Biomedical engineering advances最新文献

{"title":"Shear-thinning conductive chitosan-based nano-hybrid hydrogels by host–guest supramolecular assembled poly ethylene glycol and reduced graphene oxide dual cross-linkers","authors":"Javad Saberi ,&nbsp;Fathallah Karimzadeh ,&nbsp;Jaleh Varshosaz ,&nbsp;Sheyda Labbaf","doi":"10.1016/j.bea.2024.100141","DOIUrl":"10.1016/j.bea.2024.100141","url":null,"abstract":"<div><div>Here, a chitosan-based shear-thinning and conductive nano-hybrid hydrogel is developed based on self-assembled host-guest (HG) supramolecular interaction between beta-cyclodextrin modified chitosan (Host, Cs-CD) and adamantane grafted polyethylene glycol (Guest, PEG-AD) and secondary cross-linking with reduced graphene oxide (rGO). The concentration of HG macromers handled the rheological and mechanical behavior of the forming hydrogel, the ratio of the guest macromer, and the amount of rGO. Dual cross-linking hydrogel (macromers concentration=10 wt%) H:<em>G</em> = 1:2 (CPH 102G3) had the highest mechanical strength and toughness (about 3-folds) compared to the (10 wt%) 1:2 hydrogel (CPH 102). Also, (15 %wt) 1:2 Hydrogel (CPH 152) had mechanical strength and toughness of about 6-folds compared to (10 wt%) 1:4 hydrogel (CPH 104). The electro-conductivity of Cs-PEG/rGO nano-hybrid hydrogel was between 3.5 to 6.55 mS.cm-1 and within the myocardial tissue conductivity range. The swelling ratio and degradation rate of hydrogels were also investigated. CPH 102G3 displayed lower than 45 % weight loss after 15 days of immersion in a phosphate buffer saline solution. Finally, all hydrogel samples demonstrated non-cytotoxicity 24 h post-seeding. After 120 h, cell proliferation was observed. In conclusion, Cs-PEG/rGO hydrogel promises to emerge as an injectable scaffold with controllable properties for electroactive tissue engineering applications.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143161027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New MAO coatings on multiprincipal equimassic β TiNbTaZr and TiNbTaZrMo alloys","authors":"Rafael F.M. dos Santos ,&nbsp;Pedro A.B. Kuroda ,&nbsp;Gerson S. de Almeida ,&nbsp;Willian F. Zambuzzi ,&nbsp;Carlos R. Grandini ,&nbsp;Conrado R.M. Afonso","doi":"10.1016/j.bea.2024.100139","DOIUrl":"10.1016/j.bea.2024.100139","url":null,"abstract":"<div><div>β titanium alloys are essential in biomedical applications due to their combination of high strength, low elastic modulus, and biocompatibility. Although high-entropy alloys (BioHEAs) containing Nb, Zr, Ta, and Mo offer high mechanical strength, their elevated elastic modulus can lead to stress shielding in orthopedic applications. To address these limitations, β-stable alloys with enhanced mechanical and surface properties are being developed to support osseointegration and cellular adhesion. The work focuses on innovative medium (MEA) and high entropy (HEA) equimassic β Ti alloys (quaternary Ti-25Ta-25Nb-25Zr and quinary Ti-20Zr-20Ta-20Nb-20Mo in wt.%) treated with micro-arc oxidation (MAO) to optimize their performance as biomaterials. The MAO process generated bioactive coatings enriched with Ca, P, and Mg, promoting bone cell proliferation. X-ray diffraction (XRD) identified β phase structures and revealed amorphous or partially crystalline coatings, with a ZrO₂ cubic phase noted in the MEA quaternary Ti-25Ta-25Nb-25Zr alloy. Surface morphology assessments showed porous and lamellar topographies that varied with alloy composition, resulting in increased hydrophilicity and optimal roughness. Confocal microscopy confirmed that the MAO coating thickness on MEA quaternary Ti-25Ta-25Nb-25Zr (10.4 μm) surpassed that on HEA (high entropy alloy) quinary Ti-20Zr-20Ta-20Nb-20Mo (4.2 μm). Cell viability and adhesion assays indicated significant biocompatibility, particularly for MEA (medium entropy alloy) quaternary Ti-25Ta-25Nb-25Zr, which benefits from a Mo-free composition. These results underscore the potential of these multiprincipal equimassic bcc (body centered cubic) β alloys for biomedical applications, possibly enhancing osteoblast attachment and sustain cell viability effectively.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive study of traditional glaucoma drainage devices and emerging Micro Invasive Glaucoma Surgery (MIGS) devices: A review","authors":"Anshika Garg ,&nbsp;Gurpreet Singh ,&nbsp;Shubham Gupta ,&nbsp;Vivek Gupta ,&nbsp;Arnab Chanda","doi":"10.1016/j.bea.2024.100140","DOIUrl":"10.1016/j.bea.2024.100140","url":null,"abstract":"<div><div>Glaucoma is a neurogenerative, irreversible disorder caused by elevated intraocular pressure (IOP) in the eye, which can lead to vision loss. Currently, reducing IOP by providing an alternate pathway to aqueous humor is the only proven method for preventing glaucoma. It was found in the literature that traditional Glaucoma Drainage Devices (GDD) have proven effective in safety and reducing intraocular pressure. In recent years, a category of Micro Invasive Glaucoma Surgery (MIGS) has emerged, offering smaller and less invasive surgical procedures compared to conventional GDD. This comprehensive literature review focuses on the fluid mechanics of these implants, their structural parameters, and associated clinical studies. The goal is to assist researchers, scientists, and manufacturers in improving the design of glaucoma implants to achieve long-term success.