Analysis & sensing最新文献

Front Cover: (Anal. Sens. 3/2025) 封面：（肛门）参议员3/2025)

IF 3.4

Analysis & sensing Pub Date : 2025-05-12 DOI: 10.1002/anse.202580301

引用次数: 0

Front Cover: Titanium Mxene: A Promising Material for Next-Generation Optical Biosensors and Machine Learning Integration (Anal. Sens. 2/2025) 封面二茂钛：下一代光学生物传感器和机器学习集成的前景看好的材料（Anal. Sens.）

IF 3.4

Analysis & sensing Pub Date : 2025-03-10 DOI: 10.1002/anse.202580201

Athulya Aravind, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran

引用次数: 0

Front Cover: Metal-Organic Frameworks (MOFs) for Glucose Sensing: Advancing Non-Invasive Detection Strategies in Diabetes Management (Anal. Sens. 1/2025) 封面：用于葡萄糖传感的金属有机框架（MOFs）：推进糖尿病管理中的非侵入性检测策略。参议员1/2025)

IF 3.4

Analysis & sensing Pub Date : 2025-01-13 DOI: 10.1002/anse.202580101

P. N. Blessy Rebecca, D. Durgalakshmi, R. Ajay Rakkesh

引用次数: 0

Flavonoid-Derived Probes for the Detection of Islet Amyloid Polypeptide Aggregates 类黄酮衍生探针检测胰岛淀粉样多肽聚集体

IF 3.4

Analysis & sensing Pub Date : 2024-12-23 DOI: 10.1002/anse.202400104

Zijie Luo, Yijia Xu, Jiayi Fan, Isabel E. Lean, Thomas P. Davis, Ibrahim Javed, Amandeep Kaur

{"title":"Flavonoid-Derived Probes for the Detection of Islet Amyloid Polypeptide Aggregates","authors":"Zijie Luo, Yijia Xu, Jiayi Fan, Isabel E. Lean, Thomas P. Davis, Ibrahim Javed, Amandeep Kaur","doi":"10.1002/anse.202400104","DOIUrl":"https://doi.org/10.1002/anse.202400104","url":null,"abstract":"Type-2 diabetes (T2D) is a growing global health crisis, with over 90% of diabetes cases attributed to this condition. Misfolding and aggregation of islet amyloid polypeptide (IAPP) is a hallmark of early T2D, contributing to pancreatic β-cell dysfunction. While significant progress has been made in developing sensors for amyloids implicated in neurodegeneration, fluorescent probes for detecting IAPP aggregates remain limited. We report a series of flavonoid derivatives designed for enhanced IAPP fibril detection. The probes feature modifications, including methoxy substitution at C7 and varying amines at C4, which enhance their binding affinity for IAPP fibrils compared to the widely used Thioflavin T (ThT). The leading probes, F4 and MF1, exhibited over 10-fold increased binding affinity compared to ThT, alongside ratiometric fluorescence due to excited-state intramolecular proton transfer. F4 and MF1 were applied to image IAPP aggregates in pancreatic β-cells and zebrafish tissue sections, where both probes demonstrated specific imaging of IAPP fibrils. These probes also demonstrated reduced fluorescence when IAPP monomers were incubated with inhibitors, indicating fibril disassembly. Our results position F4 and MF1 as promising tools for exploring the pathological role of IAPP aggregation in diabetes and for high-throughput screening of IAPP aggregation inhibitors.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Screening of Secondary Plant Metabolites using Two-Dimensional Tandem Mass Spectrometry 利用二维串联质谱快速筛选植物次生代谢物

IF 3.4

Analysis & sensing Pub Date : 2024-12-11 DOI: 10.1002/anse.202400103

Thomas C. Sams, Sam E. Ying, Myles Q. Edwards, Eric T. Dziekonski, R. Graham Cooks

