Autophagy reports最新文献_第6页

A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue. 脂肪组织健康转化过程中铁通量的肝-脂肪串扰。

Autophagy reports Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.1080/27694127.2024.2396696

Jinying Yang, Limin Shi, Anna L Cubito, James F Collins, Zhiyong Cheng

{"title":"A liver-fat crosstalk for iron flux during healthy beiging of adipose tissue.","authors":"Jinying Yang, Limin Shi, Anna L Cubito, James F Collins, Zhiyong Cheng","doi":"10.1080/27694127.2024.2396696","DOIUrl":"10.1080/27694127.2024.2396696","url":null,"abstract":"Beiging of adipocytes is characteristic of a higher number of mitochondria, the central hub of metabolism in the cell. However, studies show that beiging can improve metabolic health or cause metabolic disorders. Here we discuss a liver-fat crosstalk for iron flux associated with healthy beiging of adipocytes. Deletion of the transcription factor FoxO1 in adipocytes (adO1KO mice) induces a higher iron flux from the liver to white adipose tissue, concurrent with augmented mitochondrial biogenesis that increases iron demands. In addition, adO1KO mice adopt an alternate mechanism to sustain mitophagy, which enhances mitochondrial quality control, thereby improving mitochondrial respiratory capacity and metabolic health. However, the liver-fat crosstalk is not detectable in adipose Atg7 knockout (ad7KO) mice, which undergo beiging of adipocytes but have metabolic dysregulation. Autophagic clearance of mitochondria is blocked in ad7KO mice, which accumulates dysfunctional mitochondria and elevates mitochondrial content but lowers mitochondrial respiratory capacity. Mitochondrial biogenesis is comparable in the control and ad7KO mice, and the iron influx into adipocytes and iron efflux from the liver remain unchanged. Therefore, activation of the liver-fat crosstalk is critical for mitochondrial quality control that underlies healthy beiging of adipocytes.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":"2396696"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-exploration of all ATG genes. 所有ATG基因的重新探索。

Autophagy reports Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI: 10.1080/27694127.2024.2386194

Kentaro Furukawa, Tamara Ginevskaia, Tomotake Kanki

{"title":"Re-exploration of all ATG genes.","authors":"Kentaro Furukawa, Tamara Ginevskaia, Tomotake Kanki","doi":"10.1080/27694127.2024.2386194","DOIUrl":"10.1080/27694127.2024.2386194","url":null,"abstract":"Most autophagy-related (ATG) genes have been identified and characterized through studies using the budding yeast Saccharomyces cerevisiae. However, there are no studies that comprehensively compare the contribution of each ATG gene to non-selective bulk autophagy and various types of selective autophagy, including the cytoplasm-to-vacuole targeting (Cvt) pathway, mitophagy, reticulophagy, and pexophagy. Our recent study quantified these types of autophagy in all atg mutants and showed that (i) autophagy is not completely impaired in specific deletants such as lacking the components of the two ubiquitin conjugation-like (UBL) systems, traditionally regarded as essential for autophagy in yeast, and (ii) residual autophagic activity is especially prominent in mutants of the Atg8 UBL system, which display small autophagic body-like vesicles at a low frequency. Alongside these findings, our comprehensive analysis suggested a link between mitophagy and pexophagy, and a differential contribution of Atg proteins to cargo specificity. We discuss how our datasets are useful for future autophagy research. Abbreviations: Ape1: aminopeptidase I; ATG: autophagy related; Cvt: cytoplasm-to-vacuole targeting; ER: endoplasmic reticulum; ESCRT: endosomal sorting complex required for transport; GFP: green fluorescent protein; PI3K: phosphatidylinositol 3-kinase; UBL: ubiquitin conjugation-like.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":"2386194"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy of glycogen is non-selective in Komagataella phaffii Komagataella phaffii糖原的自噬是非选择性的

Autophagy reports Pub Date : 2024-07-27 DOI: 10.1080/27694127.2024.2382659

T. Nazarko

引用次数: 0

Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus 脂质平衡和自噬作用的改变导致小鼠狼疮弥漫性肺泡出血

