{"title":"Comparison of the accuracy of six intraocular lens power calculation methods in post-myopic-LASIK eyes","authors":"Qingying Yang, Wenwen He, Kaiwen Cheng, Jiaqi Meng, Xiangjia Zhu","doi":"10.1016/j.aopr.2025.10.005","DOIUrl":"10.1016/j.aopr.2025.10.005","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the accuracy of six intraocular lens (IOL) power calculation methods in post-myopic-LASIK eyes.</div></div><div><h3>Methods</h3><div>Post-myopic-LASIK patients scheduled for cataract surgery were enrolled. Mean error (ME), mean absolute error (MAE), and median absolute error (MedAE) of ASCRS (ASCRS-Max, ASCRS-Average, ASCRS-Min), EVO 2.0, Pearl-DGS, Barrett True-K no-history, Shammas-PL, and Haigis-L were compared. The ASCRS method employed four formulas, including Shammas-PL, Haigis-L, Potvin-Hill Pentacam, and Barrett True-K no-history. Trueness, precision, and accuracy indices were evaluated by comparing trimmed-mean values with heteroscedasticity adjustment. Subgroup analyses were performed based on K value, axial length (AL), and corneal decentered ablation, respectively. Factors influencing prediction errors were analyzed.</div></div><div><h3>Results</h3><div>Totally, 87 eyes were analyzed. ASCRS-Min had the lowest MAE (0.79 D) and MedAE (0.62 D), followed by EVO 2.0, Pearl-DGS, and Barrett True-K no-history. It also had the highest percentage of absolute errors within 1.00 D. All methods outperformed ASCRS-Max in accuracy indices, and ASCRS-Min and EVO 2.0 showed superior accuracy indices compared to Shammas-PL and Haigis-L. In the subgroups of lower K value, longer AL, and larger decentration of ablation zone, ASCRS-Min, EVO 2.0, Pearl-DGS, and Barrett True-K no-history generated statistically lower MedAEs than ASCRS-Max. The accuracy of Shammas-PL was associated with AL; the accuracy of Haigis-L was associated with K value and AL; no other significant associations were found.</div></div><div><h3>Conclusions</h3><div>Generally, ASCRS-Min, EVO 2.0, Pearl-DGS, and Barrett True-K no-history achieve relatively better accuracy than the other methods, which might be considered as first choices for IOL power calculation in post-myopic-LASIK eyes.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"6 1","pages":"Pages 26-32"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145977947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Young glaucoma specialist practice patterns: Why do you do what you do?","authors":"Nicole Miranda , Jason Y. Zhang , Mary Qiu","doi":"10.1016/j.aopr.2025.07.001","DOIUrl":"10.1016/j.aopr.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Despite trabeculectomy having long been considered the gold standard surgery for treating severe or recalcitrant glaucoma, the popularity of this operation among glaucoma specialists has gradually declined in recent decades with a concurrent rise in alternative intraocular pressure (IOP)-lowering procedures being performed.</div></div><div><h3>Purpose</h3><div>This pilot study investigates how experiences of recently graduated glaucoma specialists during training might have influenced their choice to either perform trabeculectomy or favor alternative procedures in their current practice.</div></div><div><h3>Methods</h3><div>An anonymous questionnaire was distributed to American Glaucoma Society members who completed fellowship training between 2018 and 2022. Questionnaire items assessed respondents' experiences in residency and fellowship training as well as their current practice as attendings regarding four procedures: trabeculectomy, tube-shunt, XEN Gel Stent, and ab-interno angle procedures.</div></div><div><h3>Results</h3><div>Of 66 total respondents, 64 (93.9%) reported feeling somewhat or entirely comfortable performing trabeculectomy following training. However, 42 (63.6%) said they do not often perform trabeculectomy, whereas 13 (19.7%) reported that they do. Those who reported performing trabeculectomy often (N = 13) were influenced by the surgery's high success rates (92.3%), preoperative (76.9%) and intraoperative (84.6%) processes, and low postoperative complications (61.5%). Those who reported not performing trabeculectomy often (N = 42) were most discouraged by the postoperative process of trabeculectomy, as well as socioeconomic (66.7%) and sociocultural (52.4%) characteristics of their patients. Factors such as volume performed during training (47.6%), cost-effectiveness (19.0%), and reimbursement rates (19.0%) were not considerable contributors.</div></div><div><h3>Conclusions</h3><div>While most young glaucoma specialists in our study report being comfortable performing trabeculectomy, the majority stated that they do not often perform the procedure in practice. Low trabeculectomy surgical volume during training was not cited as a notable barrier, whereas patient factors and preference for alternative procedures, depending on the clinical scenario, appeared to drive this trend.