Autophagy reports最新文献

Glycogen is a neutral cargo of bulk autophagy in Komagataella phaffii.

Autophagy reports Pub Date : 2025-01-01 Epub Date: 2025-02-19 DOI: 10.1080/27694127.2025.2467454

Nimna V Wijewantha, Taras Y Nazarko

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引用次数: 0

The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration. 自噬在兴奋毒性、突触线粒体应激和神经退行性变中的作用

Autophagy reports Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.1080/27694127.2025.2464376

Charleen T Chu

{"title":"The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration.","authors":"Charleen T Chu","doi":"10.1080/27694127.2025.2464376","DOIUrl":"10.1080/27694127.2025.2464376","url":null,"abstract":"Brain and nervous system functions depend upon maintaining the integrity of synaptic structures over the lifetime. Autophagy, a key homeostatic quality control system, plays a central role not only in neuronal development and survival/cell death, but also in regulating synaptic activity and plasticity. Glutamate is the major excitatory neurotransmitter that activates downstream targets, with a key role in learning and memory. However, an excess of glutamatergic stimulation is pathological in stroke, epilepsy and neurodegeneration, triggering excitotoxic cell death or a sublethal process of excitatory mitochondrial calcium toxicity (EMT) that triggers dendritic retraction. Markers of autophagy and mitophagy are often elevated following excitatory neuronal injuries, with the potential to influence cell death or neurodegenerative outcomes of these injuries. Interestingly, leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1), two kinases linked to autophagy, mitophagy and Parkinson disease, play important roles in regulating mitochondrial calcium handling, synaptic density and function, and maturation of dendritic spines. Mutations in LRRK2, PINK1, or proteins linked to Alzheimer's disease perturb mitochondrial calcium handling to sensitize neurons to excitatory injury. While autophagy and mitophagy can play both protective and harmful roles, studies in various excitotoxicity and stroke models often implicate autophagy in a pathogenic role. Understanding the role of autophagic degradation in regulating synaptic loss and cell death following excitatory neuronal injuries has important therapeutic implications for both acute and chronic neurological disorders.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy of glycogen is non-selective in Komagataella phaffii Komagataella phaffii糖原的自噬是非选择性的

Autophagy reports Pub Date : 2024-07-27 DOI: 10.1080/27694127.2024.2382659

T. Nazarko

引用次数: 0

Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus 脂质平衡和自噬作用的改变导致小鼠狼疮弥漫性肺泡出血

Autophagy reports Pub Date : 2024-07-23 DOI: 10.1080/27694127.2024.2379193

Shuhong Han, Haoyang Zhuang, Yanpeng Diao, Mark Segal, T. Tithi, Weizhou Zhang, Westley H Reeves

引用次数: 0

Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy 释放抗肿瘤免疫力：以自噬相关蛋白 VPS34 为靶点，加强基于 STING 激动剂的疗法

Autophagy reports Pub Date : 2024-07-18 DOI: 10.1080/27694127.2024.2370728

Elisabetta Bartolini, Kris van Moer, B. Janji

引用次数: 0

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy 用于快速评估自噬通量的荧光报告器揭示了 elegans 胚后发育过程中独特的自噬特征，并确定了调节自噬的化合物

Autophagy reports Pub Date : 2024-07-11 DOI: 10.1080/27694127.2024.2371736

Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak

引用次数: 0

Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency 自噬失调引发葡萄糖脑苷脂酶缺乏症的先天性免疫激活

Autophagy reports Pub Date : 2024-07-08 DOI: 10.1080/27694127.2024.2372997

ML Atilano, Alexander Hull, Kerri J. Kinghorn

引用次数: 0

Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective. 自噬是乳腺肿瘤的治疗靶点：癌症干细胞的视角

Autophagy reports Pub Date : 2024-06-24 eCollection Date: 2024-12-31 DOI: 10.1080/27694127.2024.2358648

Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti

{"title":"Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective.","authors":"Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti","doi":"10.1080/27694127.2024.2358648","DOIUrl":"10.1080/27694127.2024.2358648","url":null,"abstract":"Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a critical role in tumor initiation, progression, and therapy resistance. The tumor microenvironment (TME) is a complex area where diverse cancer cells reside creating a highly interactive environment with secreted factors, and the extracellular matrix. Autophagy, a cellular self-digestion process, influences dynamic cellular processes in the tumor TME integrating diverse signals that regulate tumor development and heterogeneity. Autophagy acts as a double-edged sword in the breast TME, with both tumor-promoting and tumor-suppressing roles. Autophagy promotes breast tumorigenesis by regulating tumor cell survival, migration and invasion, metabolic reprogramming, and epithelial-mesenchymal transition (EMT). BCSCs harness autophagy to maintain stemness properties, evade immune surveillance, and resist therapeutic interventions. Conversely, excessive, or dysregulated autophagy may lead to BCSC differentiation or cell death, offering a potential avenue for therapeutic exploration. The molecular mechanisms that regulate autophagy in BCSCs including the mammalian target of rapamycin (mTOR), AMPK, and Beclin-1 signaling pathways may be potential targets for pharmacological intervention in breast cancer. This review provides a comprehensive overview of the relationship between autophagy and BCSCs, highlighting recent advancements in our understanding of their interplay. We also discuss the current state of autophagy-targeting agents and their preclinical and clinical development in BCSCs.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells 凸显隐秘：监测荧光 GABARAP 串联与活细胞中微管的亲和力驱动关联

Autophagy reports Pub Date : 2024-05-16 DOI: 10.1080/27694127.2024.2348899

Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold

引用次数: 0

Autophagy at the postsynapse begins with Rab11 and does not end with dendritic spine pruning 突触后的自噬始于 Rab11，并不随着树突棘的修剪而结束

Autophagy reports Pub Date : 2024-05-01 DOI: 10.1080/27694127.2024.2346064

Aleksandra Janusz-Kamińska, Jacek Jaworski

引用次数: 0