Analysis & sensing最新文献_第2页

Recent Progress in CO Detection Probes Based on Different Fluorophores 基于不同荧光团的 CO 检测探针的最新进展

IF 3.4

Analysis & sensing Pub Date : 2024-06-11 DOI: 10.1002/anse.202400021

Dr. Xinkuo Fang, Dr. Pengcheng Jiang, Prof. Haitao Yu, Dr. Yanyu Qi

引用次数: 0

Hybrid Paper/Polyester-Based Laser-Induced Graphene Electrodes for Electrochemical Detection of Tadalafil 用于电化学检测他达拉非的激光诱导石墨烯混合纸/聚酯电极

IF 3.4

Analysis & sensing Pub Date : 2024-06-11 DOI: 10.1002/anse.202400016

Shellyda G. G. Souza, Habdias A. Silva-Neto, Danielly S. Rocha, Abner de Siervo, Thiago R. L. C. Paixão, Wendell K. T. Coltro

{"title":"Hybrid Paper/Polyester-Based Laser-Induced Graphene Electrodes for Electrochemical Detection of Tadalafil","authors":"Shellyda G. G. Souza, Habdias A. Silva-Neto, Danielly S. Rocha, Abner de Siervo, Thiago R. L. C. Paixão, Wendell K. T. Coltro","doi":"10.1002/anse.202400016","DOIUrl":"10.1002/anse.202400016","url":null,"abstract":"Here, we describe for the first time the fabrication of laser-induced graphene (LIG) electrodes on a hybrid substrate composed of sandpaper and polyester. As a proof of concept, the proposed device was used as a voltammetric sensor for tadalafil (TAD) quantification in authentic tablet samples. The electrochemical TAD sensing based on differential pulse voltammetry (DPV) revealed a linear behavior in the concentration range from 25 to 250 μmol L−1(R2=0.99), a limit of detection of ~9.6 μmol L−1, sensitivity of ~0.0048 μA(μmol L−1)−1 and acceptable reproducibility values (RSD≤5.8 %). The DPV responses involving the standard addition method in pharmaceutical samples presented recovery results of TAD ranging from 93 to 108 %. Also, the proposed analytical method offered a suitable green analytical chemistry profile. We successfully demonstrated the fabrication of graphene-like sites and nanoparticles composed of alumina upon a hybrid substrate.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 6","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unimolecular Cucurbit[7]uril-Based Indicator Displacement Assay with Dual Signal-Readout for the Detection of Drugs 基于葫芦[7]脲的单分子指示剂位移测定法与双信号读出法检测药物

IF 3.4

Analysis & sensing Pub Date : 2024-06-05 DOI: 10.1002/anse.202400025

Pierre Picchetti, Maria Vittoria Balli, Seth Baker, Nilima Manoj Kumar, Patrick Gruhs, Luca Prodi, Frank Biedermann

{"title":"Unimolecular Cucurbit[7]uril-Based Indicator Displacement Assay with Dual Signal-Readout for the Detection of Drugs","authors":"Pierre Picchetti, Maria Vittoria Balli, Seth Baker, Nilima Manoj Kumar, Patrick Gruhs, Luca Prodi, Frank Biedermann","doi":"10.1002/anse.202400025","DOIUrl":"10.1002/anse.202400025","url":null,"abstract":"Point-of-care diagnostics relies on optical and electrochemical sensors to develop devices that are both compact and cost-effective. Therefore, the search for new design principles for chemosensors that enable multiple signal outputs is a particularly interesting concept. In this work, we present an unimolecular chemosensor based on cucurbit[7]uril that combines two signal readouts - namely fluorescent and electrochemical signals - in a single chemosensor design. This is achieved by utilizing the tunable fluorescence and the electrochemical properties of the reporter molecule, which depend on whether or not it is engulfed by the cucurbit[7]uril cavity in the absence or presence of the analyte. By setting up an assay using the dual readout chemosensor, illicit drug formulations containing pancuronium bromide or nicotine can be detected at low micromolar concentrations (0–100 μM). This assay is compatible with standard fluorescence plate readers and electrochemical devices, including commercially available screen-printed electrodes. Overall, the chemosensor presented in this study represents a significant advance in the development of cucurbit[7]uril chemosensors, characterized by multimodal detection capabilities. It uniquely combines traditional optical and electrochemical detection methods in a single molecular design.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141382561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ pH Modulation for Enhanced Chemical Sensing: Strategies and Applications 用于增强化学传感的原位 pH 值调节：策略与应用

IF 3.4

Analysis & sensing Pub Date : 2024-06-03 DOI: 10.1002/anse.202400013

Fabian Steininger, Klaus Koren

引用次数: 0

Bimetallic Nanoparticles as Electrochemical Labels in Immunosensors for the Detection of Biomarkers of Clinical Interest 双金属纳米粒子作为免疫传感器中的电化学标签，用于检测临床相关的生物标记物

