Advanced Composites and Hybrid Materials最新文献

{"title":"Microscopic mechanism of cellulose nanofibers modified cemented gangue backfill materials","authors":"Jiangyu Wu,&nbsp;Shuo Yang,&nbsp;Marcus Williamson,&nbsp;Hong S. Wong,&nbsp;Tushar Bhudia,&nbsp;Hai Pu,&nbsp;Qian Yin,&nbsp;Dan Ma,&nbsp;Weiqiang Chen","doi":"10.1007/s42114-025-01270-9","DOIUrl":"10.1007/s42114-025-01270-9","url":null,"abstract":"<div><p>Reinforcing the performances of cemented backfill materials to recycle gangue and tailings is crucial for the sustainable development of mineral resources and mining waste management. However, under practical constraints of low cost, high waste ratio, low carbon emission, and low binder consumption, solidifying upcycles of mining wastes with toxicity, porosity, and mollification to cemented backfill materials with superior properties are inherently contradictory and challenging. This study reported a waste-to-wealth pathway that improves cemented gangue backfill materials by cellulose nanofibers to recycle mining wastes and partially replace cement. Mechanical compression, X-ray diffraction, thermogravimetry, mercury intrusion porosimetry, scanning electron microscopy tests, fractal quantitative analyses of microstructures, and molecular dynamics simulations were carried out to reveal the action mechanism of TEMPO-modified cellulose nanofibers on cemented gangue backfill materials. The difference in the contribution of TEMPO-modified cellulose nanofibers and mechanical cellulose nanofibers to the strengths of cemented gangue backfill materials was analyzed. The results show a series of microscopic improvements of cellulose nanofibers on cemented gangue backfill materials, including regulating cemented gel polymerization, increasing hydration nucleation, inhibiting carbonization, densifying pore structure, enhancing Ca-O connections and H bonds, and preventing C-S–H fracture along interlayer water. Excessive cellulose nanofibers are also found to be harmful to this composite mainly by delaying hydration crystallization and increasing pores by entrapping air, while it still exhibits improvements in deformation resistance and energy absorption despite strength deterioration. The strength and energy absorption reinforcements of this cemented hybrid materials induced by cellulose nanofibers with optimal dosage can reach up to 30 ~ 50%.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01270-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface energy induced microstructural engineering of bio-derived N-doped carbon fibers anchored by CoNi nanoparticles for superior microwave absorption","authors":"Ying Li,&nbsp;Zhenxin Liu,&nbsp;Yuhao Lu,&nbsp;Minglong Yang,&nbsp;Peng Zhang,&nbsp;Dongyi Lei,&nbsp;Chengkan Liu,&nbsp;Sijia Wang,&nbsp;Chunlei Dong","doi":"10.1007/s42114-025-01262-9","DOIUrl":"10.1007/s42114-025-01262-9","url":null,"abstract":"<div><p>Microstructural engineering has been an effective way to modulate the performance of electromagnetic wave absorption (EMA) materials. However, there are still severe challenges in how to design and regulate the microstructure effectively and further elucidate its mechanisms. Here, three-dimensional (3D) bio-derived N-doped carbon fibers anchored by CoNi nanoparticles (N-C_f@CoNi) nanocomposites were successfully prepared using biomass cotton and ZIF-67 precursor as raw materials by a two-step impregnation-carbonization method. By ingeniously adjusting the mass ratio of the ZIF-67 precursor, the surface morphology of balsam pear-like fiber was induced by crystal surface energy to achieve a transition from a “nanotube-assembled nest-like” structures to “rice-shaped nanosheets” to “nanoparticles.” The unique microstructural engineering strategy endows the N-C_f@CoNi nanocomposites with an abundant conductive network, enhanced multiple reflection and absorption, polarization, and magnetic loss, thereby leading to distinguished EMA performance, especially ultrawide EAB values. The optimized N-C_f@CoNi nanocomposites display a minimum reflection loss (RL_min) of − 59.43dB and an effective absorption bandwidth (EAB) of 8.5 GHz at a matching thickness of 2.16 mm. The result underscores the potential of microstructural engineering induced by crystal surface energy in optimizing the microwave absorption of N-C_f@CoNi nanocomposites, laying the foundation for the development of efficient EMA materials with controllable micro-morphology.