Annals of 3D printed medicine最新文献

{"title":"A bibliometric analysis of publications in 3D printing in surgery from the web of science database","authors":"Bitesh Kumar ,&nbsp;Anjan Kumar Dhua ,&nbsp;Mohit Garg ,&nbsp;Vishesh Jain ,&nbsp;Devendra Kumar Yadav ,&nbsp;Prabudh Goel ,&nbsp;Sachit Anand ,&nbsp;Divya Jain","doi":"10.1016/j.stlm.2025.100188","DOIUrl":"10.1016/j.stlm.2025.100188","url":null,"abstract":"<div><h3>Background</h3><div>Three-dimensional (3D) printing technology, introduced by Charles Hull in 1986, has revolutionized prototyping and is increasingly applied in medical fields such as orthopedics, neurosurgery, and cardiac surgery. The technology offers numerous benefits, including reduced surgical complications, cost-effectiveness, and customization of medical devices. This study provides a bibliometric analysis of 3D printing in surgery, highlighting trends, influential countries, and key research contributors.</div></div><div><h3>Objectives</h3><div>This study aims to analyze the publication landscape of 3D printing in surgery, focusing on key metrics such as annual citation rates, growth trends, citation per year, total citations, source journals, author details, country-wise production, and institutional contributions. The study also aims to explore collaborative patterns at the author, institutional, and country levels and identify core research areas through keyword co-occurrence analysis.</div></div><div><h3>Materials and Methods</h3><div>Data were collected from the Web of Science (WoS) Core Collection on August 13, 2023, including documents published from 2001 to 2022. A total of 3,230 documents were identified and analyzed using VOSviewer and the Bibliometrix R-package. Inclusion criteria encompassed English-language documents related to 3D printing in surgery, while documents published after December 2022 were excluded.</div></div><div><h3>Results</h3><div>The analysis revealed a significant annual growth rate of 20.08 % in publications related to 3D printing in surgery, with peak years being 2022, 2021, and 2020. China and the USA dominate the research output, accounting for approximately 50 % of global publications. Shanghai Jiao Tong University and Sichuan University are leading institutions. Collaborative patterns show strong author linkages and international cooperation, particularly between the USA, China, and England. Keyword co-occurrence analysis identified \"reconstruction,\" \"accuracy,\" and \"additive manufacturing\" as core research areas.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis provides a comprehensive overview of the research landscape of 3D printing in surgery, emphasizing this technology's rapid growth and significant impact. The insights gained can guide future research, foster collaborations, and inform policy decisions to advance the field. Leading countries and institutions are crucial in driving scientific discoveries and translating research into clinical practice.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"17 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalable direct manufacturing of a functional multipurpose wrist-hand orthosis using 3D printing","authors":"Dhruv Bose ,&nbsp;Shubham Gupta ,&nbsp;Arnab Chanda","doi":"10.1016/j.stlm.2025.100186","DOIUrl":"10.1016/j.stlm.2025.100186","url":null,"abstract":"<div><div>Spinal cord injury (SCI) is one of the most debilitating injuries with no direct cure. Managing SCI thus becomes a critical task for caregivers and most importantly patients, whose lives are severely hindered both physically and psychologically. Injury at different parts of the spine corroborates to partial or complete motor loss at one or more parts of the body. The current paradigm of recuperative techniques aim at effective splinting coupled with a consistent rehabilitation regimen. This work focused on the development of a novel wrist-hand orthosis using 3D printing to aid patients inflicted by C5-C7 SCI which causes loss of motor function at the distal ends of the upper extremity. An optimized development framework was presented to achieve quick production times, scalability, ergonomics and minimal post processing activities to produce an ultra-low cost orthotic device (∼$2). The Print in Place (PIP) method was employed to diminish all post processing and assembly operations. A unique compliant wrist brace mechanism was introduced. The developed assistive device was assessed via Finite Element Analysis (FEA) prior to manufacturing and the same was verified experimentally, post-manufacturing. Overall, the developed device was found to successfully sustain the designed load requirements. It was anticipated that the use of the aforementioned methods and techniques could greatly enhance the scalability and affordability of 3D printed orthotic devices, especially in low and middle income countries where SCI cases are not only highly prevalent but also neglected, escalating the severity of injury.