biomedicine Pub Date : 2025-04-25 DOI: 10.17305/bb.2025.12567

Shuang Qu, Qiao Liao, Cheng Yu, Yue Chen, Han Luo, Xuewei Xia, Duofen He, Zaicheng Xu, Pedro A Jose, Zhuxin Li, Wei Eric Wang, Qing Rex Lyu, Chunyu Zeng

引用次数: 0

Effect of SGLT2 inhibitors on liver fat content: A meta-analysis. SGLT2抑制剂对肝脏脂肪含量的影响：荟萃分析。

Biomolecules & biomedicine Pub Date : 2025-04-25 DOI: 10.17305/bb.2025.12203

Quanli Ge, Fengling Zhang, Yong Liu

{"title":"Effect of SGLT2 inhibitors on liver fat content: A meta-analysis.","authors":"Quanli Ge, Fengling Zhang, Yong Liu","doi":"10.17305/bb.2025.12203","DOIUrl":"https://doi.org/10.17305/bb.2025.12203","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major metabolic disorder linked to increased morbidity and mortality. Sodium-glucose co-transporter-2 (SGLT2) inhibitors, commonly used to manage type 2 diabetes (T2DM), have shown potential in reducing liver fat content (LFC). However, the magnitude and consistency of this effect remain uncertain. This meta-analysis aimed to evaluate the impact of SGLT2 inhibitors on LFC in adults with metabolic disorders. A systematic search of PubMed, Embase, the Cochrane Library, and Web of Science was conducted up to January 2, 2024, to identify randomized controlled trials (RCTs) assessing the effects of SGLT2 inhibitors on LFC. Studies were included if they reported liver fat changes measured by magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) or proton magnetic resonance spectroscopy (¹H-MRS). We pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) using a random-effects model to account for variability across studies. Thirteen RCTs with 14 datasets (n = 791 participants) were included. SGLT2 inhibitors significantly reduced LFC compared to controls (SMD: -0.73, 95% CI: -0.97 to -0.50; P < 0.001), with moderate heterogeneity (I² = 62%). Subgroup and meta-regression analyses did not identify any study characteristics-such as study design, diabetic status, patient demographics, baseline LFC, type of SGLT2 inhibitor, or treatment duration-as significant contributors to heterogeneity (all P > 0.05). In conclusion, SGLT2 inhibitors are associated with a significant reduction in LFC in adults, supporting their potential role in managing MASLD.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letrozole versus coenzyme Q10 plus Clomiphene citrate for women with Polycystic Ovarian Syndrome: An efficacy and safety analysis. 来曲唑与辅酶Q10加枸橼酸克罗米芬治疗多囊卵巢综合征的疗效和安全性分析

Biomolecules & biomedicine Pub Date : 2025-04-23 DOI: 10.17305/bb.2025.11386

Juan Hou, Qingfen Chang

{"title":"Letrozole versus coenzyme Q10 plus Clomiphene citrate for women with Polycystic Ovarian Syndrome: An efficacy and safety analysis.","authors":"Juan Hou, Qingfen Chang","doi":"10.17305/bb.2025.11386","DOIUrl":"https://doi.org/10.17305/bb.2025.11386","url":null,"abstract":"Clomiphene citrate is a well-established treatment for Polycystic Ovarian Syndrome (PCOS) but has poor efficacy and adverse effects. Coenzyme Q10 supplementation improves mitochondrial function. Letrozole has been reported to be effective with fewer adverse effects but is not approved for PCOS by the USFDA. This is a retrospective study in women diagnosed with PCOS to assess treatment with either 2.5 mg/day letrozole (LO cohort, n = 103) for 5 days per cycle (for 9 cycles). The QC group received additional doses of 50 mg coenzyme Q10 three times daily (QC cohort, n = 123). A third group received only 100 mg/day clomiphene citrate (CC cohort, n = 155) from the second day of the menstrual cycle for 5 days. After treatment, the duration of the menstrual cycle decreased across all cohorts (P < 0.001 for all), with a smaller reduction observed in the LTZ cohort compared to the QC and CC cohorts (P < 0.05 for all). The number of conceived pregnancies in the LTZ cohort (P < 0.0001) and the CC + QC cohort (P < 0.0001) was significantly higher than in the CC only group. Similarly, conception was higher in the CC + Q10 group than in the CC only group (P < 0.0001 for both groups). Letrozole versus clomiphene citrate plus coenzyme Q10 showed similar efficacy in achieving pregnancy in women with PCOS.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning integration of single-cell and bulk transcriptomics identifies fibroblast-driven prognostic markers in colorectal cancer. 单细胞和大量转录组学的机器学习整合鉴定结直肠癌成纤维细胞驱动的预后标志物。

