Autophagy reports最新文献

筛选
英文 中文
TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in Toxoplasma gondii. TgATG9 是弓形虫自噬体生物生成和维持慢性感染所必需的。
Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-10-23 DOI: 10.1080/27694127.2024.2418256
Pariyamon Thaprawat, Zhihai Zhang, Eric C Rentchler, Fengrong Wang, Shreya Chalasani, Christopher J Giuliano, Sebastian Lourido, Manlio Di Cristina, Daniel J Klionsky, Vern B Carruthers
{"title":"TgATG9 is required for autophagosome biogenesis and maintenance of chronic infection in <i>Toxoplasma gondii</i>.","authors":"Pariyamon Thaprawat, Zhihai Zhang, Eric C Rentchler, Fengrong Wang, Shreya Chalasani, Christopher J Giuliano, Sebastian Lourido, Manlio Di Cristina, Daniel J Klionsky, Vern B Carruthers","doi":"10.1080/27694127.2024.2418256","DOIUrl":"10.1080/27694127.2024.2418256","url":null,"abstract":"<p><p><i>Toxoplasma gondii</i> is a ubiquitous protozoan parasite that can reside long-term within hosts as intracellular tissue cysts comprised of chronic stage bradyzoites. To perturb chronic infection requires a better understanding of the cellular processes that mediate parasite persistence. Macroautophagy/autophagy is a catabolic and homeostatic pathway that is required for <i>T. gondii</i> chronic infection, although the molecular details of this process remain poorly understood. A key step in autophagy is the initial formation of the phagophore that sequesters cytoplasmic components and matures into a double-membraned autophagosome for delivery of the cargo to a cell's digestive organelle for degradative recycling. While <i>T. gondii</i> appears to have a reduced repertoire of autophagy proteins, it possesses a putative phospholipid scramblase, TgATG9. Through structural modeling and complementation assays, we show herein that TgATG9 can partially rescue bulk autophagy in <i>atg9Δ</i> yeast. We demonstrated the importance of TgATG9 for proper autophagosome dynamics at the subcellular level using three-dimensional live cell lattice light sheet microscopy. Conditional knockdown of TgATG9 in <i>T. gondii</i> after bradyzoite differentiation resulted in markedly reduced parasite viability. Together, our findings provide insights into the molecular dynamics of autophagosome biogenesis within an early-branching eukaryote and pinpoint the indispensable role of autophagy in maintaining <i>T. gondii</i> chronic infection.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular structures and function of the autophagosome-lysosome fusion machinery. 自噬体-溶酶体融合机制的分子结构和功能。
Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-02-04 DOI: 10.1080/27694127.2024.2305594
Jiajie Diao, Calvin K Yip, Qing Zhong
{"title":"Molecular structures and function of the autophagosome-lysosome fusion machinery.","authors":"Jiajie Diao, Calvin K Yip, Qing Zhong","doi":"10.1080/27694127.2024.2305594","DOIUrl":"10.1080/27694127.2024.2305594","url":null,"abstract":"<p><p>Macroautophagy (also known as autophagy) plays a pivotal role in maintaining cellular homeostasis. The terminal step of the multi-step autophagy degradation pathway involves fusion between the cargo-laden, double-membraned autophagosome and the lytic organelle lysosome/vacuole. Over the past decade, various core components of the molecular machinery that execute this critical terminal autophagy event have been identified. This review highlights recent advances in understanding the molecular structures, biochemical functions, and regulatory mechanisms of key components of this highly sophisticated machinery including the SNARE fusogens, tethering factors, Rab GTPases and associated guanine nucleotide exchange factors, and other accessory factors.</p>","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Et tu, Brute? TFEB promotes virus replication before being cleaved by a viral protease. 你呢,布鲁特?TFEB 在被病毒蛋白酶分解之前会促进病毒复制。
Autophagy reports Pub Date : 2024-01-01 Epub Date: 2024-09-16 DOI: 10.1080/27694127.2024.2402675
Alagie Jassey, William T Jackson
{"title":"<i>Et tu, Brute</i>? TFEB promotes virus replication before being cleaved by a viral protease.","authors":"Alagie Jassey, William T Jackson","doi":"10.1080/27694127.2024.2402675","DOIUrl":"https://doi.org/10.1080/27694127.2024.2402675","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy 通过细胞外囊泡分泌的 TDP-43 受大自噬调节
Autophagy reports Pub Date : 2023-12-08 DOI: 10.1080/27694127.2023.2291250
Yoshinori Tanaka, Shun-ichi Ito, Genjiro Suzuki
{"title":"TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy","authors":"Yoshinori Tanaka, Shun-ichi Ito, Genjiro Suzuki","doi":"10.1080/27694127.2023.2291250","DOIUrl":"https://doi.org/10.1080/27694127.2023.2291250","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"9 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138589768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy deficiency protects against ocular hypertension and glaucoma 缺乏自噬功能可预防眼压升高和青光眼
Autophagy reports Pub Date : 2023-11-22 DOI: 10.1080/27694127.2023.2285214
Angela Dixon, M. Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, P. Liton