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of deep learning approaches for lung cancer detection using chest radiographs and computed tomography scans","authors":"M.N. Nguyen","doi":"10.1016/j.bea.2024.100138","DOIUrl":"10.1016/j.bea.2024.100138","url":null,"abstract":"<div><div>Lung cancer remains the most lethal cancer, primarily due to late diagnoses. Thus, early detection of lung cancer is critical to improving patient outcomes. While conventional methods like Chest X-rays (CXRs) and computed tomography (CT) scans are widely used, their effectiveness can be limited by subjective interpretation and variability in the detection of subtle lesions. Recent advancements in deep learning (DL) have shown the potential to enhance the accuracy and reliability of lung cancer diagnosis through medical image analysis. This review provides a comprehensive overview of current DL approaches applied to CXRs and CT scans for lung cancer detection. Various DL techniques and their ability are explored to address challenges such as data scarcity, imbalanced datasets, and overfitting. The current state of research, including the most utilized datasets and popular DL training methods, is also examined. Future directions for integrating DL into clinical practice are discussed. The findings are based on a review of peer-reviewed literature published between January 2023 and July 2024, aiming to offer insights into the evolving landscape of DL in lung cancer detection and to outline potential pathways for future research and clinical implementation.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"9 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of Ti-6Al-7Nb, and design for manufacturing considerations in mitigating failure of hip implants in service","authors":"Kingsley Posiyano ,&nbsp;R.V.S. Prasad ,&nbsp;Thywill Cephas Dzogbewu ,&nbsp;Eyitayo O. Olakanmi ,&nbsp;Tshenolo P. Leso ,&nbsp;Keagisitswe Setswalo ,&nbsp;Amantle T. Sello","doi":"10.1016/j.bea.2024.100136","DOIUrl":"10.1016/j.bea.2024.100136","url":null,"abstract":"<div><div>The hip prosthesis, used to repair or recreate the diseased or damaged hip joint's articulation functionality, greatly influences the outcome of total hip arthroplasty (THA). Currently, the limited lifespan (10–15 years) of hip prostheses presents a serious challenge stemming from poor materials selection, design, as well as manufacturing techniques and this has been amplified further by the rising human life expectancy. Today's hip prostheses are predominantly made of Ti-6Al-4V alloy, which frequently fail owing to wear, modulus mismatch, corrosion, and poor osseointegration. To prolong hip implants’ useful life within the body system, it is crucial to comprehend human hip anatomy and biomechanics, investigate the modes and mechanisms of prosthesis failure, and identify mitigation measures pertaining to materials selection, prosthesis design, and production processes. From this point of view, this article firstly explores the intricate hip joint's structural anatomy in the context of biomechanics principles that influence joint movement and weight bearing. Then, hip implant failure modes and mechanisms are discussed and lastly, the failure mitigation measures are proposed. From this review, Ti-6Al-7Nb known for its excellent corrosion resistance and superior biocompatibility is considered a promising substitute for the mostly used cytotoxic Ti-6Al-4V, functionally graded porosity design mimicking the human bone to enhance mechanical and biomedical properties, more precisely osseointegration and stress shielding, and utilization of the selective laser melting technique capable of fabricating Ti-6Al-7Nb components with intricate shapes and high geometrical accuracy can play a significant role in preventing current hip implant failures.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiphoton imaging for quantification of mesenchymal stem cell survival and distribution in PEG granular hydrogel scaffolds post-implantation into rat cranial bone defects","authors":"Auden P. Balouch ,&nbsp;Alexandra Z. Francis ,&nbsp;Varsha V. Rao ,&nbsp;Samantha J. Wojda ,&nbsp;Kristi S. Anseth ,&nbsp;Seth W. Donahue","doi":"10.1016/j.bea.2024.100137","DOIUrl":"10.1016/j.bea.2024.100137","url":null,"abstract":"<div><div>Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies aimed at promoting bone regeneration due to their secretory properties and osteoblastic differentiation capacity. However, typically &lt; 5% of delivered MSCs are retained at the healing site within days of delivery via injection. In this work, granular PEG hydrogel scaffolds were used to deliver MSCs, labeled with fluorescent Quantum Dots, into critical-sized rat calvarial bone defects. The presence, survival, and distribution of MSCs within the hydrogel scaffold were evaluated with multiphoton microscopy at 3- and 7-days post-implantation. Additionally, endogenous cell infiltration into scaffolds was quantified, and