Autophagy reports Pub Date : 2024-07-23 DOI: 10.1080/27694127.2024.2379193

Shuhong Han, Haoyang Zhuang, Yanpeng Diao, Mark Segal, T. Tithi, Weizhou Zhang, Westley H Reeves

引用次数: 0

Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy 释放抗肿瘤免疫力：以自噬相关蛋白 VPS34 为靶点，加强基于 STING 激动剂的疗法

Autophagy reports Pub Date : 2024-07-18 DOI: 10.1080/27694127.2024.2370728

Elisabetta Bartolini, Kris van Moer, B. Janji

引用次数: 0

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy 用于快速评估自噬通量的荧光报告器揭示了 elegans 胚后发育过程中独特的自噬特征，并确定了调节自噬的化合物

Autophagy reports Pub Date : 2024-07-11 DOI: 10.1080/27694127.2024.2371736

Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, C. Luke, Gary A Silverman, S. Pak

引用次数: 0

Autophagic dysregulation triggers innate immune activation in glucocerebrosidase deficiency 自噬失调引发葡萄糖脑苷脂酶缺乏症的先天性免疫激活

Autophagy reports Pub Date : 2024-07-08 DOI: 10.1080/27694127.2024.2372997

ML Atilano, Alexander Hull, Kerri J. Kinghorn

引用次数: 0

Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective. 自噬是乳腺肿瘤的治疗靶点：癌症干细胞的视角

Autophagy reports Pub Date : 2024-06-24 eCollection Date: 2024-12-31 DOI: 10.1080/27694127.2024.2358648

Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti

{"title":"Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective.","authors":"Sana Raza, Jawed Akhtar Siddiqui, Anubhav Srivastava, Naibedya Chattopadhyay, Rohit Anthony Sinha, Bandana Chakravarti","doi":"10.1080/27694127.2024.2358648","DOIUrl":"10.1080/27694127.2024.2358648","url":null,"abstract":"Breast cancer is a heterogeneous disease, with a subpopulation of tumor cells known as breast cancer stem cells (BCSCs) with self-renewal and differentiation abilities that play a critical role in tumor initiation, progression, and therapy resistance. The tumor microenvironment (TME) is a complex area where diverse cancer cells reside creating a highly interactive environment with secreted factors, and the extracellular matrix. Autophagy, a cellular self-digestion process, influences dynamic cellular processes in the tumor TME integrating diverse signals that regulate tumor development and heterogeneity. Autophagy acts as a double-edged sword in the breast TME, with both tumor-promoting and tumor-suppressing roles. Autophagy promotes breast tumorigenesis by regulating tumor cell survival, migration and invasion, metabolic reprogramming, and epithelial-mesenchymal transition (EMT). BCSCs harness autophagy to maintain stemness properties, evade immune surveillance, and resist therapeutic interventions. Conversely, excessive, or dysregulated autophagy may lead to BCSC differentiation or cell death, offering a potential avenue for therapeutic exploration. The molecular mechanisms that regulate autophagy in BCSCs including the mammalian target of rapamycin (mTOR), AMPK, and Beclin-1 signaling pathways may be potential targets for pharmacological intervention in breast cancer. This review provides a comprehensive overview of the relationship between autophagy and BCSCs, highlighting recent advancements in our understanding of their interplay. We also discuss the current state of autophagy-targeting agents and their preclinical and clinical development in BCSCs.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rod Steers the Globe in ATG9A-Mediated Lipid Transport. 杆状体在atg9a介导的脂质转运中起主导作用。

Autophagy reports Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI: 10.1080/27694127.2024.2360356

Alexander R van Vliet, Sharon A Tooze

引用次数: 0

Highlighting the hidden: monitoring the avidity-driven association of a fluorescent GABARAP tandem with microtubules in living cells 凸显隐秘：监测荧光 GABARAP 串联与活细胞中微管的亲和力驱动关联

Autophagy reports Pub Date : 2024-05-16 DOI: 10.1080/27694127.2024.2348899

Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, S. Hoffmann, Dieter Willbold

引用次数: 0