Advances in ophthalmology practice and research最新文献

{"title":"Real-world assessment of second-generation trabecular micro-bypass stents in open-angle glaucoma patients","authors":"Vishal Vohra ,&nbsp;Indira Madgula ,&nbsp;Harshika Chawla","doi":"10.1016/j.aopr.2024.09.002","DOIUrl":"10.1016/j.aopr.2024.09.002","url":null,"abstract":"<div><h3>Background</h3><div>To assess the safety and efficacy of iStent inject placement in individuals with glaucoma with open angles in real world clinical settings.</div></div><div><h3>Methods</h3><div>A review was conducted on the medical records of individuals who received iStent inject implants starting from March 2018. The analysis focused on reductions in intraocular pressure (IOP) and glaucoma medication usage. Safety assessments encompassed intraoperative and postoperative issues, additional surgeries, and improvements in best-corrected visual acuity (BCVA).</div></div><div><h3>Results</h3><div>Analysis of 55 eyes of 48 patients that underwent iStent implantation revealed a mean age of 77 years (range: 51–97). The initial average intraocular pressure (IOP) in these eyes was 20.2 ​± ​6.4 ​mm Hg. Following surgery, IOP decreased by ​≥ ​20% compared to preoperative levels in 21 eyes (43.8%) over the 12-month follow-up period. Notably, there was a significant reduction in medication usage by the 12-month mark (<em>P</em> ​&lt; ​0.0042). Among the evaluated eyes, 9 exhibited a response to steroids, 3 had stents that were improperly positioned, 5 had stents that were over implanted, and 1 eye experienced an episode of iris prolapse.</div></div><div><h3>Conclusions</h3><div>The findings from the 12-month follow-up of iStent inject implants in standard clinical settings demonstrate a notable decrease in both intraocular pressure (IOP) and medication usage in eyes with concurrent open-angle glaucoma.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 16-21"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing eyes with artificial tears: A simple and effective strategy to combat screen-related asthenopia and dry eye symptoms","authors":"Ning Wang ,&nbsp;Jinjin Min ,&nbsp;Xiaojing Fan ,&nbsp;Xiuming Jin","doi":"10.1016/j.aopr.2024.07.001","DOIUrl":"10.1016/j.aopr.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>The widespread use of various video display terminals (VDTs) always had a detrimental impact on ocular health. Prolonged use of smartphones has been one of the leading causes of dry eye (DE) and asthenopia. Therefore, the purpose of this study is to find a simple and effective strategy to combat screen-related DE and asthenopia.</div></div><div><h3>Methods</h3><div>A group of healthy participants aged 18 and above were randomly assigned to three groups and tasked with a 2 h smartphone reading task. After 1 ​h of usage, each group adopted different methods of rest: no rest (Group A), a 10 min eye-closed rest (Group B), or a 10 min eye-closed joint artificial tears rest (Group C). Ophthalmological examinations and questionnaires were administered to all participants before and after the 2 h reading task.</div></div><div><h3>Results</h3><div>90 qualified volunteers, including 29 males and 61 females, were randomly assigned to three groups. Group A demonstrated a significant increase in the severity of DE and asthenopia as evidenced by all the evaluated indices. On the other hand, Group C did not exhibit any notable change in DE and asthenopia symptoms, with an improvement in corneal fluorescein staining (CFS) results (<em>P</em> ​&gt; ​0.05) when compared to the pre-reading values. Group B showed a significant increase in ocular surface disease index (OSDI) (<em>P</em> ​≤ ​0.05) and a decrease in critical flicker frequency (CFF) (<em>P</em> ​≤ ​0.05).</div></div><div><h3>Conclusions</h3><div>Close-eye rest with artificial tears may be a convenient and effective prevention strategy for screen-related DE and asthenopia.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 58-65"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decline in US–China science: Can ophthalmology remain collaborative?","authors":"Kevin Y. Huang ,&nbsp;Parth A. Patel ,&nbsp;Austin Huang,&nbsp;Allen C. Ho,&nbsp;Jost B. Jonas,&nbsp;Xiaodong Sun,&nbsp;Youxin Chen,&nbsp;Yingfeng Zheng,&nbsp;Yih-Chung Tham,&nbsp;Christina Y. Weng,&nbsp;Tien Yin Wong","doi":"10.1016/j.aopr.2024.11.002","DOIUrl":"10.1016/j.aopr.2024.11.002","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 13-15"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel RP1 truncating mutation that causes autosomal dominant retinitis pigmentosa (ADRP)","authors":"Wei Wu ,&nbsp;Ying Zhang ,&nbsp;Jingjie Xu ,&nbsp;Hua Jiang ,&nbsp;Xiangjun Chen","doi":"10.1016/j.aopr.2024.08.005","DOIUrl":"10.1016/j.aopr.