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The mechanism of macroautophagy: The movie. 宏观自噬机制：电影
Autophagy reports Pub Date : 2022-09-14 DOI: 10.1080/27694127.2022.2096115
Fulvio Reggiori, Patricia Boya, David da Costa, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith Farrés, Sebastian Guettler, Claudine Kraft, Heinz Jungbluth, Ana Martinez, Etienne Morel, Ole Pless, Tassula Proikas-Cezanne, Anne Simonsen
{"title":"The mechanism of macroautophagy: The movie.","authors":"Fulvio Reggiori, Patricia Boya, David da Costa, Zvulun Elazar, Eeva-Liisa Eskelinen, Judith Farrés, Sebastian Guettler, Claudine Kraft, Heinz Jungbluth, Ana Martinez, Etienne Morel, Ole Pless, Tassula Proikas-Cezanne, Anne Simonsen","doi":"10.1080/27694127.2022.2096115","DOIUrl":"10.1080/27694127.2022.2096115","url":null,"abstract":"<p><p>This animated movie presents the mechanism of macroautophagy, hereafter autophagy, by showing the molecular features of the formation of autophagosomes, the hallmark organelle of this intracellular catabolic pathway. It is based on our current knowledge and it also illustrates how autophagosomes can recognize and eliminate selected cargoes.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":"414-417"},"PeriodicalIF":0.0,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46799467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel region within a conserved domain in ATG7 emerged in vertebrates 脊椎动物中出现了ATG7保守结构域中的一个新区域
Autophagy reports Pub Date : 2022-09-07 DOI: 10.1080/27694127.2022.2118933
V. J. Hjaltalín, V. Pogenberg, Kevin Ostacolo, Arnar Pálsson, M. H. Ogmundsdottir
{"title":"A novel region within a conserved domain in ATG7 emerged in vertebrates","authors":"V. J. Hjaltalín, V. Pogenberg, Kevin Ostacolo, Arnar Pálsson, M. H. Ogmundsdottir","doi":"10.1080/27694127.2022.2118933","DOIUrl":"https://doi.org/10.1080/27694127.2022.2118933","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45882879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma 一种针对胶质母细胞瘤STAT3和自噬的新联合治疗方法
Autophagy reports Pub Date : 2022-09-06 DOI: 10.1080/27694127.2022.2117340
S. Bhattacharya, L. Pfeffer, E. Chaum
{"title":"A Novel Combination Therapy Approach Targeting STAT3 and Autophagy in Glioblastoma","authors":"S. Bhattacharya, L. Pfeffer, E. Chaum","doi":"10.1080/27694127.2022.2117340","DOIUrl":"https://doi.org/10.1080/27694127.2022.2117340","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47835033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages produce PGE2 to promote hepatic stellate cell autophagy and liver fibrosis 巨噬细胞产生PGE2促进肝星状细胞自噬和肝纤维化
Autophagy reports Pub Date : 2022-09-04 DOI: 10.1080/27694127.2022.2119513
Liuluan Zhu, Yanxi Zhou, Rui Li, Shuwei Deng
{"title":"Macrophages produce PGE2 to promote hepatic stellate cell autophagy and liver fibrosis","authors":"Liuluan Zhu, Yanxi Zhou, Rui Li, Shuwei Deng","doi":"10.1080/27694127.2022.2119513","DOIUrl":"https://doi.org/10.1080/27694127.2022.2119513","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42211904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence MAPK15控制线粒体适应性并有助于防止细胞衰老
Autophagy reports Pub Date : 2022-08-23 DOI: 10.1080/27694127.2022.2113016
Lorenzo Franci, Giovanni Inzalaco, M. Chiariello
{"title":"MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence","authors":"Lorenzo Franci, Giovanni Inzalaco, M. Chiariello","doi":"10.1080/27694127.2022.2113016","DOIUrl":"https://doi.org/10.1080/27694127.2022.2113016","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47979911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy regulates endosymbiont distribution in early Drosophila embryogenesis 自噬调节果蝇胚胎发生早期内共生体的分布
Autophagy reports Pub Date : 2022-08-12 DOI: 10.1080/27694127.2022.2112124
A. Strunov, Katy Schmidt, M. Kapun, W. Miller