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01262-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tungsten oxide/reduced graphene oxide composite electrodes for solid-state asymmetric supercapacitor application","authors":"Sujata B. Patil,&nbsp;Ranjit P. Nikam,&nbsp;Vaibhav C. Lokhande,&nbsp;Chandrakant D. Lokhande,&nbsp;Raghunath S. Patil","doi":"10.1007/s42114-025-01268-3","DOIUrl":"10.1007/s42114-025-01268-3","url":null,"abstract":"<div><p>Tungsten oxide (WO₃) thin films were deposited on flexible stainless steel (SS) substrates via low-cost chemical bath deposition (CBD) method by varying concentration of sodium tungstate precursor (0.05–0.2 M). Also, tungsten oxide/reduced graphene oxide (WO₃/rGO) nanocomposite thin films were deposited (0.15 M sodium tungstate precursor concentration) at different rGO concentration variations (0.5, 1, and 1.5 mg mL⁻¹). The effect of precursor concentration and rGO addition on the physicochemical properties of electrodes was studied. The thin films of WR2 (deposited at 0.15 M sodium tungstate and 1 mg mL⁻¹ rGO concentration) nanocomposites exhibited a hexagonal crystal structure along with a surface morphology resembling nanorods. The appearance of rGO in WO₃/rGO was proved from the FT-IR, RAMAN, and EDAX studies. WR2 nanocomposite thin film exhibited 1060 F g⁻¹ specific capacitance at scan rate of 5 mV s⁻¹. The flexible WR2//PVA-H₂SO₄//activated carbon asymmetric (ASC) device was fabricated using WR2 as a negative electrode and activated carbon as a positive electrode which showed a specific capacitance of 175 F g⁻¹ with energy and power densities of 19.1 Wh kg⁻¹ and 0.43 KW kg⁻¹, respectively, with 81.3% capacitive retention over 5000 CV cycles.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01268-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid near-infrared-activated luminescent gold nanoparticle platform for efficient cancer therapy","authors":"Feihong Yan,&nbsp;Ruiyuan Li,&nbsp;Jiaxin Liu,&nbsp;Lulu Yang,&nbsp;Helin Liu,&nbsp;Shengcang Zhu,&nbsp;Yuhui Zhang,&nbsp;Lijun Wang,&nbsp;Lu Huang,&nbsp;Yu Wang,&nbsp;Yaqiang Qin,&nbsp;Yuhang Zhang,&nbsp;Xin Wang,&nbsp;Yuan Wang,&nbsp;Jianping Zhang,&nbsp;Yinlin Sha,&nbsp;Limin Fu,&nbsp;Zhiyong Liu,&nbsp;Rongcheng Han,&nbsp;Yuqiang Jiang","doi":"10.1007/s42114-024-01141-9","DOIUrl":"10.1007/s42114-024-01141-9","url":null,"abstract":"<div><p>The development of a multifunctional therapy nanoplatform is of crucial importance to tackle the complex challenges associated with cancer. Despite significant advancements in tumor treatment, the efficacy of these traditional approaches remains insufficient. Recurrence and metastasis following tumor treatment continue to represent a significant contributor to tumor-related mortality. This paper presents an improved, facile, and relatively green fabrication of (5-mercapto-1,3,4-thiadiazol-2-ylthio) acetic acid (TMT)-coated luminescent gold nanoparticles (L-AuNP@TMT), which exhibit highly membrane-targeting capacity and superior photodynamic properties. Furthermore, in vivo tumor-bearing mouse model experiments indicated that the L-AuNP@TMT could be used as a two-photon excited nanomedicine via pyroptosis-mediated anti-tumor immunity for effectively eliminating colorectal cancer (CRC), the third most common malignancy and the second deadliest cancer, without evident toxic side effects or tumor metastasis/recurrence. According to its facile and green fabrication approach, near-infrared light-activatable highly efficient photodynamic cancer therapy, and noninvasive imaging mode, this multifunctional nanoplatform offers significant advantages over traditional monotherapy techniques, providing an alternative for the precise clinical treatment of cancer.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-024-01141-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of ecofriendly, biodegradable electrically conductive double-layer bio-hydrogel nanocomposite for sustainable medical device applications","authors":"Zohre Jafari Vafa,&nbsp;Ehsan Nazarzadeh Zare,&nbsp;Mohammad Reza Fadavi Eslam,&nbsp;Pooyan Makvandi","doi":"10.1007/s42114-025-01226-z","DOIUrl":"10.1007/s42114-025-01226-z","url":null,"abstract":"<div><p>Electrotherapy devices used for pain relief and muscle recovery often face challenges because traditional electrode materials are not biodegradable, causing environmental issues and being less compatible with the body. While current conductive hydrogels show potential, they usually lack the combination of good electrical performance, biodegradability, and body-friendliness needed for sustainable medical devices. To address these challenges, this study presents a novel, eco-friendly, electrically conductive double-layer nanocomposite bio-hydrogel developed using tragacanth gum (TG) and polyvinyl alcohol (PVA), enhanced with carboxylated graphene (Gr_F) and polypyrrole (PPy). The innovative double-layer design represents a significant advancement over single-layer hydrogels, demonstrating reduced impedance and a substantial increase in conductivity (up to 4.99 × 10⁵ times) at frequencies relevant to electrotherapy applications. Specifically, the tragacanth gum/polyvinyl alcohol/carboxylated graphene@polypyrrole (TPG@PPy) bio-hydrogel exhibited a AC conductivity enhancement of up to 1.5 times compared to the tragacanth gum/polyvinyl alcohol@polypyrrole (TP@PPy) bio-hydrogel at frequency of 80 Hz. Additionally, the material’s high biodegradability, with up to 49% mass loss over 60 days in soil, confirms environmental safety. These results show that the double-layer bio-hydrogel could be a better, eco-friendly option for future electrotherapy devices, making it different from current conductive hydrogels.