Analysis & sensing最新文献

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Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS-CoV-2 Variants 识别多种严重急性呼吸系统综合征冠状病毒2型变异株刺突蛋白的不同DNA适体的比较表征
Analysis & sensing Pub Date : 2023-02-01 DOI: 10.1002/anse.202300001
Dr. Zijie Zhang, Dr. Jiuxing Li, Ryan Amini, Alexandria Mansfield, Jimmy Gu, Jianrun Xia, Prof. John D. Brennan, Prof. Yingfu Li
{"title":"Comparative Characterization of Diverse DNA Aptamers for Recognition of Spike Proteins of Multiple SARS-CoV-2 Variants","authors":"Dr. Zijie Zhang,&nbsp;Dr. Jiuxing Li,&nbsp;Ryan Amini,&nbsp;Alexandria Mansfield,&nbsp;Jimmy Gu,&nbsp;Jianrun Xia,&nbsp;Prof. John D. Brennan,&nbsp;Prof. Yingfu Li","doi":"10.1002/anse.202300001","DOIUrl":"https://doi.org/10.1002/anse.202300001","url":null,"abstract":"<p>Many DNA aptamers have been reported to target the spike protein (S-protein) of SARS-CoV-2. These aptamers display different affinities or recognize different epitopes of the S-protein. We conducted a comparative study of 9 DNA aptamers for binding to several variants of the S-protein and pseudoviruses using the same testing methods, including dot-blot assays and enzyme-linked aptamer binding assays, to evaluate their affinity ranking and analytical utility. Moreover, the binding sites of these aptamers on the S-protein were examined using aptamer competition assays to understand the effect of S-protein mutations on aptamer affinity and the degree of overlapping of the binding sites by these aptamers.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202300001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50115993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cover Feature: Single-Atom Materials as Electrochemical Sensors: Sensitivity, Selectivity, and Stability (Anal. Sens. 3/2023) 封面特征:作为电化学传感器的单原子材料:灵敏度、选择性和稳定性(Anal.Sens.3/2023)
Analysis & sensing Pub Date : 2023-01-30 DOI: 10.1002/anse.202300007
Dr. Weiran Zheng
{"title":"Cover Feature: Single-Atom Materials as Electrochemical Sensors: Sensitivity, Selectivity, and Stability (Anal. Sens. 3/2023)","authors":"Dr. Weiran Zheng","doi":"10.1002/anse.202300007","DOIUrl":"https://doi.org/10.1002/anse.202300007","url":null,"abstract":"<p><b>The cover feature image shows</b> electrochemical sensing using single-atom materials (SAMs) featuring isolated metal sites embedded inside inorganic or organic supports. Thanks to the well-defined active sites, SAMs have demonstrated expectational performance. The current research progress of metal-inorganic/organic SAMs is discussed, providing an introductive outline of the rational sensor design toward higher sensitivity, selectivity, and stability. Cover design by Weiran Zheng. More information can be found in the Review by Weiran Zheng.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202300007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50147874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Feature: Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications? (Anal. Sens. 5/2023) 封面特征:磷脂酸在哺乳动物组织中普遍存在还是在质谱成像应用中被过度强调?(分析Sens.5/2023)
Analysis & sensing Pub Date : 2023-01-30 DOI: 10.1002/anse.202300009
Gregory W. Vandergrift, Jessica K. Lukowski, Michael J. Taylor, Kevin J. Zemaitis, Theodore Alexandrov, Josie G. Eder, Heather M. Olson, Jennifer E. Kyle, Christopher Anderton
{"title":"Cover Feature: Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications? (Anal. Sens. 5/2023)","authors":"Gregory W. Vandergrift,&nbsp;Jessica K. Lukowski,&nbsp;Michael J. Taylor,&nbsp;Kevin J. Zemaitis,&nbsp;Theodore Alexandrov,&nbsp;Josie G. Eder,&nbsp;Heather M. Olson,&nbsp;Jennifer E. Kyle,&nbsp;Christopher Anderton","doi":"10.1002/anse.202300009","DOIUrl":"https://doi.org/10.1002/anse.202300009","url":null,"abstract":"<p><b>The cover feature image shows</b> a cartoon representation of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), which can produce in-source fragmentation of lipids and cause artificial annotations from biological samples, particularly for phosphatidic acids. Whether these annotations are endogenous or artificial may be assessed by comparison with nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI-MSI). More information can be found in the Research Article by Christopher Anderton and co-workers.