Autophagy reports最新文献_第7页

Sorting trash from treasure: Separate pathways for autophagy and endocytic trafficking in axons 从宝藏中分类垃圾:轴突中自噬和内吞运输的不同途径

Autophagy reports Pub Date : 2023-01-19 DOI: 10.1080/27694127.2023.2166322

V. V. Kulkarni, Sandra Maday

引用次数: 0

Sugar coating autophagy: exploring the links between the inhibition of NGLY1 (N-glycanase 1) and autophagy induction 糖衣自噬：探索NGLY1（N-多糖酶1）的抑制与自噬诱导之间的联系

Autophagy reports Pub Date : 2023-01-16 DOI: 10.1080/27694127.2023.2166324

H. Kramer, Sarah A Allman

引用次数: 0

PRKN regulates inner mitochondrial membrane PHB2 during mitophagy PRKN在线粒体自噬过程中调控线粒体内膜PHB2

Autophagy reports Pub Date : 2023-01-16 DOI: 10.1080/27694127.2022.2164643

Shan Sun, Hongfeng Wang, Q. Ma, Ningning Li, Mian Cao, K. Tam, Z. Ying

引用次数: 0

A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy 一种新的选择性自噬调节因子：TNIP1/ABIN-1调节线粒体自噬

Autophagy reports Pub Date : 2023-01-11 DOI: 10.1080/27694127.2023.2165269

R. Merline, L. Schaefer

引用次数: 0

Neuronal Autophagy by the Numbers 神经元自噬的数量

Autophagy reports Pub Date : 2023-01-11 DOI: 10.1080/27694127.2022.2163091

Sydney E. Cason, Saurabh S. Mogre, Elena F. Koslover, E. Holzbaur

引用次数: 1

The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy 泛素E3连接酶TRIM27作为线粒体自噬的新参与者出现

Autophagy reports Pub Date : 2023-01-05 DOI: 10.1080/27694127.2022.2164089

Anne Kristin McLaren Berge, Juncal Garcia-Garcia, E. Sjøttem, Hallvard Lauritz Olsvik

引用次数: 0

Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration. ESCRT通路和多泡体的上调加速了与神经变性相关的蛋白质的降解。

Autophagy reports Pub Date : 2023-01-01 DOI: 10.1080/27694127.2023.2166722

Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S Weisman

{"title":"Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.","authors":"Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S Weisman","doi":"10.1080/27694127.2023.2166722","DOIUrl":"https://doi.org/10.1080/27694127.2023.2166722","url":null,"abstract":"Many neurodegenerative diseases, including Huntington's disease (HD) and Alzheimer's disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing the levels of these proteins mitigates disease phenotypes. We previously reported a small molecule, NCT-504, which reduces cellular levels of mutant huntingtin (mHTT) in patient fibroblasts as well as mouse striatal and cortical neurons from an HdhQ111 mutant mouse. Here, we show that NCT-504 has a broader potential, and in addition reduces levels of Tau, a protein associated with Alzheimer's disease, as well as other tauopathies. We find that in untreated cells, Tau and mHTT are degraded via autophagy. Notably, treatment with NCT-504 diverts these proteins to multivesicular bodies (MVB) and the ESCRT pathway. Specifically, NCT-504 causes a proliferation of endolysosomal organelles including MVB, and an enhanced association of mHTT and Tau with endosomes and MVB. Importantly, depletion of proteins that act late in the ESCRT pathway blocked NCT-504 dependent degradation of Tau. Moreover, NCT-504-mediated degradation of Tau occurred in cells where Atg7 is depleted, which indicates that this pathway is independent of canonical autophagy. Together, these studies reveal that upregulation of traffic through an ESCRT-dependent MVB pathway may provide a therapeutic approach for neurodegenerative diseases.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101321/pdf/nihms-1884781.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9328582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between septins and ubiquitin-mediated xenophagy during Shigella entrapment. 志贺氏菌包埋过程中sepins与泛素介导的异种吞噬之间的相互作用。

Autophagy reports Pub Date : 2023-01-01 Epub Date: 2023-05-17 DOI: 10.1080/27694127.2023.2213541

Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E Divine, Jonathan N Pruneda, Serge Mostowy

