Analysis & sensing最新文献_第2页

Electronic Nose Based on a Multi-Thin Film Transistor Sensor Array Structure for Detecting Odorants with High Selectivity 基于多薄膜晶体管传感器阵列结构的电子鼻检测高选择性气味

IF 2.9

Analysis & sensing Pub Date : 2025-03-26 DOI: 10.1002/anse.202500003

Sohee Kim, Goeun Pyo, Wonhyuk Choi, Hyun Woo Jang, Hyeokjin Kwon, Kwangsu Kim, Su Jin Heo, Dong Su Kim, Jongyoun Kim, Youngu Lee, Hongki Kang, Hyuk-Jun Kwon, Cheil Moon, Jae Eun Jang

{"title":"Electronic Nose Based on a Multi-Thin Film Transistor Sensor Array Structure for Detecting Odorants with High Selectivity","authors":"Sohee Kim, Goeun Pyo, Wonhyuk Choi, Hyun Woo Jang, Hyeokjin Kwon, Kwangsu Kim, Su Jin Heo, Dong Su Kim, Jongyoun Kim, Youngu Lee, Hongki Kang, Hyuk-Jun Kwon, Cheil Moon, Jae Eun Jang","doi":"10.1002/anse.202500003","DOIUrl":"10.1002/anse.202500003","url":null,"abstract":"Electrical noses that mimic the human olfactory system have been developed to detect odors or flavors. Unfortunately, little research on sensing reactions to various odors like a human nose can be found in the literature. Herein, an electronic nose is proposed using a multi-thin film transistor (TFT) sensor array with various polymer selectors and multi-output signal processing to detect various odorants with high selectivity. Through the combination of multi-output produced by eight polymer variables based on indium gallium zinc oxide (IGZO) TFTs, a specific radar pattern and its selectivity are generated for the eight different odor substances. Eight multi-output signal processing reduced the correlation coefficient of similarity from 77.9% to 45% relative to the case of four multi-output processing. Because the polymers have different functional groups, polymers showed specific reactions to various odorants, like the human's system, and multi-output analysis could distinguish various odors, even if polymers did not show single selectivity to a specific odor. And the sensitivity improved when compared to two-terminal structures by using TFTs based on IGZO. The advantage is that it can classify multiple odors with good selectivity and sensitivity. This sensor and signal processing concept can be applied to E-nose systems capable of odor monitoring.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroanalytical Immunotechnology for Minimally Invasive Assessment of Toll-Like Receptor 2, a Key Inflammatory Component in Colorectal Cancer Progression 电分析免疫技术用于微创评估toll样受体2，结直肠癌进展中的关键炎症成分

IF 2.9

Analysis & sensing Pub Date : 2025-03-10 DOI: 10.1002/anse.202500014

Sandra Tejerina-Miranda, Maria Gamella, María Pedrero, Ana Montero-Calle, José M. Pingarrón, Rodrigo Barderas, Susana Campuzano

{"title":"Electroanalytical Immunotechnology for Minimally Invasive Assessment of Toll-Like Receptor 2, a Key Inflammatory Component in Colorectal Cancer Progression","authors":"Sandra Tejerina-Miranda, Maria Gamella, María Pedrero, Ana Montero-Calle, José M. Pingarrón, Rodrigo Barderas, Susana Campuzano","doi":"10.1002/anse.202500014","DOIUrl":"10.1002/anse.202500014","url":null,"abstract":"Toll-like receptor 2 (TLR2) is involved in infectious diseases, inflammatory processes and carcinogenesis. Soluble TLR2 (sTLR2) can be released into circulation stream acting as an endogenous negative regulator of TLR2 signaling, essential for the prevention of chronic inflammation and tissue destruction. In this context, we propose pioneering electrochemical biotechnology for the determination of sTLR2 in plasma of colorectal cancer (CRC) patients. The method involves the use of magnetic particles as micro-supports for the implementation of a sandwich immunoassay using a pair of specific antibodies and horseradish peroxidase as enzymatic tracer to carry out the amperometric transduction on screen-printed carbon electrodes in the presence of H2O2 and hydroquinone. The proposed immunoplatform shows attractive operational and analytical characteristics, reaching a low limit of detection of 241 pg mL−1 for TLR2 standards in buffered solutions, and showing an excellent reproducibility (RSD 1.4 %), and a wide dynamic range (804 to 25000 pg mL−1). It has been applied to the analysis of a cohort of 21 plasma samples from healthy individuals and CRC patients at different stages of the disease, demonstrating precise quantitative determinations, in just 45 min and requiring minimal sample amount and pre-treatments. The results demonstrate the promising utility of TRL2 plasma levels for minimally invasive monitoring of CRC progression.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover: Titanium Mxene: A Promising Material for Next-Generation Optical Biosensors and Machine Learning Integration (Anal. Sens. 2/2025) 封面二茂钛：下一代光学生物传感器和机器学习集成的前景看好的材料（Anal. Sens.）

