Advanced Composites and Hybrid Materials最新文献

{"title":"Polyimide-modified epoxy coatings reinforced with functional fillers for enhanced thermal stability and corrosion resistance","authors":"Mengde Wu,&nbsp;Ge Cao,&nbsp;Zhenggang Xiao","doi":"10.1007/s42114-025-01265-6","DOIUrl":"10.1007/s42114-025-01265-6","url":null,"abstract":"<p>The protection of combustible cartridge cases (CCCs) benefits from applying composite coatings, which significantly extend their heat resistance time and improve their waterproof properties and corrosion resistance. In this study, a series of polyimide-modified epoxy resin composite films (NPMFs) was developed and applied as protective coatings. The polyimide-modified epoxy resin was designed through cross-linking reactions between epoxy resin and polyimide, forming the film material. The heat resistance and flame retardation of the NPMFs were attributed to the introduction of inorganic fillers. The results demonstrated that NPMF-3 significantly delayed the ignition of CCCs, withstanding temperatures of 270 °C for 109 s, thus, enhancing heat resistance by 104.1%. Meanwhile, the saltwater absorption rate of NPMF-4 was only 6.92 wt%, which was reduced by 82.10 wt% compared to the uncoated CCC sample. The maximum storage modulus value of all NPMFs exceeded 2000 MPa. Compared to the uncoated CCC sample, the tensile strength and elongation at break of NPMF-3 increased by 203.52% and 570.24%, respectively. Additionally, the corrosion rate of the Zn-Fe alloy samples coated with NPMFs was significantly lower than the uncoated samples, indicating strong protection against salt corrosion. These performance results were among the highest currently observed for CCCs. Therefore, these NPMFs not only possessed excellent thermal stability and corrosion resistance, but may also play an important role in CCC protection and marine corrosion resistance applications.</p>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01265-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual stresses in intrinsic thermoset-thermoplastic hybrid composites","authors":"Nicolas Dorr,&nbsp;Gabriel Fabrini Ribeiro,&nbsp;Janik Schmidt,&nbsp;Arne Björn Busch,&nbsp;Sathis Kumar Selvarayan,&nbsp;Robert Brandt","doi":"10.1007/s42114-025-01263-8","DOIUrl":"10.1007/s42114-025-01263-8","url":null,"abstract":"<div><p>Combining different materials in a thermally activated manufacturing process into a hybrid composite can lead to residual stresses if there is a difference between the adhesion temperature T_AD and the application temperature T_AP. If such hybrid composites are subjected to high cyclic loads, residual stresses may influence their durability. While residual stress analysis has been extensively studied in the context of metal-plastic hybrids, the residual stress condition is unknown for thermoset-thermoplastic hybrids produced by injection molding. Therefore, we firstly apply a calculational model to estimate the residual stress for the investigated material combination of glass fiber-filled polyamide (PA6.6 GF30) and a unidirectional glass fiber-reinforced plastic (UD-GFRP) with a polyurethane acrylate matrix. Secondly, these results are compared to a corresponding computational simulation model. Integrating Fiber-Bragg-Grating (FBG) sensors in the UD-GFRP allows for the determination of residual strain in the thermoset component at different temperatures and thereby both the calculational and computational simulation methods could be validated against experimental results. The results show that process-related residual stresses occur in the hybrid composite and are not negligible. Normal stresses of − 39.6 MPa have been observed in thermoset material. Furthermore, the calculational determined normal stresses are in accordance with the experimentally determined values.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01263-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of lignocellulose nanofibrils based on biochemical mechanical pulp from wheat straw","authors":"Qingao Zeng,&nbsp;Zhongjian Tian,&nbsp;Xingxiang Ji,&nbsp;Shan Liu,&nbsp;Chuanling Si","doi":"10.1007/s42114-024-01200-1","DOIUrl":"10.1007/s42114-024-01200-1","url":null,"abstract":"<div><p>Due to the inherent stability of plant cell wall structure, the utilization of various fiber raw materials is limited in terms of diversification. Therefore, it is crucial to explore a simple, environmentally friendly, and cost-effective strategy for the high-value utilization of fiber raw materials. Herein, lignocellulose nanofibrils (LCNFs) were prepared from wheat straw by a combination of high-yield pulp production technology and mechanical methods. By using the mild biochemical mechanical pulp pretreatment technology, the whole process avoids the use of other organic solvents; only recycled sodium hydroxide chemical reagents are needed. The prepared LCNFs exhibited small particle size range (&lt; 10 nm) and high thermal stability (T_Max up to 350.8 °C). Moreover, by adjusting the front-end conditions during preparation, the properties of LCNFs films such as crystallinity, hydrophobicity, and water absorption can be controlled. Overall, this study provides a simple and efficient way for valorizing agricultural waste as well as a feasible alternative to incineration.