Annals of 3D printed medicine最新文献_第4页

Applications of 3D printing in medicine: A review 三维打印在医学中的应用：综述

Annals of 3D printed medicine Pub Date : 2024-02-07 DOI: 10.1016/j.stlm.2024.100149

Chensong Dong, Marko Petrovic, Ian J. Davies

{"title":"Applications of 3D printing in medicine: A review","authors":"Chensong Dong, Marko Petrovic, Ian J. Davies","doi":"10.1016/j.stlm.2024.100149","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100149","url":null,"abstract":"<div><p>3D printing, or additive manufacturing, has transformed various industries with its layer-by-layer fabrication approach. In medicine, 3D printing, or biofabrication, has seen significant advancements, particularly in the creation of patient-specific medical models and custom-made drug tablets. Bioprinting, a key aspect of biofabrication, encompasses three approaches: biomimicry, autonomous self-assembly, and microtissues, each with its unique advantages and disadvantages. This comprehensive review explores the merits and limitations of these bioprinting approaches and outlines the three main phases of the entire bioprinting process: pre-processing, processing, and post-processing. By enhancing patients’ quality of life, reducing healthcare costs, and tapping into the global medical device market, biofabrication technologies hold immense promise for the future of medicine. This literature review focuses on the applications of 3D printing technologies in creating medical devices, including bone tissues, joint tissues, 3D printed tablets, and medical models.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000080/pdfft?md5=15cfa452bb14e83f9962e24405463f3e&pid=1-s2.0-S2666964124000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed Biphasic Calcium Phosphate Scaffold to augment cytocompatibility evaluation for load-bearing implant applications 三维打印双相磷酸钙支架用于增强承重植入物应用的细胞相容性评估

Annals of 3D printed medicine Pub Date : 2024-02-06 DOI: 10.1016/j.stlm.2024.100148

K. Prem Ananth , Naidu Dhanpal Jayram , Kandasamy Muthusamy

{"title":"3D-printed Biphasic Calcium Phosphate Scaffold to augment cytocompatibility evaluation for load-bearing implant applications","authors":"K. Prem Ananth , Naidu Dhanpal Jayram , Kandasamy Muthusamy","doi":"10.1016/j.stlm.2024.100148","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100148","url":null,"abstract":"<div><p>In this work, we developed and analyzed a biphasic calcium phosphate (BC<sub>P</sub>) bioceramic for bone regeneration using stereolithography (SLA). The SLA method is a promising additive manufacturing (AM) technique capable of creating BCp parts with high accuracy and efficiency. However, the ceramic suspension used in SLA exhibits significantly higher viscosity and is not environmentally friendly. Therefore, adequate preparation of a suspension with low viscosity and high solid loading is essential. In this paper, we optimized the effects of surfactant doses and solid loading on the BCp slurry, and initially examined the process parameters of photocuring, debinding, and sintering. The utilization of 9 wt % Disperbyk (BYK) with a 40 vol % loading of BCp bioceramics exhibited a reasonably low viscosity of 8.9 mPa·s at a shear level of 46.5 s<sup>−1</sup>. Functional and structural analyses confirmed that BCp was retained after photocuring and subsequent treatment, which were incorporated into the BYK dispersion. The 3D printed objects with different sintered temperatures, specifically at 1100 °C, 1200 °C, and 1300 °C, were further optimized. Additionally, the surface roughness, porosity, and mechanical properties of BCp green parts were systematically investigated. Most importantly, <em>in vitro</em> analysis of cell attachment, differentiation, and red alizarin analysis could support the application of bone regeneration.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000079/pdfft?md5=3da89ec7743eb77b19fd4fb98a128884&pid=1-s2.0-S2666964124000079-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semi-automatic design concept of 3D-printed individualized template for interstitial brachytherapy of vaginal tumors 用于阴道肿瘤间质近距离治疗的 3D 打印个性化模板的半自动设计理念

Annals of 3D printed medicine Pub Date : 2024-02-05 DOI: 10.1016/j.stlm.2024.100147