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Retinitis pigmentosa (RP) is a genetically and clinically heterogeneous group of hereditary degenerative disorders affecting approximately one in every 4000 people worldwide. Abnormalities in the retina's photoreceptors can cause night blindness or even complete vision loss. Retinitis Pigmentosa 1 (RP1), also known as the oxygen-regulated protein-1, is a microtubule-associated protein (MAP) that organizes the outer segment of the photoreceptor. Besides, mutations in the <em>RP1</em> gene are associated with dominant or recessive form of RP. This study aims to identify the potential pathogenic genes in Chinese RP patients and to elucidate the association relationship between the mutant gene and the phenotypes.</div></div><div><h3>Methods</h3><div>Multiple ophthalmic examinations, whole-exome sequencing, sanger sequencing, and <em>in silico</em> analysis were performed to evaluate the clinical features and pathogenic genes in a five-generation Chinese family diagnosed with RP.</div></div><div><h3>Results</h3><div>Our findings revealed a novel truncating mutation c.2015_2018del p. (Lys672Argfs∗9) in <em>RP1</em> that may result in the translation of a protein with deleterious effects on photoreceptors. Therefore, resulting in autosomal dominant retinitis pigmentosa (ADRP).</div></div><div><h3>Conclusions</h3><div>This study broaden the range of genetic mutations associated with <em>RP1</em> in ADRP and make a valuable contribution to the ongoing endeavors aimed at characterizing the molecular aspects of Chinese ADRP. Future studies would pay more attention in determining the characterization of the mutantations in <em>RP1</em> gene and the relationship between genotype and phenotype in RP patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 1","pages":"Pages 41-48"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-eye axis","authors":"Weixin Zheng ,&nbsp;Mingzhi Su ,&nbsp;Ningxi Hong ,&nbsp;Panpan Ye","doi":"10.1016/j.aopr.2025.01.003","DOIUrl":"10.1016/j.aopr.2025.01.003","url":null,"abstract":"<div><h3>Background</h3><div>The gut microbiome, colonizing the human gastrointestinal tract, is increasingly recognized for its symbiotic relationship with the immune system in maintaining overall host health. This emerging understanding raises intriguing questions about potential connections between the gut microbiome and anatomically distant organs, such as the eye, possibly mediated through immune pathways.</div></div><div><h3>Main text</h3><div>This review synthesizes contemporary research on ocular diseases with the framework of the burgeoning \"gut-eye axis\" concept. Investigations spanning from the ocular surface to the fundus suggest correlations between the gut microbiome and various ocular disorders. By elucidating the putative pathogenic mechanisms underlying these ocular conditions, we offer novel perspectives to inform future diagnostic and therapeutic interventions in ophthalmology.</div></div><div><h3>Conclusions</h3><div>By presenting a critical analysis of current knowledge regarding the role of gastrointestinal microbiota in ocular health, this review shed light on the complex interplay between gut dysbiosis and eye disorders. Our work endeavors to catalyze interdisciplinary research and foster innovative clinical applications, thereby bridging the gap between the gut microbiota and the ocular well-being.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 3","pages":"Pages 165-174"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the accuracy of advanced language learning models in ophthalmology: A comparative study of ChatGPT-4o and Meta AI's Llama 3.1","authors":"Trevor Lin ,&nbsp;Ryan T. Lin ,&nbsp;Rahul Mhaskar ,&nbsp;Curtis E. Margo","doi":"10.1016/j.aopr.2025.01.002","DOIUrl":"10.1016/j.aopr.2025.01.002","url":null,"abstract":"","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 95-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of COVID-19 on visual outcome and dry eye after SMILE","authors":"Zhi Fang ,&nbsp;Yan Li ,&nbsp;Dejuan Song,&nbsp;Xiaoying He,&nbsp;Kai Zhang,&nbsp;Tiepei Zhu,&nbsp;Wei Han","doi":"10.1016/j.aopr.2025.01.001","DOIUrl":"10.1016/j.aopr.2025.01.001","url":null,"abstract":"<div><h3>Purposes</h3><div>To evaluate the impact of coronavirus disease 2019 (COVID-19) on postoperative visual acuity, optical quality, and severity of dry eye disease in patients after small incision lenticule extraction (SMILE).