Analysis & sensing最新文献_第2页

Characterization of Nanoparticles by Taylor Dispersion Analysis Hyphenated to Charge Detection Mass Spectrometry 纳米粒子的泰勒色散-电荷检测质谱分析表征

IF 2.9

Analysis & sensing Pub Date : 2026-03-09 DOI: 10.1002/anse.202500245

Tessa Reinert, Séléna Ferreres, Lilou Duplantier, Dipankar Bain, Guillaume Montagne, Sylvain Maclot, Martinus H. V. Werts, Rodolphe Antoine

引用次数: 0

Extracting a Large Set of 1H–1H Residual Dipolar Couplings From a Liquid-Quality 1H NMR Spectrum in Compressed PMMA Gels: A Case Study for Strychnine 从压缩PMMA凝胶液质1H NMR谱中提取大量1H - 1H残余偶极偶联：以士的宁为例

IF 2.9

Analysis & sensing Pub Date : 2026-03-06 DOI: 10.1002/anse.70059

Áron Szigetvári, Márton Weber, Zoltán Béni

引用次数: 0

Rapid Detection of Antibiotics and Pesticide Residues Using a Tungsten–Gold Nanoparticle-Based Surface-Enhanced Raman Scattering Substrate 基于钨金纳米粒子表面增强拉曼散射衬底的抗生素和农药残留快速检测

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500201

Yuqing Zhang, Qi Zhang, Ya Wang, Liming Hu, Cong Wang, Lin Zhang, Shanyan Mo, Qingbian Ma, Qiang Ma

{"title":"Rapid Detection of Antibiotics and Pesticide Residues Using a Tungsten–Gold Nanoparticle-Based Surface-Enhanced Raman Scattering Substrate","authors":"Yuqing Zhang, Qi Zhang, Ya Wang, Liming Hu, Cong Wang, Lin Zhang, Shanyan Mo, Qingbian Ma, Qiang Ma","doi":"10.1002/anse.202500201","DOIUrl":"https://doi.org/10.1002/anse.202500201","url":null,"abstract":"Pervasive residues of antibiotics and pesticides present a dual threat: acute poisoning and chronic antimicrobial resistance (AMR) risks. To address the technical bottleneck of complex sample pretreatment in traditional methods for acute poisoning incidents, this study developed a highly sensitive and stable surface-enhanced Raman scattering (SERS) substrate for rapid detection of poisoning substances. Using electrophoretic deposition, we achieved ordered, dense assembly of tungsten–gold nanoparticles on a gold film. This engineered structure, combined with the excellent adsorption properties of tungsten oxide single atoms, enables a synergistic enhancement in both signal intensity and uniformity. The substrate exhibits high SERS performance, with an enhancement factor of ≈107 and a relative standard deviation (RSD) below 20%. The detection limit for various analytes reached 1 ppb. In spiked serum tests, recovery rates were 80%–120% with RSD < 15%, demonstrating strong matrix resistance and practical reliability. This work provides a universal SERS platform for ultrasensitive, rapid (<5 min) detection of multiple antibiotics and pesticides, supporting on-site emergency diagnosis and large-scale monitoring of long-term exposure and AMR risks.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Detection of Antibiotics and Pesticide Residues Using a Tungsten–Gold Nanoparticle-Based Surface-Enhanced Raman Scattering Substrate 基于钨金纳米粒子表面增强拉曼散射衬底的抗生素和农药残留快速检测

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500201

Yuqing Zhang, Qi Zhang, Ya Wang, Liming Hu, Cong Wang, Lin Zhang, Shanyan Mo, Qingbian Ma, Qiang Ma