markers for M1 and M2 macrophages were identified with immunohistochemistry. This multiphoton microscopy technique provides a quantitative analysis of exogenous MSC presence and survival and allows for micron-level spatial resolution of cell distribution throughout the implanted scaffolds. When ∼750,000 MSCs were implanted in a calvarial bone defect via PEG granular hydrogel scaffolds, ∼27% and ∼8% survived 3- and 7-days post-implantation, respectively. At 3- and 7-days post-implantation, exogenous MSCs and infiltrating endogenous cells, including M1 and M2 macrophages, were well distributed throughout the scaffolds. This multiphoton microscopy technique could be used to assess biomaterial delivery systems that can improve exogenous MSC presence and survival, facilitate endogenous cell infiltration, and investigate exogenous-endogenous cell interactions for bone regeneration therapies.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the tunable micro-/macro-structure enabled by alginate-gelatin bioinks for tissue engineering","authors":"Lucas Lemarié ,&nbsp;Jérôme Sohier ,&nbsp;Edwin-Joffrey Courtial","doi":"10.1016/j.bea.2024.100135","DOIUrl":"10.1016/j.bea.2024.100135","url":null,"abstract":"<div><div>This study explores the development of optimized alginate-gelatin (AG) bioinks for advanced 3D bioprinting applications, particularly in tissue engineering. Central to our investigation is the establishment of a method for producing AG bioinks with highly tunable viscoelastic properties and the ability to create both macro- and micro-porous scaffolds through a liquid-liquid emulsion technique applied to chemically crosslinked hydrogels and shaped by microextrusion. Our methodology encompasses a comprehensive evaluation of homogenization, pasteurization techniques, and rheological assessments to optimize the mechanical properties of AG hydrogels, ensuring their suitability for bioprinting.</div><div>The study demonstrates that dynamic homogenization and conventional pasteurization methods yield superior dissolution and sterility of the bioinks, crucial for maintaining optical quality and biological compatibility. Crosslinking optimization significantly enhanced the elasticity and reduced post-crosslinking shrinkage of the hydrogels, a key factor in achieving desired cell viability and function within the engineered tissues. The incorporation of porosity through a controlled liquid-liquid emulsion process was found to enhance cellular interactions and integration within the bioprinted constructs.</div><div>Our findings confirm that the rheological properties of bioinks play a crucial role in determining bioprintability, with temperature modulation emerging as a key tool for tailoring these characteristics. The biocompatibility and functional performance of the AG hydrogels were validated through in vitro experiments, demonstrating promising cell viability and proliferation. This research lays the groundwork for the development of advanced bioinks capable of supporting complex tissue architectures in regenerative medicine and tissue engineering. By marrying the versatility of alginate and gelatin with innovative fabrication techniques, our study advances the frontier of 3D bioprinting, paving the way for the creation of biomimetic tissues with enhanced physiological relevance and therapeutic potential.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142417477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic airway clearance devices: A systematic review of experimental and numerical studies","authors":"Arife Uzundurukan ,&nbsp;Sébastien Poncet ,&nbsp;Daria Camilla Boffito ,&nbsp;Philippe Micheau","doi":"10.1016/j.bea.2024.100134","DOIUrl":"10.1016/j.bea.2024.100134","url":null,"abstract":"<div><div>The global respiratory care devices market, including acoustic airway clearance devices (ACDs), is expected to experience a compound annual growth rate of 6.10 % from 2023 to 2030. However, there are a number of inconsistencies in the categorization and working frequency range from one discipline to another one. A better understanding of the mechanisms of action of these devices is therefore of prime importance in order for physicians, physiotherapists, scientists, and engineers to remain abreast of up-to-date studies in the field and specifically on the frequency range used. In the present review, we have categorized acoustic ACDs according to their working principles while reviewing their existing shortcomings in both experimental and numerical studies, thereby paving the way for future research directions. A total of 14 different ACDs are discussed, taking into account their working principle and frequency range, and classified as follows: mechano-acoustic devices, high-frequency chest wall compression (HFCWC), and high-frequency chest wall oscillation (HFCWO) for high-frequency chest compression (HFCC) and oral high-frequency oscillation (OHFO). Existing studies highlight that ACDs with HFCWC distinguish themselves from other devices by supplying compression in a homogeneous manner, allowing the delivery of both efficient and gentle therapy up to approximately 40 Hz. Notwithstanding, a stark difference in the working frequency range across the various devices was found and identified as a literature gap. Given that this difference arises from both experimental and numerical studies between the various disciplines, the studies are further classified according to their respective objectives, methodology and outputs to help readers quickly and straightforwardly locate the articles of interest for potential future investigations. The review also brings to light the interdisciplinary nature of ACDs, whereby numerical biomedical studies can actively assist experimental studies in terms of reproducibility and reliability, creating a digital twin of the human chest and its respective components.