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01226-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyimide-modified epoxy coatings reinforced with functional fillers for enhanced thermal stability and corrosion resistance","authors":"Mengde Wu,&nbsp;Ge Cao,&nbsp;Zhenggang Xiao","doi":"10.1007/s42114-025-01265-6","DOIUrl":"10.1007/s42114-025-01265-6","url":null,"abstract":"<p>The protection of combustible cartridge cases (CCCs) benefits from applying composite coatings, which significantly extend their heat resistance time and improve their waterproof properties and corrosion resistance. In this study, a series of polyimide-modified epoxy resin composite films (NPMFs) was developed and applied as protective coatings. The polyimide-modified epoxy resin was designed through cross-linking reactions between epoxy resin and polyimide, forming the film material. The heat resistance and flame retardation of the NPMFs were attributed to the introduction of inorganic fillers. The results demonstrated that NPMF-3 significantly delayed the ignition of CCCs, withstanding temperatures of 270 °C for 109 s, thus, enhancing heat resistance by 104.1%. Meanwhile, the saltwater absorption rate of NPMF-4 was only 6.92 wt%, which was reduced by 82.10 wt% compared to the uncoated CCC sample. The maximum storage modulus value of all NPMFs exceeded 2000 MPa. Compared to the uncoated CCC sample, the tensile strength and elongation at break of NPMF-3 increased by 203.52% and 570.24%, respectively. Additionally, the corrosion rate of the Zn-Fe alloy samples coated with NPMFs was significantly lower than the uncoated samples, indicating strong protection against salt corrosion. These performance results were among the highest currently observed for CCCs. Therefore, these NPMFs not only possessed excellent thermal stability and corrosion resistance, but may also play an important role in CCC protection and marine corrosion resistance applications.</p>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01265-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual stresses in intrinsic thermoset-thermoplastic hybrid composites","authors":"Nicolas Dorr,&nbsp;Gabriel Fabrini Ribeiro,&nbsp;Janik Schmidt,&nbsp;Arne Björn Busch,&nbsp;Sathis Kumar Selvarayan,&nbsp;Robert Brandt","doi":"10.1007/s42114-025-01263-8","DOIUrl":"10.1007/s42114-025-01263-8","url":null,"abstract":"<div><p>Combining different materials in a thermally activated manufacturing process into a hybrid composite can lead to residual stresses if there is a difference between the adhesion temperature T_AD and the application temperature T_AP. If such hybrid composites are subjected to high cyclic loads, residual stresses may influence their durability. While residual stress analysis has been extensively studied in the context of metal-plastic hybrids, the residual stress condition is unknown for thermoset-thermoplastic hybrids produced by injection molding. Therefore, we firstly apply a calculational model to estimate the residual stress for the investigated material combination of glass fiber-filled polyamide (PA6.6 GF30) and a unidirectional glass fiber-reinforced plastic (UD-GFRP) with a polyurethane acrylate matrix. Secondly, these results are compared to a corresponding computational simulation model. Integrating Fiber-Bragg-Grating (FBG) sensors in the UD-GFRP allows for the determination of residual strain in the thermoset component at different temperatures and thereby both the calculational and computational simulation methods could be validated against experimental results. The results show that process-related residual stresses occur in the hybrid composite and are not negligible. Normal stresses of − 39.6 MPa have been observed in thermoset material. Furthermore, the calculational determined normal stresses are in accordance with the experimentally determined values.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01263-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of lignocellulose nanofibrils based on biochemical mechanical pulp from wheat straw","authors":"Qingao Zeng,&nbsp;Zhongjian Tian,&nbsp;Xingxiang Ji,&nbsp;Shan Liu,&nbsp;Chuanling Si","doi":"10.1007/s42114-024-01200-1","DOIUrl":"10.1007/s42114-024-01200-1","url":null,"abstract":"<div><p>Due to the inherent stability of plant cell wall structure, the utilization of various fiber raw materials is limited in terms of diversification. Therefore, it is crucial to explore a simple, environmentally friendly, and cost-effective strategy for the high-value utilization of fiber raw materials. Herein, lignocellulose nanofibrils (LCNFs) were prepared from wheat straw by a combination of high-yield pulp production technology and mechanical methods. By using the mild biochemical mechanical pulp pretreatment technology, the whole process avoids the use of other organic solvents; only recycled sodium hydroxide chemical reagents are needed. The prepared LCNFs exhibited small particle size range (&lt; 10 nm) and high thermal stability (T_Max up to 350.8 °C). Moreover, by adjusting the front-end conditions during preparation, the properties of LCNFs films such as crystallinity, hydrophobicity, and water absorption can be controlled. Overall, this study provides a simple and efficient way for valorizing agricultural waste as well as a feasible alternative to incineration.