IF 2.9

Analysis & sensing Pub Date : 2025-03-10 DOI: 10.1002/anse.202580201

Athulya Aravind, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran

引用次数: 0

Dicyanovinyl Appended Carbazole Based Colorimetric Sensor for Volatile Organic Amines 双氰乙烯基附加咔唑基挥发性有机胺比色传感器

IF 2.9

Analysis & sensing Pub Date : 2025-03-07 DOI: 10.1002/anse.202400109

S. Arunkumar, Gokul Raj Mini Rajendran, Aniket Chowdhury, George Rajendra Kumar

引用次数: 0

Immobilization of Ru(II) Complex Onto the Glassy Carbon Electrode for the Detection of Tetracycline Residue in Chicken Egg and Cow Milk Ru（II）配合物在玻璃碳电极上固定化检测鸡蛋和牛奶中四环素残留

IF 2.9

Analysis & sensing Pub Date : 2025-03-04 DOI: 10.1002/anse.202500005

P. Jeba Sagana, T. Shankar, K. Swarnalatha

{"title":"Immobilization of Ru(II) Complex Onto the Glassy Carbon Electrode for the Detection of Tetracycline Residue in Chicken Egg and Cow Milk","authors":"P. Jeba Sagana, T. Shankar, K. Swarnalatha","doi":"10.1002/anse.202500005","DOIUrl":"10.1002/anse.202500005","url":null,"abstract":"This study highlights the electrochemical drug (ECD) sensor with a glassy carbon electrode modified with ruthenium(II) complex (RBNH), which showed a stronger response to the detection of tetracycline (TC) antibiotic residue in real samples like chicken eggs and cow milk compared to other substrate materials. Glassy carbon electrodes are covalently functionalized with ruthenium(II) complex containing the redox active 2, 2 bipyridine, and a hydrazone ligand (BNH) via., drop casting method. This results in the electrocatalytic behavior of the modified electrode (GCE/RBNH) on the oxidation of TC. Further, the modified electrode′s sustainability was tested with various antibiotics, including different concentrations of tetracycline, and scan rates by different techniques like cyclic voltammetry (CV), linear sweep voltammetry (LSV). Then a GCE/RBNH was used to create a linear calibration curve for TC concentrations ranging from 10 to 100 μmol L−1 (R2=0.99), with a limit of detection and quantification 0.0675 μmol L−1 and 0.224 μmol L−1. The current approach, which possesses an effortless electrode modification step and offers the lowest detection limit and a comparatively wider linear dynamic range, performed better for determining TC in chicken eggs and milk samples than recently reported voltammetric methods.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifying the Morphology, Doping, and Electroanalytical Performance of Carbon Nanofibers by Varying the Ratio of Etchant and Feedstock Gases 通过改变蚀刻剂和原料气体的比例来改变碳纳米纤维的形貌、掺杂和电分析性能