{"title":"Rapid Screening of Secondary Plant Metabolites using Two-Dimensional Tandem Mass Spectrometry","authors":"Thomas C. Sams, Sam E. Ying, Myles Q. Edwards, Eric T. Dziekonski, R. Graham Cooks","doi":"10.1002/anse.202400103","DOIUrl":"https://doi.org/10.1002/anse.202400103","url":null,"abstract":"The full 2D tandem mass spectrometry (MS/MS) data domain provides a rapid survey of the chemical components of complex plant extracts without subjecting them to prior chromatographic separation. Nano electrospray ionization (nESI), desorption electrospray ionization (DESI) and paper spray ionization are used to create an ion mixture representative of the chemical constituents of a plant extract, then mass-selective collision-induced dissociation (CID) is used to automatically record fragments from each precursor ion in the mixture. Signal extraction from the 2D data domain yields matching spectra to conventional product and precursor ion scans and displays distributions of compounds bearing a chosen functionality. These features and other manipulations of the 2D MS/MS data are demonstrated using crude extracts of Artemisia annua (Sweet wormwood). Similarities and differences in the secondary metabolites of plant species are established rapidly by inspection of the 2D MS/MS plots. The methodology is characterized by the high speed of data acquisition while the limited mass resolution still allows high speed snapshots of chemistry.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Interference-Free Acridine-Calix[4]Arene-Based Fluorescence paper and Electrochemical Sensor for Cyanazine from Agricultural Produces 研制无干扰吖啶杯芳烃基荧光纸及农产品中氰胺的电化学传感器

IF 3.4

Analysis & sensing Pub Date : 2024-12-06 DOI: 10.1002/anse.202400088

Heni Soni, Malvika Shukla, Divyesh Chaudhari, Sahaj Gandhi, Alok Pandya, Pinkesh G. Sutariya

{"title":"Unveiling Interference-Free Acridine-Calix[4]Arene-Based Fluorescence paper and Electrochemical Sensor for Cyanazine from Agricultural Produces","authors":"Heni Soni, Malvika Shukla, Divyesh Chaudhari, Sahaj Gandhi, Alok Pandya, Pinkesh G. Sutariya","doi":"10.1002/anse.202400088","DOIUrl":"https://doi.org/10.1002/anse.202400088","url":null,"abstract":"The construction of fluorescence sensor L1 for cyanazine (CNZ) by using calix[4]arene scaffold allied with 9-Aminoacridine moiety has been reported. The recognized triazine herbicide CNZ decreased the fluorescence intensity of L1 by exhibiting “turn-off” phenomenon having detection limit to be 7.79 μM obtained from emission study. The quenching response of L1: CNZ was observed between the range of 5–105 μM possessing binding constant calculated to be 9.201×106 M−1. The spiking experiment of CNZ into L1 has also been performed to evaluate potency of L1 using vegetables and cereals. Also, a paper-based device has been prepared in order to implement this strategy for on-spot monitoring of CNZ. The L1:CNZ binding has been confirmed by conducting electrochemical studies like cyclic voltammetry, differential pulse voltammetry, 1H NMR, FT-IR, MALDI-TOF, 1H NMR titration, PXRD investigation and computational analysis.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-Directed Capture-SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection pH-Directed Capture-SELEX用于卡那霉素检测的纳摩尔亲和力适配体

IF 3.4

Analysis & sensing Pub Date : 2024-12-03 DOI: 10.1002/anse.202400099

Yichen Zhao, Juewen Liu

{"title":"pH-Directed Capture-SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection","authors":"Yichen Zhao, Juewen Liu","doi":"10.1002/anse.202400099","DOIUrl":"https://doi.org/10.1002/anse.202400099","url":null,"abstract":"Kanamycin A is a widely used antibiotic, although it has a narrow therapeutic window demanding highly accurate monitoring. The sensing of kanamycin A using aptamers is of great interest since aptamers can be used for continuous monitoring with a rapid response. While kanamycin has been the target for at least four previous aptamer selections, the binding affinities of the reported DNA aptamers are still sub-optimal. All the previous aptamer selections were performed at pH 7.5 or higher. Given that kanamycin A has four amino groups with pKa values close to 7, we herein selected DNA aptamers for kanamycin A at both pH 6 and pH 8. The selection at pH 6 enriched aptamers although the pH 8 selection library remained highly diverse in the end. The best aptamer named KAN6-1 showed a dissociation constant of around 320 nM measured using isothermal titration calorimetry in the selection buffer. In buffers without salt, binding can happen from pH 6 to 8. Specific binding was confirmed using mutation studies. A strand displacement assay was developed with a limit of detection (LOD) of 100 nM in buffer. Similar LOD values were also obtained in lake water and in 10 % human serum. Comparisons were also made with some previously reported DNA aptamers. This study shows the importance of pH value on the selection of aptamers and provides a new aptamer for kanamycin A detection.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anse.202400099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titanium Mxene: A Promising Material for Next-Generation Optical Biosensors and Machine Learning Integration 二茂钛：下一代光学生物传感器和机器学习集成的理想材料