{"title":"Rapid Detection of Antibiotics and Pesticide Residues Using a Tungsten–Gold Nanoparticle-Based Surface-Enhanced Raman Scattering Substrate","authors":"Yuqing Zhang, Qi Zhang, Ya Wang, Liming Hu, Cong Wang, Lin Zhang, Shanyan Mo, Qingbian Ma, Qiang Ma","doi":"10.1002/anse.202500201","DOIUrl":"https://doi.org/10.1002/anse.202500201","url":null,"abstract":"Pervasive residues of antibiotics and pesticides present a dual threat: acute poisoning and chronic antimicrobial resistance (AMR) risks. To address the technical bottleneck of complex sample pretreatment in traditional methods for acute poisoning incidents, this study developed a highly sensitive and stable surface-enhanced Raman scattering (SERS) substrate for rapid detection of poisoning substances. Using electrophoretic deposition, we achieved ordered, dense assembly of tungsten–gold nanoparticles on a gold film. This engineered structure, combined with the excellent adsorption properties of tungsten oxide single atoms, enables a synergistic enhancement in both signal intensity and uniformity. The substrate exhibits high SERS performance, with an enhancement factor of ≈107 and a relative standard deviation (RSD) below 20%. The detection limit for various analytes reached 1 ppb. In spiked serum tests, recovery rates were 80%–120% with RSD < 15%, demonstrating strong matrix resistance and practical reliability. This work provides a universal SERS platform for ultrasensitive, rapid (<5 min) detection of multiple antibiotics and pesticides, supporting on-site emergency diagnosis and large-scale monitoring of long-term exposure and AMR risks.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid-State Nanochannels Functionalized With Metal–Organic and Covalent Organic Frameworks: Applications in Sensing 用金属有机和共价有机框架功能化的固态纳米通道：在传感中的应用

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202600001

Qimin Yuan, Shuhan Yang, Yu Dai

{"title":"Solid-State Nanochannels Functionalized With Metal–Organic and Covalent Organic Frameworks: Applications in Sensing","authors":"Qimin Yuan, Shuhan Yang, Yu Dai","doi":"10.1002/anse.202600001","DOIUrl":"https://doi.org/10.1002/anse.202600001","url":null,"abstract":"Biological nanopores facilitate the continuous exchange of ions, molecules, and energy between living organisms and their environment. Scientists have used biological nanopores for sensing, such as gene sequencing and single-molecule detection. However, biological nanopores are inherently fragile. Inspired by biological nanopores, scientists have developed solid-state nanopores/nanochannels. These synthetic systems have stable physical properties, adjustable geometric shapes, and chemically modifiable surfaces. Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) overcome the limitations of traditional solid-state nanochannel surface functionalization through their designable framework structures. Here, we summarize the functionalization strategies and applications of MOFs and COFs on the inner wall and outer surface of solid-state nanochannels. The functionalization can precisely regulate surface properties, chemical environment, and pore size, thereby achieving high sensitivity, selectivity, and specificity in solid-state nanochannel sensing. Finally, the future development opportunities in this research field were discussed.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Homogeneous Digital Immunoassay for a Potential Noninvasive Urinary Biomarker of p62 for Neuronal Intranuclear Inclusion Disease 神经元核内包涵病潜在的无创尿p62生物标志物的同质数字免疫分析

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500222

Ye Rong, Xiaowen Li, Jin Tian, Lei Bao, Dandan Zhao, Hao Chen, Xiaojun Liu, Hongwei Gai

{"title":"A Homogeneous Digital Immunoassay for a Potential Noninvasive Urinary Biomarker of p62 for Neuronal Intranuclear Inclusion Disease","authors":"Ye Rong, Xiaowen Li, Jin Tian, Lei Bao, Dandan Zhao, Hao Chen, Xiaojun Liu, Hongwei Gai","doi":"10.1002/anse.202500222","DOIUrl":"https://doi.org/10.1002/anse.202500222","url":null,"abstract":"Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder currently diagnosed through invasive biopsies or genetic testing with ethnic limitations. Existing biomarkers from cerebrospinal fluid or plasma are not fully noninvasive, and no urine-based biomarker has been identified. There is an urgent need for a noninvasive, definitive diagnostic tool to distinguish NIID from other neurodegenerative diseases and healthy individuals. We developed a homogeneous digital immunoassay using two-color quantum dot (QD)-labeled antibodies to quantify p62 in urinary cell nuclei, achieving a detection limit of 47 fM. The assay demonstrated high selectivity and a wide dynamic range across three orders of magnitude. Analysis of urine samples from 10 NIID patients, 4 healthy controls, and 13 patients with other neurodegenerative disorders (myasthenia gravis, cerebral infarction, and Parkinson's disease) revealed that p62 levels were significantly elevated only in NIID patients. Spike recovery tests confirmed measurement accuracy (91%–106%), and p62 levels showed no correlation with disease stage in this limited cohort. This study introduces the first noninvasive urinary biomarker for NIID using a novel homogeneous digital immunoassay. The significantly elevated p62 levels specifically in NIID patients highlight its potential as a reliable, noninvasive diagnostic tool, enabling distinction from other neurodegenerative conditions and facilitating earlierand more accessible diagnosis.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QDs-Based SERS Technology: Breakthroughs and Prospects From Biosensing to Food Safety 基于qds的SERS技术：从生物传感到食品安全的突破与展望

