Analysis & sensing最新文献_第3页

Screen-Printed Electrode-Based Biosensors for POCT and Wearable Applications: A Review 用于POCT和可穿戴设备的丝网印刷电极生物传感器：综述

IF 3.3

Analysis & sensing Pub Date : 2026-08-18 DOI: 10.1002/anse.70117

Zhiqi Li, Lu Zhang, Yuankai Chen, Chenfei Liu, Yong Xia, Lei Mou

{"title":"Screen-Printed Electrode-Based Biosensors for POCT and Wearable Applications: A Review","authors":"Zhiqi Li, Lu Zhang, Yuankai Chen, Chenfei Liu, Yong Xia, Lei Mou","doi":"10.1002/anse.70117","DOIUrl":"https://doi.org/10.1002/anse.70117","url":null,"abstract":"The growing demand for rapid, decentralized, and continuous health monitoring is driving the development of point-of-care testing (POCT) and wearable biosensing technologies. Electrochemical sensors have emerged as a leading platform owing to their high sensitivity, rapid response, and compatibility with miniaturized systems. Among these, screen-printed electrodes (SPEs) offer distinct advantages, including low cost, scalable fabrication, and facile integration into portable devices. This mini-review summarizes recent advances in SPE-based electrochemical biosensors, focusing on fabrication strategies, surface modification approaches, and emerging biomedical applications. The incorporation of functional materials has significantly improved analytical performance, enabling sensitive and selective detection of diverse biomarkers—from small molecules and ions to hormones, proteins, and nucleic acids—in biofluids such as blood, sweat, and interstitial fluid (ISF). These developments have facilitated practical implementations in POCT and wearable systems. Current challenges and future perspectives are also discussed, including scalable manufacturing, long-term operational stability, and system-level integration. This review provides a concise overview of recent progress and highlights opportunities for advancing next-generation portable and wearable biosensing platforms.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NMR Investigation of Water in Mesoporous Silica Materials With Different Surfaces 不同表面介孔二氧化硅材料中水的核磁共振研究

IF 3.3

Analysis & sensing Pub Date : 2026-08-18 DOI: 10.1002/anse.70109

Yanjing Zhao, Christian Weinberger, Michael Tiemann, Claudia Schmidt

{"title":"NMR Investigation of Water in Mesoporous Silica Materials With Different Surfaces","authors":"Yanjing Zhao, Christian Weinberger, Michael Tiemann, Claudia Schmidt","doi":"10.1002/anse.70109","DOIUrl":"https://doi.org/10.1002/anse.70109","url":null,"abstract":"The influence of the hydrophilicity of mesoporous silica on wetting with water was investigated by comparing a standard hydrophilic MCM-41 and a partially hydrophobicized material obtained by trimethylsilylation of MCM-41. The materials were characterized using X-ray diffraction, N2 physisorption, thermogravimetric analysis, infrared spectroscopy, as well as 29Si and 13C solid-state nuclear magnetic resonance spectroscopy. Trimethylsilylation leads to a reduction of the pore diameter (determined using density functional theory) from 3.8 to 3.6 nm. Using proton solid-state nuclear magnetic resonance (NMR) under magic-angle spinning, it was found that the filling of these narrow pores with increasing amounts of water follows an axial mode, independent of surface hydrophilicity. The axial model of pore-filling is supported by the coexistence of two characteristic 1H NMR water signals, one from physisorbed water molecules, which can exchange protons with silanol groups, and one from bulk-like water in completely filled pores, where water molecules are in exchange between sites at the pore wall and sites closer to the center of the pore.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saccharide Chemosensors Based on Boronic Acid-Appended Heavy-Metal Complexes 基于硼酸附加重金属配合物的糖类化学传感器