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202300009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50155764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: A Non-Destructive Electrical Assay of Stem Cell Differentiation Based on Semiconductor Biosensing (Anal. Sens. 2/2023) 封面:基于半导体生物传感的干细胞分化的无损电学测定(Anal.Sens.2/2023)
Analysis & sensing Pub Date : 2023-01-30 DOI: 10.1002/anse.202300003
Prof. Sho Hideshima, Dr. Hiroki Hayashi, Sayoko Saito, Prof. Hiroaki Tateno, Prof. Toshiyuki Momma, Prof. Tetsuya Osaka
{"title":"Front Cover: A Non-Destructive Electrical Assay of Stem Cell Differentiation Based on Semiconductor Biosensing (Anal. Sens. 2/2023)","authors":"Prof. Sho Hideshima,&nbsp;Dr. Hiroki Hayashi,&nbsp;Sayoko Saito,&nbsp;Prof. Hiroaki Tateno,&nbsp;Prof. Toshiyuki Momma,&nbsp;Prof. Tetsuya Osaka","doi":"10.1002/anse.202300003","DOIUrl":"https://doi.org/10.1002/anse.202300003","url":null,"abstract":"<p><b>The cover picture shows</b> a semiconductor-based biosensor with potential to detect the presence of a specific biomarker of human induced pluripotent stem cell (hiPSCs) in a culture medium. More information can be found in the Research Article by S. Hideshima, T. Osaka, and co-workers.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202300003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50155740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Primer on Luminescence Sensing 发光传感入门
Analysis & sensing Pub Date : 2023-01-30 DOI: 10.1002/anse.202200113
Prof. Hans H. Gorris, Prof. Zdeněk Farka, Prof. Niko Hildebrandt
{"title":"A Primer on Luminescence Sensing","authors":"Prof. Hans H. Gorris,&nbsp;Prof. Zdeněk Farka,&nbsp;Prof. Niko Hildebrandt","doi":"10.1002/anse.202200113","DOIUrl":"https://doi.org/10.1002/anse.202200113","url":null,"abstract":"<p>This Perspective provides a concise overview of the field of <i>Luminescence Sensing</i>, which enables highly sensitive, selective, and versatile measurements. The emergence of new luminescent nanomaterials and the prospective of deploying new luminescence-based detection schemes for solving real-world problems, e. g., in medical diagnosis, food safety, and environmental sciences, has led to a continuous growth of the field over recent years. The contributions to the Special Collection on <i>Luminescence Sensing</i> – with a focus on the versatility and advantages of lanthanide complexes for advanced biosensing – serve as an excellent foundation to highlight and discuss recent developments and challenges.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202200113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50155741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Identification of Proteins Using Supramolecular Gold Nanoparticle-Dye Sensor Arrays 利用超分子金纳米颗粒-染料传感器阵列鉴定蛋白质
Analysis & sensing Pub Date : 2023-01-20 DOI: 10.1002/anse.202200080
Mingdi Jiang, Aarohi Gupta, Xianzhi Zhang, Aritra Nath Chattopadhyay, Stefano Fedeli, Rui Huang, Junwhee Yang, Prof. Vincent M. Rotello
{"title":"Identification of Proteins Using Supramolecular Gold Nanoparticle-Dye Sensor Arrays","authors":"Mingdi Jiang,&nbsp;Aarohi Gupta,&nbsp;Xianzhi Zhang,&nbsp;Aritra Nath Chattopadhyay,&nbsp;Stefano Fedeli,&nbsp;Rui Huang,&nbsp;Junwhee Yang,&nbsp;Prof. Vincent M. Rotello","doi":"10.1002/anse.202200080","DOIUrl":"10.1002/anse.202200080","url":null,"abstract":"<p>The rapid detection of proteins is very important in the early diagnosis of diseases. Gold nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially. Cross-reactive sensor arrays have high sensitivity for sensing proteins using differential interactions between sensor elements and bioanalytes. A new sensor array was fabricated using surface-charged AuNPs with dyes supramolecularly encapsulated into the AuNP monolayer. The fluorescence of dyes is partially quenched by the AuNPs and can be restored or further quenched due to the differential interactions between AuNPs with proteins. This sensing system enables the discrimination of proteins in both buffer and human serum, providing a potential tool for real-world disease diagnostics.