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Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart 自噬通量受损导致糖尿病心脏缺血再灌注损伤加重
Autophagy reports Pub Date : 2024-03-21 DOI: 10.1080/27694127.2024.2330327
Jialing Tang, Nanyoung Yoon, K. Dadson, Hye Kyoung Sung, Yubin Lei, Thanh Q. Dang, Wing Yan Chung, Saher Ahmed, A. Abdul-Sater, Jun Wu, Ren-Ke Li, James Jonkman, Trevor McKee, Justin Grant, Jeffrey D. Peterson, Gary Sweeney
{"title":"Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart","authors":"Jialing Tang, Nanyoung Yoon, K. Dadson, Hye Kyoung Sung, Yubin Lei, Thanh Q. Dang, Wing Yan Chung, Saher Ahmed, A. Abdul-Sater, Jun Wu, Ren-Ke Li, James Jonkman, Trevor McKee, Justin Grant, Jeffrey D. Peterson, Gary Sweeney","doi":"10.1080/27694127.2024.2330327","DOIUrl":"https://doi.org/10.1080/27694127.2024.2330327","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 65","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140221504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PINK1 regulated mitophagy is evident in skeletal muscles. PINK1 对有丝分裂的调控在骨骼肌中非常明显。
Autophagy reports Pub Date : 2024-03-11 DOI: 10.1080/27694127.2024.2326402
Francois Singh, Lea Wilhelm, Alan R Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H Ogmundsdottir, Ian G Ganley
{"title":"PINK1 regulated mitophagy is evident in skeletal muscles.","authors":"Francois Singh, Lea Wilhelm, Alan R Prescott, Kevin Ostacolo, Jin-Feng Zhao, Margret H Ogmundsdottir, Ian G Ganley","doi":"10.1080/27694127.2024.2326402","DOIUrl":"10.1080/27694127.2024.2326402","url":null,"abstract":"<p><p>PINK1, mutated in familial forms of Parkinson's disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most tissues. To further characterize this pathway <i>in vivo</i>, we used <i>mito</i>-QC mice in which loss of PINK1 was combined with the mitochondrial-associated POLG<sup>D257A</sup> mutation. We focused on skeletal muscle as gene expression data indicates that this tissue has the highest PINK1 levels. We found that loss of PINK1 in oxidative hindlimb muscle significantly reduced mitophagy. Of interest, the presence of the POLG<sup>D257A</sup> mutation, while having a minor effect in most tissues, restored levels of muscle mitophagy caused by the loss of PINK1. Although our observations highlight that multiple mitophagy pathways operate within a single tissue, we identify skeletal muscle as a tissue of choice for the study of PINK1-dependant mitophagy under basal conditions.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":"2326402"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GRB2, a protein known for a long time with a new autophagy-regulating function GRB2，一种具有新的自噬调节功能的已知蛋白质
Autophagy reports Pub Date : 2024-03-06 DOI: 10.1080/27694127.2024.2325265
S. Vega-Rubín-de-Celis
{"title":"GRB2, a protein known for a long time with a new autophagy-regulating function","authors":"S. Vega-Rubín-de-Celis","doi":"10.1080/27694127.2024.2325265","DOIUrl":"https://doi.org/10.1080/27694127.2024.2325265","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy α-突触核蛋白聚集体引发心磷脂外化和有丝分裂
Autophagy reports Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2314361
Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain
{"title":"Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy","authors":"Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain","doi":"10.1080/27694127.2024.2314361","DOIUrl":"https://doi.org/10.1080/27694127.2024.2314361","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140426767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure 心肌自噬与无菌性炎症在心力衰竭发病过程中的相互影响
Autophagy reports Pub Date : 2024-02-27 DOI: 10.1080/27694127.2024.2320605
Jialing Tang, Eddie Tam, Erfei Song, Aimin Xu, Gary Sweeney
{"title":"Crosstalk between myocardial autophagy and sterile inflammation in the development of heart failure","authors":"Jialing Tang, Eddie Tam, Erfei Song, Aimin Xu, Gary Sweeney","doi":"10.1080/27694127.2024.2320605","DOIUrl":"https://doi.org/10.1080/27694127.2024.2320605","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