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 227-234"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomechanical contributions to cataract development and implications for treatment strategies","authors":"Yingying Zheng , Wenxin Yang , Jiarui Guo, Silong Chen, Zicai Pan, Yibo Yu","doi":"10.1016/j.aopr.2025.09.004","DOIUrl":"10.1016/j.aopr.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>Cataracts remain the leading cause of blindness worldwide, primarily due to the progressive opacification of the crystalline lens. While surgical removal is the only definitive treatment, no pharmacological therapies have proven effective in reversing or significantly delaying disease progression.</div></div><div><h3>Main text</h3><div>Alterations in the biomechanical properties of the lens and their role in cataract formation. Biomechanics plays a crucial role in maintaining the normal structure and function of living organisms. As a mechanical material, the lens is subject to long-term regulation by the ciliary body, with its mechanical deformability being closely linked to the function of visual accommodation. Additionally, with age, the mechanical properties of the lens and its components undergo gradual changes, resulting in increased stiffness, reduced elasticity, and impaired accommodative capacity. These changes highlight the potential role of lens biomechanics in the onset and progression of cataracts. Understanding the patterns of biomechanical alterations during cataract formation may improve early diagnosis, enable better prediction of disease progression, optimize surgical approaches, and contribute to the development of non-surgical interventions, including pharmacological therapies and novel intraocular lens designs.</div></div><div><h3>Conclusions</h3><div>Focusing on biomechanical changes during the onset and progression of cataracts is essential for the development of new diagnostic and therapeutic strategies. This paper provides an overview of the anatomical structure of the lens, reviews existing literature on age-related biomechanical changes in the lens and their direct link to cataract pathogenesis, and discusses future research directions and applications of biomechanics in cataract research.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 293-302"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johanna Wiedemann , Claus Cursiefen , Peter Wiedemann
{"title":"Nothing in life is to be feared; it is only to be understood","authors":"Johanna Wiedemann , Claus Cursiefen , Peter Wiedemann","doi":"10.1016/j.aopr.2025.09.002","DOIUrl":"10.1016/j.aopr.2025.09.002","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 303-304"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TOC","authors":"","doi":"10.1016/S2667-3762(25)00061-7","DOIUrl":"10.1016/S2667-3762(25)00061-7","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages iii-iv"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongzhe Li , Jiaying Cen , Wentao Tong , Fuman Yang , Ruiwen Zhang , Dandan Wang , Pingjun Chang , Yune Zhao
{"title":"Intraocular lens tilt and decentration and optical quality after primary intraocular lens implantation in pediatric cataract patients","authors":"Hongzhe Li , Jiaying Cen , Wentao Tong , Fuman Yang , Ruiwen Zhang , Dandan Wang , Pingjun Chang , Yune Zhao","doi":"10.1016/j.aopr.2025.09.003","DOIUrl":"10.1016/j.aopr.2025.09.003","url":null,"abstract":"<div><h3>Purposes</h3><div>To investigate the characteristics and associated factors of intraocular lens (IOL) tilt and decentration in pediatric cataract patients undergoing primary IOL implantation and to explore their impact on postoperative optical quality.</div></div><div><h3>Methods</h3><div>Children who underwent cataract extraction with posterior capsulotomy, primary anterior vitrectomy, and in-the-bag IOL implantation over 6 months were enrolled. Patient data and ocular biometric parameters were retrieved from electronic files. Retroillumination images were obtained to evaluate capsular outcomes. IOL tilt and decentration were assessed using the swept-source optical coherence tomography, and wavefront aberrations were measured with the OPD-Scan III.</div></div><div><h3>Results</h3><div>A total of 125 eyes from 125 patients with a mean age at surgery of 4.74 ± 1.49 years were included. The IOLs demonstrated a mean tilt of 6.02 ± 1.97° toward the temporal direction and a mean decentration of 0.28 ± 0.13 mm toward the superior-temporal direction. Multivariate analysis revealed that shorter axial length (AL; <em>P</em> = 0.009) and significant cortical proliferation (<em>P</em> = 0.021) were associated with greater IOL tilt. In addition, smaller corneal diameter (CD; <em>P</em> = 0.008) and incomplete capsulorhexis-IOL overlap (<em>P</em> = 0.022) were associated with larger IOL decentration. Patients with IOL tilt ≥ 7° and decentration ≥ 0.40 mm exhibited higher internal total higher-order aberrations (tHOA) and internal astigmatism, both of which were positively correlated with IOL misalignment (all <em>P</em> < 0.05)</div></div><div><h3>Conclusions</h3><div>Shorter AL, smaller CD, significant cortical proliferation, and incomplete capsulorhexis-IOL overlap contributed to greater IOL misalignment in pediatric cataract patients with primary in-the-bag IOL implantation, which may compromise postoperative optical quality by increasing internal tHOA and astigmatism.