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PINK1 regulated mitophagy is evident in skeletal muscles. PINK1 对有丝分裂的调控在骨骼肌中非常明显。
Autophagy reports Pub Date : 2024-03-11 DOI: 10.1080/27694127.2024.2326402
Francois Singh, Lea Wilhelm, Alan R Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H Ogmundsdottir, Ian G Ganley
{"title":"PINK1 regulated mitophagy is evident in skeletal muscles.","authors":"Francois Singh, Lea Wilhelm, Alan R Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H Ogmundsdottir, Ian G Ganley","doi":"10.1080/27694127.2024.2326402","DOIUrl":"10.1080/27694127.2024.2326402","url":null,"abstract":"<p><p>PINK1, mutated in familial forms of Parkinson's disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most tissues. To further characterize this pathway <i>in vivo</i>, we used <i>mito</i>-QC mice in which loss of PINK1 was combined with the mitochondrial-associated POLG<sup>D257A</sup> mutation. We focused on skeletal muscle as gene expression data indicates that this tissue has the highest PINK1 levels. We found that loss of PINK1 in oxidative hindlimb muscle significantly reduced mitophagy. Of interest, the presence of the POLG<sup>D257A</sup> mutation, while having a minor effect in most tissues, restored levels of muscle mitophagy caused by the loss of PINK1. Although our observations highlight that multiple mitophagy pathways operate within a single tissue, we identify skeletal muscle as a tissue of choice for the study of PINK1-dependant mitophagy under basal conditions.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GRB2, a protein known for a long time with a new autophagy-regulating function GRB2，一种具有新的自噬调节功能的已知蛋白质
Autophagy reports Pub Date : 2024-03-06 DOI: 10.1080/27694127.2024.2325265
S. Vega-Rubín-de-Celis
{"title":"GRB2, a protein known for a long time with a new autophagy-regulating function","authors":"S. Vega-Rubín-de-Celis","doi":"10.1080/27694127.2024.2325265","DOIUrl":"https://doi.org/10.1080/27694127.2024.2325265","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy α-突触核蛋白聚集体引发心磷脂外化和有丝分裂
Autophagy reports Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2314361
Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain
{"title":"Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy","authors":"Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain","doi":"10.1080/27694127.2024.2314361","DOIUrl":"https://doi.org/10.1080/27694127.2024.2314361","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure 心肌自噬与无菌性炎症在心力衰竭发病过程中的相互影响
Autophagy reports Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2320605
Jialing Tang, Eddie Tam, Erfei Song, Aimin Xu, Gary Sweeney
{"title":"Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure","authors":"Jialing Tang, Eddie Tam, Erfei Song, Aimin Xu, Gary Sweeney","doi":"10.1080/27694127.2024.2320605","DOIUrl":"https://doi.org/10.1080/27694127.2024.2320605","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
{"title":"Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells","authors":"M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon","doi":"10.1080/27694127.2024.2306086","DOIUrl":"https://doi.org/10.1080/27694127.2024.2306086","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
{"title":"Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells","authors":"M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon","doi":"10.1080/27694127.2024.2306086","DOIUrl":"https://doi.org/10.1080/27694127.2024.2306086","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses ATG3 受氧化还原调节，以确保 ATG8 在产生 ROS 的压力下脂化
Autophagy reports Pub Date : 2024-01-08 DOI: 10.1080/27694127.2023.2300622
Manuel J. Mallén-Ponce, M. Pérez-Pérez
{"title":"ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses","authors":"Manuel J. Mallén-Ponce, M. Pérez-Pérez","doi":"10.1080/27694127.2023.2300622","DOIUrl":"https://doi.org/10.1080/27694127.2023.2300622","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes 龙胆草素抑制葡萄糖转运，诱导 PRKAA1 介导的自噬，清除原发性星形胶质细胞中的β淀粉样蛋白和相关炎症
Autophagy reports Pub Date : 2024-01-05 DOI: 10.1080/27694127.2023.2296209
Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar
{"title":"Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes","authors":"Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar","doi":"10.1080/27694127.2023.2296209","DOIUrl":"https://doi.org/10.1080/27694127.2023.2296209","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139383661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular structures and function of the autophagosome-lysosome fusion machinery. 自噬体-溶酶体融合机制的分子结构和功能。
Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-02-04 DOI: 10.1080/27694127.2024.2305594
Jiajie Diao, Calvin K Yip, Qing Zhong
{"title":"Molecular structures and function of the autophagosome-lysosome fusion machinery.","authors":"Jiajie Diao, Calvin K Yip, Qing Zhong","doi":"10.1080/27694127.2024.2305594","DOIUrl":"10.1080/27694127.2024.2305594","url":null,"abstract":"<p><p>Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome and the lytic organelle lysosome/vacuole. Over the past decade, various core components of the molecular machinery that execute this critical terminal autophagy event have been identified. This review highlights recent advances in understanding the molecular structures, biochemical functions, and regulatory mechanisms of key components of this highly sophisticated machinery including the SNARE fusogens, tethering factors, Rab GTPases and associated guanine nucleotide exchange factors, and other accessory factors.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Et tu, Brute? TFEB promotes virus replication before being cleaved by a viral protease. 你呢，布鲁特？TFEB 在被病毒蛋白酶分解之前会促进病毒复制。
Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-09-16 DOI: 10.1080/27694127.2024.2402675
Alagie Jassey, William T Jackson
{"title":"<i>Et tu, Brute</i>? TFEB promotes virus replication before being cleaved by a viral protease.","authors":"Alagie Jassey, William T Jackson","doi":"10.1080/27694127.2024.2402675","DOIUrl":"https://doi.org/10.1080/27694127.2024.2402675","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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