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Autophagy of glycogen is non-selective in Komagataella phaffii Komagataella phaffii糖原的自噬是非选择性的
Autophagy reports Pub Date : 2024-07-27 DOI: 10.1080/27694127.2024.2382659
T. Nazarko
{"title":"Autophagy of glycogen is non-selective in\u0000 Komagataella phaffii","authors":"T. Nazarko","doi":"10.1080/27694127.2024.2382659","DOIUrl":"https://doi.org/10.1080/27694127.2024.2382659","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus 脂质平衡和自噬作用的改变导致小鼠狼疮弥漫性肺泡出血
Autophagy reports Pub Date : 2024-07-23 DOI: 10.1080/27694127.2024.2379193
Shuhong Han, Haoyang Zhuang, Yanpeng Diao, Mark Segal, T. Tithi, Weizhou Zhang, Westley H Reeves
{"title":"Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus","authors":"Shuhong Han, Haoyang Zhuang, Yanpeng Diao, Mark Segal, T. Tithi, Weizhou Zhang, Westley H Reeves","doi":"10.1080/27694127.2024.2379193","DOIUrl":"https://doi.org/10.1080/27694127.2024.2379193","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"58 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141813214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy 释放抗肿瘤免疫力：以自噬相关蛋白 VPS34 为靶点，加强基于 STING 激动剂的疗法
Autophagy reports Pub Date : 2024-07-18 DOI: 10.1080/27694127.2024.2370728
Elisabetta Bartolini, Kris van Moer, B. Janji
{"title":"Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy","authors":"Elisabetta Bartolini, Kris van Moer, B. Janji","doi":"10.1080/27694127.2024.2370728","DOIUrl":"https://doi.org/10.1080/27694127.2024.2370728","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy 用于快速评估自噬通量的荧光报告器揭示了 elegans 胚后发育过程中独特的自噬特征，并确定了调节自噬的化合物
Autophagy reports Pub Date : 2024-07-11 DOI: 10.1080/27694127.2024.2371736
Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak
{"title":"A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during\u0000 C. elegans\u0000 post-embryonic development and identifies compounds that modulate autophagy","authors":"Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak","doi":"10.1080/27694127.2024.2371736","DOIUrl":"https://doi.org/10.1080/27694127.2024.2371736","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency 自噬失调引发葡萄糖脑苷脂酶缺乏症的先天性免疫激活
Autophagy reports Pub Date : 2024-07-08 DOI: 10.1080/27694127.2024.2372997
ML Atilano, Alexander Hull, Kerri J. Kinghorn
{"title":"Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency","authors":"ML Atilano, Alexander Hull, Kerri J. Kinghorn","doi":"10.1080/27694127.2024.2372997","DOIUrl":"https://doi.org/10.1080/27694127.2024.2372997","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 957","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective. 自噬是乳腺肿瘤的治疗靶点：癌症干细胞的视角
Autophagy reports Pub Date : 2024-06-24 eCollection Date: 2024-12-31 DOI: 10.1080/27694127.2024.2358648
Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti
{"title":"Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective.","authors":"Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti","doi":"10.1080/27694127.2024.2358648","DOIUrl":"10.1080/27694127.2024.2358648","url":null,"abstract":"<p><p>Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a critical role in tumor initiation, progression, and therapy resistance. The tumor microenvironment (TME) is a complex area where diverse cancer cells reside creating a highly interactive environment with secreted factors, and the extracellular matrix. Autophagy, a cellular self-digestion process, influences dynamic cellular processes in the tumor TME integrating diverse signals that regulate tumor development and heterogeneity. Autophagy acts as a double-edged sword in the breast TME, with both tumor-promoting and tumor-suppressing roles. Autophagy promotes breast tumorigenesis by regulating tumor cell survival, migration and invasion, metabolic reprogramming, and epithelial-mesenchymal transition (EMT). BCSCs harness autophagy to maintain stemness properties, evade immune surveillance, and resist therapeutic interventions. Conversely, excessive, or dysregulated autophagy may lead to BCSC differentiation or cell death, offering a potential avenue for therapeutic exploration. The molecular mechanisms that regulate autophagy in BCSCs including the mammalian target of rapamycin (mTOR), AMPK, and Beclin-1 signaling pathways may be potential targets for pharmacological intervention in breast cancer. This review provides a comprehensive overview of the relationship between autophagy and BCSCs, highlighting recent advancements in our understanding of their interplay. We also discuss the current state of autophagy-targeting agents and their preclinical and clinical development in BCSCs.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells 凸显隐秘：监测荧光 GABARAP 串联与活细胞中微管的亲和力驱动关联
Autophagy reports Pub Date : 2024-05-16 DOI: 10.1080/27694127.2024.2348899
Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold
{"title":"Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells","authors":"Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold","doi":"10.1080/27694127.2024.2348899","DOIUrl":"https://doi.org/10.1080/27694127.2024.2348899","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140971170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning 突触后的自噬始于 Rab11，并不随着树突棘的修剪而结束
Autophagy reports Pub Date : 2024-05-01 DOI: 10.1080/27694127.2024.2346064
Aleksandra Janusz-Kamińska, Jacek Jaworski
{"title":"Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning","authors":"Aleksandra Janusz-Kamińska, Jacek Jaworski","doi":"10.1080/27694127.2024.2346064","DOIUrl":"https://doi.org/10.1080/27694127.2024.2346064","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"18 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining doxorubicin and miR-218-5p: a new strategy to fight breast cancer? 多柔比星与 miR-218-5p：抗击乳腺癌的新策略？
Autophagy reports Pub Date : 2024-04-25 DOI: 10.1080/27694127.2024.2342129
F. D. Naso, F. Strappazzon
{"title":"Combining doxorubicin and miR-218-5p: a new strategy to fight breast cancer?","authors":"F. D. Naso, F. Strappazzon","doi":"10.1080/27694127.2024.2342129","DOIUrl":"https://doi.org/10.1080/27694127.2024.2342129","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"30 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma 同时激活和阻断自噬以抗击肝细胞癌
Autophagy reports Pub Date : 2024-03-28 DOI: 10.1080/27694127.2024.2326241
Hala Shalhoub, Patrick Gonzalez, Alexandre Dos Santos, Julie Guillermet-Guibert, Nicolas Moniaux, Nicolas Dupont, J. Faivre
{"title":"Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma","authors":"Hala Shalhoub, Patrick Gonzalez, Alexandre Dos Santos, Julie Guillermet-Guibert, Nicolas Moniaux, Nicolas Dupont, J. Faivre","doi":"10.1080/27694127.2024.2326241","DOIUrl":"https://doi.org/10.1080/27694127.2024.2326241","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"27 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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