{"title":"Interplay between septins and ubiquitin-mediated xenophagy during Shigella entrapment.","authors":"Damián Lobato-Márquez, José Javier Conesa, Ana Teresa López-Jiménez, Michael E Divine, Jonathan N Pruneda, Serge Mostowy","doi":"10.1080/27694127.2023.2213541","DOIUrl":"10.1080/27694127.2023.2213541","url":null,"abstract":"Septins are cytoskeletal proteins implicated in numerous cellular processes including cytokinesis and morphogenesis. In the case of infection by Shigella flexneri, septins assemble into cage-like structures that entrap cytosolic bacteria targeted by autophagy. The interplay between septin cage entrapment and bacterial autophagy is poorly understood. We used a correlative light and cryo-soft X-ray tomography (cryo-SXT) pipeline to study septin cage entrapment of Shigella in its near-native state. Septin cages could be identified as X-ray dense structures, indicating they contain host cell proteins and lipids consistent with their autophagy links. Airyscan confocal microscopy of Shigella-septin cages showed that septins and lysine 63 (K63)-linked ubiquitin chains are present in separate bacterial microdomains, suggesting they are recruited separately. Finally, Cryo-SXT and live-cell imaging revealed an interaction between septins and microtubule-associated protein light chain 3B (LC3B)-positive membranes during autophagy of Shigella. Collectively our data present a new model for how septin-caged Shigella are targeted to autophagy.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10264059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9671939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY. 眼睛中的自噬：从生理学到病理生理学。

Autophagy reports Pub Date : 2023-01-01 Epub Date: 2023-03-01 DOI: 10.1080/27694127.2023.2178996

Paloma B Liton, Kathleen Boesze-Battaglia, Michael E Boulton, Patricia Boya, Thomas A Ferguson, Ian G Ganley, Anu Kauppinnen, Gordon W Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A Thompson, David N Zacks

{"title":"AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.","authors":"Paloma B Liton, Kathleen Boesze-Battaglia, Michael E Boulton, Patricia Boya, Thomas A Ferguson, Ian G Ganley, Anu Kauppinnen, Gordon W Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A Thompson, David N Zacks","doi":"10.1080/27694127.2023.2178996","DOIUrl":"10.1080/27694127.2023.2178996","url":null,"abstract":"Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a critical cellular pathway, involved in a variety of physiological and pathophysiological processes. Autophagy dysregulation is associated with an increasing number of diseases, including ocular diseases. On one hand, mutations in autophagy-related genes have been linked to cataracts, glaucoma, and corneal dystrophy; on the other hand, alterations in autophagy and lysosomal pathways are a common finding in essentially all diseases of the eye. Moreover, LC3-associated phagocytosis, a form of non-canonical autophagy, is critical in promoting visual cycle function. This review collects the latest understanding of autophagy in the context of the eye. We will review and discuss the respective roles of autophagy in the physiology and/or pathophysiology of each of the ocular tissues, its diurnal/circadian variation, as well as its involvement in diseases of the eye.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9708880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein disorder in the regulatory control of mitophagy. 有丝分裂调节控制中的蛋白质紊乱。

Autophagy reports Pub Date : 2023-01-01 Epub Date: 2023-08-01 DOI: 10.1080/27694127.2023.2242054

Sheridan Mikhail, Scott A Soleimanpour

{"title":"Protein disorder in the regulatory control of mitophagy.","authors":"Sheridan Mikhail, Scott A Soleimanpour","doi":"10.1080/27694127.2023.2242054","DOIUrl":"10.1080/27694127.2023.2242054","url":null,"abstract":"Mitophagy is a central component of the mitochondrial quality control machinery, which is necessary for cellular viability and bioenergetics. The E3 ubiquitin ligase CLEC16A (C-type lectin domain containing 16A) forms a tripartite mitophagy regulatory complex together with the E3 ligase RNF41 (ring finger protein 41) and the ubiquitin-specific peptidase USP8 (ubiquitin specific peptidase 8), yet CLEC16A structural/functional domains relevant for mitophagy are unknown. We identify that CLEC16A contains an internal intrinsically disordered region (IDR), which is important for CLEC16A function and stability. IDRs are flexible domains lacking fixed secondary structure and regulate an emerging number of diverse processes, yet they have been largely unstudied in mitophagy. We observe that the internal CLEC16A IDR is essential for CLEC16A degradation and is bound by RNF41 to promote CLEC16A turnover. This IDR also promotes assembly of the CLEC16A-RNF41-USP8 mitophagy regulatory complex. Thus, our study revealed the importance of IDRs in mitophagy via the regulation of CLEC16A abundance by RNF41, opening new structural insights into mitochondrial quality control.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10316274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0