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Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells Venetoclax抑制慢性淋巴细胞白血病细胞的自噬
Autophagy reports Pub Date : 2023-02-07 DOI: 10.1080/27694127.2023.2169518
Yongqiang Chen, S. Kost, Xiaoyan Yang, V. Banerji, J. Johnston, S. Katyal, S. Gibson
{"title":"Venetoclax inhibits autophagy in chronic lymphocytic leukemia cells","authors":"Yongqiang Chen, S. Kost, Xiaoyan Yang, V. Banerji, J. Johnston, S. Katyal, S. Gibson","doi":"10.1080/27694127.2023.2169518","DOIUrl":"https://doi.org/10.1080/27694127.2023.2169518","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41688165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peroxin 14 tags peroxisomes and interacts with Nbr1 for pexophagy in the filamentous insect pathogenic fungus Beauveria bassiana 过氧化物酶14标记过氧化物酶体并与Nbr1相互作用以实现丝状昆虫病原真菌白僵菌的pexophage
Autophagy reports Pub Date : 2023-01-29 DOI: 10.1080/27694127.2023.2168337
Hai-Yan Lin, J. Lei, Jin-Li Ding, Yue-Jin Peng, Hao Zhang, M. Feng, S. Ying
{"title":"Peroxin 14 tags peroxisomes and interacts with Nbr1 for pexophagy in the filamentous insect pathogenic fungus Beauveria bassiana","authors":"Hai-Yan Lin, J. Lei, Jin-Li Ding, Yue-Jin Peng, Hao Zhang, M. Feng, S. Ying","doi":"10.1080/27694127.2023.2168337","DOIUrl":"https://doi.org/10.1080/27694127.2023.2168337","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49357386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Fatal attraction: Dengue Virus and the Mitochondrial Connection 致命的吸引力:登革热病毒和线粒体的联系
Autophagy reports Pub Date : 2023-01-19 DOI: 10.1080/27694127.2023.2167429
Bharati Singh, Avula Kiran, S. Sufi, G. Syed
{"title":"Fatal attraction: Dengue Virus and the Mitochondrial Connection","authors":"Bharati Singh, Avula Kiran, S. Sufi, G. Syed","doi":"10.1080/27694127.2023.2167429","DOIUrl":"https://doi.org/10.1080/27694127.2023.2167429","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44606715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons 从宝藏中分类垃圾:轴突中自噬和内吞运输的不同途径
Autophagy reports Pub Date : 2023-01-19 DOI: 10.1080/27694127.2023.2166322
V. V. Kulkarni, Sandra Maday
{"title":"Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons","authors":"V. V. Kulkarni, Sandra Maday","doi":"10.1080/27694127.2023.2166322","DOIUrl":"https://doi.org/10.1080/27694127.2023.2166322","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sugar coating autophagy: exploring the links between the inhibition of NGLY1 (N-glycanase 1) and autophagy induction 糖衣自噬：探索NGLY1（N-多糖酶1）的抑制与自噬诱导之间的联系
Autophagy reports Pub Date : 2023-01-16 DOI: 10.1080/27694127.2023.2166324
H. Kramer, Sarah A Allman
{"title":"Sugar coating autophagy: exploring the links between the inhibition of NGLY1 (N-glycanase 1) and autophagy induction","authors":"H. Kramer, Sarah A Allman","doi":"10.1080/27694127.2023.2166324","DOIUrl":"https://doi.org/10.1080/27694127.2023.2166324","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48364730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PRKN regulates inner mitochondrial membrane PHB2 during mitophagy PRKN在线粒体自噬过程中调控线粒体内膜PHB2
Autophagy reports Pub Date : 2023-01-16 DOI: 10.1080/27694127.2022.2164643
Shan Sun, Hongfeng Wang, Q. Ma, Ningning Li, Mian Cao, K. Tam, Z. Ying
{"title":"PRKN regulates inner mitochondrial membrane PHB2 during mitophagy","authors":"Shan Sun, Hongfeng Wang, Q. Ma, Ningning Li, Mian Cao, K. Tam, Z. Ying","doi":"10.1080/27694127.2022.2164643","DOIUrl":"https://doi.org/10.1080/27694127.2022.2164643","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45295196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy 一种新的选择性自噬调节因子：TNIP1/ABIN-1调节线粒体自噬
Autophagy reports Pub Date : 2023-01-11 DOI: 10.1080/27694127.2023.2165269
