Biomolecules & biomedicine最新文献

{"title":"Integrative PANoptosis gene profiling reveals prognostic and therapeutic insights in prostate cancer.","authors":"Yi Wang, Yiheng Du, Xizhi Wang, Jiang Yu, Qing Gu, Guangquan Yuan, Yifei Zhu, Liyang Gu, Jun Ouyang","doi":"10.17305/bb.2025.11998","DOIUrl":"https://doi.org/10.17305/bb.2025.11998","url":null,"abstract":"<p><p>Prostate cancer (PCa) remains a significant global health challenge, representing the most common solid tumor in men and the fifth leading cause of cancer-related death. Despite therapeutic advances, achieving a definitive cure remains difficult. Early diagnosis and personalized treatment strategies are crucial for improving patient outcomes. Programmed cell death-particularly PANoptosis, an inflammatory pathway that integrates pyroptosis, apoptosis, and necroptosis-has emerged as a promising therapeutic target in oncology. In this study, individuals with PCa were categorized into PANoptosis-high and PANoptosis-low subgroups based on the expression levels of 45 PANoptosis-related genes. Differential gene expression analysis and subsequent enrichment analyses were conducted to explore the biological pathways associated with each subgroup. A four-gene risk signature (CASP7, ADAR, DNM1L, and NAIP) was identified, showing strong predictive value for overall survival (OS) in both training and validation cohorts. This signature was independently associated with OS and showed meaningful correlations with the tumor microenvironment, particularly immune cell infiltration and immunotherapy responsiveness. These findings suggest that the PANoptosis-related gene signature may serve as a valuable prognostic biomarker and inform immunotherapeutic strategies in PCa management.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrins and pulmonary fibrosis: Pathogenic roles and therapeutic opportunities.","authors":"Zhangyang Bi, Guodong Zang, Xiaodong Wang, Li Tian, Wei Zhang","doi":"10.17305/bb.2025.12545","DOIUrl":"https://doi.org/10.17305/bb.2025.12545","url":null,"abstract":"<p><p>Characterized by the formation of fibrotic scars, pulmonary fibrosis (PF) involves a complex pathogenesis, limited treatment options, and a high mortality rate. Integrins-heterodimeric transmembrane proteins composed of α and β subunits-mediate extracellular matrix remodeling and regulate the physiological functions of epithelial, mesenchymal, and immune cells through \"inside-out\" and \"outside-in\" signaling pathways. These molecules play a critical role in the initiation and progression of PF. Due to their central regulatory functions, a range of integrin-targeted therapies has been developed. However, the complex pathophysiology of PF and the structural diversity of integrins pose significant challenges to targeted treatment. In this study, we systematically delineated the signaling networks mediated by the full spectrum of integrin family members and uncovered the molecular mechanisms by which they contribute to PF through immunoregulatory pathways. We also reviewed the development of integrin-based therapies from preclinical studies to clinical trials and discussed current priorities in clinical, basic, and translational research. These insights may provide new perspectives for the diagnosis and treatment of PF.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter regarding \"Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study.\"","authors":"Zhang-Yang Xu, Yun-Xia Wang, Wen-Jun Su","doi":"10.17305/bb.2025.12760","DOIUrl":"https://doi.org/10.17305/bb.2025.12760","url":null,"abstract":"<p><p>This response addresses constructive feedback on our CHARLS cohort study linking the triglyceride-glucose (TyG) index to depressive symptoms. As noted by the letter's author, a substantial body of research on TyG-related composite indices and mental disorders has emerged, with inconsistencies in cutoff values and the shape of dose-response curves observed among different indices. Our decision to focus solely on the single TyG index in this study was primarily motivated by the following two considerations. Firstly, the study population consisted of elderly individuals, among whom BMI levels cannot effectively reflect metabolic status. Secondly, this study represents a continuation of our group's preliminary preclinical research, thus specifically focusing on the factor of insulin resistance. Different findings derived from different indices necessitate consideration of various factors, including different application contexts, variations in the study populations, and differences in data processing methods. Finally, we believe more large randomized controlled trials and related pharmacological intervention studies are essential to validate the use of TyG and its related indices in the diagnosis and treatment of psychiatric disorders. This is the response to Letter to the Editor which you can read here: https://www.bjbms.org/ojs/index.php/bjbms/article/view/12739.