Autophagy reportsPub Date : 2023-01-01Epub Date: 2023-02-07DOI: 10.1080/27694127.2023.2174337
Rajeshwary Ghosh, J Scott Pattison
{"title":"Chaperone-Mediated Autophagy Regulates Hypoxic Pathology in Cardiomyocytes.","authors":"Rajeshwary Ghosh, J Scott Pattison","doi":"10.1080/27694127.2023.2174337","DOIUrl":"10.1080/27694127.2023.2174337","url":null,"abstract":"<p><p>Tight regulation of protein degradation pathways is essential for maintaining cardiac homeostasis. The goal of this work was to define the role of chaperone-mediated autophagy (CMA), in cardiomyocytes. CMA acts as a selective degradation pathway of proteins using a cytosolic and lysosomal co-chaperone, HSPA8/HSC70, and the CMA-specific LAMP2A (lysosomal-associated membrane protein 2A) receptor. LAMP2A protein levels are known to be necessary for CMA function. While CMA was shown to exert protection against neurodegenerative disorders and cancer, the role of CMA during cardiac pathology was not known. It was hypothesized that enhancing CMA could mitigate hypoxic pathology in cardiomyocytes. Thus, a genetic gain- and loss-of-CMA-function approach was employed using a <i>Lamp2a</i>-overexpressing adenovirus and a <i>Lamp2a</i>-silencing siRNA, respectively, in primary cardiomyocytes treated with CoCl<sub>2</sub> (a hypoxia-mimetic agent) or vehicle control. The experiments performed clearly showed that <i>Lamp2a</i>-overexpression leads to CMA activation that is sufficient to attenuate hypoxia-induced cardiomyocyte death and toxicity.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45102936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-12-19DOI: 10.1080/27694127.2022.2143214
Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, J. Fitzgerald, S. Geimer, B. Westermann, B. Maček, P. Kahle
{"title":"Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy","authors":"Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, J. Fitzgerald, S. Geimer, B. Westermann, B. Maček, P. Kahle","doi":"10.1080/27694127.2022.2143214","DOIUrl":"https://doi.org/10.1080/27694127.2022.2143214","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41732847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-10-26DOI: 10.1080/27694127.2022.2134254
Ananya Ray, N. Surolia
{"title":"The ART of Resistance","authors":"Ananya Ray, N. Surolia","doi":"10.1080/27694127.2022.2134254","DOIUrl":"https://doi.org/10.1080/27694127.2022.2134254","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46507003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-10-25DOI: 10.1080/27694127.2022.2136604
Coralie F. Daussy, Noémie Pied, F. Rayne, H. Wodrich
{"title":"The missing link: TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry","authors":"Coralie F. Daussy, Noémie Pied, F. Rayne, H. Wodrich","doi":"10.1080/27694127.2022.2136604","DOIUrl":"https://doi.org/10.1080/27694127.2022.2136604","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41466758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-10-12DOI: 10.1080/27694127.2022.2111151
Jacob H. Brock, M. A. Rahman, Richard J. Chi
{"title":"Vps501 links sorting nexins to TORC1 regulation in budding yeast","authors":"Jacob H. Brock, M. A. Rahman, Richard J. Chi","doi":"10.1080/27694127.2022.2111151","DOIUrl":"https://doi.org/10.1080/27694127.2022.2111151","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47926270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-10-11DOI: 10.1080/27694127.2022.2132446
Yukako Oe, T. Yoshimori, Shuhei Nakamura
{"title":"Novel insights into the molecular mechanism of amphisome-lysosome fusion","authors":"Yukako Oe, T. Yoshimori, Shuhei Nakamura","doi":"10.1080/27694127.2022.2132446","DOIUrl":"https://doi.org/10.1080/27694127.2022.2132446","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48662741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-10-11DOI: 10.1080/27694127.2022.2132447
Paola Zanfardino, V. Petruzzella
{"title":"Autophagy and proliferation are dysregulated in Charcot-Marie-Tooth disease type 2A cells harboring MFN2 (mitofusin 2) mutation","authors":"Paola Zanfardino, V. Petruzzella","doi":"10.1080/27694127.2022.2132447","DOIUrl":"https://doi.org/10.1080/27694127.2022.2132447","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42490142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}