Autophagy reports最新文献_第8页

Autophagy reports Pub Date : 2024-02-01 eCollection Date: 2024-12-31 DOI: 10.1080/27694127.2024.2306766

Hortense de Calbiac, Sebastian Montealegre, Marjolène Straube, Solène Renault, Hugo Debruge, Loïc Chentout, Sorana Ciura, Apolline Imbard, Edouard Le Guillou, Anca Marian, Nicolas Goudin, Laure Caccavelli, Sylvie Fabrega, Arnaud Hubas, Peter van Endert, Nicolas Dupont, Julien Diana, Edor Kabashi, Pascale de Lonlay

{"title":"TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning.","authors":"Hortense de Calbiac, Sebastian Montealegre, Marjolène Straube, Solène Renault, Hugo Debruge, Loïc Chentout, Sorana Ciura, Apolline Imbard, Edouard Le Guillou, Anca Marian, Nicolas Goudin, Laure Caccavelli, Sylvie Fabrega, Arnaud Hubas, Peter van Endert, Nicolas Dupont, Julien Diana, Edor Kabashi, Pascale de Lonlay","doi":"10.1080/27694127.2024.2306766","DOIUrl":"10.1080/27694127.2024.2306766","url":null,"abstract":"Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis episodes precipitated by fasting. Autophagy functioning was analyzed in vitro, in primary skeletal myoblasts from TANGO2 patients, in basal and fasting conditions, and TANGO2 mutations were associated with reduced LC3-II levels upon starvation. In zebrafish larvae, tango2 inhibition induced locomotor defects which were exacerbated by exposure to atorvastatin, a compound known to cause rhabdomyolysis. Importantly, rhabdomyolysis features of tango2 knockdown were associated with autophagy and mitophagy defects in zebrafish. Calpeptin treatment was sufficient to rescue the locomotor properties thanks to its beneficial effect on autophagy functioning in zebrafish and to improve LC3-II levels in starved primary muscle cells of TANGO2 patients. Overall, we demonstrated that TANGO2 plays an important role in autophagy thus giving rise to new therapeutic perspectives in the prevention of RM life-threatening episodes.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses ATG3 受氧化还原调节，以确保 ATG8 在产生 ROS 的压力下脂化

Autophagy reports Pub Date : 2024-01-08 DOI: 10.1080/27694127.2023.2300622

Manuel J. Mallén-Ponce, M. Pérez-Pérez

引用次数: 0

Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes 龙胆草素抑制葡萄糖转运，诱导 PRKAA1 介导的自噬，清除原发性星形胶质细胞中的β淀粉样蛋白和相关炎症

Autophagy reports Pub Date : 2024-01-05 DOI: 10.1080/27694127.2023.2296209

Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar

引用次数: 0

Alterations of PINK1-PRKN signaling in mice during normal aging. 小鼠正常衰老过程中PINK1-PRKN信号的改变。

Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-12-07 DOI: 10.1080/27694127.2024.2434379

Zahra Baninameh, Jens O Watzlawik, Xu Hou, Tyrique Richardson, Nicholas W Kurchaba, Tingxiang Yan, Damian N Di Florio, DeLisa Fairweather, Lu Kang, Justin H Nguyen, Takahisa Kanekiyo, Dennis W Dickson, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Matthew S Goldberg, Ian G Ganley, Kelly L Stauch, Fabienne C Fiesel, Wolfdieter Springer