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding \"Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study.\"","authors":"Seshadri Reddy Varikasuvu, Subodh Kumar","doi":"10.17305/bb.2025.12739","DOIUrl":"https://doi.org/10.17305/bb.2025.12739","url":null,"abstract":"<p><p>This correspondence addresses the recent study by Xu et al. examining the relationship between the triglyceride-glucose (TyG) index and depression in older Chinese adults. The study's identification of a J-shaped association between TyG levels and depressive symptoms adds meaningful insight into the connection between metabolic health and mental well-being. However, when considered alongside other findings, including those using combined indices such as TyG-BMI and TyG-WHtR, the results suggest that a broader, multidimensional approach may offer greater predictive value. Supporting studies have linked these composite measures not only to depression but also to wider metabolic and cardiovascular risks. Additionally, other reviews highlight the potential link between TyG and more severe psychiatric conditions. The letter emphasizes the need for further research, especially longitudinal and interventional studies, to clarify causal relationships and explore whether improving metabolic health can help prevent or reduce depressive symptoms. The authors encourage continued exploration of metabolic indicators not just as risk markers but as possible targets for intervention.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national trends in thyroid cancer burden (1990-2021): Insights from the GBD 2021 study.","authors":"Ming Tang, Jiarui Li, Mingxiu Sun, Xin Song, Kaize Zheng, Xiaoting Luo, Zhirui Xue, Likun Du","doi":"10.17305/bb.2025.12503","DOIUrl":"https://doi.org/10.17305/bb.2025.12503","url":null,"abstract":"<p><p>The global incidence of thyroid cancer (TC) has been steadily increasing and is now recognized as one of the most prevalent endocrine malignancies. This study provides a comprehensive evaluation of the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with TC from 1990 to 2021. Data for this study were sourced from the 2021 Global Burden of Disease, Injuries, and Risk Factors Study (GBD). To quantify temporal patterns and assess trends in age-standardized TC metrics-namely, age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and DALYs-estimated annual percentage changes (EAPCs) were calculated. The analysis was stratified by sex, 20 age groups, 21 GBD regions, 204 countries/territories, and five Socio-demographic Index (SDI) quintiles. Statistical analyses and plotting were conducted using R statistical software version 4.4.2 and Joinpoint software. The study found that the global burden of thyroid cancer remains substantial, with a significant increase in the total number of cases. In 2021, regions with high SDI reported the highest ASPR, showing an upward trend compared to 1990; however, this trend began to decline significantly after 2009. Conversely, regions with low and low-middle SDI exhibited noticeable increases in ASPR, ASIR, ASDR, and DALYs. The highest prevalence and incidence were observed in the 55-59 age group, followed by a gradual decline. The majority of affected individuals were women. A high body mass index (BMI) was identified as the primary risk factor for TC, and both prevalence and incidence are expected to continue rising through 2040.