IF 3.4

Analysis & sensing Pub Date : 2024-11-28 DOI: 10.1002/anse.202400095

Athulya Aravind, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran

{"title":"Titanium Mxene: A Promising Material for Next-Generation Optical Biosensors and Machine Learning Integration","authors":"Athulya Aravind, Durgalakshmi Dhinasekaran, Ajay Rakkesh Rajendran","doi":"10.1002/anse.202400095","DOIUrl":"https://doi.org/10.1002/anse.202400095","url":null,"abstract":"Nano biosensors based on MXenes have been emerging as a promising tool in the detection of biomarkers, for the discrimination of diseases and in the detection of environmental pollutants. Their potential in sensing applications has also drawn a lot of attention to their unique qualities such as their high conductivity, huge surface area, outstanding hydrophilicity, biocompatibility, and simplicity of surface functionalization. The development of scalable synthesis techniques is essential to the large-scale manufacturing and broad application of MXene-based sensors. Furthermore, the stability of the MXene layers in diverse environmental circumstances continues to be a difficulty for their practical application. To increase the dependability and precision of MXene-based sensors, their selectivity must be increased through functionalization and tuning. With innovative technologies like machine learning, MXene biosensor is now taken advantage of new opportunities. Personalized healthcare solutions, remote data analysis, and real-time monitoring are all possible when MXene sensors and AI algorithms work together. Herein, the optical properties, synthesis approaches, role of MXene biosensors in machine learning, its significant challenges and future prospects of MXene-based nano(bio)sensors are deliberated.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen Gas Sensing Performance of Iron Oxide-Decorated Carbon Nanotubes: The Influence of Iron Oxide Species and Concentration 氧化铁修饰碳纳米管的氢气传感性能：氧化铁种类和浓度的影响

IF 3.4

Analysis & sensing Pub Date : 2024-11-21 DOI: 10.1002/anse.202400092

Eliton Ricardo Cardoso, Nina Tverdokhleb, Marcelo Eising, Ederson Esteves da Silva, Sergio Humberto Domingues, Alessandro Francisco Martins, Matt J. Kipper, Lucimara Stolz Roman, Shirong Huang, Gianaurelio Cuniberti, Felipe de Almeida La Porta, Carlos Eduardo Cava

{"title":"Hydrogen Gas Sensing Performance of Iron Oxide-Decorated Carbon Nanotubes: The Influence of Iron Oxide Species and Concentration","authors":"Eliton Ricardo Cardoso, Nina Tverdokhleb, Marcelo Eising, Ederson Esteves da Silva, Sergio Humberto Domingues, Alessandro Francisco Martins, Matt J. Kipper, Lucimara Stolz Roman, Shirong Huang, Gianaurelio Cuniberti, Felipe de Almeida La Porta, Carlos Eduardo Cava","doi":"10.1002/anse.202400092","DOIUrl":"https://doi.org/10.1002/anse.202400092","url":null,"abstract":"In this study, a solvothermal method was used to synthesize a composite of iron oxide nanostructures on carbon nanotubes (CNTs), which was applied as a resistive sensor for hydrogen gas (H2) detection. The nanocomposite was produced with three different iron oxide concentrations (Fe1@CNT, Fe2@CNT, and Fe3@CNT) to investigate the effect of iron species on CNTs and their interaction with hydrogen. Electron microscopy revealed that increasing iron oxide content led to the deterioration of the CNT walls. Raman and FTIR spectra confirmed the predominant presence of α-Fe2O3 (hematite) on the CNTs, while XPS analysis verified the presence of multiple iron oxides species. High-resolution XPS of the Fe 2p region indicated the existence of Fe3O4 (magnetite), Fe2O3 (hematite), and FeO (iron(II) oxide) associated with the CNTs. The sample with the lowest iron oxide concentration (Fe1@CNT) showed a 45 % sensor response to hydrogen in a dry air atmosphere and the longest recovery time, suggesting a stronger interaction between hydrogen and the nanocomposite. Density functional theory calculations further revealed that the presence of iron oxide on the CNT surface significantly altered its electronic properties, particularly by introducing more electronic states near the Fermi level, which enhanced electronic exchange between H2 and the carbon nanotube containing iron oxide.","PeriodicalId":72192,"journal":{"name":"Analysis & sensing","volume":"5 3","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Microfluidic-Assisted Strategies for Synthesis and Applications of Molecularly Imprinted Polymers 分子印迹聚合物的微流体辅助合成及应用综述

IF 3.4

Analysis & sensing Pub Date : 2024-11-15 DOI: 10.1002/anse.202400029

Ramya Karunakaran, Chiara Luna Onorati, Khairunnisa Amreen, Sanket Goel, Peter A. Lieberzeit

引用次数: 0