</div></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100134"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent ultrasonic aspirator: Advancing tissue differentiation through hierarchical classification during hand-held resection","authors":"Niclas Erben ,&nbsp;Daniel Schetelig ,&nbsp;Jan Buggisch ,&nbsp;Matteo Mario Bonsanto ,&nbsp;Steffen Buschschlüter ,&nbsp;Floris Ernst","doi":"10.1016/j.bea.2024.100133","DOIUrl":"10.1016/j.bea.2024.100133","url":null,"abstract":"<div><p>Modern neurosurgery strives to maximize tumor removal while preserving healthy tissue integrity. Accurate intraoperative differentiation between tumor and healthy tissue is crucial yet challenging. Often neurosurgeons rely on their experience and haptic feedback during palpation to distinguish between tumor and healthy tissue. A commonly used hand-held tool for tissue removal during neurosurgery is the ultrasonic aspirator, which changes its electrical properties as it interacts with tissue. The goal is to equip the ultrasonic aspirator with the ability to differentiate between different types of tissue while at the same time not interfering with the surgical workflow and providing comprehensible outcomes. To this end, a hierarchical classification approach is employed as a proof of concept, enabling precise identification of tissue stiffness during resection.</p><p>The hierarchical approach is compared with the standard flat classification, commonly used in machine learning. Within the hierarchical approach, two strategies are employed: mandatory leaf-node predictions (MLNP) and non-mandatory leaf-node predictions (NMLNP). The NMLNP allows prediction to revert to a parent node when certainty is low. Data are acquired on three artificial tissue models – differing in stiffness – with an ultrasonic aspirator in a hand-held manner. The dataset comprises 1,821 data points for training and 186 for testing after balancing.</p><p>The results indicate a slight performance advantage for the hierarchical classification MLNP approach over the flat classification approach in the absence of confidence thresholds, with weighted F2-scores of 0.781 and 0.762, respectively. However, the application of confidence thresholds results in both approaches exhibiting comparable performance, with the hierarchical NMLNP approach achieving a weighted F1-score of 0.920, thereby demonstrating superior overall performance. The effects of enforcing these thresholds and excluding data with low certainty are thoroughly investigated. This work emphasizes the feasibility of tissue differentiation using a hand-held ultrasound aspirator while resecting tissue. Moreover, it highlights the capability of hierarchical classification in advancing tissue differentiation accuracy during neurosurgical procedures, which could ultimately aid surgeons and enhance the safety of intraoperative workflows.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099224000227/pdfft?md5=af67c249a08b023db2baec85d4ad7062&pid=1-s2.0-S2667099224000227-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in the application of biomaterials in neural tissue engineering: A review","authors":"Iyad A Hammam,&nbsp;Ryan Winters,&nbsp;Zhongkui Hong","doi":"10.1016/j.bea.2024.100132","DOIUrl":"10.1016/j.bea.2024.100132","url":null,"abstract":"<div><p>Tissue engineering approaches have revolutionized the treatment of neural nerve injuries caused by disruption to axonal route or tract. Neurodegenerative diseases, traumatic brain injury (TBI), spinal cord injury (SCI), and peripheral nerve injury (PNI) change the intricate architecture, resulting in growth inhibition and loss of guidance over long distances. Neural tissue engineering aims to overcome limitations of cell-based therapeutics. Efforts are being made to create an optimal scaffold using natural, synthetic, and conductive polymers that match the biological, mechanical, and electrical properties of the native neural tissue. Combining biomaterials, cells, and biochemicals promotes axonal regrowth, facilitating functional recovery from neural nerve disorders. This review focuses on the recent advancements in neural tissue engineering technologies and their applications.</p></div>","PeriodicalId":72384,"journal":{"name":"Biomedical engineering advances","volume":"8 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667099224000215/pdfft?md5=cf01a0fe31738c79d83c0e8e55f875b6&pid=1-s2.0-S2667099224000215-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}