\u0000</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-024-01200-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing charge transfer in hybrid solar cells: the role of pulse laser-assisted hydrothermally synthesized Au@N-S-doped fluorescent carbon quantum dots as Forster Resonance Energy Transfer antennas","authors":"Pankaj K. Bhujbal,&nbsp;Abhijit T. Supekar,&nbsp;Prathamesh A. Kadam,&nbsp;Naveen Vashishth,&nbsp;Almas Mujawar,&nbsp;Utkarsh Singh,&nbsp;Bishakha Ray,&nbsp;Sharad A. Mahadik,&nbsp;Suwarna Datar,&nbsp;Bhaskar Majumdar,&nbsp;Shashikant P. Patole,&nbsp;Devnath Dhirhe,&nbsp;Habib M. Pathan","doi":"10.1007/s42114-025-01256-7","DOIUrl":"10.1007/s42114-025-01256-7","url":null,"abstract":"<div><p>The strategic selection and design of antenna materials can significantly improve the light-harvesting efficiency of acceptor dye in Forster Resonance Energy Transfer (FRET)-based hybrid solar cells. This study uses innovative pulse laser-assisted hydrothermally synthesized Au-decorated nitrogen and sulphur-doped fluorescent carbon quantum dots (Au@NSCDs) as FRET relay antennas. They have unique properties, such as large surface areas for biomolecule attachment, broad spectral absorption, efficient charge carrier extraction, and rapid charge transport. We investigate hybrid solar cell integration with N3 dyes as energy acceptors and Au@NSCDs as donors. The study reveals the existence of FRET and the interaction between Au@NSCDs and the N3 dye. The FRET efficiency is 22.17%, while the Radiative Energy Transfer (RET) efficiency is 20%. Co-sensitization of Au@NSCDs with N3 dye in DSSCs leads to a 1.29% power conversion efficiency (PCE), 0.45 V open circuit voltage, a 1.77 mA/cm² short-circuit current density, and a 30% improvement compared to TiO₂/BaTiO₃/N3-based DSSCs. Au@NSCDs also mitigate charge recombination, increasing open-circuit voltage to 670 mV. The TiO₂/BaTiO₃/N3-Au@NSCD configuration had an effective lifetime (17.57 ms), excellent charge carrier retention, and the highest charge collection efficiency (0.99). Au@NSCD antenna material can reduce charge recombination, indicating potential for future hybrid solar cell technology advancements.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01256-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilayer drug-release microneedles loaded with functional exosomes constitute a multidimensional therapeutic system for the treatment of liver injury","authors":"Zhenyu Song,&nbsp;Shenyi Lu,&nbsp;Xueliang Zhang,&nbsp;Hai Wang,&nbsp;Qiuming Yao,&nbsp;Linke Bian,&nbsp;Zhaorong Wu,&nbsp;Taihua Yang,&nbsp;Ji Wu,&nbsp;Dan Liu,&nbsp;Zhigang Zheng","doi":"10.1007/s42114-025-01247-8","DOIUrl":"10.1007/s42114-025-01247-8","url":null,"abstract":"<div><p>Due to the difficulty in addressing multifactorial complex diseases such as chronic liver injury, we designed multilayer structured microneedles based on multiple pathogenic factors. This study addresses chronic liver injury characterized by high tissue fibrosis and hepatocyte necrosis by utilizing hepatocyte growth factor (HGF) and stem cell exosome solution (HGF@EV) to encapsulate a slow-release antifibrotic drug, nintedanib, within soluble microneedles (H@EV-H/G/N MNP). Applying the patch directly to the skin allows for continuous absorption and gradual degradation of nintedanib in vivo. In vitro experiments showed that nintedanib inhibits M2 polarization, reduces TGF-β secretion, and, in combination with microneedles, suppresses fibroblast proliferation and migration, thus hindering liver fibrosis progression. The regenerative effect of the HGF-loaded stem cell exosome solution led to significant hepatocyte proliferation. Under this dual action, the liver function and quality of life of the mice were effectively improved. By extension, different multilayer microneedles can be constructed to target the pathogenic characteristics of various diseases. This multimodal therapeutic system addresses complex refractory diseases characterized by multiple pathogenic factors.