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500177

Yuanying Ni, Yuening Wang, Xiangyu Meng, Jie Lin, Xiaotian Wang

{"title":"QDs-Based SERS Technology: Breakthroughs and Prospects From Biosensing to Food Safety","authors":"Yuanying Ni, Yuening Wang, Xiangyu Meng, Jie Lin, Xiaotian Wang","doi":"10.1002/anse.202500177","DOIUrl":"https://doi.org/10.1002/anse.202500177","url":null,"abstract":"Quantum dots (QDs) have emerged as a promising substrate in surface-enhanced Raman scattering (SERS), due to their quantum confinement effects and tunable optical properties. QDs provide a new solution to the limitations faced by SERS technology, such as poor stability, high cost, and biological toxicity, and demonstrate promising application prospects. This review summarizes recent progress in QDs-based SERS, including synthesis, enhancement mechanisms, and applications. In terms of synthesis strategies, various approaches such as chemical, physical, and biological ones are commonly employed to prepare quantum dots, in order to control their size, morphology, and surface functionalization. In terms of the enhancement mechanism, QDs-based SERS substrate typically combines the advantages of electromagnetic field enhancement and chemical enhancement. For instance, by taking advantage of the quantum size effect and oxygen vacancy engineering to dynamically adjust the local surface plasmon resonance, highly efficient electromagnetic hotspots can be generated in QD semiconductors or in the composite structures of noble metals/QDs. Meanwhile, the quantized energy levels enhance selectivity through resonant charge transfer. Importantly, QDs-based SERS substrate have been applied in wide fields including label-free biosensing of cancer cells, virus identification, multimodal tumor diagnosis, and food safety detection, etc. Despite these advancements, QDs-based SERS substrates still face challenges in terms of anti-interference ability, scalability in manufacturing, and long-term stability. And we propose that enhancing the selectivity and stability of QDs-SERS substrates through methods such as surface modification is an important approach to improving their SERS activity. Additionally, integrating artificial intelligence with composite material design is expected to accelerate its industrialization and sustainable application in the fields of medicine and food safety.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidoreductase-Mimicking Nanozyme-Based Biosensors for Bacteria Detection in Complex Scenarios 复杂环境下细菌检测的模拟氧化还原酶纳米酶生物传感器

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500230

Caiyue Wang, Jinsong Fan, Pingping Wan, Yuping Bao, Qingyun Liu, Kun Li

{"title":"Oxidoreductase-Mimicking Nanozyme-Based Biosensors for Bacteria Detection in Complex Scenarios","authors":"Caiyue Wang, Jinsong Fan, Pingping Wan, Yuping Bao, Qingyun Liu, Kun Li","doi":"10.1002/anse.202500230","DOIUrl":"https://doi.org/10.1002/anse.202500230","url":null,"abstract":"Bacterial infectious diseases pose a serious challenge to global public health, making the development of rapid, sensitive, and low-cost bacterial detection technologies critically important. Nanozymes, as a class of nanomaterials exhibiting enzyme-like activities, demonstrate unique advantages for this purpose due to their outstanding stability, tunable catalytic properties, and multifunctionality. Particularly, oxidoreductase-mimicking nanozymes exhibit great potential in biosensing. This review systematically summarizes the recent advances of their applications in bacterial detection. We discuss the design principles and synthesis methodologies of metal-based, oxide-/sulfide-based, carbon-based, and composite nanozymes, followed by their various oxidation–reduction reaction catalytic mechanisms and utilization strategies in designing bacterial assays. Their applications span clinical diagnostics, food safety monitoring, environmental surveillance, and the detection of drug-resistant bacteria and detection in special scenarios. More importantly, we focus on the strategic approaches to enhance nanozyme-based detection, including sensitivity improvement, specificity enhancement, detection mode innovation, and function expansion. Finally, the current challenges and future research directions in this field are proposed. This review provides a comprehensive reference for further research and practical application of nanozymes in bacterial detection, aiming to promote the translational application of nanozyme technology in the diagnosis and prevention of infectious diseases.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QDs-Based SERS Technology: Breakthroughs and Prospects From Biosensing to Food Safety 基于qds的SERS技术：从生物传感到食品安全的突破与展望