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202200080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9550934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable Electrodes for Lactate: Applications in Enzyme-Based Sensors and Energy Biodevices 乳酸可穿戴电极:在基于酶的传感器和能量生物设备中的应用
Analysis & sensing Pub Date : 2023-01-13 DOI: 10.1002/anse.202200066
Natcha Rasitanon, Dr. Sirawit Ittisoponpisan, Kanyawee Kaewpradub, Dr. Itthipon Jeerapan
{"title":"Wearable Electrodes for Lactate: Applications in Enzyme-Based Sensors and Energy Biodevices","authors":"Natcha Rasitanon,&nbsp;Dr. Sirawit Ittisoponpisan,&nbsp;Kanyawee Kaewpradub,&nbsp;Dr. Itthipon Jeerapan","doi":"10.1002/anse.202200066","DOIUrl":"https://doi.org/10.1002/anse.202200066","url":null,"abstract":"<p>Wearable bioelectronics is a promising next-generation technology for its versatility in personalized applications. Measuring lactate is one of the growing trends in wearable biosensing research. To achieve this goal, enzymes capable of catalyzing reactions involving lactate must be coupled with bioelectrode components, creating a variety of biodevices such as biosensors, biofuel cells, and other devices harvesting energy from wearers. This review provides a brief history of noninvasive and minimally invasive enzyme-based lactate biosensors and energy biodevices. We introduce key principles of lactate oxidase and lactate dehydrogenase, together with immobilization strategies for efficient electrical contacts between redox enzymes and electrode supports. Additionally, we discuss recent examples of advanced wearable enzymatic lactate sensors and elaborate on a collection of self-powered wearable energy biodevices (e. g., biofuel cells, triboelectric nanogenerators, and piezoelectric devices). Lastly, we finish this review with discussions on challenges in developing lactate bioelectronics and provide our outlook on the prospects and future directions of this compelling technology.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50140389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Pushing Differential Sensing Further: The Next Steps in Design and Analysis of Bio-Inspired Cross-Reactive Arrays 进一步推动差分传感:生物激励交叉反应阵列设计和分析的下一步
Analysis & sensing Pub Date : 2023-01-10 DOI: 10.1002/anse.202200095
Dr. Hazel A. Fargher, Dr. Simon d'Oelsnitz, Daniel J. Diaz, Prof. Eric V. Anslyn
{"title":"Pushing Differential Sensing Further: The Next Steps in Design and Analysis of Bio-Inspired Cross-Reactive Arrays","authors":"Dr. Hazel A. Fargher,&nbsp;Dr. Simon d'Oelsnitz,&nbsp;Daniel J. Diaz,&nbsp;Prof. Eric V. Anslyn","doi":"10.1002/anse.202200095","DOIUrl":"https://doi.org/10.1002/anse.202200095","url":null,"abstract":"<p>Differential sensing is a technique that uses an array of cross-reactive receptors to create a unique fingerprint to detect analytes. Over the past two decades significant progress in the field has highlighted the power of this approach, enabling detection with commercially available or synthetically simple sensors, discrimination of structurally similar and challenging analytes, and low concentration detection. In this Concept paper, we briefly review developments in the field and highlight areas for future exploration. We believe there is still much room to grow, particularly in designing biosensor arrays, achieving simultaneous quantification of multiple analytes (i. e., multiplexing), and implementation of more advanced machine learning algorithms in array response analysis.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50127316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitive Detection of p-Chlorobenzaldehyde in Environmental Water Based on Au@Ag-MOFs Nanoparticle by Surface-Enhanced Raman Scattering 基于Au@Ag-MOFs纳米粒子表面增强拉曼散射的环境水中对氯苯甲醛的灵敏检测