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01247-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly porous hollow 3D devices obtained by a combined melt-wet processing for long-term controlled release","authors":"Marta Balsamo,&nbsp;Maria Chiara Mistretta,&nbsp;Roberto Scaffaro","doi":"10.1007/s42114-025-01255-8","DOIUrl":"10.1007/s42114-025-01255-8","url":null,"abstract":"<div><p>The possibility to obtain resistant and reusable hollow devices with differentiated high porosity for storage and tunable long-term controlled release of substances is difficult to achieve efficiently. To solve this problem, we propose a combined melt-wet processing, which allows predictable and tunable morphologies. The process consists in combining Material Extrusion (MEX) with an eco-friendly salt leaching in distilled water, by using a biostable polymer and high percentages of saline porogen. Three blends with PA6/NaCl-30/70wt% composition were extruded, varying the salt particles size, that shows good dispersion in all the filaments, with a spontaneous tendency for bigger particles to accumulate in the central region of the cross-sections, attributable to fluid-dynamic reasons. Blends rheological and mechanical properties appeared suitable for the printing process. The hollow devices were then printed and successfully leached, resulting in homogeneously dispersed pores, with size ranges comparable to those of the porogen for each blend; therefore, the morphology of the pores can be directly predicted by the porogen and it was not altered during processing. Leaching occurred completely, in fact the real porosity for each device was consistent with the theoretical one. Despite the high percentage of voids, the hollow devices appeared to be mechanically resistant and therefore suitable for the application. Controlled release up to 11 days of a model molecule (methylene blue) was tested and predictable kinetics related to pore size were achieved so, therefore, they are easily tunable and versatile. Release data were fitted according to Peppas-Korsmeyer-model to describe the release mechanism related to porosity.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01255-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding double perovskite BCNF as a CO2 splitting catalyst for industrial decarbonisation","authors":"Weiwei Zhao,&nbsp;Hongkun Ma,&nbsp;Zixuan Wang,&nbsp;Benjamin Grégoire,&nbsp;Ao Lin,&nbsp;Siyuan Dai,&nbsp;Xuefeng Lin,&nbsp;Ting Liang,&nbsp;Jie Chen,&nbsp;Tongtong Zhang,&nbsp;Yulong Ding","doi":"10.1007/s42114-025-01253-w","DOIUrl":"10.1007/s42114-025-01253-w","url":null,"abstract":"<div><p>The foundation industry, particularly the steel sector, is one of the major sources of global CO₂ emissions, with each ton of steel produced using iron ores contributing approximately 1.4 (direct reduced iron-based process) to 2 (blast furnace-based process) tons of CO₂, with ironmaking accounting for approximately 70% of these emission. Here, we present a study on the potential of using a double perovskite, Ba₂Ca_0.66Nb_0.34FeO_6-δ (BCNF), as a CO₂ splitting catalyst that converts CO₂ into carbon monoxide (CO), a reducing agent in ironmaking, which can be reintegrated into the ironmaking process to enable ‘in-process’ decarbonisation and facilitate close-loop carbon recirculation. The study combines thermodynamic modelling, molecular dynamics simulations, material characterisation, and lab-scale experimental system design, demonstrating the efficiency and practicality of the use of BCNF for CO₂ emission reduction at a moderate temperature range. Simultaneous Thermal Analysis and COMSOL-based simulations were employed to optimise reactor design, maximising CO yield. An economic analysis further supports the scalability of this technology for decarbonising the steelmaking industry, which bears significance with the broader applicability to other foundation industrial sectors, including non-ferrous metal smelting, cement, glass, ceramics, and chemicals. This innovation offers a promising pathway towards sustainable industrial practices and contributes to global efforts to address climate change challenges.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01253-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The construction of a stable physical–chemical multi-crosslinking structure through a simplified FROMP strategy synergistically enhances the flame retardancy and mechanical properties of PDCPD","authors":"Ping Wang,&nbsp;Mengting Shi,&nbsp;Jiacheng Ling,&nbsp;Li Yang,&nbsp;Wenxiu Liu,&nbsp;Yiyang Zhou,&nbsp;Jie Xu,&nbsp;Mei Chen,&nbsp;Guilin Li","doi":"10.1007/s42114-025-01254-9","DOIUrl":"10.1007/s42114-025-01254-9","url":null,"abstract":"<div><p>The enhancement of the flame retardancy of polydicyclopentadiene (PDCPD) while maintaining its excellent mechanical properties has long been an important and critical technical challenge for many years. In this contribution, we designed and synthesized a new flame-retardant monomer containing double norbornene groups (NB-PDP) which can undergo the frontal ring-opening metathesis polymerization (FROMP) with dicyclopentadiene (DCPD) and 5-dicyclopentadiene-2-carboxylic acid (NB-COOH). Through the formulation optimization, the flame retardancy and mechanical properties of the copolymers could be easily regulated. To investigate the influencing mechanism of the NB-PDP and NB-COOH on the properties of the copolymers, the thermodynamics and kinetics of the FROMP, as well as the micro-structures, mechanical properties, and flame-retardant performance of the PDCPD/NB-PDP/NB-COOH copolymers were systematically studied. The findings suggest that the integration of NB-PDP and NB-COOH resulted in a diverse array of physical