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 285-292"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multimodal data-driven approaches in retinal vein occlusion: A narrative review integrating machine learning and bioinformatics","authors":"Chunlan Liang, Lian Liu, Jingxiang Zhong","doi":"10.1016/j.aopr.2025.07.002","DOIUrl":"10.1016/j.aopr.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Retinal vein occlusion (RVO) is a leading cause of visual impairment on a global scale. Its pathological mechanisms involve a complex interplay of vascular obstruction, ischemia, and secondary inflammatory responses. Recent interdisciplinary advances, underpinned by the integration of multimodal data, have established a new paradigm for unraveling the pathophysiological mechanisms of RVO, enabling early diagnosis and personalized treatment strategies.</div></div><div><h3>Main text</h3><div>This review critically synthesizes recent progress at the intersection of machine learning, bioinformatics, and clinical medicine, focusing on developing predictive models and deep analysis, exploring molecular mechanisms, and identifying markers associated with RVO. By bridging technological innovation with clinical needs, this review underscores the potential of data-driven strategies to advance RVO research and optimize patient care.</div></div><div><h3>Conclusions</h3><div>Machine learning-bioinformatics integration has revolutionised RVO research through predictive modelling and mechanistic insights, particularly via deep learning-enhanced retinal imaging and multi-omics networks. Despite progress, clinical translation requires resolving data standardisation inconsistencies and model generalizability limitations. Establishing multicentre validation frameworks and interpretable AI tools, coupled with patient-focused data platforms through cross-disciplinary collaboration, could enable precision interventions to optimally preserve vision.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 235-244"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaona Ping, Juno Kim, Nayuta Yoshioka, Padmaja Sankaridurg
{"title":"Exploration of virtual reality applications in myopia: A systematic review","authors":"Xiaona Ping, Juno Kim, Nayuta Yoshioka, Padmaja Sankaridurg","doi":"10.1016/j.aopr.2025.10.002","DOIUrl":"10.1016/j.aopr.2025.10.002","url":null,"abstract":"<div><h3>Background</h3><div>Multiple interventions are available to prevent or slow myopia progression, the rapidly rising prevalence highlights the need to enhance both the development of novel approaches and adherence to existing strategies. Virtual reality (VR) is an emerging technology in ophthalmology and vision science, yet its potential applications in myopia remain underexplored.</div></div><div><h3>Main text</h3><div>To explore the prior application, if any, of VR in myopia research. A systematic search was conducted across nine databases, including PubMed, Cochrane Library, Embase, Scopus, Web of Science, IEEE Xplore, ACM Digital Library, SpringerLink, and ScienceDirect, to identify journal articles and conference proceedings reporting application of VR in myopia. The search terms used were \"Virtual Reality\", \"VR\", \"myopia\", \"nearsightedness\", \"shortsightedness\", \"refractive errors\", and \"refractive disorder\". The search covered publications from inception to April 6, 2025. Risk of bias was assessed using the Revised Cochrane risk-of-bias tool and the Joanna Briggs Institute Critical Appraisal Checklist, with assessments performed independently by two authors.</div></div><div><h3>Conclusion</h3><div>A total of sixteen articles fit the criteria and were included in the review. Of these, seven investigated VR-based interventions for myopia, an additional four were focused on testing and diagnostic applications, three articles reported on vision training, and the remaining two articles were related to educational uses. None were related to myopia control. All studies were published between 2016 and 2024. With respect to the VR technologies, eleven studies utilized commercial VR headsets and/or smartphones paired with VR viewers as experimental devices. Fully immersive virtual environments or systems were also commonly employed in the included studies. Most studies focused on the usability and validity of VR technologies in this context.</div></div><div><h3>Conclusions</h3><div>None of the articles reported on the efficacy of VR in preventing or slowing myopia progression, however, our review identified the potential of VR in auxiliary aspects of myopia, including testing, diagnosis, intervention, vision training, and education. Further research is warranted to evaluate the practical feasibility, clinical effectiveness, safety, and broader applicability of VR technologies in myopia.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 305-314"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanshan Cao , Yong Liu , Mingming Sun , Yuan Zhang , Yonghua Sun , Quangang Xu , Shihui Wei , Huanfen Zhou