IF 3.3

Analysis & sensing Pub Date : 2026-08-17 DOI: 10.1002/anse.202500179

Yota Suzuki, Koji Ishihara, Tomoaki Sugaya

{"title":"Saccharide Chemosensors Based on Boronic Acid-Appended Heavy-Metal Complexes","authors":"Yota Suzuki, Koji Ishihara, Tomoaki Sugaya","doi":"10.1002/anse.202500179","DOIUrl":"https://doi.org/10.1002/anse.202500179","url":null,"abstract":"Boronic acids (BAs) have long attracted attention as building blocks for designing simple chemosensors for saccharides. In the molecular design of BA-based chemosensors, the incorporation of a signaling unit to visualize the target is essential. Heavy-metal complexes are among the basic structures of the signaling units used to date. Owing to their excellent luminescence and electrochemical properties, numerous heavy-metal complex-based chemosensors have been reported over several decades. Nevertheless, studies on the development of saccharide chemosensors using BA-appended heavy-metal complexes are limited and have not advanced as rapidly as the development of conventional chemosensors using organic compounds as signaling units. This review mainly covers BA-appended heavy-metal complex-based saccharide chemosensors, reported from 1998 to 2025, with a particular focus on iridium, ruthenium, rhenium, platinum, osmium, and related systems. The designed chemosensors exhibit a variety of signals, mainly phosphorescence or related luminescence responses, while a smaller number of systems exploit electrochemical and electrochemiluminescent responses. These properties enable saccharide recognition through diverse signal transduction mechanisms, although selective recognition of specific saccharides, especially D-glucose, remains challenging in many cases. Some of these properties are difficult to achieve with conventional organic dyes but can be accessed in heavy-metal complex-based chemosensors through metal complexation and ligand design. This review also highlights the difficulties currently faced, compares the reported systems in terms of signal mode, selectivity, and sensing conditions, and ends with suggestions for future directions in this research area.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Resolved Upconversion Lifetime Sensing for Selective Blood L-Lactate Analysis During Postoperative Analgesia 时间分辨上转换寿命传感用于术后镇痛中选择性血l -乳酸分析

IF 3.3

Analysis & sensing Pub Date : 2026-08-15 DOI: 10.1002/anse.70104

Dongmei Hong, Tangyihua Li, Guanghui An, Enduo Feng

{"title":"Time-Resolved Upconversion Lifetime Sensing for Selective Blood L-Lactate Analysis During Postoperative Analgesia","authors":"Dongmei Hong, Tangyihua Li, Guanghui An, Enduo Feng","doi":"10.1002/anse.70104","DOIUrl":"https://doi.org/10.1002/anse.70104","url":null,"abstract":"Accurate and robust quantification of metabolic biomarkers in complex biological matrices is essential for understanding physiological responses during postoperative analgesia. Herein, we report a time-resolved upconversion luminescence lifetime sensing platform for selective detection of L-lactate in human blood. NaGdF4/Yb/Er@NaGdF4/Yb nanoparticle was integrated with L-lactate-specific aptamer to construct a lifetime responsive nanointerface for L-lactate quantification. Benefiting from the intrinsic stability of lifetime-based readouts, the proposed platform enabled reliable quantification independent of excitation fluctuations and probe concentration. The sensing system exhibited a linear detection range of 0–10 mM with a limit of detection of 0.39 mM, along with excellent selectivity against potential interferents and clear stereoselective discrimination between L- and D-lactate. Moreover, the clinical applicability was validated in blood samples from healthy volunteers, showing strong agreement with standard clinical assays (R2 = 0.969). Furthermore, dynamic monitoring of postoperative patients revealed that circulating L-lactate levels correlate with patient-controlled analgesia demand, enabling effective pain stratification with an AUC of 0.894, achieving a sensitivity of 93.75% and a specificity of 84.38% at an optimal cutoff of 3.39 mM. This work provided a robust analytical strategy for integrating metabolic sensing with clinically relevant physiological assessment, offering new opportunities for objective pain evaluation in perioperative medicine.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraclass Classification of Volatile Amines Using Impedance Spectroscopy Platform 用阻抗光谱平台对挥发性胺类内分类

IF 3.3

Analysis & sensing Pub Date : 2026-08-12 DOI: 10.1002/anse.70114

Palwinder Kaur, Amol P. Bhondekar, Sudeshna Bagchi

{"title":"Intraclass Classification of Volatile Amines Using Impedance Spectroscopy Platform","authors":"Palwinder Kaur, Amol P. Bhondekar, Sudeshna Bagchi","doi":"10.1002/anse.70114","DOIUrl":"https://doi.org/10.1002/anse.70114","url":null,"abstract":"Amines are ubiquitous, yet polymer-based DC resistive gas sensors often lack the selectivity required for intragroup discrimination. Moreover, concentration-dependent classification of intraclass amines using a single sensor platform has not been previously reported to the best of our knowledge. This work presents a machine-learning-enabled impedance spectroscopy approach that uses a tin oxide–polypyrrole composite sensor to form a virtual sensor array for intraclass amine classification. The sensor's impedance response to four representative amines, ammonia, dimethylamine, triethylamine, and trimethylamine, was investigated and classified over a wide frequency range (100 Hz to 8 MHz). The sensor exhibited frequency-dependent impedance behavior in response to different amines, enabling concentration-dependent classification using unique set of frequencies as features. PCA was employed to visualize 20 distinct classes of the four different amines at five concentrations each (4 × 5 matrix). A SVM classifier was trained and tested on the obtained dataset using a 60%:40% train–test split. The tested data were classified with a maximum accuracy of 93% across all 20 classes, followed by a wrapper-based feature selection approach to enhance model efficiency and reduce computational complexity. This work presents a powerful strategy for selectively classifying amines and highlights its real-time prediction ability.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148753518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal Stability of the Guinea Green B Solution With Substrate and Its Application for the Detection of Cholinesterase Inhibitors 底物几内亚绿B溶液的热稳定性及其在胆碱酯酶抑制剂检测中的应用