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glioblastoma induces CAF-like astrocyte activation via the AKT/mTOR-SERPINH1/COL5A1 axis.","authors":"Jingxian Zhang, Yajia Chen, Hongwu Xu","doi":"10.17305/bb.2025.11898","DOIUrl":"https://doi.org/10.17305/bb.2025.11898","url":null,"abstract":"<p><p>Glioblastoma multiforme (GBM), the most aggressive form of glioma, remains the most malignant tumor of the central nervous system. Despite a range of therapeutic strategies, the prognosis for GBM patients remains poor, underscoring the urgent need for novel treatments to inhibit GBM progression. The tumor microenvironment (TME) plays a critical role in tumor development, with cancer-associated fibroblasts (CAFs) acting as key components. However, the origin, composition, and spatial distribution of CAFs within the GBM microenvironment remain poorly understood. To address this gap, our research aims to investigate the etiology, cellular composition, and precise localization of CAFs in GBM, with the goal of elucidating their role in oncogenesis and tumor progression, thereby providing new avenues for therapeutic intervention. In this study, we developed a novel CAF-related prognostic model using data from the TCGA and GEO databases and identified SERPINH1 and COL5A1 as CAF-related genes in GBM. We established a GBM mouse model as well as a GBM cell and astrocyte co-culture system to examine the expression of SERPINH1 and COL5A1 in astrocytes under a simulated tumor microenvironment. Our findings revealed that these genes were more highly expressed in peritumoral tissue compared to normal brain tissue and showed strong co-localization with astrocytes. Furthermore, we found that normal astrocytes can be induced by GBM cells to activate the AKT/mTOR signaling pathway, migrate to the peritumoral region, and upregulate CAF-associated proteins (SERPINH1/COL5A1). These results suggest that astrocytes may serve as a potential source of CAF precursor cells within the GBM tumor microenvironment.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Rab8a/SNARE complex activation promotes vesicle anchoring and transport in spinal astrocytes to drive neuropathic pain.","authors":"","doi":"10.17305/bb.2025.12773","DOIUrl":"https://doi.org/10.17305/bb.2025.12773","url":null,"abstract":"<p><p>In the article \"Rab8a/SNARE complex activation promotes vesicle anchoring and transport in spinal astrocytes to drive neuropathic pain\" (Xiao et al., DOI: https://doi.org/10.17305/bb.2024.10441), published on 6 September 2024, an incorrect version of Figure 2 was inadvertently published due to an editorial oversight. The article has been corrected online to include the accurate figure. This correction does not affect the study's results, interpretations, or conclusions. We apologize for the error and thank the authors for bringing it to our attention.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma serotonin precursors and metabolites as diagnostic and therapeutic biomarkers for osteoporosis in postmenopausal women.","authors":"Peiying Li, Shuyi Wu, Wenshan Chen, Minjuan Liu","doi":"10.17305/bb.2025.11513","DOIUrl":"https://doi.org/10.17305/bb.2025.11513","url":null,"abstract":"<p><p>This study aims to evaluate the diagnostic and therapeutic potential of plasma 5-hydroxytryptamine (5-HT) precursors and metabolites in postmenopausal osteoporosis (PMOP). A total of 287 consecutive postmenopausal women were retrospectively enrolled. Data including age, body mass index (BMI), serum calcium, serum phosphorus, menopausal duration, and bone mineral density (BMD) of the lumbar spine and femoral neck, as well as serum and plasma samples were collected. Based on BMD measurements, participants were categorized into normal, osteopenia, and osteoporosis (OP) groups. Serum β-CTX and PINP, along with plasma levels of 5-HT precursors and metabolites, were measured using ELISA. Receiver operating characteristic (ROC) curve analysis, multivariate analysis, and Kaplan-Meier curves were employed to assess the predictive value of 5-HT precursors and metabolites in PMOP and to evaluate the association between their expression levels and PMOP risk. Plasma levels of 5-hydroxytryptophan (5-HTP), 5-HT, and 5-hydroxyindoleacetic acid (5-HIAA) were elevated in PMOP patients and showed correlations with bone turnover markers and BMD. These biomarkers were identified as independent risk factors for PMOP. Combined analysis of the three biomarkers demonstrated greater predictive value than individual markers. Elevated levels were particularly pronounced in women with ≥ 12 years since menopause (YSM), and were associated with a higher risk of developing PMOP. In summary, 5-HT precursors and metabolites are significantly associated with bone turnover and BMD in postmenopausal women. They serve as independent risk factors and show strong predictive value for PMOP, suggesting their potential as plasma biomarkers for diagnosis and treatment. Furthermore, their relationship with YSM highlights their promise as therapeutic targets to delay the onset of osteoporosis in postmenopausal women.