{"title":"Exploring rare mitochondrial DNA in Leber hereditary optic neuropathy","authors":"Shanshan Cao , Yong Liu , Mingming Sun , Yuan Zhang , Yonghua Sun , Quangang Xu , Shihui Wei , Huanfen Zhou","doi":"10.1016/j.aopr.2025.08.001","DOIUrl":"10.1016/j.aopr.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder primarily caused by mutations in MT-ND1, MT-ND4, and MT-ND6, leading to retinal ganglion cell degeneration and severe vision loss. While 90%–95% of cases involve three common mutations (m.11778G > A, m.3460G > A, m.14484T > C), the genetic and clinical profiles of rare mutations remain poorly characterized, contributing to diagnostic challenges.</div></div><div><h3>Methods</h3><div>This cohort study analyzed 26 genetically confirmed LHON patients harboring rare mitochondrial DNA (mtDNA) mutations. Patients underwent best-corrected visual acuity (BCVA), optical coherence tomography (OCT) measurements (peripapillary retinal nerve fiber layer [pRNFL] and macular ganglion cell layer [GCL] thickness), and neuroimaging findings. Prognostic outcomes were compared between pediatric (≤16 years) and adult (>16 years) subgroups.</div></div><div><h3>Results</h3><div>The cohort (male:female = 4.2:1) exhibited a median onset age of 17 years (range:4–42), with 30.77% unilateral involvement. Rare mutations were distributed in MT-ND4(34.62%,m.11696G > A), MT-ND1(34.62%,including m.3733G > A/m.3866T > C), and MT-ND6 (23.08%, m.14502T>C), with 26.92% harboring dual mutations. Younger patients showed significantly better visual recovery (59.09% vs. 22.73% achieving BCVA ≥ 0.3, <em>P</em> = 0.014), despite comparable baseline vision and structural OCT parameters (pRNFL/GCL thickness, all <em>P</em> > 0.05). T2 hyperintensity in the optic nerve magnetic resonance imaging (MRI) was present in 38.46% of cases.</div></div><div><h3>Conclusions</h3><div>Our study probes into the clinical and genetic diversity of LHON with rare mtDNA mutations, revealing varied clinical presentations, such as more frequent unilateral involvement and enhanced optic nerve T2 MRI signals. Visual recovery was significantly better in the younger cohort. These results suggest the need for broader genetic testing in atypical LHON cases and offer insights into better prognostic strategies for new therapies.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 278-284"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zewei Zhang , Lingfeng Lv , Dongmei Chen , Yusheng Chen , Weijie Zhang , Fang Li , Jibo Zhou
{"title":"Shaping the future of myopia with artificial intelligence: Mapping trends and promising directions","authors":"Zewei Zhang , Lingfeng Lv , Dongmei Chen , Yusheng Chen , Weijie Zhang , Fang Li , Jibo Zhou","doi":"10.1016/j.aopr.2025.07.004","DOIUrl":"10.1016/j.aopr.2025.07.004","url":null,"abstract":"<div><h3>Background</h3><div>The worldwide increase in myopia and its associated complications has sparked a growing interest in the application of artificial intelligence (AI). This study aims to provide a comprehensive bibliometric analysis of the application of AI in myopia.</div></div><div><h3>Methods</h3><div>Articles and review articles on AI in myopia were retrieved from the Web of Science Core Collection (WoSCC). VOSviewer and CiteSpace served as the core tools for bibliometric analysis.</div></div><div><h3>Results</h3><div>Our study included a total of 305 relevant articles, with a steady increase in publications observed from 2010 to 2024. The People's Republic of China secured the top position among the most published countries and Capital Medical University and Sun Yat-sen University emerged as the most active institutions. Xu Xun and Zhou Xingtao contributed the most papers in this area. Translational Vision Science & Technology was the most prolific journal. Keywords analysis highlighted myopia management, orthokeratology and atropine, optical coherence tomography, refractive surgery, and myopia complications as key research areas. While notable advancements have been achieved in early screening, precise diagnosis, and progression prediction of myopia, research on intervention prognosis prediction and intervention decision-making remains inadequate.</div></div><div><h3>Conclusions</h3><div>While AI has revolutionized myopia screening and diagnosis. further investigation is needed into clinical decision-making on interventions for myopia care. Balancing intervention costs, efficacy, and side effects is critical to advancing the development of AI in myopia in the future.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 4","pages":"Pages 245-258"},"PeriodicalIF":3.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}