Accounts of materials research最新文献

{"title":"Recent Advances in Angle-Resolved Polarized Raman Spectroscopy for van der Waals Materials","authors":"Jia-Liang Xie, Miao-Ling Lin, Ping-Heng Tan","doi":"10.1021/accountsmr.6c00015","DOIUrl":"https://doi.org/10.1021/accountsmr.6c00015","url":null,"abstract":"<p>van der Waals (vdW) materials,covering bothindividual monolayersand multilayer stacks with strong in-plane bonding and weak interlayerinteractions, if any, offer a versatile platform for investigatingnovel quantum phenomena and designing atomic-scale heterostructures.The growing diversity of this material family, ranging from isotropicgraphene to anisotropic black phosphorus and emerging magnetic layers,requires advanced characterization tools to probe their lattice structureand lattice vibration information. In this scenario, Raman spectroscopyhas established itself as a key nondestructive method for analyzinglattice vibrations and material properties. Recently, angle-resolvedpolarized Raman (ARPR) spectroscopy has evolved from a tool for basicsymmetry identification into a powerful quantitative technique forelucidating multidimensional light–matter interactions withinvdW systems and their artificial stacks by disentangling intrinsicphonon properties from extrinsic optical effects. In condensed matterphysics, this technique provides a vital, noninvasive bridge betweenmicroscopic lattice behavior and macroscopic optical response, enablingthe rational design of materials with tailored vibrational, electronic,and optical functionalities. Its ability to operate under diverseconditions, including in situ, under strain, or in applied externalfields, makes ARPR spectroscopy an indispensable tool in the advancingtoolkit for vdW material research.</p><p>In this Account, we detailthe transition of the significant advancesin ARPR spectroscopy from a qualitative symmetry probe to a quantitativeplatform for investigating vdW systems. We begin with a conceptualintroduction to polarized Raman scattering, explaining how to describeand further probe phonon symmetry with the involvement of the Ramantensor and the Raman selection rule. A central theme is the distinctiveconcepts of the intrinsic Raman tensor <strong><em>R</em></strong><sup>int</sup>, which captures the inherent electron–phonon/photoninteractions of materials, and the effective Raman tensor <strong><em>R</em></strong><sup>eff</sup>, which additionally incorporatesthe complicated dependence on the optical properties of the sampleand underlying substrates. Technically, we highlight key experimentaladvances, such as in situ polarization control for high-quality ARPRacquisition and Zenith-ARPR configurations that extend phonon characterizationto the out-of-plane dimension. We next demonstrate some fundamentalsymmetry analysis based on Raman spectroscopy in isotropic crystals,finally clarify the anomalous ARPR response in anisotropic materials,and further demonstrate how our recently developed quantitative frameworkresolves the puzzling thickness-, wavelength-, and substrate-dependentARPR anomalies that have long hindered interpretation. Taking blackphosphorus as a representative, we show that an intrinsic <strong><em>R</em></strong><sup>int</sup> can predict ARPR responses acrossdiverse sample struct","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 6","pages":"601–612"},"PeriodicalIF":14.1,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Cost-Effective Stable Zn Battery Anodes: Design Concepts for Scalable Electrochemical Energy Storage","authors":"Shuo Jin, Shifeng Hong, Lynden A. Archer","doi":"10.1021/accountsmr.6c00024","DOIUrl":"https://doi.org/10.1021/accountsmr.6c00024","url":null,"abstract":"<p>Zinc (Zn) metal batteries areamong the most extensively studiedand practically deployed electrochemical energy storage systems, owingto their low cost, intrinsic safety, environmental benignity, andnatural compatibility with aqueous electrolytes. These attributesrender Zn-based batteries attractive for large-scale stationary storage,wearable and flexible electronics, and emerging applications thatrequire high operational safety and mechanical robustness. Despitethese advantages, the widespread adoption of Zn metal batteries islimited by their relatively low energy density and poor cycling stability,which originate primarily from the complex, dynamic, and typicallyunstable electrochemical behavior of the Zn metal anode during repeatedplating and stripping. Addressing these challenges requires a mechanisticunderstanding of Zn electrodeposition and interfacial processes acrossmultiple length and time scales, spanning atomistic ion transportand interfacial reactions, mesoscale morphology evolution, and macroscopicnno-planargrowth of the deposits to ultimately compromise cell performance.In this Account, we summarize our recent efforts to elucidate andengineer Zn metal anodes for reversible and stable operation underboth conventional and extreme electrochemical conditions, with thegoal of bridging fundamental insights into Zn deposition dynamicswith practical strategies for enhancing battery durability and performance.We begin by establishing the fundamental principles governing Zn electrodeposition,with a particular focus on the crystallographic control of Zn growth.By inducing