IF 3.3

Analysis & sensing Pub Date : 2026-08-11 DOI: 10.1002/anse.70108

Lukáš Matějovský, Vladimír Pitschmann

引用次数: 0

Direct Electrochemical Sensing of Water-Soluble Dyes in Hyperporous Carbon: Analyte Concentration by Micropore Absorption 高孔碳中水溶性染料的直接电化学传感：微孔吸收分析物浓度

IF 3.3

Analysis & sensing Pub Date : 2026-08-10 DOI: 10.1002/anse.70106

Youssef A. Darwish, Hend S. Magar, Rabeay Y. A. Hassan, Mohamed H. Alkordi, Saad Makhseed

{"title":"Direct Electrochemical Sensing of Water-Soluble Dyes in Hyperporous Carbon: Analyte Concentration by Micropore Absorption","authors":"Youssef A. Darwish, Hend S. Magar, Rabeay Y. A. Hassan, Mohamed H. Alkordi, Saad Makhseed","doi":"10.1002/anse.70106","DOIUrl":"https://doi.org/10.1002/anse.70106","url":null,"abstract":"Electrochemical sensing of water-soluble small organic molecules provides a facile method for monitoring water quality in different water streams. In this report, we demonstrate the crucial role played by micropores in a highly porous carbon electrode (surface area 2543 m2/g) in facilitating direct sensing of such water-soluble molecules. The micropores of the electronically conductive porous carbon facilitate adsorptive pre-concentration of the water-soluble molecules at the pores of the electrode, in effect enhancing the effective concentration at the electrode–electrolyte interface, thus enhancing the detection limit of such soluble molecules. Moreover, as the sensing mechanism relies on direct redox reactions of the target molecules over the carbon surface, selective sensing of such materials was readily observed, with an excellent level of detection reaching down to 25–65 ppb. This is in contrast with previous reports utilizing catalytic action of several nanomaterials, mostly metal oxides, for indirect sensing of water-soluble molecules. The versatility of this approach is outlined through electrochemical sensing of four anionic dyes, namely phenol red, eosin yellow, methyl orange, eriochrome black T, and two cationic dyes, methylene blue and malachite green.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring and Analysis of Human Biomechanical Signals Based on Flexible Wearable Sensors: Opportunities and Challenges 基于柔性可穿戴传感器的人体生物力学信号监测与分析：机遇与挑战

IF 3.3

Analysis & sensing Pub Date : 2026-08-10 DOI: 10.1002/anse.70105

Zihan Lin, Ziyuan Zhou, Zihan Wang, Zhenhua Song, Yiwen Liu, Xinyan Wang, Bo Fang, Chuanwen Li, Xicheng Huang, Haoyu Lan, Maogao Gong, Feifei Deng, Qi Hong, Yunong Zhao, Xiaohui Guo

{"title":"Monitoring and Analysis of Human Biomechanical Signals Based on Flexible Wearable Sensors: Opportunities and Challenges","authors":"Zihan Lin, Ziyuan Zhou, Zihan Wang, Zhenhua Song, Yiwen Liu, Xinyan Wang, Bo Fang, Chuanwen Li, Xicheng Huang, Haoyu Lan, Maogao Gong, Feifei Deng, Qi Hong, Yunong Zhao, Xiaohui Guo","doi":"10.1002/anse.70105","DOIUrl":"https://doi.org/10.1002/anse.70105","url":null,"abstract":"With the growing demand for precision medicine and health monitoring, flexible wearable tactile/pressure sensors have become a key technology for capturing human biomechanical and physiological signals. This paper aims to provide a systematic review of the latest research advances, application scenarios, and challenges. First, this paper describes mainstream sensing mechanisms such as piezoresistive, capacitive, triboelectric, and piezoelectric types and delves into the mechanisms by which nanocomposites—such as carbon-based conductive nanomaterials (carbon nanoparticles, carbon nanotubes, etc.) and two-dimensional conductive materials (MXene, graphene, etc.)—along with biomimetic microstructure designs, enhance sensor sensitivity, linearity, and detection range. Subsequently, the paper focuses on the application in capturing multiscale biomechanical signals from the human body, including weak physiological pulses (such as epidermal arterial pulses) and respiratory rates and large-scale gait phases and limb joint movements. For specific application scenarios, the paper also discusses encapsulation and implantation strategies for intraocular pressure and intracranial pressure monitoring. Finally, this paper identifies key scientific issues and challenges currently facing the field, such as motion artifacts, long-term biocompatibility stability, and multimodal data fusion, and outlines future development directions for intelligent, self-powered, and self-healing flexible sensor, aiming to provide theoretical support for the clinical translation of smart wearable devices.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterial-Based Electrochemical Sensors for Cell Analysis in Microphysiological Systems 微生理系统中用于细胞分析的纳米材料电化学传感器