Shuhei Sekii , Kento Morita , Ryuichi Yada , Kayoko Tsujino

{"title":"Semi-automatic design concept of 3D-printed individualized template for interstitial brachytherapy of vaginal tumors","authors":"Shuhei Sekii , Kento Morita , Ryuichi Yada , Kayoko Tsujino","doi":"10.1016/j.stlm.2024.100147","DOIUrl":"https://doi.org/10.1016/j.stlm.2024.100147","url":null,"abstract":"<div><p>We aimed to introduce a novel semi-automatic design approach for fabricating individualized, three-dimensional printed template dedicated to interstitial brachytherapy in vaginal tumor treatment. The central component of this concept involved the development of a cylindrical template with strategically placed tunnels to optimize applicator placement. These tunnels originated from the template's base, meticulously designed to prevent any potential overlap or interference. For precise tumor localization, we employed a method wherein the tumor's mask image was projected onto a spherical surface. Subsequently, we employed the k-means algorithm to segment the terminal points, with each cluster's center serving as the terminal point. To ensure the optimal starting point for the tunnels, we utilized the conjugate gradient method, considering the following factors: inter-starting point distance, angles between tunnels, inter-tunnel distance, and the starting point's position relative to the base of the template (inside or outside). We established a semi-automatic design paradigm for fabricating three-dimensional printed template tailored for vaginal brachytherapy. While our initial findings are promising, further comprehensive investigations are imperative to validate the clinical efficacy of this innovative concept.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"14 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000067/pdfft?md5=381afcfb59d7a28295b6c0056e8891d1&pid=1-s2.0-S2666964124000067-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amalgamation of nano and 3-D printing technology: Design, optimization, and assessment 纳米和 3-D 打印技术的融合：设计、优化和评估

Annals of 3D printed medicine Pub Date : 2024-02-01 DOI: 10.1016/j.stlm.2024.100144

Hardik Rana, Dipika Chavada, Vaishali Thakkar

{"title":"Amalgamation of nano and 3-D printing technology: Design, optimization, and assessment","authors":"Hardik Rana, Dipika Chavada, Vaishali Thakkar","doi":"10.1016/j.stlm.2024.100144","DOIUrl":"10.1016/j.stlm.2024.100144","url":null,"abstract":"<div><p>Personalized medicine is the need of today's era, as one therapy does not fit all. The study aims to develop a novel patient-customized formulation using the integration of 3-D printing and Nanotechnology concepts. Valsartan (VLS) was chosen as a model drug for the study due to its poor bioavailability and dose-dependent toxicity. The Polycaprolactone (PCL)-VLS bionanoparticles (PCVBio) were formulated using a modified solvent evaporation method, inculcating the approach of Quality by Design (QbD). The amount of PCL and Polaxomer-188 (PLX) significantly influenced the PCVBio properties, which central composite design (CCD) ascertained. The results of DSC confirm the conversion of crystalline to amorphous structure. The zeta potential, PDI, and particle size ensure stability and nano size. The optimized PCVBio was further loaded into the multi-channel 3-D printed tablet (M3DPT). M3DPT was formulated by the fused deposition modeling method. The process parameters,% infill, and layer height significantly influenced the tablet's quality. The PCVbio M3DPT was able to release the VLS up to 12 h. The optimal formulation was found stable and effective. The new conjugated advanced formulation will improve the effectiveness, safety, and patient adherence. It unlocks the new research direction toward improving patients' lives.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000031/pdfft?md5=763ab9035eadb4656cb5f134de4b763f&pid=1-s2.0-S2666964124000031-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An adjustable and customised finger splint to improve mallet finger treatment compliance and outcomes 可调节和定制的手指夹板可提高槌状指治疗的依从性和效果

Annals of 3D printed medicine Pub Date : 2024-02-01 DOI: 10.1016/j.stlm.2024.100142