preferentially textured (002) Zn anodes, we demonstratethat dendritic and mossy Zn growth can be effectively suppressed inmildly acidic or neutral electrolytes, enabling smoother and morereversible Zn plating/stripping. These results provide a frameworkthat links microscopic deposition dynamics to macroscopic electrochemicalperformance metrics, including Coulombic efficiency, cycling stability,and rate capability. Building on this foundation, we investigate theformation and functional roles of salt-induced solid–electrolyteinterphases (SEIs) and artificially engineered interphases on Zn metalsubstrates. Through electrolyte engineering and interfacial designstrategies, including initiated chemical vapor deposition (iCVD),we show that tailored interphases can regulate Zn<sup>2+</sup> transport,homogenize interfacial ion flux, suppress parasitic side reactions,and stabilize the Zn/electrolyte interface over prolonged cycling.These interphases function not merely as passive protective layers,but as active regulators of interfacial electrochemistry that enablesustained Zn metal reversibility under demanding conditions. Importantly,we further explore Zn metal cycling under extreme environments, includinghighly alkaline electrolytes and electrochemical regimes characterizedby hydrodynamic instability. Although such conditions are conventionallyregarded as detrimental to Zn stabil","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 6","pages":"613–623"},"PeriodicalIF":14.1,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148666519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Design of Oligomers toward Efficient and Stable Organic Solar Cells","authors":"Jinfeng Liu, Zhen Wang, Xiaobo Sun, Yanming Sun","doi":"10.1021/accountsmr.5c00329","DOIUrl":"10.1021/accountsmr.5c00329","url":null,"abstract":"<p>Organicsolar cells (OSCs) haveadvanced rapidly over the pastdecade, with single-junction power conversion efficiencies (PCEs)now exceeding 20%, largely driven by the development of nonfullereneacceptors. Despite these achievements, translating record efficienciesinto durable and scalable technologies remains a major challenge.Small-molecule acceptors offer precise molecular structures and excellentbatch reproducibility but often suffer from morphological instabilityarising from low glass-transition temperatures and rapid moleculardiffusion. In contrast, polymer acceptors provide improved thermaland morphological robustness but typically involve greater syntheticcomplexity and batch-to-batch variability. These trade-offs motivatethe exploration of alternative material platforms that can simultaneouslycombine efficiency, stability, and synthetic controllability. Oligomershave recently emerged as a promising molecular design strategy thatbridges the gap between small molecules and polymers, integratingstructural precision with enhanced morphological robustness. In addition,oligomerization offers flexible control over molecular conformation,intermolecular packing, and nanoscale phase separation through thedesign of linkage motifs, connection geometries, and repeating-unitcomposition.</p><p>In this Account, we summarize our recent researchon oligomericacceptors for efficient and stable OSCs, with an emphasis on how moleculararchitecture governs device performance and operational durability.First, we introduce stepwise and controllable synthetic methodologiesfor oligomers, including single-sided and bilateral tin-intermediateStille coupling strategies that improve reaction selectivity, productpurity, and structural definition. These methods provide a reliablefoundation for systematically correlating molecular structure withdevice properties. Second, we discuss molecular design strategiesfor dimeric acceptors, highlighting the roles of π-bridge engineering,flexible conjugation-broken linkers, end-group isomerization, backbonerigidification, and terminal asymmetry in balancing aggregation strength,electronic coupling, and morphological stability. Third, we extendthese concepts to trimer systems, where repeating-unit hybridizationand crystallization-kinetics regulation enable optimized fibrillarnetworks, nonhalogenated solvent processing, and competitive deviceefficiencies. Finally, we discuss the extension of oligomer designconcepts to cathode interfacial layers. Looking forward, further progressin oligomer-based OSCs will rely on coordinated advances in syntheticmethodology, molecular design, and scalable device processing. Developingefficient and scalable synthetic routes, expanding monomer buildingblocks, integrating emissive or rigid structural units to suppressnonradiative losses, and optimizing linker structures to balance electroniccoupling and morphology will all be critical. Simplifying moleculararchitectures to reduce synthetic cost while ma","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"520–535"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Reticular Chemistry: From Structural Discovery to Programmable Matter and Artificial Intelligence","authors":"Zhe Wang, Yingbo Zhao, Yue-Biao Zhang","doi":"10.1021/accountsmr.6c00087","DOIUrl":"10.1021/accountsmr.6c00087","url":null,"abstract":"","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"425–430"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimuli-Responsive