{"title":"Autophagy regulates endosymbiont distribution in early Drosophila embryogenesis","authors":"A. Strunov, Katy Schmidt, M. Kapun, W. Miller","doi":"10.1080/27694127.2022.2112124","DOIUrl":"https://doi.org/10.1080/27694127.2022.2112124","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41342689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy. 脂质翻转酶Drs2在自噬过程中调节Atg9的顺行转运
Autophagy reports Pub Date : 2022-08-09 DOI: 10.1080/27694127.2022.2104781
Franziska Kriegenburg, Wouter Huiting, Fleur van Buuren-Broek, Emma Zwilling, Ralph Hardenberg, Muriel Mari, Claudine Kraft, Fulvio Reggiori
{"title":"The lipid flippase Drs2 regulates anterograde transport of Atg9 during autophagy.","authors":"Franziska Kriegenburg, Wouter Huiting, Fleur van Buuren-Broek, Emma Zwilling, Ralph Hardenberg, Muriel Mari, Claudine Kraft, Fulvio Reggiori","doi":"10.1080/27694127.2022.2104781","DOIUrl":"10.1080/27694127.2022.2104781","url":null,"abstract":"<p><p>Macroautophagy/autophagy is a conserved catabolic pathway during which cellular material is sequestered within newly formed double-membrane vesicles called autophagosomes and delivered to the lytic compartment of eukaryotic cells for degradation. Autophagosome biogenesis depends on the core autophagy-related (Atg) machinery, and involves a massive supply and remodelling of membranes. To gain insight into the lipid remodelling mechanisms during autophagy, we have systematically investigated whether lipid flippases are required for this pathway in the yeast <i>Saccharomyces cerevisiae</i>. We found that the flippase Drs2, which transfers phosphatidylserine and phosphatidylethanolamine from the lumenal to the cytosolic leaflet of the limiting membrane at the trans-Golgi network, is required for normal progression of autophagy. We also show that Drs2 is important for the trafficking of the core Atg protein Atg9. Atg9 is a transmembrane protein important for autophagosome biogenesis and its anterograde transport from its post-Golgi reservoirs to the site of autophagosome formation is severely impaired in the absence of Drs2. Thus, our results identify a novel autophagy player and highlight that membrane asymmetry regulates early autophagy steps.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":"345-367"},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46287281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microgravity inhibits autophagy in human capillary endothelial cells in space flight 微重力抑制太空飞行中人毛细血管内皮细胞的自噬
Autophagy reports Pub Date : 2022-07-29 DOI: 10.1080/27694127.2022.2102363
Ivana Barravecchia, D. Angeloni
{"title":"Microgravity inhibits autophagy in human capillary endothelial cells in space flight","authors":"Ivana Barravecchia, D. Angeloni","doi":"10.1080/27694127.2022.2102363","DOIUrl":"https://doi.org/10.1080/27694127.2022.2102363","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41472355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy, a novel player in acetaminophen (APAP)-induced hepatotoxicity 自噬，对乙酰氨基酚（APAP）诱导肝毒性的新参与者
Autophagy reports Pub Date : 2022-07-29 DOI: 10.1080/27694127.2022.2103779
Hui-hui Ye, F. Cubero
{"title":"Autophagy, a novel player in acetaminophen (APAP)-induced hepatotoxicity","authors":"Hui-hui Ye, F. Cubero","doi":"10.1080/27694127.2022.2103779","DOIUrl":"https://doi.org/10.1080/27694127.2022.2103779","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49015772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of diacylglycerol kinase in autophagy, ER biogenesis, and triterpene metabolism 二酰基甘油激酶在自噬、内质网生物发生和三萜代谢中的作用
Autophagy reports Pub Date : 2022-07-26 DOI: 10.1080/27694127.2022.2105455
Kalyani Sai Reju, C. S., Ravi Manjithaya, Venkata Rao Dk
{"title":"Role of diacylglycerol kinase in autophagy, ER biogenesis, and triterpene metabolism","authors":"Kalyani Sai Reju, C. S., Ravi Manjithaya, Venkata Rao Dk","doi":"10.1080/27694127.2022.2105455","DOIUrl":"https://doi.org/10.1080/27694127.2022.2105455","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42375497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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