Autophagy reportsPub Date : 2022-08-23DOI: 10.1080/27694127.2022.2113016
Lorenzo Franci, Giovanni Inzalaco, M. Chiariello
{"title":"MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence","authors":"Lorenzo Franci, Giovanni Inzalaco, M. Chiariello","doi":"10.1080/27694127.2022.2113016","DOIUrl":"https://doi.org/10.1080/27694127.2022.2113016","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47979911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-08-12DOI: 10.1080/27694127.2022.2112124
A. Strunov, Katy Schmidt, M. Kapun, W. Miller
{"title":"Autophagy regulates endosymbiont distribution in early Drosophila embryogenesis","authors":"A. Strunov, Katy Schmidt, M. Kapun, W. Miller","doi":"10.1080/27694127.2022.2112124","DOIUrl":"https://doi.org/10.1080/27694127.2022.2112124","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41342689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-08-09DOI: 10.1080/27694127.2022.2104781
Franziska Kriegenburg, Wouter Huiting, Fleur van Buuren-Broek, Emma Zwilling, Ralph Hardenberg, Muriel Mari, Claudine Kraft, Fulvio Reggiori
{"title":"The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy.","authors":"Franziska Kriegenburg, Wouter Huiting, Fleur van Buuren-Broek, Emma Zwilling, Ralph Hardenberg, Muriel Mari, Claudine Kraft, Fulvio Reggiori","doi":"10.1080/27694127.2022.2104781","DOIUrl":"10.1080/27694127.2022.2104781","url":null,"abstract":"<p><p>Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation. Autophagosome biogenesis depends on the core autophagy-related (Atg) machinery, and involves a massive supply and remodelling of membranes. To gain insight into the lipid remodelling mechanisms during autophagy, we have systematically investigated whether lipid flippases are required for this pathway in the yeast <i>Saccharomyces cerevisiae</i>. We found that the flippase Drs2, which transfers phosphatidylserine and phosphatidylethanolamine from the lumenal to the cytosolic leaflet of the limiting membrane at the trans-Golgi network, is required for normal progression of autophagy. We also show that Drs2 is important for the trafficking of the core Atg protein Atg9. Atg9 is a transmembrane protein important for autophagosome biogenesis and its anterograde transport from its post-Golgi reservoirs to the site of autophagosome formation is severely impaired in the absence of Drs2. Thus, our results identify a novel autophagy player and highlight that membrane asymmetry regulates early autophagy steps.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46287281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-29DOI: 10.1080/27694127.2022.2102363
Ivana Barravecchia, D. Angeloni
{"title":"Microgravity inhibits autophagy in human capillary endothelial cells in space flight","authors":"Ivana Barravecchia, D. Angeloni","doi":"10.1080/27694127.2022.2102363","DOIUrl":"https://doi.org/10.1080/27694127.2022.2102363","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41472355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-29DOI: 10.1080/27694127.2022.2103779
Hui-hui Ye, F. Cubero
{"title":"Autophagy, a novel player in acetaminophen (APAP)-induced hepatotoxicity","authors":"Hui-hui Ye, F. Cubero","doi":"10.1080/27694127.2022.2103779","DOIUrl":"https://doi.org/10.1080/27694127.2022.2103779","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49015772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-26DOI: 10.1080/27694127.2022.2105455
Kalyani Sai Reju, C. S., Ravi Manjithaya, Venkata Rao Dk
{"title":"Role of diacylglycerol kinase in autophagy, ER biogenesis, and triterpene metabolism","authors":"Kalyani Sai Reju, C. S., Ravi Manjithaya, Venkata Rao Dk","doi":"10.1080/27694127.2022.2105455","DOIUrl":"https://doi.org/10.1080/27694127.2022.2105455","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42375497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-22DOI: 10.1080/27694127.2022.2095591
Putu Yuliandari, Chieko Matsui, Lin Deng, T. Abe, Hiroyuki Mori, S. Taguwa, C. Ono, T. Fukuhara, Y. Matsuura, I. Shoji
{"title":"Hepatitis C virus NS5A protein promotes the lysosomal degradation of diacylglycerol O-acyltransferase 1 (DGAT1) via endosomal microautophagy","authors":"Putu Yuliandari, Chieko Matsui, Lin Deng, T. Abe, Hiroyuki Mori, S. Taguwa, C. Ono, T. Fukuhara, Y. Matsuura, I. Shoji","doi":"10.1080/27694127.2022.2095591","DOIUrl":"https://doi.org/10.1080/27694127.2022.2095591","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46272397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-21DOI: 10.1080/27694127.2022.2100041
M. Aguilera, M. Colombo
{"title":"FKBP8, a new member of the PIK3C3/VPS34 complex","authors":"M. Aguilera, M. Colombo","doi":"10.1080/27694127.2022.2100041","DOIUrl":"https://doi.org/10.1080/27694127.2022.2100041","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44158083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Autophagy reportsPub Date : 2022-07-21DOI: 10.1080/27694127.2022.2101335
Z. Leung, Hailey L M Hunter, B. Abu Rafea, A. J. Watson, D. Betts
{"title":"Evaluating Autophagy in Preimplantation Embryos","authors":"Z. Leung, Hailey L M Hunter, B. Abu Rafea, A. J. Watson, D. Betts","doi":"10.1080/27694127.2022.2101335","DOIUrl":"https://doi.org/10.1080/27694127.2022.2101335","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45436496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}