Aging and health research最新文献_第5页

Corrigendum to “Social-behavioral interventions for Asian and Hispanic American dementia caregivers: An integrative review” [Aging and Health Research Vol 1 Issue 3 (September 2021) 100027] “亚洲和西班牙裔美国人痴呆症护理人员的社会行为干预：综合回顾”的勘误表[老龄化与健康研究Vol 1 Issue 3（2021年9月）100027]

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-08-11 DOI: 10.1016/j.ahr.2025.100246

Hu Mengyao, Ma Chenjuan, Tina Sadarangani, Wu Bei

引用次数: 0

Corrigendum to “Sensory impairments and cognitive decline in older adults: A review from a population-based perspective” [Aging and Health Research Vol 1 Issue 1 (March 2021) 100002] “老年人的感觉障碍和认知能力下降：从人口为基础的角度回顾”的勘误表[老龄化与健康研究第1卷第1期（2021年3月）100002]

IF 2

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-07-21 DOI: 10.1016/j.ahr.2025.100251

Zhenxu Xiao , Wanqing Wu , Qianhua Zhao , Jiayi Zhang , Zhen Hong , Ding Ding

引用次数: 0

Polypharmacy and deprescribing among geriatric patients 老年患者的综合用药和处方化

Aging and health research Pub Date : 2025-09-01 Epub Date: 2025-07-17 DOI: 10.1016/j.ahr.2025.100256

Nokwanda Nhlanzeko Ngcobo

{"title":"Polypharmacy and deprescribing among geriatric patients","authors":"Nokwanda Nhlanzeko Ngcobo","doi":"10.1016/j.ahr.2025.100256","DOIUrl":"10.1016/j.ahr.2025.100256","url":null,"abstract":"<div><h3>Background</h3><div>Polypharmacy is increasingly common among middle-aged and geriatric patients, raising concerns about overprescribing, adverse outcomes, and healthcare costs. While appropriate polypharmacy can improve clinical outcomes when tailored to individual needs, inappropriate use heightens risks such as adverse drug reactions, falls, frailty, non-adherence, and increased mortality.</div></div><div><h3>Methods</h3><div>This review synthesises current literature examining the impact of polypharmacy in older adults. It highlights evidence-based strategies aimed at promoting appropriate prescribing practices and mitigating the risks associated with multiple medication use.</div></div><div><h3>Results</h3><div>Evidence indicates that polypharmacy in the aging population contributes to treatment non-adherence, higher incidence of adverse events, and increased healthcare expenditures. The risk of harm escalates with the number of prescribed medications and underlying comorbidities. Interventions such as medication reviews, clinician education, patient counselling, deprescribing protocols, and adherence support have shown promise in reducing medication-related harm.</div></div><div><h3>Conclusion</h3><div>Addressing polypharmacy requires a multifaceted approach, including raising clinician awareness, promoting rational prescribing, and implementing patient-centred interventions. Emphasising appropriate polypharmacy and deprescribing can significantly reduce adverse outcomes and improve overall quality of care in geriatric populations.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 3","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validity and reliability of the Persian version of Alzheimer's disease-related quality of life (P-ADRQL) questionnaire among older Iranian adults 波斯语版阿尔茨海默病相关生活质量（P-ADRQL）问卷在伊朗老年人中的效度和可靠性