Biomolecules & biomedicine Pub Date : 2025-04-22 DOI: 10.17305/bb.2025.12038

Ning Zhang, Ruiyan Liu, Siya Wu, Chenxi Feng, Boxiang Wang, Qiaoqiao Zheng, Linru Jie, Ruihua Kang, Xiaoli Guo, Xiaoyang Wang, Shaokai Zhang, Jiangong Zhang

{"title":"Machine learning integration of single-cell and bulk transcriptomics identifies fibroblast-driven prognostic markers in colorectal cancer.","authors":"Ning Zhang, Ruiyan Liu, Siya Wu, Chenxi Feng, Boxiang Wang, Qiaoqiao Zheng, Linru Jie, Ruihua Kang, Xiaoli Guo, Xiaoyang Wang, Shaokai Zhang, Jiangong Zhang","doi":"10.17305/bb.2025.12038","DOIUrl":"https://doi.org/10.17305/bb.2025.12038","url":null,"abstract":"Single-cell RNA sequencing (scRNA-seq) has significantly advanced our understanding of cellular heterogeneity and the complex interplay within the tumor microenvironment (TME) of colorectal cancer (CRC). However, translating these molecular insights into clinically actionable prognostic biomarkers and therapeutic strategies remains a considerable challenge. In this study, we conducted a comprehensive scRNA-seq analysis of 306 CRC samples comprising 448,255 cells to characterize the TME in depth. By constructing intercellular communication networks based on connection counts and communication probabilities, we identified fibroblasts as central regulatory hubs within the TME. Using Wilcoxon rank-sum tests and univariate survival analyses, we initially identified 23 prognostic fibroblast markers. These were refined to a seven-gene fibroblast-related prognostic signature via an integrated machine learning approach. The signature exhibited robust predictive performance in the The Cancer Genome Atlas - Colon Adenocarcinoma (TCGA-COAD) training cohort (n=351; C-index=0.65) and was successfully validated in the GSE17536 dataset (n=177; C-index=0.63). Functional enrichment analyses revealed that this signature is involved in immune regulation and multiple tumor-associated cellular pathways. Notably, high-risk patients displayed increased macrophage and NK cell infiltration, impaired immune function, and elevated immune rejection scores, while low-risk patients demonstrated heightened sensitivity to camptothecin and irinotecan. Together, our findings underscore the prognostic value of fibroblast-derived signatures in CRC and support their potential utility in risk stratification and the development of personalized therapeutic strategies, contributing to the advancement of precision oncology.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of robotic, conventional, and endoscopic nipple-sparing mastectomy with immediate prosthetic breast reconstruction for breast cancer: A systematic review and meta-analysis. 机器人、传统和内窥镜保留乳头乳房切除术与立即假体乳房重建术对乳腺癌的比较：一项系统回顾和荟萃分析。

Biomolecules & biomedicine Pub Date : 2025-04-21 DOI: 10.17305/bb.2025.11687

Na An, Wenjuan Wang, Dandan Dai, Fei Yuan, Yufeng Zhang

{"title":"Comparison of robotic, conventional, and endoscopic nipple-sparing mastectomy with immediate prosthetic breast reconstruction for breast cancer: A systematic review and meta-analysis.","authors":"Na An, Wenjuan Wang, Dandan Dai, Fei Yuan, Yufeng Zhang","doi":"10.17305/bb.2025.11687","DOIUrl":"https://doi.org/10.17305/bb.2025.11687","url":null,"abstract":"In this network meta-analysis (NMA), we aimed to evaluate the relative efficacy of robotic nipple-sparing mastectomy (RNSM), conventional nipple-sparing mastectomy (CNSM), and endoscope-assisted nipple-sparing mastectomy (ENSM), each combined with immediate prosthetic breast reconstruction (IPBR), for the treatment of breast cancer. Relevant studies published up to June 15, 2024, were identified through searches of PubMed, Embase, the Cochrane Library, and Web of Science. Data extracted from these studies were analyzed using Stata 15.1 and the Gemtc 1.0.1 package in R 4.2.3. A Bayesian framework and a Markov Chain Monte Carlo model were employed to conduct the NMA. Additionally, a ranking chart was generated to compare the advantages and disadvantages of the surgical methods. Ten studies met the inclusion criteria and were included in the NMA. The results indicated that ENSM with immediate implant-based reconstruction was associated with a smaller incision compared to CNSM. RNSM combined with IPBR was linked to a lower incidence of total complications, Grade 3 complications, and nipple-areola complex necrosis than CNSM. Furthermore, RNSM with IPBR demonstrated a lower recurrence rate than CNSM. However, CNSM with IPBR showed better outcomes in terms of surgical time, hospital stay, and positive margin infiltration. In contrast, RNSM and ENSM, both combined with IPBR, outperformed CNSM in terms of incision length, complication rates, and recurrence outcomes.","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0