{"title":"Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells","authors":"M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon","doi":"10.1080/27694127.2024.2306086","DOIUrl":"https://doi.org/10.1080/27694127.2024.2306086","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells 自噬决定人类羊膜细胞和绒毛膜细胞的不同细胞命运
Autophagy reports Pub Date : 2024-02-07 DOI: 10.1080/27694127.2024.2306086
M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon
{"title":"Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells","authors":"M. Severino, Lauren S. Richardson, A. Kammala, E. Radnaa, K. Khanipov, Leslie Michelle M. Dalmacio, Indira U. Mysorekar, Marian Kacerovsky, Ramkumar Menon","doi":"10.1080/27694127.2024.2306086","DOIUrl":"https://doi.org/10.1080/27694127.2024.2306086","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"112 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. tango2相关的横纹肌溶解症状与自噬功能异常有关。
Autophagy reports Pub Date : 2024-02-01 eCollection Date: 2024-12-31 DOI: 10.1080/27694127.2024.2306766
Hortense de Calbiac, Sebastian Montealegre, Marjolène Straube, Solène Renault, Hugo Debruge, Loïc Chentout, Sorana Ciura, Apolline Imbard, Edouard Le Guillou, Anca Marian, Nicolas Goudin, Laure Caccavelli, Sylvie Fabrega, Arnaud Hubas, Peter van Endert, Nicolas Dupont, Julien Diana, Edor Kabashi, Pascale de Lonlay
{"title":"TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning.","authors":"Hortense de Calbiac, Sebastian Montealegre, Marjolène Straube, Solène Renault, Hugo Debruge, Loïc Chentout, Sorana Ciura, Apolline Imbard, Edouard Le Guillou, Anca Marian, Nicolas Goudin, Laure Caccavelli, Sylvie Fabrega, Arnaud Hubas, Peter van Endert, Nicolas Dupont, Julien Diana, Edor Kabashi, Pascale de Lonlay","doi":"10.1080/27694127.2024.2306766","DOIUrl":"10.1080/27694127.2024.2306766","url":null,"abstract":"<p><p>Patients with pathogenic variants in the <i>TANGO2</i> gene suffer from severe and recurrent rhabdomyolysis episodes precipitated by fasting. Autophagy functioning was analyzed <i>in vitro</i>, in primary skeletal myoblasts from TANGO2 patients, in basal and fasting conditions, and <i>TANGO2</i> mutations were associated with reduced LC3-II levels upon starvation. In zebrafish larvae, <i>tango2</i> inhibition induced locomotor defects which were exacerbated by exposure to atorvastatin, a compound known to cause rhabdomyolysis. Importantly, rhabdomyolysis features of <i>tango2</i> knockdown were associated with autophagy and mitophagy defects in zebrafish. Calpeptin treatment was sufficient to rescue the locomotor properties thanks to its beneficial effect on autophagy functioning in zebrafish and to improve LC3-II levels in starved primary muscle cells of TANGO2 patients. Overall, we demonstrated that TANGO2 plays an important role in autophagy thus giving rise to new therapeutic perspectives in the prevention of RM life-threatening episodes.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses ATG3 受氧化还原调节，以确保 ATG8 在产生 ROS 的压力下脂化
Autophagy reports Pub Date : 2024-01-08 DOI: 10.1080/27694127.2023.2300622
Manuel J. Mallén-Ponce, M. Pérez-Pérez
{"title":"ATG3 is subjected to redox regulation to quarantee ATG8 lipidation under ROS-generating stresses","authors":"Manuel J. Mallén-Ponce, M. Pérez-Pérez","doi":"10.1080/27694127.2023.2300622","DOIUrl":"https://doi.org/10.1080/27694127.2023.2300622","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes 龙胆草素抑制葡萄糖转运，诱导 PRKAA1 介导的自噬，清除原发性星形胶质细胞中的β淀粉样蛋白和相关炎症
Autophagy reports Pub Date : 2024-01-05 DOI: 10.1080/27694127.2023.2296209
Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar
{"title":"Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes","authors":"Ankita Sharma, Sukhleen Kaur, A. Wani, D. Kour, Mehboob Ali, Syed Mudassir Ali, Lakhvinder Singh, Abhishek Gour, Utpal Nandi, Manish Datt, Parduman Raj Sharma, Conrad C Weihl, Gurdarshan Singh, Ajay Kumar","doi":"10.1080/27694127.2023.2296209","DOIUrl":"https://doi.org/10.1080/27694127.2023.2296209","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"72 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139383661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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