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1016/j.ahr.2025.100229

Masoud Gharib , Jafar Hajghani , Hamed Cheraghmakani , Vahid Rashedi

{"title":"Validity and reliability of the Persian version of Alzheimer's disease-related quality of life (P-ADRQL) questionnaire among older Iranian adults","authors":"Masoud Gharib , Jafar Hajghani , Hamed Cheraghmakani , Vahid Rashedi","doi":"10.1016/j.ahr.2025.100229","DOIUrl":"10.1016/j.ahr.2025.100229","url":null,"abstract":"<div><h3>Background</h3><div>Assessing quality of life (QOL) in individuals with Alzheimer's disease (AD) is particularly challenging due to the subjective nature of the concept and the cognitive deficits associated with the condition. This study aimed to translate the AD-Related QOL (ADRQL) questionnaire into Persian and rigorously evaluate its reliability and validity in this population.</div></div><div><h3>Methods</h3><div>This cross-sectional methodological study was conducted between March 2021 and August 2022, involving 220 patients diagnosed with AD according to DSM-IV criteria, along with their primary caregivers. The Persian version of the ADRQL (P-ADRQL) and the QOL in Late-Stage Dementia (QUALID) scales were used to collect data, allowing for a thorough assessment of QOL across multiple domains.</div></div><div><h3>Results</h3><div>The P-ADRQL demonstrated excellent psychometric properties, with an overall Cronbach's alpha of 0.92, indicating strong internal consistency. This suggests that the items reliably measure the construct of QOL in patients with AD. Additionally, test-retest analysis revealed consistent scores across all subscales, confirming the stability of caregiver assessments over time. Significant correlations between P-ADRQL and QUALID further supported the convergent validity of the instrument, affirming its ability to measure QOL in alignment with established dementia assessment tools.</div></div><div><h3>Conclusion</h3><div>The P-ADRQL is a robust and reliable instrument for evaluating QOL in older Iranian adults with AD. Its strong psychometric properties ensure accurate and consistent assessments, addressing a critical need within Iran's healthcare system.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Your soul will rest in the fresh air” health-influencing factors among older adult Russian and Spanish-speaking (im)migrants in Southeastern, Wisconsin, United States “你的灵魂将安息在新鲜空气中”——美国威斯康星州东南部俄语和西班牙语（非）成年移民的健康影响因素

Aging and health research Pub Date : 2025-06-01 Epub Date: 2024-12-15 DOI: 10.1016/j.ahr.2024.100214

Maren M. Hawkins , Noelani M. Winters , Khadejah Bloomfield , Nina Familiant , Esmeralda Santacruz Salas , Lucy Mkandawire-Valhmu , Peninnah Kako , Young Cho , Paul Florsheim , Derek Johnson , Lance Weinhardt

{"title":"“Your soul will rest in the fresh air” health-influencing factors among older adult Russian and Spanish-speaking (im)migrants in Southeastern, Wisconsin, United States","authors":"Maren M. Hawkins , Noelani M. Winters , Khadejah Bloomfield , Nina Familiant , Esmeralda Santacruz Salas , Lucy Mkandawire-Valhmu , Peninnah Kako , Young Cho , Paul Florsheim , Derek Johnson , Lance Weinhardt","doi":"10.1016/j.ahr.2024.100214","DOIUrl":"10.1016/j.ahr.2024.100214","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adult immigrants experience unique factors that influence their health within the context of the place.</div></div><div><h3>Methods</h3><div>In this Community-Engaged Participatory Narrative Inquiry Photovoice project, we examined factors impacting the health and wellbeing of older adult Russian and Spanish-speaking immigrants in Wisconsin.</div></div><div><h3>Results</h3><div>(1) <em>The Environment</em> - <em>Your soul will rest in the fresh air</em>, and (2) <em>Social Support - You think you are by yourself but you're not alon</em>e, and (3) <em>Outsiderness – We're human.</em></div></div><div><h3>Discussion</h3><div>The built environment in which this study took place positively impacted participants self of well-being, while feelings of otherness contributed to perceptions of being permanent outsiders.</div></div><div><h3>Conclusion</h3><div>Place-specific factors affected the health of older adult immigrants in this study.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology 揭示阿尔茨海默病病理生理中维生素缺乏的分子机制

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-03-23 DOI: 10.1016/j.ahr.2025.100226

Vipul Sharma, Khadga Raj Aran

{"title":"Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology","authors":"Vipul Sharma, Khadga Raj Aran","doi":"10.1016/j.ahr.2025.100226","DOIUrl":"10.1016/j.ahr.2025.100226","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is the most prevalent progressive neurodegenerative disease often characterized by memory loss, cognitive decline, and behavioral changes. The actual pathophysiology of AD remains unclear, but several factors including genetic, environmental, and lifestyle contribute significantly to the pathogenesis of AD. Even after over two decades of combined efforts to create novel interventions that can retard the progress of the disease, researchers still only have a small number of alternate medicines with poor efficacy. There is a recent growth of interest in the role of nutrients in brain health as we learn more about what nutrients are and how they impact hormonal and neurological processes that can result in a variety of neurological and psychiatric conditions. Additionally, deficiency of vitamins also gained attention for their pivotal roles in cognitive health. Vitamins, a crucial dietary supplement, regulate various physiological functions and maintain neuronal health, energy metabolism, and antioxidant defence. Vitamin B, such as B1, B6, and B12, are chief constituents for the metabolism of homocysteine and the release of neurotransmitters, a decrease in vitamin E and D may result in increased oxidative damage, which further contributes to neuronal loss. Vitamin deficiencies may make AD degenerative processes more severe as increased amyloid-beta (Aβ) plaque development and tau protein phosphorylation, are two characteristics of AD. This review explores a comprehensive summary of the most widely used vitamins and discusses the findings of recent research on the relationship between these vital micronutrients and AD.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential associations of the stages of pressure and stasis ulcers and social engagement among nursing home residents 不同阶段的压力和瘀疮与社会参与养老院的居民