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"17 ","pages":"Article 100186"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective laser sintering at the Point-of-Care 3D printing laboratory in hospitals for cranio-maxillo-facial surgery: A further step into industrial additive manufacturing made available to clinicians","authors":"Alessandro Tel ,&nbsp;Erik Kornfellner ,&nbsp;Enikő Molnár ,&nbsp;Shiden Johannes ,&nbsp;Francesco Moscato ,&nbsp;Massimo Robiony","doi":"10.1016/j.stlm.2024.100175","DOIUrl":"10.1016/j.stlm.2024.100175","url":null,"abstract":"<div><p>Additive manufacturing has developed rapidly in recent years and has many useful applications in the clinical field. In particular, cranio-maxillo-facial (CMF) surgery requires high precision, which can be obtained with 3D printed patient-specific surgical guides and anatomical models. Among the many different printing options, selective laser sintering (SLS) seems to be rarely used in point-of-care applications, considering its apparent characteristics.</p><p>This article examines the advantages and disadvantages of SLS printers for CMF point-of-care (PoC) by reviewing the literature and comparing in-house printed SLS and stereolithography (SLA) prints.</p><p>The investigation showed that the easily sterilizable and robust materials processed by SLS printing are well suited for CMF surgical guides and have clear advantages over SLA parts.</p><p>Some barriers to the use of SLS printers in PoC are likely to be the slightly higher complexity and cost.</p><p>However, these will decrease as 3D printing technology advances and surgeon acceptance increases, making SLS a practical PoC tool.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666964124000328/pdfft?md5=037c1ca9dd25fb3fe20e781d2e8ea7f2&pid=1-s2.0-S2666964124000328-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive manufacturing of personalized scaffolds for vascular cell studies in large arteries: A case study on carotid arteries in sickle cell disease patients","authors":"Saskia Eckert ,&nbsp;Christian Kassasseya ,&nbsp;Weiqiang Liu ,&nbsp;Eliott Benichou ,&nbsp;Irène Vignon-Clementel ,&nbsp;Smaïne Kouidri ,&nbsp;Kim-Anh Nguyen-Peyre ,&nbsp;Pablo Bartolucci ,&nbsp;Frédéric Segonds","doi":"10.1016/j.stlm.2024.100178","DOIUrl":"10.1016/j.stlm.2024.100178","url":null,"abstract":"<div><div>Patient-specific models have increasingly gained significance in medical and research domains. In the context of hemodynamic studies, computational fluid dynamics emerges as a highly innovative and promising approach. We propose to augment these computational studies with cell-based experiments in individualized artery geometries using personalized scaffolds and vascular cell experiments. Previous research has demonstrated that the development of Sickle Cell Disease (SCD)-Related Vasculopathy is dependent on personal geometries and flow characteristics of the carotid artery. This fact leaves conventional animal experiments unsuitable for gaining patient-specific insights into cellular signaling, as they cannot replicate the personalized geometry. These personalized dynamics of cellular signaling may further impact disease progression, yet remains unclear. This paper presents a six-step methodology for creating personalized large artery scaffolds, focusing on high-precision models that yield biologically interpretable patient-specific results. The methodology outlines the creation of personalized large artery models via Additive Manufacturing suitably for supporting cell culture and other cellular experiments. Additionally, it discusses how different Computer-Aided-Design (CAD) construction modes can be used to obtain high-precision personalized models, while simplifying model reconfigurations and facilitating adjustments to general designs such as system connections to bioreactors, fluidic systems and visualization tools. A proposal for quality control measures to ensure geometric congruence for biological relevance of the results is added. This innovative, interdisciplinary approach appears promising for gaining patient-specific insights into pathophysiology, highlighting the importance of personalized medicine for understanding complex diseases.