IF 2.9

Analysis & sensing Pub Date : 2025-02-23 DOI: 10.1002/anse.202400097

Ishan Pande, Khadijeh Nekoueian, Jani Sainio, Tomi Laurila

{"title":"Modifying the Morphology, Doping, and Electroanalytical Performance of Carbon Nanofibers by Varying the Ratio of Etchant and Feedstock Gases","authors":"Ishan Pande, Khadijeh Nekoueian, Jani Sainio, Tomi Laurila","doi":"10.1002/anse.202400097","DOIUrl":"10.1002/anse.202400097","url":null,"abstract":"Ammonia (NH3) is a widely used etchant gas in the plasma-enhanced chemical vapor deposition (PECVD) synthesis of carbon nanofibers (CNFs). In addition to being an effective etchant, NH3 also serves as a dopant by providing N heteroatoms. However, this secondary role has not been comprehensively investigated. Moreover, the influence of N-doping on the electroanalytical performance of CNFs has not been thoroughly assessed. In this work, we have prepared CNFs of two varieties by altering the ratio of etchant and feedstock gases (NH3 and C2H2, respectively), resulting in N-doped CNFs with different doping levels. Differences were also observed in the morphology and electrochemical characteristics of the CNFs. While inner sphere redox (ISR) characteristics were not significantly affected, a significant shift between the peak potentials of ascorbic acid (AA) and dopamine (DA) was detected in the higher doped CNFs, resulting in enhanced selectivity towards DA. Our results demonstrate a simple yet effective method for enhancing the electroanalytical properties of CNFs.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On-Paper Enzyme-Linked and Metal-Linked Immunosorbent Assays for Low-Cost Decentralized Testing of Carcinoembryonic Antigen 纸上酶联和金属联免疫吸附法低成本分散检测癌胚抗原

IF 2.9

Analysis & sensing Pub Date : 2025-02-11 DOI: 10.1002/anse.202400113

Electra Mermiga, Dr. Varvara Pagkali, Dionysios Soulis, Dr. Christos Kokkinos, Prof. Anastasios Economou

{"title":"On-Paper Enzyme-Linked and Metal-Linked Immunosorbent Assays for Low-Cost Decentralized Testing of Carcinoembryonic Antigen","authors":"Electra Mermiga, Dr. Varvara Pagkali, Dionysios Soulis, Dr. Christos Kokkinos, Prof. Anastasios Economou","doi":"10.1002/anse.202400113","DOIUrl":"10.1002/anse.202400113","url":null,"abstract":"This work reports two simplified paper-based approaches for immunosensing of carcinoembryonic antigen (CEA) in serum. On-paper enzyme-linked immunosorbent assay (p-ELISA) (using enzymatic generation of a colored product) and metal-linked immunosorbent assay (p-MeLISA) (using gold nanoparticles (AuNPs) as labels) were implemented using low-cost diagnostic bio-conjugated paper mini disks as platforms for the fast colorimetric immunosensing of CEA in human serum. The colour intensity was captured with a commercial scanner and analyzed using an open-source software. Different parameters of the preparation of the bioconjugated disks and of the immunoassays were studied and, under the selected conditions, LODs of 0.4 ng mL−1 with p-ELISA and 0.1 ng mL−1 with p-MeLISA were achieved while recoveries of CEA in serum samples were in the range from 88 to 112 % with coefficient of variation of <12 %. The assay time was 90 s for p-ELISA and 85 s for p-MeLISA. The immunoassays exhibited satisfactory selectivity in the presence of other cancer biomarkers and good stability under storage. Thanks to simple and rapid fabrication and modification, simple analysis protocol, affordability (<0.05 € per device), equipment-free quantification, low sample and reagents requirments, stability and satisfactory analytical characteristics, these approaches are fit-for-purpose for assay of CEA in serum at the point-of care in resource-limited settings.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paper Electrochemical Sensor Utilizing Nano Ag-Decorated Cu2O Nanoparticles for Ascorbic Acid Detection in Tablets 利用纳米ag修饰Cu2O纳米颗粒的纸质电化学传感器检测片剂中的抗坏血酸

IF 2.9

Analysis & sensing Pub Date : 2025-02-04 DOI: 10.1002/anse.202400118

A. Venkadesh, Anumol Mathew, Thayyil K. Fahmeeda, J. Sonia, B. N. Kumara, K. Sudhakara Prasad

{"title":"Paper Electrochemical Sensor Utilizing Nano Ag-Decorated Cu2O Nanoparticles for Ascorbic Acid Detection in Tablets","authors":"A. Venkadesh, Anumol Mathew, Thayyil K. Fahmeeda, J. Sonia, B. N. Kumara, K. Sudhakara Prasad","doi":"10.1002/anse.202400118","DOIUrl":"10.1002/anse.202400118","url":null,"abstract":"The accurate and selective detection of vitamins are very much needed in the food, and pharmaceutical industries and health care. In this study, a new sustainable disposable electrochemical platform was fabricated with nano silver/Cu2O composite (nAg/Cu2O) for sensing ascorbic acid (vitamin C). The modified electrode exhibited reduced resistance to charge transfer and improved electro active area. The analyte displayed excellent electrochemical activity on the surface of nAg/Cu2O modified paper electrode and showed a concentration-dependent response between 0.05 to 500 μM with a detection limit (S/N=3), 0.04 μM. Furthermore, the anti-interference studies revealed that the nAg/Cu2O nanocomposites have high selectivity towards ascorbic acid. Notably, the sensor based on nAg/Cu2O showed exceptional stability and reproducibility, with a relative standard deviation for peak currents measuring approximately 7 % or less while testing for a week of time. The real-world application and analytical performance was realized by identifying ascorbic acid in commercial vitamin C tablets with satisfactory results.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Breath Biomarker Detection with Chemiresistive Metal Oxide Nanostructures: A Pathway to Next-Generation Diagnostic Tools 利用化学阻性金属氧化物纳米结构推进呼吸生物标志物检测：通往下一代诊断工具的途径