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1016/j.ahr.2025.100230

Anyah Prasad , Anthony P. Nunes , Bill M. Jesdale , Natalia N. Nielsen , Catherine E. Dubé , Deborah S. Mack , Kate L. Lapane

{"title":"Differential associations of the stages of pressure and stasis ulcers and social engagement among nursing home residents","authors":"Anyah Prasad , Anthony P. Nunes , Bill M. Jesdale , Natalia N. Nielsen , Catherine E. Dubé , Deborah S. Mack , Kate L. Lapane","doi":"10.1016/j.ahr.2025.100230","DOIUrl":"10.1016/j.ahr.2025.100230","url":null,"abstract":"<div><h3>Background</h3><div>Social engagement is an important determinant of health in older adults. Skin ulcers may adversely impact social engagement among nursing home residents. This study sought to quantify the differential associations between pressure and stasis ulcers and social engagement among long-stay US nursing home residents.</div></div><div><h3>Methods</h3><div>Cross-sectional, nationally representative data was obtained from the Minimum Data Set 2.0 on US nursing home residents aged ≥ 50 years with an annual assessment between Oct 1, 2009 and Sept 30, 2010. Adjusted prevalence ratios (aPR) of low social engagement among residents with the four stages of pressure and stasis ulcers and 95 % confidence intervals (CI) were estimated from multivariable Poisson models using a generalized estimating equation approach to account for residents nested within nursing homes.</div></div><div><h3>Results</h3><div>Among the 771,634 residents, 4.5 % had pressure ulcers, and 1.1 % had stasis ulcers. The presence of pressure ulcers, regardless of the stage, was associated with an increased risk of low social engagement (stage 1 aPR: 1.05 (95 % CI: 1.03–1.07); stage 4 aPR: 1.07 (95 % CI: 1.05–1.08)). Residents with stage 1 to 3 stasis ulcers were less likely than those without any skin ulcers to have low social engagement. In contrast, those with stage 4 stasis ulcers had an increased prevalence of low social engagement (aPR: 1.10 (95 % CI: 1.06–1.14)).</div></div><div><h3>Conclusion</h3><div>Social engagement should be monitored and addressed in residents with skin ulcers. Since pressure and stasis ulcers have different etiologies and treatment modalities, they should be considered separately in the empirical work on their association with social engagement.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contribution of chronic conditions to mortality: Differences by race and ethnicity 慢性病对死亡率的贡献：种族和民族的差异

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-04-23 DOI: 10.1016/j.ahr.2025.100231

Miriam R. Elman , Ana R. Quiñones , Gail J. McAvay , Brent Vander Wyk , Corey L. Nagel , Heather G. Allore