IF 3.4

Analysis & sensing Pub Date : 2024-05-17 DOI: 10.1002/anse.202400017

David Valero-Calvo, Francisco Javier García-Alonso, Alfredo de la Escosura-Muñiz

引用次数: 0

Small-Molecule Fluorescent Probes for Plant Hormones and their Receptors 植物激素及其受体的小分子荧光探针

IF 3.4

Analysis & sensing Pub Date : 2024-05-14 DOI: 10.1002/anse.202400020

Zibo Lin, Junhao Xiong, Zihao Zhou, Prof. Qiong Chen, Prof. Jun Yin

{"title":"Small-Molecule Fluorescent Probes for Plant Hormones and their Receptors","authors":"Zibo Lin, Junhao Xiong, Zihao Zhou, Prof. Qiong Chen, Prof. Jun Yin","doi":"10.1002/anse.202400020","DOIUrl":"10.1002/anse.202400020","url":null,"abstract":"Plant hormones and their receptors play a crucial role in regulating plant growth and adapting to the stress environment. The exploration of interaction between plant hormones and their receptors is significant to comprehend the molecular mechanisms of plant growth and development, the response mechanisms of adaptation to environmental changes, and to optimize the traits and stress-resistance of crops. Since the biosynthesis, transport, and metabolism of hormones in plants are closely relevant to spatio-temporal changes, and their content and distribution are highly dynamic, there is an urgent need for a qualitative and quantitative tool to accurately, real-time, and in situ monitor the dynamic changes of hormones in plants without injury. Fluorescent probes have been widely used in the sensing and imaging of plant hormones and their receptors, due to their high spatio-temporal resolution, high selectivity, non-invasive, high sensitivity, and tailored molecular structures. Here, this paper provides a systematical overview of the research progress in the sensing and imaging of plant hormones and their receptors using fluorescent probes. In addition, the potential prospects and remaining challenges are also discussed to design fluorescent probes with better performance and promote the development of this field.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Stable 2D Conductive Lanthanide Organic Frameworks (Lu-HHTP) for High-Performance Humidity Sensors 为高性能湿度传感器合成稳定的二维导电镧系元素有机框架 (Lu-HHTP)

IF 3.4

Analysis & sensing Pub Date : 2024-05-09 DOI: 10.1002/anse.202400024

Dr. Shan Jiang, Xichao Mo, Xuefei Zhao, Xiaohui Yan, Zhaorui Zhang, Jiahao Liu, Huashuai Hu, Nan Wang, Prof. Minghui Yang

{"title":"Synthesis of Stable 2D Conductive Lanthanide Organic Frameworks (Lu-HHTP) for High-Performance Humidity Sensors","authors":"Dr. Shan Jiang, Xichao Mo, Xuefei Zhao, Xiaohui Yan, Zhaorui Zhang, Jiahao Liu, Huashuai Hu, Nan Wang, Prof. Minghui Yang","doi":"10.1002/anse.202400024","DOIUrl":"10.1002/anse.202400024","url":null,"abstract":"Two-dimensional conductive metal-organic frameworks (MOFs) featuring structural diversity and high porosity represent promising platforms for chemiresistive humidity sensing. The precise control of the structure of lanthanide-based MOFs and an exploration of its impact on charge transport and sensing applications have consistently been focal points for researchers. In this study, we present the synthesis and characterization of Lu-HHTP (HHTP=2,3,6,7,10,11-hexahydroxytriphenylene) as highly crystalline and conductive porous materials. The polymeric framework of Lu-HHTP encompasses 1D hexagonal channels and exhibits interlayer π–π stacking, resulting in a material with a high surface area and uniform rod-like microstructure. Benefiting from its elevated electrical conductivity, the Lu-HHTP-based humidity sensor exhibited commendable sensing properties within the relative humidity range of 33 % to 95 % at room temperature (25 °C), achieving a response value as high as 19 at 95 % relative humidity. Furthermore, the sensor displayed superior repeatability, characterized by rapid response and recovery speeds in the presence of moisture. These findings indicate that Lu-HHTP holds substantial promise as a material for humidity sensors.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Odor Biosensors Based on Cell Expressing Olfactory Receptor: Recent Advances 基于表达嗅觉受体细胞的气味生物传感器：最新进展