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system.","authors":"Saniya Jawed,&nbsp;Satish CS","doi":"10.1016/j.stlm.2024.100176","DOIUrl":"10.1016/j.stlm.2024.100176","url":null,"abstract":"<div><div>In the current research work, 3d printed capsules were printed by using FDM based 3D printer. A model drug punched into matrix tablets was put inside and encapsulated in the capsule. It was compared with the highly advanced ready-to-fill enteric-coated capsule Eudracap™ capsule. Solid Works and slicing software were used to design and cast off the shape of the capsule shell. The design of the cap and body was made and capsules were printed accordingly. All were evaluated for acid uptake and disintegration tests. In an acidic medium at pH 1.2, it has not been disintegrated or opened. While in the intestinal pH at 6.8 body and cap got separated after 45 ± 05 min. All sizes of capsules were also assessed for dosage form they can uphold. This could be a good option for customized drug delivery for human and animal studies.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal 3D printing for orthopaedics: An experience after 500 cases","authors":"Shirong Huang,&nbsp;Muhammad Farhan Bin Mohd Fadil,&nbsp;Michael Gui Jie Yam","doi":"10.1016/j.stlm.2024.100179","DOIUrl":"10.1016/j.stlm.2024.100179","url":null,"abstract":"<div><div>There has been a surge in the use of 3D printing in modern medicine due to the plethora of benefits that it brings - shorter operative times with reduced operating room costs, along with higher quality patient and medical student education. Despite its undeniable benefits, there remains challenges left unaddressed. How can a centre start and maintain an efficient 3D printing centre? In our paper, we aim to share our set of recommendations for optimal 3D printing in Orthopaedics, leveraging on our experience after more than 500 cases.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printable customized drug delivery system for the vaginal delivery of therapeutics: Unlocking potential prospects for women care","authors":"Suraj Kumar ,&nbsp;Rishabha Malviya ,&nbsp;Sathvik Belagodu Sridhar","doi":"10.1016/j.stlm.2024.100177","DOIUrl":"10.1016/j.stlm.2024.100177","url":null,"abstract":"<div><div>The current traditional medication administration method is characterized by a prevalent \"one-size-fits-all\" approach poses challenges in tailoring medications to individual pharmacokinetic profiles, limiting its applicability in the pharmaceutical sector. In response to this, three-dimensional (3D) printable medical devices for vaginal drug delivery are gaining popularity, due to advancements in Fused Deposition Modeling (FDM) or additive manufacturing (AM) technology. These devices offer distinct Strengths over conventional medication delivery methods, enabling the customization of drugs and the creation of intricate three-dimensional structures with personalized designs. In an additional point of interest, the development of multi-material printing integrates the beneficial properties of a variety of functional substances, presenting diverse opportunities to enhance the efficacy of vaginal drug delivery. Although there have been substantial advancements in manufacturing processes, challenges such as cost-effectiveness, scalability, and compliance with regulations remain substantial hurdles. This review focuses on the recent progress made in the field of printed using three-dimensional technology for vaginal medication delivery devices, addresses the primary challenges that need to be overcome, and explores the potential of manufacturing techniques in shaping the future of dosage forms and drug administration systems.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel approach to hallucal sesamoid pathology utilizing a 3D printed patient specific total sesamoid replacement implant: Case series","authors":"Tyler R. Rodericks ,&nbsp;Adam D. Perler ,&nbsp;Hans C. Humrick","doi":"10.1016/j.stlm.2024.100174","DOIUrl":"10.1016/j.stlm.2024.100174","url":null,"abstract":"<div><h3>Background</h3><p>Sesamoidectomy can be associated with multiple complications secondary to loss of the intrinsic function of the excised sesamoid. We sought to mitigate these complications by preserving sesamoid function with a total sesamoid replacement (TSR) in lieu of sesamoidectomy.