and chemical cross-linking networks within the system. Consequently, the tensile strength of the copolymers reached a maximum of 63.1 MPa and the elongation at break achieved up to 28.5%, representing the increases of 43.0% and 154.0% compared to that of PDCPD without any modification, respectively. It is worth mentioning that except the flame-retardant NB-PDP, NB-COOH could also serve as the carbon source to enhance the char formation and further improve the flame-retardant properties, such as the limiting oxygen index (LOI), peak heat release rate (PHRR), total heat release (THR), and total smoke production (TSP). These phenomena indicate that the material exhibits excellent mechanical properties and conspicuous flame retardancy. This work provided an efficient method for the preparation of the intrinsically flame-retardant PDCPD materials and a new strategy for the constructing of the thermosetting materials with excellent comprehensive performance.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01254-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143184664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aramid nanofibers at ultralow loadings: driving significant multifunctionality in epoxy composite dielectrics","authors":"Haowen Yuan,&nbsp;Zi Wang,&nbsp;Di Lan,&nbsp;Siyuan Zhang,&nbsp;Zicheng Zang,&nbsp;Guoqing Jiang,&nbsp;Huachao Wei,&nbsp;Yiyi Zhang,&nbsp;Jiajia Zheng,&nbsp;Junwen Ren,&nbsp;Guanglei Wu,&nbsp;Shenli Jia","doi":"10.1007/s42114-025-01222-3","DOIUrl":"10.1007/s42114-025-01222-3","url":null,"abstract":"<div><p>Epoxy dielectrics with superior insulation, mechanical, and thermal performance are of great interest for electrical equipment and power electronics. However, integrating these excellent advantages into epoxy presents a formidable challenge. Herein, we detail a simple yet effective strategy for the concurrent enhancement of the dielectric breakdown strength, mechanical toughness, mechanical strength, and the glass transition temperature (<i>T</i>_g) of the epoxy dielectrics by incorporation of a minimal amount of aramid nanofibers (ANFs). It is revealed that a robust interfacial interaction is established between epoxy matrix and the high aspect ratio of ANFs as corroborated by both molecular dynamics simulations and dielectric relaxation spectroscopy. The strong interaction facilitates an optimized interface that enables efficient transfer of interfacial stress and energy dissipation, in turn conferring the ANFs/Epoxy with exceptional mechanical strength (up to 75.68 MPa) and toughness (195 MJ/m³) as well as high <i>T</i>_g (155 °C), respectively. Furthermore, the incorporation of ANFs introduces a multitude of deep traps which effectively impede the migration of charge carriers, contributing to a substantial improvement of the dielectric breakdown strength (196.8 kV/mm) of the ANFs/Epoxy composite, which is almost 4.1 times higher than that of epoxy.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01222-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic reprogramming of fibroblast-like synoviocytes with a supramolecular nano-drug for osteoarthritis therapy","authors":"Yibo Ma,&nbsp;Jiaxing Dong,&nbsp;Xiangqian Zou,&nbsp;Xiaohua Jiang,&nbsp;Linhua Liu,&nbsp;Bing Wang,&nbsp;Xiulin Mao,&nbsp;Liangfeng Gong,&nbsp;Guoshu Li,&nbsp;Changjian Chen","doi":"10.1007/s42114-025-01245-w","DOIUrl":"10.1007/s42114-025-01245-w","url":null,"abstract":"<div><p>Metabolic reprogramming is fundamental to synovium remodeling with drug delivery for osteoarthritis (OA) therapy. Mitochonic acid 5-MASM7@MnTBAP nanoparticles (MM@MT NPs) with various physicochemical properties and biological activities may be developed as a supramolecular nano-drug delivering to articulus for regulating mitochondrial metabolism of synovium. This study aims to explore the feasibility, efficacy, and mechanism of MM@MT NPs, which possibly excavates a novel perspective for OA therapy. Herein, for feasibility, MM@MT NPs has been indicated to possess excellent photothermal, reactive oxygen species (ROS) response, and oxygen release performances. For efficacy, MM@MT NPs has been confirmed to promote extracellular matrix (ECM) regeneration. For mechanism, MM@MT NPs has been illustrated to restore the mitochondrial membrane potential and recover the mitochondrial dynamics, which is beneficial for maintaining mitochondrial homeostasis. Moreover, MM@MT NPs has been demonstrated to stimulate the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in mitochondria as well as enhance antioxidant capacity and eliminate oxidative stress, which is reflected in regulating the adenosine triphosphate (ATP) and ROS metabolism. Therefore, MM@MT NPs can remodel the homeostasis of mitochondria via reprogramming metabolism in synovium, which achieves the symptomatic and etiological treatments of OA.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01245-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143108055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}