R. Merline, L. Schaefer
{"title":"A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy","authors":"R. Merline, L. Schaefer","doi":"10.1080/27694127.2023.2165269","DOIUrl":"https://doi.org/10.1080/27694127.2023.2165269","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44202756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal Autophagy by the Numbers 神经元自噬的数量
Autophagy reports Pub Date : 2023-01-11 DOI: 10.1080/27694127.2022.2163091
Sydney E. Cason, Saurabh S. Mogre, Elena F. Koslover, E. Holzbaur
{"title":"Neuronal Autophagy by the Numbers","authors":"Sydney E. Cason, Saurabh S. Mogre, Elena F. Koslover, E. Holzbaur","doi":"10.1080/27694127.2022.2163091","DOIUrl":"https://doi.org/10.1080/27694127.2022.2163091","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47769787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy 泛素E3连接酶TRIM27作为线粒体自噬的新参与者出现
Autophagy reports Pub Date : 2023-01-05 DOI: 10.1080/27694127.2022.2164089
Anne Kristin McLaren Berge, Juncal Garcia-Garcia, E. Sjøttem, Hallvard Lauritz Olsvik
{"title":"The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy","authors":"Anne Kristin McLaren Berge, Juncal Garcia-Garcia, E. Sjøttem, Hallvard Lauritz Olsvik","doi":"10.1080/27694127.2022.2164089","DOIUrl":"https://doi.org/10.1080/27694127.2022.2164089","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47284843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration. ESCRT通路和多泡体的上调加速了与神经变性相关的蛋白质的降解。
Autophagy reports Pub Date : 2023-01-01 DOI: 10.1080/27694127.2023.2166722
Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S Weisman
{"title":"Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.","authors":"Ron Benyair,&nbsp;Sai Srinivas Panapakkam Giridharan,&nbsp;Pilar Rivero-Ríos,&nbsp;Junya Hasegawa,&nbsp;Emily Bristow,&nbsp;Eeva-Liisa Eskelinen,&nbsp;Merav D Shmueli,&nbsp;Vered Fishbain-Yoskovitz,&nbsp;Yifat Merbl,&nbsp;Lisa M Sharkey,&nbsp;Henry L Paulson,&nbsp;Phyllis I Hanson,&nbsp;Samarjit Patnaik,&nbsp;Ismael Al-Ramahi,&nbsp;Juan Botas,&nbsp;Juan Marugan,&nbsp;Lois S Weisman","doi":"10.1080/27694127.2023.2166722","DOIUrl":"https://doi.org/10.1080/27694127.2023.2166722","url":null,"abstract":"<p><p>Many neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing the levels of these proteins mitigates disease phenotypes. We previously reported a small molecule, NCT-504, which reduces cellular levels of mutant huntingtin (mHTT) in patient fibroblasts as well as mouse striatal and cortical neurons from an Hdh<sup>Q111</sup> mutant mouse. Here, we show that NCT-504 has a broader potential, and in addition reduces levels of Tau, a protein associated with Alzheimer's disease, as well as other tauopathies. We find that in untreated cells, Tau and mHTT are degraded via autophagy. Notably, treatment with NCT-504 diverts these proteins to multivesicular bodies (MVB) and the ESCRT pathway. Specifically, NCT-504 causes a proliferation of endolysosomal organelles including MVB, and an enhanced association of mHTT and Tau with endosomes and MVB. Importantly, depletion of proteins that act late in the ESCRT pathway blocked NCT-504 dependent degradation of Tau. Moreover, NCT-504-mediated degradation of Tau occurred in cells where Atg7 is depleted, which indicates that this pathway is independent of canonical autophagy. Together, these studies reveal that upregulation of traffic through an ESCRT-dependent MVB pathway may provide a therapeutic approach for neurodegenerative diseases.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101321/pdf/nihms-1884781.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9328582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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