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202500177

Yuanying Ni, Yuening Wang, Xiangyu Meng, Jie Lin, Xiaotian Wang

{"title":"QDs-Based SERS Technology: Breakthroughs and Prospects From Biosensing to Food Safety","authors":"Yuanying Ni, Yuening Wang, Xiangyu Meng, Jie Lin, Xiaotian Wang","doi":"10.1002/anse.202500177","DOIUrl":"10.1002/anse.202500177","url":null,"abstract":"Quantum dots (QDs) have emerged as a promising substrate in surface-enhanced Raman scattering (SERS), due to their quantum confinement effects and tunable optical properties. QDs provide a new solution to the limitations faced by SERS technology, such as poor stability, high cost, and biological toxicity, and demonstrate promising application prospects. This review summarizes recent progress in QDs-based SERS, including synthesis, enhancement mechanisms, and applications. In terms of synthesis strategies, various approaches such as chemical, physical, and biological ones are commonly employed to prepare quantum dots, in order to control their size, morphology, and surface functionalization. In terms of the enhancement mechanism, QDs-based SERS substrate typically combines the advantages of electromagnetic field enhancement and chemical enhancement. For instance, by taking advantage of the quantum size effect and oxygen vacancy engineering to dynamically adjust the local surface plasmon resonance, highly efficient electromagnetic hotspots can be generated in QD semiconductors or in the composite structures of noble metals/QDs. Meanwhile, the quantized energy levels enhance selectivity through resonant charge transfer. Importantly, QDs-based SERS substrate have been applied in wide fields including label-free biosensing of cancer cells, virus identification, multimodal tumor diagnosis, and food safety detection, etc. Despite these advancements, QDs-based SERS substrates still face challenges in terms of anti-interference ability, scalability in manufacturing, and long-term stability. And we propose that enhancing the selectivity and stability of QDs-SERS substrates through methods such as surface modification is an important approach to improving their SERS activity. Additionally, integrating artificial intelligence with composite material design is expected to accelerate its industrialization and sustainable application in the fields of medicine and food safety.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid-State Nanochannels Functionalized With Metal–Organic and Covalent Organic Frameworks: Applications in Sensing 用金属有机和共价有机框架功能化的固态纳米通道：在传感中的应用

IF 2.9

Analysis & sensing Pub Date : 2026-03-03 DOI: 10.1002/anse.202600001

Qimin Yuan, Shuhan Yang, Yu Dai

{"title":"Solid-State Nanochannels Functionalized With Metal–Organic and Covalent Organic Frameworks: Applications in Sensing","authors":"Qimin Yuan, Shuhan Yang, Yu Dai","doi":"10.1002/anse.202600001","DOIUrl":"https://doi.org/10.1002/anse.202600001","url":null,"abstract":"Biological nanopores facilitate the continuous exchange of ions, molecules, and energy between living organisms and their environment. Scientists have used biological nanopores for sensing, such as gene sequencing and single-molecule detection. However, biological nanopores are inherently fragile. Inspired by biological nanopores, scientists have developed solid-state nanopores/nanochannels. These synthetic systems have stable physical properties, adjustable geometric shapes, and chemically modifiable surfaces. Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) overcome the limitations of traditional solid-state nanochannel surface functionalization through their designable framework structures. Here, we summarize the functionalization strategies and applications of MOFs and COFs on the inner wall and outer surface of solid-state nanochannels. The functionalization can precisely regulate surface properties, chemical environment, and pore size, thereby achieving high sensitivity, selectivity, and specificity in solid-state nanochannel sensing. Finally, the future development opportunities in this research field were discussed.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0