Shi Lei Teng , Yoke Rung Wong , Peggy Poh Hoon Lim , Duncan Angus McGrouther

{"title":"An adjustable and customised finger splint to improve mallet finger treatment compliance and outcomes","authors":"Shi Lei Teng , Yoke Rung Wong , Peggy Poh Hoon Lim , Duncan Angus McGrouther","doi":"10.1016/j.stlm.2024.100142","DOIUrl":"10.1016/j.stlm.2024.100142","url":null,"abstract":"<div><h3>Objective</h3><p>Tendinous mallet finger injuries are normally treated conservatively by finger splinting, whereby the injured finger is immobilised in extension to allow the ruptured extensor tendon to heal. However, current splints including the Stack and Zimmer reported high failure rates of almost 50 %. Reasons are attributed to poor splint fit, skin complications and discomfort which cause non-compliance to splint regimens. To address the above mentioned issues, we designed and developed a 3D printed adjustable and customised finger splint.</p></div><div><h3>Participants and interventions</h3><p>The 3D printed finger splint, Zimmer and Stack splint were worn by 24 healthy volunteers on their middle fingers for 24 h.</p></div><div><h3>Main outcome measures</h3><p>The finger extension angle, splint fit, splint comfort and skin maceration were assessed via angle measurement and subjects’ feedback using a questionnaire.</p></div><div><h3>Results</h3><p>The 3D printed finger splint was capable to maintain the distal interphalangeal joint at an extended angle of 8.1° However, 70.8 % of the subjects reported that the 3D printed finger splint shifted or came off wholly during 24 h of wear. This proportion is higher compared to the Zimmer (45.8 %) and the Stack (37.5 %). While 91.7 % of the subjects were satisfied with the ease of wearing and removing the 3D printed finger splint, subjects experienced difficulty performing work and washing activities owing to the design and material.</p></div><div><h3>Conclusion</h3><p>Our proposed design fulfils its function of holding the fingertip in extension and improves ease of application. The design of 3D printed finger splint could be further refined to provide better splint fit and comfort, so as to achieve better treatment compliance.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000018/pdfft?md5=6170706bec2d4641b8733208f0a3d61c&pid=1-s2.0-S2666964124000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Comparison of Traditional Plaster Cast and 3D-Printed Orthosis for External Coaptation of Distal Radius Fractures 用于桡骨远端骨折外固定的传统石膏模型与 3D 打印矫形器的生物力学比较

Annals of 3D printed medicine Pub Date : 2024-02-01 DOI: 10.1016/j.stlm.2024.100146

Marcelo P. D'Amado, João Bourbon de Albuquerque, W. Bezold, Brett D. Crist, James L. Cook

引用次数: 0

Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note. 创建三维打印骨盆模型，探索放射组学分析中磁共振（MR）扫描仪噪音的影响，技术说明。

Annals of 3D printed medicine Pub Date : 2024-02-01 DOI: 10.1016/j.stlm.2024.100143

Richard Collier , Michelle Leech , Laure Marignol , John Gaffney , Ralph Leijenaar , Ciaran Malone

{"title":"Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note.","authors":"Richard Collier , Michelle Leech , Laure Marignol , John Gaffney , Ralph Leijenaar , Ciaran Malone","doi":"10.1016/j.stlm.2024.100143","DOIUrl":"10.1016/j.stlm.2024.100143","url":null,"abstract":"<div><p>Reproducibility of radiomics features necessitates that scanner noise be considered prior to feature extraction. Phantom research provides the opportunity for such ‘ground truth’ measurements, without the additional complication of patient-related factors. The aim of this technical note was to create a 3D printed Magnetic Resonance Imaging (MRI)-compatible pelvic phantom that can be used for subsequent analysis of the impact of scanner noise on the reproducibility of radiomics features.</p><p>A 3D printed phantom of a male pelvis was created using fused deposition modelling technology. It was 3D printed using the high density MRI-compatible acrylonitrile butadiene styrene (ABS). The ‘negative’ mould created was then filled with silicone, and the prostate gland and femoral heads were also simulated.</p><p>We successfully created an MRI-compatible 3D printed pelvic phantom, with a test scan. The phantom will subsequently be utilised to determine the impact of MRI scanner noise on radiomics feature reproducibility.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696412400002X/pdfft?md5=59d77aaebd690ce9c87e3924132fd3c6&pid=1-s2.0-S266696412400002X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of a low-cost 3-D printed microscope for evaluating esophageal biopsies 低成本 3-D 打印显微镜在评估食管活检中的应用

Annals of 3D printed medicine Pub Date : 2024-02-01 DOI: 10.1016/j.stlm.2024.100145

Daniel G. Rosen , Evandro Sobroza de Mello , Sadhna Dhingra , Sanford M. Dawsey , Joe Knapper , Richard Bowman , Sharmila Anandasabapathy

