Autophagy reports最新文献_第5页

Tweaking Ire1 to Unlock Autophagy in Yeast 调整Ire1解锁酵母中的自噬

Autophagy reports Pub Date : 2023-08-13 DOI: 10.1080/27694127.2023.2241124

Eshita Das, Ipsita Roy

引用次数: 0

Discovery of small-molecule inhibitors for the protein-protein interactions involving ATG5 ATG5蛋白-蛋白质相互作用小分子抑制剂的发现

Autophagy reports Pub Date : 2023-05-27 DOI: 10.1080/27694127.2023.2215617

Honggang Xiang, Renxiao Wang

引用次数: 0

Cargo-interacting regions (CIR) of CCPG1 capture ER luminal cargos for reticulophagy CCPG1的货物相互作用区(CIR)捕获内质网吞噬的管腔货物

Autophagy reports Pub Date : 2023-05-16 DOI: 10.1080/27694127.2023.2213560

Haruka Chino, S. Ishii, N. Mizushima, Eisuke Itakura

引用次数: 0

Conserved regulation of autophagosome-lysosome fusion through YKT6 phosphorylation YKT6磷酸化对自噬体-溶酶体融合的调控作用

Autophagy reports Pub Date : 2023-05-10 DOI: 10.1080/27694127.2023.2210946

Pablo Sánchez-Martín, C. Kraft

引用次数: 0

Autophagy safeguards conidial environmental persistence in filamentous fungi 自噬保护丝状真菌分生孢子环境的持久性

Autophagy reports Pub Date : 2023-04-25 DOI: 10.1080/27694127.2023.2205343

Jin-Li Ding, M. Feng, S. Ying

引用次数: 0

Autophagy reports Pub Date : 2023-04-10 DOI: 10.1080/27694127.2023.2200341

Takeshi Yamamoto, Jun Nakamura, Yoshitsugu Takabatake, Y. Isaka

引用次数: 0

A novel autophagy inhibitor, bTBT, disturbs autophagosome formation 一种新的自噬抑制剂，bTBT，干扰自噬体的形成

Autophagy reports Pub Date : 2023-04-06 DOI: 10.1080/27694127.2023.2194620

Momoka Chiba, Mai Yanagawa, Yurika Oyama, Shingo Harada, T. Nemoto, Akira Matsuura, Eisuke Itakura

引用次数: 0

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia BNIP3磷酸化和泛素化之间的相互作用调节低氧条件下的线粒体自噬

Autophagy reports Pub Date : 2023-04-04 DOI: 10.1080/27694127.2023.2197637

Yun-Ling He, J. Li, Yan Cao, Haitao Wu, Li-Ying Wu

引用次数: 0

Atg8 family proteins, LIR/AIM motifs and other interaction modes. Atg8家族蛋白、LIR/AIM基序和其他相互作用模式

Autophagy reports Pub Date : 2023-03-19 eCollection Date: 2023-12-31 DOI: 10.1080/27694127.2023.2188523

Vladimir V Rogov, Ioannis P Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A Tooze, Ivan Dikic, Trond Lamark, Terje Johansen

{"title":"Atg8 family proteins, LIR/AIM motifs and other interaction modes.","authors":"Vladimir V Rogov, Ioannis P Nezis, Panagiotis Tsapras, Hong Zhang, Yasin Dagdas, Nobuo N Noda, Hitoshi Nakatogawa, Martina Wirth, Stephane Mouilleron, David G McEwan, Christian Behrends, Vojo Deretic, Zvulun Elazar, Sharon A Tooze, Ivan Dikic, Trond Lamark, Terje Johansen","doi":"10.1080/27694127.2023.2188523","DOIUrl":"10.1080/27694127.2023.2188523","url":null,"abstract":"The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, C. elegans and Drosophila to humans. Although varying in number of homologs, from one in yeast to seven in humans, and more than ten in some plants, there is a strong evolutionary conservation of structural features and interaction modes. The most prominent interaction mode is between the LC3 interacting region (LIR), also called Atg8 interacting motif (AIM), binding to the LIR docking site (LDS) in Atg8 homologs. There are variants of these motifs like \"half-LIRs\" and helical LIRs. We discuss details of the binding modes and how selectivity is achieved as well as the role of multivalent LIR-LDS interactions in selective autophagy. A number of LIR-LDS interactions are known to be regulated by phosphorylation. New methods to predict LIR motifs in proteins have emerged that will aid in discovery and analyses. There are also other interaction surfaces than the LDS becoming known where we presently lack detailed structural information, like the N-terminal arm region and the UIM-docking site (UDS). More interaction modes are likely to be discovered in future studies.","PeriodicalId":72341,"journal":{"name":"Autophagy reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49651386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy 细胞内病原体对mTORC1-或trpml1 - tfeb诱导的异种吞噬反应的存活

Autophagy reports Pub Date : 2023-03-19 DOI: 10.1080/27694127.2023.2191918

M. Capurro, A. Prashar, Xiaodong Gao, N. Jones

引用次数: 0