</div></div><div><h3>Methods</h3><div>This is a retrospective, comparative study. Patients who underwent SMILE were included and divided into two groups according to the period at the eye center of the Second Affiliated Hospital of Zhejiang University. The first group included patients who underwent SMILE before the large-scale COVID-19 pandemic in China (Group 1). The second group comprised patients who underwent SMILE during the pandemic with a confirmed infection of COVID-19 (Group 2). The visual acuity, the severity of dry eye, ocular surface disease index (OSDI), oculus keratography analysis, and individual Zernike coefficients were evaluated and compared between the 2 groups.</div></div><div><h3>Results</h3><div>A total of 43 eyes of 23 patients and 45 eyes of 26 patients were included in Groups 1 and 2, respectively. The OSDI score in Group 2 was significantly higher than Group 1 (<em>P</em> ​&lt; ​0.01). The corrected distance visual acuity (CDVA, logMAR) at 3 months postoperatively in Group 1 was better than in Group 2 (<em>P</em> ​&lt; ​0.001). Despite the improvement over 1 month after the COVID-19 infection, the OSDI score was still higher in Group 2 than in Group 1 (<em>P</em> ​&lt; ​0.01). The bulbar and limbal redness were significantly higher in Group 2 than in Group 1 ​at both 1 month and 3 months (<em>P</em> ​&lt; ​0.05), while no significant differences were found in tear breakup time or tear meniscus height. Spherical aberration (SA) at the 4 ​mm zone was significantly higher in Group 2 than in Group 1 both at 1 month and 3 months (<em>P</em> ​&lt; ​0.001), while no significant changes were observed in corneal total higher-order aberrations. No significant correlation was found between the bulbar/limbal redness index and SA.</div></div><div><h3>Conclusions</h3><div>COVID-19 infection impaired visual outcomes and aggravated dry eye severity among postoperative SMILE patients.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 149-155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of popular large language models in glaucoma patient education: A randomized controlled study","authors":"Yuyu Cao ,&nbsp;Wei Lu ,&nbsp;Runhan Shi ,&nbsp;Fuying Liu ,&nbsp;Steven Liu ,&nbsp;Xinwei Xu ,&nbsp;Jin Yang ,&nbsp;Guangyu Rong ,&nbsp;Changchang Xin ,&nbsp;Xujiao Zhou ,&nbsp;Xinghuai Sun ,&nbsp;Jiaxu Hong","doi":"10.1016/j.aopr.2024.12.002","DOIUrl":"10.1016/j.aopr.2024.12.002","url":null,"abstract":"<div><h3>Purpose</h3><div>The advent of chatbots based on large language models (LLMs), such as ChatGPT, has significantly transformed knowledge acquisition. However, the application of LLMs in glaucoma patient education remains elusive. In this study, we comprehensively compared the performance of four common LLMs – Qwen, Baichuan 2, ChatGPT-4.0, and PaLM 2 – in the context of glaucoma patient education.</div></div><div><h3>Methods</h3><div>Initially, senior ophthalmologists were asked with scoring responses generated by the LLMs, which were answers to the most frequent glaucoma-related questions posed by patients. The Chinese Readability Platform was employed to assess the recommended reading age and reading difficulty score of the four LLMs. Subsequently, optimized models were filtered, and 29 glaucoma patients participated in posing questions to the chatbots and scoring the answers within a real-world clinical setting. Attending ophthalmologists were also required to score the answers across five dimensions: correctness, completeness, readability, helpfulness, and safety. Patients, on the other hand, scored the answers based on three dimensions: satisfaction, readability, and helpfulness.</div></div><div><h3>Results</h3><div>In the first stage, Baichuan 2 and ChatGPT-4.0 outperformed the other two models, though ChatGPT-4.0 had higher recommended reading age and reading difficulty scores. In the second stage, both Baichuan 2 and ChatGPT-4.0 demonstrated exceptional performance among patients and ophthalmologists, with no statistically significant differences observed.</div></div><div><h3>Conclusions</h3><div>Our research identifies Baichuan 2 and ChatGPT-4.0 as prominent LLMs, offering viable options for glaucoma education.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 88-94"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-based drug delivery systems for the treatment of non-infectious uveitis","authors":"Xingdi Wu ,&nbsp;Mengyuan Hu ,&nbsp;Yilu Cai ,&nbsp;Fan Jia ,&nbsp;Yang Ye ,&nbsp;Naiji Yu ,&nbsp;Min Chen ,&nbsp;Kaijun Wang","doi":"10.1016/j.aopr.2024.11.003","DOIUrl":"10.1016/j.aopr.