Analysis & sensing Pub Date : 2023-01-10 DOI: 10.1002/anse.202200108
Dr. Yuanting Li, Mengmeng Zhang, Zhouya Wu, Dr. Xiaoli Bao
{"title":"Sensitive Detection of p-Chlorobenzaldehyde in Environmental Water Based on Au@Ag-MOFs Nanoparticle by Surface-Enhanced Raman Scattering","authors":"Dr. Yuanting Li,&nbsp;Mengmeng Zhang,&nbsp;Zhouya Wu,&nbsp;Dr. Xiaoli Bao","doi":"10.1002/anse.202200108","DOIUrl":"https://doi.org/10.1002/anse.202200108","url":null,"abstract":"<p>Surface enhanced Raman scattering (SERS) is difficult to detect molecules with weak adsorption, like aldehydes. Herein, we fabricated core-shell Au@Ag-MOFs nanoparticles as SERS substrate. The shell can be controllably synthesized, with the thickness about 3 nm. After the morphology and SERS activity characterization, Au@Ag-MOFs were employed to sensitive and label-free detect <i>p</i>-chlorobenzaldehyde (PCB) in water samples. The pore structure and large surface area of Ag-MOFs shell results more adsorption of PCB, dragging more molecules to “hot spots” area. The abundant amino group in Ag-MOFs allows the occurrence of Schiff base reaction with aldehyde group in PCB. Taking the synergistic effect of both physical and chemical enhancement, SERS signals of PCB were greatly boosted. The method showed good linearity between 5.0×10<sup>−12</sup> M to 1.0×10<sup>−8</sup> M for PCB with the limit of detection (LOD) down to 3.3×10<sup>−12</sup> M. The proposed method has great potential to be a reliable analytical strategy for aldehydes in real samples.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"109166978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications? 磷脂酸在哺乳动物组织中普遍存在还是在质谱成像应用中被过度强调?
Analysis & sensing Pub Date : 2023-01-09 DOI: 10.1002/anse.202200112
Gregory W. Vandergrift, Jessica K. Lukowski, Michael J. Taylor, Kevin J. Zemaitis, Theodore Alexandrov, Josie G. Eder, Heather M. Olson, Jennifer E. Kyle, Christopher Anderton
{"title":"Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications?","authors":"Gregory W. Vandergrift,&nbsp;Jessica K. Lukowski,&nbsp;Michael J. Taylor,&nbsp;Kevin J. Zemaitis,&nbsp;Theodore Alexandrov,&nbsp;Josie G. Eder,&nbsp;Heather M. Olson,&nbsp;Jennifer E. Kyle,&nbsp;Christopher Anderton","doi":"10.1002/anse.202200112","DOIUrl":"https://doi.org/10.1002/anse.202200112","url":null,"abstract":"<p>Mass spectrometry imaging (MSI) is an invaluable tool for the spatial visualization of molecules in vivo. However, the question of whether observed annotations are endogenous or artificial (i. e., from in-source fragmentation) is critical and has been largely unexplored in multimodal MSI. In matrix-assisted laser desorption/ionization (MALDI)-MSI datasets from researchers worldwide, PAs were found to represent up to 18 % of annotations in rat brain. Rat brain was additionally imaged here using nanospray desorption electrospray ionization (nano-DESI), a softer ionization strategy. No PAs observed with MALDI were present in the nano-DESI dataset. Further investigation strongly indicated lipid fragmentation to PAs for MALDI-MSI, but not with nano-DESI-MSI. We finally extend this observation to the MALDI-MSI analyses of human tissues, showing that PA annotations comprised up to 16 % of annotations. Therefore, this study shows that MSI annotations should be carefully interrogated, as in-source fragmentation or modification of lipids may contribute substantially to false annotations and incorrect biological interpretations.</p>","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202200112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50136194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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