{"title":"Utility of a low-cost 3-D printed microscope for evaluating esophageal biopsies","authors":"Daniel G. Rosen , Evandro Sobroza de Mello , Sadhna Dhingra , Sanford M. Dawsey , Joe Knapper , Richard Bowman , Sharmila Anandasabapathy","doi":"10.1016/j.stlm.2024.100145","DOIUrl":"10.1016/j.stlm.2024.100145","url":null,"abstract":"<div><p>In this manuscript we assessed the utility of a low-cost 3D printed microscope to evaluate esophageal biopsies. We conducted a comparative analysis between the traditional microscope and our 3-D printed microscope, utilizing a set of esophageal biopsy samples obtained from patients undergoing screening endoscopy. Two pathologists independently examined 30 esophageal biopsies by light microscopy and digital images obtained using a low-cost 3D printed microscope (Observer 1 and 2). The glass slide consensus diagnosis was compared to the findings of 2 additional pathologist who independently just reviewed the digital images (Observer 3 and 4). The intra-observer agreement was substantial to almost perfect for observer 1 (k:0.64) and 2 (k:0.84). All four observers had 100 % sensitivity and negative predictive value, whereas specificity ranged from 59 % to 100 % and positive predictive value ranged from 21 % to 100 %. The PPV and specificity were lower for the two Observers (3 and 4) who just examined the digital images. Overall, our results suggest that telepathology may be used with high sensitivity and specificity, utilizing the pictures produced by our 3D-printed microscope.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100145"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000043/pdfft?md5=20599d8cd70420b473c241a29607bbed&pid=1-s2.0-S2666964124000043-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139453563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of 3D printing techniques for biomaterial-based scaffold fabrication in bone tissue engineering 3D打印技术在骨组织工程中用于生物材料支架制造的综合综述

Annals of 3D printed medicine Pub Date : 2023-11-23 DOI: 10.1016/j.stlm.2023.100141

K. Prem Ananth, Naidu Dhanpal Jayram

{"title":"A comprehensive review of 3D printing techniques for biomaterial-based scaffold fabrication in bone tissue engineering","authors":"K. Prem Ananth, Naidu Dhanpal Jayram","doi":"10.1016/j.stlm.2023.100141","DOIUrl":"https://doi.org/10.1016/j.stlm.2023.100141","url":null,"abstract":"<div><p>Three-dimensional (3D) printing technology is developing as a dominant tool for biomedical engineering by supporting 3D cell culture within compound 3D biomimetic buildings. Biomaterial and Tissue engineering has developed as a favorable alternative method in the treatment of bones, teeth, and organs. This paper summarizes the current research status and attention of the 3D biomaterials scaffolds in bone tissue engineering applications. Several 3D scaffolds fabricated from several types of biodegradable materials have been established. The crucial topics of 3D printing techniques are recognized and deliberated with the future improvement of innovative biomaterials. There has been a prompt development in the applications of 3D printing in engineering customized implants, drug delivery devices, prostheses, and 3D scaffolds for regenerative medicine and tissue engineering. Medical 3D printing technologies are classified into the following categories: Fused Deposition Modeling (FDM), Extrusion-based 3D bioprinting, Selective Laser Sintering (SLS)/Selective Laser melting (SLM), Electron Beam Manufacturing (EBM), Stereolithography (SLA) and Digital Light Processing (DLP) printing techniques, and their clinical applications, different types of biomaterials currently used by researchers, and key limitations are discussed in detail. In Addition, the most advanced and commonly used metals, bioceramics, polymers, and composites in tissue engineering are briefly reviewed as well.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"13 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964123000425/pdfft?md5=4a0070e01c548f0d9f6c56f15b576285&pid=1-s2.0-S2666964123000425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total navicular and cuboid replacement utilizing patient specific 3D printed implants for treatment of osteonecrosis of the midfoot: Case report and technique guide 利用患者特异性3D打印植入物治疗中足骨坏死的全舟状和长方体置换:病例报告和技术指南

Annals of 3D printed medicine Pub Date : 2023-11-22 DOI: 10.1016/j.stlm.2023.100140

John R. Constantino , Adam D. Perler

引用次数: 0