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning and inflammatory markers predict early response to immunotherapy in unresectable NSCLC: A multicenter study.","authors":"Lei Yuan, Qi Wang, Fei Sun, Hongcan Shi","doi":"10.17305/bb.2025.12324","DOIUrl":"https://doi.org/10.17305/bb.2025.12324","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) demonstrate substantial interpatient variability in clinical efficacy for unresectable non-small cell lung cancer (NSCLC), underscoring the unmet need for noninvasive biomarkers to predict early therapeutic responses and improve survival outcomes. To address this, we developed a CT-based deep learning model integrated with the systemic immune-inflammatory-nutritional index (SIINI) for early prediction of ICI response. In a retrospective multicenter study of 265 patients treated with ICIs (incorporating chest CT and laboratory data), the cohort was divided into training (70%), internal validation (30%), and external validation sets. The combined model-leveraging DenseNet121-derived deep radiomic features alongside SIINI-achieved strong predictive performance, with AUCs of 0.865 (95% CI: 0.7709-0.9595) in the internal validation cohort and 0.823 (95% CI: 0.6627-0.9827) in the external validation cohort. Gradient-weighted class activation mapping (Grad-CAM) highlighted key CT regions contributing to model predictions, enhancing interpretability for clinical application. These findings highlight the potential of integrating deep learning with inflammatory biomarkers to support personalized ICI therapy in unresectable NSCLC. Future directions include incorporating multi-omics biomarkers, expanding multicenter validation, and increasing sample sizes to further improve predictive accuracy and facilitate clinical translation.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated balloon treatment for tasc c/d infrapopliteal disease: Two-year matched cohort outcomes.","authors":"Yu Yan, Haixia Tu, Mingxuan Li","doi":"10.17305/bb.2025.12157","DOIUrl":"https://doi.org/10.17305/bb.2025.12157","url":null,"abstract":"<p><p>As the most common form of peripheral arterial disease, lower extremity arterial disease-caused by atherosclerotic stenosis or occlusion-has led to widespread concern due to the high risk of postoperative restenosis. This study aimed to evaluate the effectiveness of drug-coated balloon (DCB) angioplasty in treating severe infrapopliteal artery (IPA) lesions. Plain old balloon (POB) angioplasty served as the control. Patients who underwent procedures at our center for Trans-Atlantic Inter-Society Consensus (TASC) C/D IPA lesions between June 2020 and June 2022 and met the inclusion criteria were enrolled in this retrospective cohort study, which used the propensity score matching (PSM) method. The primary outcomes were the 2-year cumulative rates and survival trends of primary patency (PP) and target lesion revascularization (TLR), based on the treated lesions. Secondary outcomes included limb-based major amputation (MA) and patient-based all-cause death (ACD). A total of 278 target lesions were initially included, with significant differences (p < 0.05) observed in some non-outcome variables. After PSM, analyses were conducted on 240 target lesions, 221 limbs, and 195 patients. The PSM models satisfied both the common support and parallel trend assumptions. In terms of PP, the 2-year cumulative rate in the DCB group was significantly higher than in the POB group (48.0% vs. 22.9%, p < 0.001). The log-rank test yielded a p-value of < 0.001, and the adjusted hazard ratio (HR) from Cox regression analysis was 2.303 [95% confidence interval (CI): 1.518-3.495]. However, there was no statistically significant difference in TLR between the two groups: the 2-year cumulative rates were 25.0% vs. 27.1% (p = 0.767), the log-rank test p-value was 0.563, and the adjusted HR was 0.956 (95% CI: 0.523-1.747). Similarly, no significant differences were found between groups in MA or ACD (p > 0.05). Based on these findings, the study concludes that for severe IPA lesions such as TASC C/D, DCB angioplasty is superior to POB angioplasty in maintaining primary patency over a 2-year period, without any inferiority in other clinical outcomes.</p>","PeriodicalId":72398,"journal":{"name":"Biomolecules & biomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}