IF 3.4

Analysis & sensing Pub Date : 2024-04-26 DOI: 10.1002/anse.202400006

Hongchao Deng, Takamichi Nakamoto

{"title":"Odor Biosensors Based on Cell Expressing Olfactory Receptor: Recent Advances","authors":"Hongchao Deng, Takamichi Nakamoto","doi":"10.1002/anse.202400006","DOIUrl":"https://doi.org/10.1002/anse.202400006","url":null,"abstract":"Inspired by the powerful biological olfaction, scientists extracted numerous materials such as olfactory sensory neuron, olfactory receptor (OR) protein, and odorant binding protein from animal olfactory systems, then combined them with transducers to form multiple odor biosensors. These biosensors, despite well inheriting the sensing ability of creatures, have several drawbacks, such as complex preparation process, unstable sensing material characteristics, and high cost. Unlike the biological materials listed above, cell expressing heterologous OR maintains a stable sensing performance after passaging for multiple generations, also its experimental operation is simple, and cost is low. Therefore, odor biosensors based on cell expressing OR have been well developed in recent years. In this review, we first listed several odor biosensors based on cell expressing OR, mainly focusing on fluorescent and electrophysiological measurement methods. Furthermore, we illustrated the techniques to improve the biosensor performance, e. g., wider detection range, longer lifetime, more OR types, and higher quantification efficiency. In addition, we explained the possible prospects such as big sensor array and predicting odor response.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Dual-Channel Molecularly Imprinted Electrochemical Sensor for Simultaneously Monitoring Sweat Cortisol and Lactate Levels 用于同时监测汗液皮质醇和乳酸盐水平的柔性双通道分子印迹电化学传感器

IF 3.4

Analysis & sensing Pub Date : 2024-04-23 DOI: 10.1002/anse.202400003

Siying Pei, Dr. Wenhui Ji, Ya Yang, Tianwei Liu, Shuo Yang, Prof. Dr. Jiayi Wu, Jiangxuan Dai, Dr. Xiyan Hou, Qiong Wu, Prof. Dr. Lin Li

{"title":"Flexible Dual-Channel Molecularly Imprinted Electrochemical Sensor for Simultaneously Monitoring Sweat Cortisol and Lactate Levels","authors":"Siying Pei, Dr. Wenhui Ji, Ya Yang, Tianwei Liu, Shuo Yang, Prof. Dr. Jiayi Wu, Jiangxuan Dai, Dr. Xiyan Hou, Qiong Wu, Prof. Dr. Lin Li","doi":"10.1002/anse.202400003","DOIUrl":"10.1002/anse.202400003","url":null,"abstract":"While exercise offers significant potential to enhance overall well-being, unscientific exercise practices often cause exercise fatigue, posing a threat to human health. Flexible sweat sensors have garnered considerable attention owing to their ability to continuously, non-invasively, and dynamically monitor human health during exercise at the molecular level. Therefore, in this study, we constructed a flexible molecularly imprinted polymer (MIP) sensor for the real-time monitoring of cortisol and lactate levels in sweat using cortisol or lactate as template molecules and pyrrole (Py) as functional monomer. Prussian blue (PB) was embedded into the MIP as a built-in redox probe, eliminating the need for an additional probe and facilitating the simultaneous quantification of cortisol and lactate concentrations. Moreover, the MIP-doped platinum nanoparticles (PtNPs) ehanced the electron transfer capability, further improving the sensitivity of the sensors. The fabricated flexibile cortisol and lactate MIP sensors demonstrated low limits of detection (LOD; 1.07 nM and 1.09 mM, respectively), high sensitivity (0.09 μA lg[nM]−1 and 1.28 μA lg[nM]−1), and exceptional stability and selectivity. The flexible MIP sensors could continuously and dynamically monitor changes in sweat cortisol and lactate concentrations, thus contributing to the advancement of next-generation flexible sweat electrochemical sensors and providing a crucial tool for monitoring exercise fatigue.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 5","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upconversion Luminescence Based Direct Hybridization Assay to Detect Subfemtomolar miR-20 a DNA Analogue in Plasma 基于上转换发光的直接杂交测定法检测血浆中的亚母摩尔 miR-20a DNA 类似物

IF 3.4

Analysis & sensing Pub Date : 2024-04-22 DOI: 10.1002/anse.202400005

Saara Kuusinen, Satu Lahtinen, Tero Soukka

{"title":"Upconversion Luminescence Based Direct Hybridization Assay to Detect Subfemtomolar miR-20 a DNA Analogue in Plasma","authors":"Saara Kuusinen, Satu Lahtinen, Tero Soukka","doi":"10.1002/anse.202400005","DOIUrl":"10.1002/anse.202400005","url":null,"abstract":"MicroRNAs (miRNAs) are promising biomarkers especially for early-stage cancer diagnostics, but the implementation of miRNA-based diagnostic tests is still hindered by the limitations of current analytical methods. The small size, low concentrations in biofluids and high sequence homology of miRNAs are challenges for assay development. Currently, most of the sensitive detection methods rely on enzymatic amplification steps, which complicate the analysis and can lead to biases in quantitation. Therefore, there is an increasing need to develop enzyme-free detection methods that are sensitive, specific and user-friendly. In this study, a simple direct hybridization assay for the DNA analogue of miR-20a was developed. The assay is based on upconverting nanoparticle labels, which enable ultrasensitive detection, and hairpin structured probes, which provide additional hybridization stability due to base stacking. The limit of detection was 0.73 fM with plasma recoveries between 76 % and 111 %, demonstrating that the assay could be used for direct detection of miRNAs from complex sample matrices without isolation of RNA. Due to the simplicity and the excellent sensitivity for an amplification-free method, the assay has a great potential for miRNA-based clinical applications.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"4 4","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140678057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0