{"title":"Alterations of PINK1-PRKN signaling in mice during normal aging.","authors":"Zahra Baninameh, Jens O Watzlawik, Xu Hou, Tyrique Richardson, Nicholas W Kurchaba, Tingxiang Yan, Damian N Di Florio, DeLisa Fairweather, Lu Kang, Justin H Nguyen, Takahisa Kanekiyo, Dennis W Dickson, Sachiko Noda, Shigeto Sato, Nobutaka Hattori, Matthew S Goldberg, Ian G Ganley, Kelly L Stauch, Fabienne C Fiesel, Wolfdieter Springer","doi":"10.1080/27694127.2024.2434379","DOIUrl":"10.1080/27694127.2024.2434379","url":null,"abstract":"The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro upon acute and complete depolarization of mitochondria, the significance of PINK1-PRKN mitophagy in vivo is less well established. Here we used a novel approach to study PINK1-PRKN signaling in different energetically demanding tissues of mice during normal aging. We demonstrate a generally increased expression of both genes and enhanced enzymatic activity with aging across tissue types. Collectively our data suggest a distinct regulation of PINK1-PRKN signaling under basal conditions with the most pronounced activation and flux of the pathway in mouse heart compared to brain or skeletal muscle. Our biochemical analyses complement existing mitophagy reporter readouts and provide an important baseline assessment in vivo, setting the stage for further investigations of the PINK1-PRKN pathway during stress and in relevant disease conditions.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular structures and function of the autophagosome-lysosome fusion machinery. 自噬体-溶酶体融合机制的分子结构和功能。

Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-02-04 DOI: 10.1080/27694127.2024.2305594

Jiajie Diao, Calvin K Yip, Qing Zhong

引用次数: 0

TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii. TgATG9 是弓形虫自噬体生物生成和维持慢性感染所必需的。

Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-10-23 DOI: 10.1080/27694127.2024.2418256

Pariyamon Thaprawat, Zhihai Zhang, Eric C Rentchler, Fengrong Wang, Shreya Chalasani, Christopher J Giuliano, Sebastian Lourido, Manlio Di Cristina, Daniel J Klionsky, Vern B Carruthers

{"title":"TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii.","authors":"Pariyamon Thaprawat, Zhihai Zhang, Eric C Rentchler, Fengrong Wang, Shreya Chalasani, Christopher J Giuliano, Sebastian Lourido, Manlio Di Cristina, Daniel J Klionsky, Vern B Carruthers","doi":"10.1080/27694127.2024.2418256","DOIUrl":"10.1080/27694127.2024.2418256","url":null,"abstract":"Toxoplasma gondii is a ubiquitous protozoan parasite that can reside long-term within hosts as intracellular tissue cysts comprised of chronic stage bradyzoites. To perturb chronic infection requires a better understanding of the cellular processes that mediate parasite persistence. Macroautophagy/autophagy is a catabolic and homeostatic pathway that is required for T. gondii chronic infection, although the molecular details of this process remain poorly understood. A key step in autophagy is the initial formation of the phagophore that sequesters cytoplasmic components and matures into a double-membraned autophagosome for delivery of the cargo to a cell's digestive organelle for degradative recycling. While T. gondii appears to have a reduced repertoire of autophagy proteins, it possesses a putative phospholipid scramblase, TgATG9. Through structural modeling and complementation assays, we show herein that TgATG9 can partially rescue bulk autophagy in atg9Δ yeast. We demonstrated the importance of TgATG9 for proper autophagosome dynamics at the subcellular level using three-dimensional live cell lattice light sheet microscopy. Conditional knockdown of TgATG9 in T. gondii after bradyzoite differentiation resulted in markedly reduced parasite viability. Together, our findings provide insights into the molecular dynamics of autophagosome biogenesis within an early-branching eukaryote and pinpoint the indispensable role of autophagy in maintaining T. gondii chronic infection.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Et tu, Brute? TFEB promotes virus replication before being cleaved by a viral protease. 你呢，布鲁特？TFEB 在被病毒蛋白酶分解之前会促进病毒复制。

Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-09-16 DOI: 10.1080/27694127.2024.2402675

Alagie Jassey, William T Jackson

引用次数: 0

TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy 通过细胞外囊泡分泌的 TDP-43 受大自噬调节

Autophagy reports Pub Date : 2023-12-08 DOI: 10.1080/27694127.2023.2291250

Yoshinori Tanaka, Shun-ichi Ito, Genjiro Suzuki

引用次数: 0

Autophagy deficiency protects against ocular hypertension and glaucoma 缺乏自噬功能可预防眼压升高和青光眼

Autophagy reports Pub Date : 2023-11-22 DOI: 10.1080/27694127.2023.2285214

Angela Dixon, M. Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, P. Liton