{"title":"Autophagy deficiency protects against ocular hypertension and glaucoma","authors":"Angela Dixon, M. Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, P. Liton","doi":"10.1080/27694127.2023.2285214","DOIUrl":"https://doi.org/10.1080/27694127.2023.2285214","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1 疱疹病毒裂解感染通过病毒干扰素调节因子 1 诱导有丝分裂
Autophagy reports Pub Date : 2023-11-14 DOI: 10.1080/27694127.2023.2281135
Mai Tram Vo, Y. Choi
{"title":"Herpesvirus lytic infection-induced mitophagy via viral interferon regulatory factor 1","authors":"Mai Tram Vo, Y. Choi","doi":"10.1080/27694127.2023.2281135","DOIUrl":"https://doi.org/10.1080/27694127.2023.2281135","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"63 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139276697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relative dependence: Autophagy in the mother plant and the embryo contributes to Arabidopsis seed development 相对依赖性:母株和胚胎中的自噬作用有助于拟南芥种子的发育
Autophagy reports Pub Date : 2023-11-14 DOI: 10.1080/27694127.2023.2278946
O. Erlichman, Tamar Avin-Wittenberg
{"title":"Relative dependence: Autophagy in the mother plant and the embryo contributes to Arabidopsis seed development","authors":"O. Erlichman, Tamar Avin-Wittenberg","doi":"10.1080/27694127.2023.2278946","DOIUrl":"https://doi.org/10.1080/27694127.2023.2278946","url":null,"abstract":"","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"33 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling 内皮细胞中的自噬可以控制血流介导的血管反应性和重塑,并调节VEGFR2亚细胞定位和信号传导
Autophagy reports Pub Date : 2023-11-13 DOI: 10.1080/27694127.2023.2277585
Pierre-Louis Tharaux, Olivia Lenoir
{"title":"Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling","authors":"Pierre-Louis Tharaux, Olivia Lenoir","doi":"10.1080/27694127.2023.2277585","DOIUrl":"https://doi.org/10.1080/27694127.2023.2277585","url":null,"abstract":"Pharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging. However, the identity of the specific cellular processes that autophagy controls in endothelial cells remained unclear. In this punctum, we discuss our recent findings on the multiple functions of autophagy in the endothelium. Particularly, we highlighted that autophagy controls flow-mediated vascular reactivity and remodeling. We have also focused on the role of autophagy machinery in regulating protein distribution within the cell and on the results demonstrating how autophagy modulates the cellular response to the microenvironment changes.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136347006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural biology of the Atg8 and Atg12 conjugation systems at8和Atg12偶联体系的结构生物学
Autophagy reports Pub Date : 2023-11-10 DOI: 10.1080/27694127.2023.2277582
Nobuo N. Noda
{"title":"Structural biology of the Atg8 and Atg12 conjugation systems","authors":"Nobuo N. Noda","doi":"10.1080/27694127.2023.2277582","DOIUrl":"https://doi.org/10.1080/27694127.2023.2277582","url":null,"abstract":"Atg8 and Atg12 are ubiquitin-like proteins, conjugated to phosphatidylethanolamine (PE) and Atg5, respectively, through enzymatic reactions similar to ubiquitylation. The resultant Atg8–PE and Atg12–Atg5 conjugates play crucial roles in autophagy. Structural studies have been extensively performed on all Atg proteins (Atg3, Atg4, Atg5, Atg7, Atg8, Atg10, Atg12, Atg16) involved in these conjugation systems. This review summarizes structural studies and discusses mechanisms of conjugation and deconjugation reactions, as well as autophagic functions of the Atg8 and Atg12 conjugation systems.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans MALT-1通过抑制秀丽隐杆线虫肠道内的自噬而缩短寿命
Autophagy reports Pub Date : 2023-11-09 DOI: 10.1080/27694127.2023.2277584
Julie Vérièpe-Salerno, Silvia Podavini, Marcus J.C. Long, Irina Kolotuev, Muriel Cuendet, Margot Thome
{"title":"MALT-1 shortens lifespan by inhibiting autophagy in the intestine of <i>C. elegans</i>","authors":"Julie Vérièpe-Salerno, Silvia Podavini, Marcus J.C. Long, Irina Kolotuev, Muriel Cuendet, Margot Thome","doi":"10.1080/27694127.2023.2277584","DOIUrl":"https://doi.org/10.1080/27694127.2023.2277584","url":null,"abstract":"The caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode C. elegans. To discover more ancient, NF-κB -independent MALT1 functions, we analysed the phenotype of C. elegans upon silencing of MALT-1 expression systemically or in a tissue-specific manner. MALT-1 silencing in the intestine caused a significant increase in life span, whereas intestinal overexpression of MALT-1 shortened life expectancy. Interestingly, MALT-1-deficient animals showed higher constitutive levels of autophagy in the intestine, which were particularly evident in aged or starved nematodes. Silencing of the autophagy regulators ATG-13, BEC-1 or LGG-2, but not the TOR homolog LET-363, reversed lifespan extension caused by MALT-1 deficiency. These findings suggest that MALT-1 limits the lifespan of C. elegans by acting as an inhibitor of an early step of autophagy in the intestine.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135242845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信