IF 3.3

Analysis & sensing Pub Date : 2026-08-10 DOI: 10.1002/anse.70110

Shaimah Rinda Sari, Kaoru Hiramoto, Kosuke Ino

{"title":"Nanomaterial-Based Electrochemical Sensors for Cell Analysis in Microphysiological Systems","authors":"Shaimah Rinda Sari, Kaoru Hiramoto, Kosuke Ino","doi":"10.1002/anse.70110","DOIUrl":"https://doi.org/10.1002/anse.70110","url":null,"abstract":"Microphysiological systems (MPS) are advanced cell culture systems emerging as powerful tools for replicating human tissue-level function in vitro. These systems provide dynamic environments for studying cellular behavior, drug responses, and disease mechanisms that have high physiological relevance. To fully realize their potential, in situ real-time monitoring technologies are required, particularly for detecting cell-secreted analytes and metabolic changes. Electrochemical (bio)sensors, known for their sensitivity, miniaturizability, and compatibility with microfluidics, are well-suited for integration into MPS platforms, and nanomaterials have revolutionized electrochemical sensor design by enhancing electron transfer, surface reactivity, and biocompatibility. Examples of these nanomaterials include carbon-based nanostructures, metal nanoparticles, hybrid nanocomposites, and conducting polymers, which enable the precise detection of analytes, such as dopamine, nitric oxide, hydrogen peroxide, glucose, lactate, and cytokines within confined microenvironments. This review consolidates advances from 2018 to 2026 in nanomaterial-based electrochemical (bio)sensors tailored for MPS applications, focusing on material selection, sensor architecture, and analyte specificity. Key challenges, including biofouling, long-term stability, and multiplexing, are discussed, along with future directions encompassing standardization, AI-assisted signal interpretation, and adaptive biosensing platforms. By bridging nanotechnology and physiological modeling, these innovations advance the development of integrated, next-generation MPS platforms for drug screening, disease modeling, and precision diagnostics.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 5","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Economical Electrode Material Enabling Stable and Selective Nonenzymatic Urea Sensing 一种经济的电极材料，使稳定和选择性的非酶尿素传感

IF 3.3

Analysis & sensing Pub Date : 2026-07-27 DOI: 10.1002/anse.70107

Merin Pulikkottil, Muralidharan Malamal Neelanchery, Ansari Seema

{"title":"An Economical Electrode Material Enabling Stable and Selective Nonenzymatic Urea Sensing","authors":"Merin Pulikkottil, Muralidharan Malamal Neelanchery, Ansari Seema","doi":"10.1002/anse.70107","DOIUrl":"https://doi.org/10.1002/anse.70107","url":null,"abstract":"The detection of urea is a significant concern across various sectors, including medical, environmental, and agricultural fields. Here, we developed a highly efficient and cost-effective activated carbon (AC)-nickel oxide (NiO) composite electrode material for urea sensing applications through the coprecipitation method. The material characteristics of prepared composite materials were evaluated using physicochemical characterization techniques. The suitability of the AC-NiO composite for urea sensing was validated by performing cyclic voltammetry analysis at various scan rates for different concentrations of urea. The lowest limit of detection was found to be 1.69 μM, which is significant compared to previous studies. Furthermore, the system exhibited a high sensitivity of 1620 μA mM−1 cm−2, indicating accurate and reliable measurements. These remarkable values suggest the potential of the AC-NiO composite material for urea sensing applications. Furthermore, the common challenges faced by non-enzymatic electrochemical sensors, such as selectivity, repeatability, reproducibility, and their application in real-life samples, have also been investigated. The AC-NiO composite-based electrode demonstrates exceptional performance and can effectively address these challenges. This study suggests that the AC-NiO composite is a cost-effective and efficient sensing material, making it a promising candidate for future sensor technologies.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"6 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0