\u0000</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-024-01200-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing charge transfer in hybrid solar cells: the role of pulse laser-assisted hydrothermally synthesized Au@N-S-doped fluorescent carbon quantum dots as Forster Resonance Energy Transfer antennas","authors":"Pankaj K. Bhujbal,&nbsp;Abhijit T. Supekar,&nbsp;Prathamesh A. Kadam,&nbsp;Naveen Vashishth,&nbsp;Almas Mujawar,&nbsp;Utkarsh Singh,&nbsp;Bishakha Ray,&nbsp;Sharad A. Mahadik,&nbsp;Suwarna Datar,&nbsp;Bhaskar Majumdar,&nbsp;Shashikant P. Patole,&nbsp;Devnath Dhirhe,&nbsp;Habib M. Pathan","doi":"10.1007/s42114-025-01256-7","DOIUrl":"10.1007/s42114-025-01256-7","url":null,"abstract":"<div><p>The strategic selection and design of antenna materials can significantly improve the light-harvesting efficiency of acceptor dye in Forster Resonance Energy Transfer (FRET)-based hybrid solar cells. This study uses innovative pulse laser-assisted hydrothermally synthesized Au-decorated nitrogen and sulphur-doped fluorescent carbon quantum dots (Au@NSCDs) as FRET relay antennas. They have unique properties, such as large surface areas for biomolecule attachment, broad spectral absorption, efficient charge carrier extraction, and rapid charge transport. We investigate hybrid solar cell integration with N3 dyes as energy acceptors and Au@NSCDs as donors. The study reveals the existence of FRET and the interaction between Au@NSCDs and the N3 dye. The FRET efficiency is 22.17%, while the Radiative Energy Transfer (RET) efficiency is 20%. Co-sensitization of Au@NSCDs with N3 dye in DSSCs leads to a 1.29% power conversion efficiency (PCE), 0.45 V open circuit voltage, a 1.77 mA/cm² short-circuit current density, and a 30% improvement compared to TiO₂/BaTiO₃/N3-based DSSCs. Au@NSCDs also mitigate charge recombination, increasing open-circuit voltage to 670 mV. The TiO₂/BaTiO₃/N3-Au@NSCD configuration had an effective lifetime (17.57 ms), excellent charge carrier retention, and the highest charge collection efficiency (0.99). Au@NSCD antenna material can reduce charge recombination, indicating potential for future hybrid solar cell technology advancements.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01256-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilayer drug-release microneedles loaded with functional exosomes constitute a multidimensional therapeutic system for the treatment of liver injury","authors":"Zhenyu Song,&nbsp;Shenyi Lu,&nbsp;Xueliang Zhang,&nbsp;Hai Wang,&nbsp;Qiuming Yao,&nbsp;Linke Bian,&nbsp;Zhaorong Wu,&nbsp;Taihua Yang,&nbsp;Ji Wu,&nbsp;Dan Liu,&nbsp;Zhigang Zheng","doi":"10.1007/s42114-025-01247-8","DOIUrl":"10.1007/s42114-025-01247-8","url":null,"abstract":"<div><p>Due to the difficulty in addressing multifactorial complex diseases such as chronic liver injury, we designed multilayer structured microneedles based on multiple pathogenic factors. This study addresses chronic liver injury characterized by high tissue fibrosis and hepatocyte necrosis by utilizing hepatocyte growth factor (HGF) and stem cell exosome solution (HGF@EV) to encapsulate a slow-release antifibrotic drug, nintedanib, within soluble microneedles (H@EV-H/G/N MNP). Applying the patch directly to the skin allows for continuous absorption and gradual degradation of nintedanib in vivo. In vitro experiments showed that nintedanib inhibits M2 polarization, reduces TGF-β secretion, and, in combination with microneedles, suppresses fibroblast proliferation and migration, thus hindering liver fibrosis progression. The regenerative effect of the HGF-loaded stem cell exosome solution led to significant hepatocyte proliferation. Under this dual action, the liver function and quality of life of the mice were effectively improved. By extension, different multilayer microneedles can be constructed to target the pathogenic characteristics of various diseases. This multimodal therapeutic system addresses complex refractory diseases characterized by multiple pathogenic factors.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 2","pages":""},"PeriodicalIF":23.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-025-01247-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}