{"title":"Contribution of chronic conditions to mortality: Differences by race and ethnicity","authors":"Miriam R. Elman , Ana R. Quiñones , Gail J. McAvay , Brent Vander Wyk , Corey L. Nagel , Heather G. Allore","doi":"10.1016/j.ahr.2025.100231","DOIUrl":"10.1016/j.ahr.2025.100231","url":null,"abstract":"<div><h3>Background</h3><div>Racial and ethnic health disparities are persistent in the United States. The accumulation of chronic conditions and mortality are important contributors to these observed inequities.</div></div><div><h3>Methods</h3><div>We assessed the contribution of coexisting conditions to mortality among Hispanic, non-Hispanic White, and non-Hispanic Black older adults born in the United States. We used nationally-representative data from the Health and Retirement Study (HRS) from 1998–2020 (<em>n</em> = 10,430). Estimates for the absolute additive contributions of nine chronic conditions using a longitudinal extension of the average attributable fraction (LE-AAF) were derived from survey-weighted multivariable discrete survival models adjusted for sociodemographic and health characteristics.</div></div><div><h3>Results</h3><div>Death occurred in 42.2 % (95 % confidence interval [CI]=37.4, 47.0) of Hispanic, 42.7 % (95 % CI=41.7, 44.2) of White, and 46.4 % (95 % CI=42.7, 50.1) of Black respondents. The eight conditions increasing the risk of death contributed 73.9 % (95 % CI=50.7, 100.0) of mortality events among Hispanic respondents, 66.2 % (95 % CI=48.9, 81.5) among Black respondents, and 57.7 % (95 % CI=52.1, 62.5) among White respondents. Dementia had the strongest association with mortality with an adjusted odds ratio of 3.23 for Hispanic (95 % CI=1.90, 5.49), 3.14 for White (95 % CI=2.61, 3.78), and 2.11 for Black (95 % CI=1.63, 2.73) respondents. The development and progression of cancer malignancies contributed most to mortality for White adults. In contrast, hypertension, contributed most to mortality for Hispanic and Black adults.</div></div><div><h3>Conclusions</h3><div>Hispanic, Black, and White Americans differed in the prevalence and incidence of chronic conditions, as well as their association with mortality. Together, these conditions resulted in contributions to mortality that varied substantially.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent validity of quantitative upper extremity function tests in Parkinson's disease: 9HPT, MDS-UPDRS, and MAM-36 定量上肢功能测试在帕金森病中的并发效度：9HPT、MDS-UPDRS和MAM-36

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-03-24 DOI: 10.1016/j.ahr.2025.100225

Narges Azari Jafari, Reza Daneshvar Kakhki, Mohammad Shahab Shafaei

引用次数: 0

Virtual reality-based robotic training for lower limb rehabilitation in stroke patients with Hemiplegia: A pilot study 基于虚拟现实的机器人训练用于脑卒中偏瘫患者下肢康复：一项试点研究

Aging and health research Pub Date : 2025-06-01 Epub Date: 2025-05-11 DOI: 10.1016/j.ahr.2025.100233

Lijing Chen , Huanzhi Zhu , Jing Wang , Rongrong Lu , Jing Tian , Bei Wu , Jing Chu , Juan Li

{"title":"Virtual reality-based robotic training for lower limb rehabilitation in stroke patients with Hemiplegia: A pilot study","authors":"Lijing Chen , Huanzhi Zhu , Jing Wang , Rongrong Lu , Jing Tian , Bei Wu , Jing Chu , Juan Li","doi":"10.1016/j.ahr.2025.100233","DOIUrl":"10.1016/j.ahr.2025.100233","url":null,"abstract":"<div><h3>Background</h3><div>More than half of stroke survivors suffer from movement disorders after receiving routine rehabilitation treatment. Evidence suggests that virtual reality (VR)-based robotic training for lower limb rehabilitation is a promising approach for improving motor function recovery.</div></div><div><h3>Methods</h3><div>A pilot open-label randomized controlled trial was conducted to explore the feasibility and preliminary effects of VR-based robotic training for lower limb rehabilitation in stroke patients with hemiplegia. We enrolled 42 stroke patients with hemiplegia, 21 received VR-based robotic training for lower limb rehabilitation and conventional rehabilitation treatment as the intervention, and 21 only received conventional rehabilitation treatment as the control.</div></div><div><h3>Results</h3><div>Forty participants completed the trial. We found a statistically significant difference in lower limb motor function scores from baseline to week 4 between the intervention and control group (mean difference (MD): 6.5 vs 3.3, <em>p</em><0.001). At week 4, participants in the intervention group demonstrated significant enhancements in balancing function, walking ability, activities of daily living, and quality of life (<em>p</em><0.05). However, the intervention group did not show a significant improvement in global cognitive function compared to the control group (MD: 3.8 vs 3.7, <em>p</em> = 0.873). No adverse events were observed during the trial.</div></div><div><h3>Conclusion</h3><div>The VR-based robotic training for lower limb rehabilitation showed promise in improving motor function, activities of daily living, and quality of life in stroke patients with hemiplegia. These preliminary findings support the feasibility of this approach and highlight the need for large-scale studies to validate its effectiveness.</div></div>","PeriodicalId":72129,"journal":{"name":"Aging and health research","volume":"5 2","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0