Polymeric Nanosystems for Precision Cancer Nanovaccines","authors":"Kang Xia, Xin Li, Chao Qi, Xikuang Yao, Wei Huang, Xiqun Jiang","doi":"10.1021/accountsmr.5c00355","DOIUrl":"10.1021/accountsmr.5c00355","url":null,"abstract":"<p>The developmentof appealingcancer vaccines marks a significantadvancement in precision cancer immunotherapy. Its core mechanisminvolves delivering tumor antigens to activate host dendritic cells(DCs), thereby initiating and amplifying specific T-cell immune responsesto be capable of recognizing and eliminating cancer cells. However,the clinical efficacy of this approach faces several major challenges,including tumor heterogeneity and immune evasion mechanisms withinthe tumor immunosuppressive microenvironment (TIME). Furthermore,traditional delivery systems often lack spatiotemporal control andfail to ensure the efficient uptake of antigens and adjuvants by lymphnode-resident DCs, thereby limiting the generation of effective immuneresponses. To address these limitations, cancer nanovaccines haveevolved from single-antigen formulations toward systemic remodelingof the TIME. Modern immunotherapies aim to disrupt the local immunosuppressivestate of tumors and establish a self-sustaining antitumor immune cycle.However, the nonspecific systemic distribution of immunomodulatorydrugs can readily induce immune-related adverse events, promptingthe development of powerful delivery systems with targeted and controlledrelease properties. In recent years, stimuli-responsive polymericnanosystems have emerged as intelligent nanoplatforms for drug delivery.These nanosystems can be engineered to maintain the structural stabilityin circulation, accumulate in tumor regions via an enhanced permeabilityand retention (EPR) effect, and respond to various stimuli at desiredsites. Upon TIME-specific signals or exogenous stimuli, these nanostructuresundergo conformational changes or degradation, enabling spatiotemporallycontrolled release of loaded immune agonists, checkpoint inhibitors,or cytokines. This strategy not only significantly enhances the bioavailabilityof immunomodulators at target sites and reduces systemic toxicitiesbut also enables the sequential codelivery of synergistic therapeuticagents. As a result, the immunotherapy combined with stimuli-responsivepolymeric nanosystems can efficiently transform immunologically “cold”tumor into “hot” tumor, ultimately achieving profoundand sustained modulation of the antitumor immune responses.</p><p>This Account highlights recent advances in stimuli-responsive polymericnanosystems with a particular focus on four pivotal functions in cancervaccines: First, they can serve as versatile carriers for immunomodulatorsvia diverse nanostructures; second, specific structural motifs withinpolymers can confer intrinsic adjuvant effects to enhance the activationof the immune system; third, they act as <em>in situ</em> nanovaccinesthrough targeted induction of immunogenic cell death (ICD); last,they can behave as precision regulators of the TIME, converting immunologically“cold” tumor into “hot” tumor. We furtherprovide an in-depth discussion on the design and fabrication of polymericnanovaccines that are responsive to endogenou","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"485–498"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Materials to Devices: An Engineering Perspective on Designing Gallium-Based Liquid Metal Bioelectronics","authors":"Moo Hyun Kim, Jae-Hyun Lee, Jang-Ung Park","doi":"10.1021/accountsmr.5c00349","DOIUrl":"10.1021/accountsmr.5c00349","url":null,"abstract":"<p>Gallium-based liquid metals(LMs) are rapidly revolutionizing thefield of soft and stretchable electronics, especially within the rapidlyevolving biomedical sector. It has excellent biocompatibility, near-zerovapor pressure, and viscosity similar to that of water. It also hasone of the highest surface tensions of any liquid at room temperature.However, it can adopt an adaptive shape form because a thin solidoxide skin forms spontaneously when exposed to oxygen. With the increasingneed for flexible electronic devices capable of seamlessly interfacingwith biological systems, LM offers unparalleled advantages due totheir unique combination of metallic conductivity, fluidic flexibility,and inherent low mechanical modulus. The potential of these materialsto dramatically enhance device functionality and comfort in wearableand implantable technologies has positioned them at the forefrontof emerging bioelectronic solutions. Despite these attractive properties,integrating gallium-based LMs into practical electronic devices remainsa considerable challenge, primarily due to intrinsic material behaviorssuch as high surface tension, instantaneous oxide layer formation,and difficulties in adhering effectively to target substrates. Successfullyovercoming these limitations is critical not only for achieving reliablefunctionality but also for fully realizing the transformative potentialof LM microfabrication technologies.