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Uveitis is one of the most prevalent causes of global visual impairment. The current approaches to treating non-infectious uveitis (NIU) involve the utilization of corticosteroids, immunosuppressant and biologics agents. Nevertheless, the intricate ocular anatomy barriers and adverse side effects of the drugs pose significant obstacles to effective treatment outcomes.</div></div><div><h3>Main text</h3><div>To improve drug bioavailability and therapeutic outcomes for NIU while minimize side effects, researchers are committed to developing novel nano-based drug delivery systems (DDS), which have the capacity to achieve targeted delivery, increase bioavailability, achieve sustained release, reduce side effects and improve therapeutic effects. Thus, DDS based on nanotechnology, including liposome, dendrimer, hydrogels, nanoparticles, nanomicelles, nanosuspensions and nanoemulsions have emerged as promising alternatives to conventional ocular delivery methods for the management of NIU.</div></div><div><h3>Conclusions</h3><div>In this review, we summarize the current therapeutic challenges faced by NIU and describe various nano-based intraocular DDS involved in the treatment of NIU. It is concluded that nano-based DDS is an appealing approach to addressing the unmet needs for the treatment of NIU.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 124-134"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of refraction disorders in 204 countries and territories from 1990 to 2021: A systematic analysis from the global burden of disease 2021","authors":"Yunhan Shen ,&nbsp;Linyan Wang ,&nbsp;Yuxin Cui ,&nbsp;Bangxun Mao ,&nbsp;Grace Loy Ming Hooi ,&nbsp;Oluwatobi Idowu ,&nbsp;Juan Ye ,&nbsp;Tiansheng Zhu","doi":"10.1016/j.aopr.2024.11.001","DOIUrl":"10.1016/j.aopr.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Refraction disorders are common eye conditions that cause blurred vision and, if left uncorrected, remain a leading cause of moderate to severe visual impairment worldwide. Despite this, a comprehensive assessment of the associated burden is lacking. This study aims to describe and predict the burden and regional distribution of refraction disorders using data from the 2021 Global Burden of Disease (GBD) study.</div></div><div><h3>Methods</h3><div>This study utilized data from the Global Burden of Disease (GBD) 2021 on refraction disorders from 1990 to 2021. We analyzed the prevalence and disability-adjusted life years (DALYs) of refraction disorders and calculated the corresponding average annual percentage changes (AAPCs) in different gender and age groups across 204 countries and territories and 21 geographical regions. We employed the Bayesian Age-Period-Cohort (BAPC) model to predict the future burden of refraction disorders.</div></div><div><h3>Results</h3><div>From 1990 to 2021, the global age-standardized prevalence rate (ASPR) of refraction disorders decreased from 2053.56 (per 100000, 95% Uncertainty Interval [UI]: 1835.31 to 2275.80) to 1919.66 (per 100000, 95%UI: 1715.24 to 2135.28), with an average annual percentage change (AAPC) of −0.21% (95% Confidence Interval [CI]: −0.23% to −0.19%). The age-standardized DALY (Disability-Adjusted Life Years) rate also declined from 88.04 (per 100000, 95%UI: 62.19 to 125.15) to 79.11 (per 100000, 95%UI: 54.94 to 114.14) with an AAPC of −0.33% (95%CI: −0.36% to −0.31%). Refraction disorders remain a significant burden in regions with lower Socio-demographic Index (SDI), particularly in parts of South Asia and Western Sub-Saharan Africa. Older individuals and females are disproportionately affected. The age-standardized DALY rate is expected to decline steadily before stabilising at approximately 77.94 per 100000 by 2030.</div></div><div><h3>Conclusions</h3><div>From 1990 to 2021, the disease burden of refraction disorders showed a declining trend, but the decrease was not substantial. In some low-middle SDI regions, the burden remains high. Moreover, globally, women bear a higher burden than men. This study provides important information for the treatment and prevention of refraction disorders.</div></div>","PeriodicalId":72103,"journal":{"name":"Advances in ophthalmology practice and research","volume":"5 2","pages":"Pages 79-87"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}