IF 2.9

Analysis & sensing Pub Date : 2025-02-03 DOI: 10.1002/anse.202400111

Jesse Nii Okai Amu-Darko

{"title":"Advancing Breath Biomarker Detection with Chemiresistive Metal Oxide Nanostructures: A Pathway to Next-Generation Diagnostic Tools","authors":"Jesse Nii Okai Amu-Darko","doi":"10.1002/anse.202400111","DOIUrl":"10.1002/anse.202400111","url":null,"abstract":"Breath biomarker detection represents a transformative frontier in non-invasive diagnostics, offering rapid, real-time insights into health conditions ranging from metabolic disorders to cancer. Metal oxide nanostructures (MONs) have emerged as key materials in this research because of their large surface area, adjustable electrical characteristics, and sensitivity to gaseous biomarkers at trace quantities. This paper examines current advances in chemiresistive MON-based sensors, focusing on the importance of structural optimization, hybrid material systems, and functionalization strategies in improving performance. Exploring the study of complicated datasets, the prediction of biomarker signatures, and dynamic aims in tuning the quality of the sensors. Functionalization strategies also play a vital role in enhancing the performance of MON-based sensors. By modifying the surface chemistry of chemiresistive metal oxides, researchers can tailor the sensors to preferentially adsorb certain gaseous biomarkers while minimizing interference from other compounds present in breath. Future opportunities include the development of multimodal sensors, simplified and portable devices, and durable, reusable platforms capable of long-term operation in real-world environments. With the confluence of nanotechnology and data-driven analytics, MON-based breath sensors have the potential to transform customized healthcare by providing worldwide early detection, illness monitoring, and preventative medication.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Smartphone-Integrated Coated Microneedle Sensor for In-Situ Extraction and Rapid Detection of Total Phenols in Fruits and Vegetables 智能手机集成涂层微针传感器用于果蔬中总酚的原位提取和快速检测

IF 2.9

Analysis & sensing Pub Date : 2025-01-24 DOI: 10.1002/anse.202400114

Rui Li, Shiyu Liu, Long Chen, Chao Huang, Prof. Xin Jia

{"title":"A Smartphone-Integrated Coated Microneedle Sensor for In-Situ Extraction and Rapid Detection of Total Phenols in Fruits and Vegetables","authors":"Rui Li, Shiyu Liu, Long Chen, Chao Huang, Prof. Xin Jia","doi":"10.1002/anse.202400114","DOIUrl":"10.1002/anse.202400114","url":null,"abstract":"As interest in monitoring the nutritional and antioxidant levels in fruits and vegetables grows, the need for efficient, non-invasive detection methods increases. In this work, a novel coated microneedle colorimetric sensing platform is designed to rapidly and sensitively detect total phenolic compounds (TPC) in fruits and vegetables, which is the key indicator of their nutritional and antioxidant properties. The platform utilizes a swollen microneedle structure to efficiently collect juice samples, enhancing detection efficiency through colorimetric analysis and eliminating the complexity of traditional methods. The microneedles are fabricated from a composite material consisting of 10,12-pentacosadiynoic acid (PCDA) and methacrylated gelatin (GelMA), with a secondary layer containing α-cyclodextrin to selectively bind polyphenols, thereby inducing a visible color change for the specific detection of TPC. The colorimetric response is directly correlated with the concentration of TPC, facilitating on-site analysis. Using phenol as a model molecule, the detection range of the system for phenol is 10–60 mM, with an LOD of 0.5 mM. Furthermore, a mobile application enables portable detection and analysis, reducing detection time from several hours to just 30 min. This technology offers a promising approach for the rapid, reliable monitoring of phenolic content in fresh produce, with potential applications in food quality control, nutritional analysis, and agricultural monitoring.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0