</p><p>In this Account, we systematicallyaddress the engineering challengesassociated with integrating gallium-based LMs. We begin by thoroughlyexamining their fundamental material properties, such as electricaland thermal conductivity, surface tension, and oxide skin behavior,and explicitly link these attributes to practical implications indevice manufacturing and performance. We provide a detailed analysisof oxide skin formation and explain how this influences LM fabricationhandling and long-term device stability. Next, we outline and introducevarious LM microfabrication techniques, including direct printing,stencil patterning, and selective metal wetting methods, and introduceour newly developed patterning method using an external magnetic field.Each LM technique is discussed in depth, highlighting its strengthsand limitations, and emphasizing the critical material considerationsrequired for each method, based on our experiences of research andfindings. Current strategies for integrating LM into bioelectronicswill be explained in two primary categories: (1) mechanically robust3D interconnects used in flexible devices such as smart contact lensesand antennas, and (2) active electrodes designed for interfacing withsoft biological tissues. Special attention is given to sensing andstimulation applications with a focus on optimizing performance, stability,and biocompatibility. We also highlight approaches to mitigate issuesrelated to oxide layers and strategies to improve the electrode reliabilitythrough surface modifications. Finally, this Accou","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"473–484"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Recovery of Keratin from Chicken Feather Waste and Its Processing for Biomedical Applications","authors":"Cariny Polesca,&nbsp;Helena Passos,&nbsp;Jason P. Hallett,&nbsp;João A. P. Coutinho,&nbsp;Mara G. Freire","doi":"10.1021/accountsmr.5c00368","DOIUrl":"10.1021/accountsmr.5c00368","url":null,"abstract":"<p>The globalpoultry industry has grown significantly in recent decadesand is currently producing vast amounts of chicken feather waste,corresponding to around 7 wt % of the total weight of an adult chicken.This waste, which is typically incinerated or landfilled, poses bothenvironmental and economic challenges, while being inconsistent withthe principles of the circular economy. Chicken feathers are composedprimarily of keratin (approximately 90 wt % on a dry weight basis),a natural protein with valuable properties, namely, anti-inflammatoryand antioxidant activities, superior cytocompatibility, and abilityto promote cellular migration. These characteristics make keratinan ideal candidate for various biomedical applications. However, traditionalmethods of recovering keratin from natural biomass are inefficientand costly and involve the use of toxic chemicals, limiting the broaderuse of this waste. In this Account, we discuss a sustainable and efficientprocess for keratin recovery and processing using ionic liquids. Byemploying acetate-based ionic liquids (80 wt % in water), we havedeveloped a method that not only dissolves chicken feathers but alsoallows for high-yield keratin recovery. The developed process significantlyreduces the need for harmful chemicals and energy-intensive stepstraditionally associated with keratin recovery. Furthermore, the ionicliquids can be recovered and reused, which are important elementshighlighted by our technoeconomic assessment. According to the processsimulation, the minimum selling price for keratin is 22 $ per kg,based on a productivity of 350 tons of keratin per year, which issuitable for biomedical applications. The recovered keratin has beenused to develop biocompatible films and hydrogels for wound healing,incorporated into biocomposites with melanin, cellulose, and chitinto enable tunable material properties, and integrated into advanced3D printing technologies for tissue engineering applications. Theproduced keratin films exhibit remarkable properties, including strongantioxidant and anti-inflammatory effects and the potential to promotecell proliferation, thereby accelerating wound closure. Furthermore,the hydrogels produced with keratin and melanin presented outstandingUV-blocking capabilities (up to 99.9%), while the 3D printed scaffoldsexhibited a dynamic shape-change over time, mediated by cellular tractionforces, highlighting their potential for 4D printing toward innovativebioapplications. The work developed demonstrates the feasibility oftransforming a largely untapped waste stream into high-value materials,contributing to both environmental sustainability and advancementsin biomedical technologies. By offering a scalable and cost-effectivemethod for keratin recovery, we aim to inspire future research inthe development of keratin-based materials and the exploration ofother waste-to-resource opportunities.