</p></div><div><h3>Method</h3><p>Patient specific 3D printed TSR implants were designed and implanted for three patients who had exhaustively failed conservative measures. Follow up ranges from 7-36 months during which we evaluated for complications, symptom resolution, and patient satisfaction.</p></div><div><h3>Result</h3><p>All patients had complete resolution of pain between 3.5-12 months postop and have remained satisfied with their outcome. No evidence of the aforementioned complications was observed.</p></div><div><h3>Conclusion</h3><p>TSR may represent a viable alternative treatment option for most cases in which sesamoidectomy would otherwise be considered.</p></div><div><h3>Level of evidence</h3><p>IV, case series.</p></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696412400033X/pdfft?md5=72667af06e2e994bed040877460fd39c&pid=1-s2.0-S266696412400033X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewing the literature of 3D printing of bones and cartilage: Evidence and practice","authors":"Arunkumar Subramanian ,&nbsp;Jaishree Mohanbabu ,&nbsp;Trisha Srinivasan ,&nbsp;Tamilanban T ,&nbsp;Vetriselvan Subramaniyan ,&nbsp;Manimaran V ,&nbsp;Mahendran Sekar ,&nbsp;Ling Shing Wong","doi":"10.1016/j.stlm.2024.100180","DOIUrl":"10.1016/j.stlm.2024.100180","url":null,"abstract":"<div><div>The cutting-edge innovations offer diverse opportunities in medicine; one such inductive approach is 3D bio-printing, in which cells and desired biomaterials cohesively synthesize living macro tissues. The rapidly increasing demand for reconstruction and restoration of highly intricate and responsive bone implants has encouraged bone tissue engineering to yield implants that substitute the native bone, both physically and biologically. As this technology is still in its infancy, different limitations can be encountered, such as the lack of in-depth characterization of scaffolds and limited visualization of a general framework, which can be overcome with further explorative studies. With computerized bio-fabrication, 3D printing aims to perfectly adapt implants, individually analyzing data at the level of cells, tissues, organs, and organic systems, ending this entire process under pre-bioprinting. The locus and susceptibility to bare load are primary considerations in selecting among widely available biomaterial options and printing techniques, including bio-ceramics, metals, bioinks, selective laser melting, directed energy deposition (laser or e-beam), and drop-on-powder printing. The addition of growth factors and mesenchymal stem cells allows the maintenance of the balance between osteoclasts and osteoblasts, the cartilage tissue formation, and contributes to the overall bone remodeling and regeneration processes. This review address and highlights relevant aspects on pre-bioprinting procedures, bio-materials selection, bio-printers, bone remodeling mechanism, and in-vivo responses of fibrin scaffold.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed collagen scaffold for heart valve repair","authors":"Henrique Luis Piva,&nbsp;Vitoria Olegario Leite,&nbsp;Antonio Claudio Tedesco","doi":"10.1016/j.stlm.2024.100181","DOIUrl":"10.1016/j.stlm.2024.100181","url":null,"abstract":"<div><div>Three-dimensional (3D) bioprinting has emerged as a promising approach for the development of functional tissues and organs, including the heart valves. In this study, we investigated the interaction of 3D printed collagen scaffolds with H9c2(2–1) and NIH/3T3 cells to improve heart-valve repair strategies. Type I collagen was extracted from rat tails, characterized using SDS-PAGE and Raman spectroscopy, and used as a biomaterial ink for 3D printing. The rheological properties were evaluated. The FRESH technique was used to support the printed construct. In vitro assessments were performed to determine the cell viability and distribution within the scaffold. These results demonstrated the successful extraction and characterization of Type I collagen, which exhibited suitable rheological properties for 3D bioprinting. The printed collagen scaffolds supported the growth and distribution of H9c2(2–1) and NIH/3T3 cells, indicating their potential application in heart valve repair. This study highlights the importance of collagen as a biomaterial in 3D bioprinting and provides insights into the development of advanced strategies for heart valve repair.</div></div>","PeriodicalId":72210,"journal":{"name":"Annals of 3D printed medicine","volume":"16 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}