</p>","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"499–509"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application-Oriented Advanced Oxidation Processes: Key Challenges and Pathways toward Large-Scale Deployment","authors":"Yue Jiang,&nbsp;Mingyang Xing","doi":"10.1021/accountsmr.6c00036","DOIUrl":"10.1021/accountsmr.6c00036","url":null,"abstract":"&lt;p&gt;Advanced oxidation technologiesbased on environmental functionalmaterials are widely recognized as a key technical foundation forachieving deep industrial pollution control while simultaneously enablingcarbon mitigation. However, a pronounced gap persists between laboratory-scaleresearch and practical engineering implementation. Many material systemsthat exhibit excellent performance at the milligram scale under well-controlledlaboratory conditions often fail to meet the requirements of real-worldtreatment scenarios, which typically involve ton-scale throughput,continuous operation, and highly complex operating environments. Thisfundamental mismatch is not merely a materials issue, but rather aconsequence of a prevailing research paradigm that has long prioritizedmaximizing intrinsic material performance and refining catalytic reactionmechanisms, while largely overlooking the inevitable constraints associatedwith scale-up, including engineering feasibility, economic sustainability,operational robustness, as well as low-carbon and safety considerations.&lt;/p&gt;&lt;p&gt;In real industrial scenarios, catalytic materials do not functionas isolated entities; rather, their practical effectiveness is tightlyintertwined with reactor configuration, mass-transfer efficiency,and energy delivery modes. Under such conditions, an overemphasison maximizing intrinsic metrics often proves counterproductive duringscale-up. These laboratory-optimized designs may exacerbate catalystdeactivation, intensify energy demand, drive up operational costs,and even introduce cumulative environmental risks, thereby erodingthe overall technological advantage under realistic operating conditions.Collectively, these limitations highlight the necessity of shiftingaway from a strictly “material-centric” research paradigmtoward a process-oriented design strategy that is explicitly guidedby real-world operating demands, with integrated consideration oflow-carbon performance, environmental safety, and long-term operationalrobustness.&lt;/p&gt;&lt;p&gt;Based on these considerations, this review proposesan industry-orientedclosed-loop research paradigm aimed at bridging the gap between laboratoryinnovation and practical deployment. Specifically, real engineeringdemands are first used to backward-define the functional positioningand optimization of materials, thereby aligning material design withapplication-relevant performance targets. Subsequently, material–equipmentintegration is achieved through dedicated reactor and process development,enabling the effective translation of intrinsic material capabilitiesinto system-level efficiency at the reactor scale. Furthermore, life-cycleassessment (LCA) and techno-economic analysis (TEA) are systematicallyincorporated to impose upstream constraints on energy consumption,carbon emissions, cost and environmental risks, ensuring environmentaland economic sustainability of the proposed technological pathway.Finally, through the establishment of industry standards an","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"510–519"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148651007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling Nucleic Acid Affinity Interactions and Adsorption Dynamics on Electrode Material Surfaces for Biosensing Applications","authors":"Kevin M. Koo,&nbsp;Prerna Tripathy,&nbsp;Sophie E. Kenny,&nbsp;Fatema Zerin Farhana,&nbsp;Muhammad J. A. Shiddiky","doi":"10.1021/accountsmr.5c00276","DOIUrl":"10.1021/accountsmr.5c00276","url":null,"abstract":"&lt;p&gt;The inherent interactions betweennucleic acid (NA) biomoleculesand electrode surface materials are broadly fascinating due to theintricate surface chemistries involved as well as wide-ranging applicationsin electrochemical biosensor development.&lt;/p&gt;&lt;p&gt;Through various surfaceanalysis techniques, it was found thatdifferent NA bases (adenine, guanine, cytosine, thymine, and uracil)can interact with gold electrode surfaces with varying degrees ofadsorption affinity. For instance, gold electrode surface adsorptionof oligonucleotides containing solely adenine bases strongly dominatedover those of counterparts consisting of other NA bases. Thus, theunderstanding and manipulation of these NA affinity interaction factorshave allowed specific and controlled NA adsorption on gold electrodesurfaces for electrochemical biosensing applications, such as thesurface assembly of nonthiolated NA capture probes or direct adsorptionof NA targets onto electrodes for biosensing.&lt;/p&gt;&lt;p&gt;For the past decade,our research has focused on devising a varietyof novel NA electrochemical biosensing strategies by uniquely exploitingthe phenomenon of differential NA base-electrode material adsorptionaffinities. This Account summarizes our research programs in usingfundamental knowledge of NA affinity interactions with electrode materialsto develop adsorption-based electrochemical biosensing applicationsfor different major NA biomarker species. We worked on NA targetsthat are representative of current disease-relevant NA biomarker types,such as DNA methylation, microRNA (miRNA), fusion gene mRNA (mRNA),and long noncoding RNA (lncRNA). Hence, this highlights our distinctivebiosensing research expertise in innovatively utilizing basic NA physicochemicalproperties for controlling the interactions between NA sequences andelectrode materials, all toward the frontiers of biomedical, clinical,and agricultural applications.&lt;/p&gt;&lt;p&gt;In this Account, we first providean overview of different intermolecularforces (including electrostatic interaction, hydrophobic force, NAbase stacking, or hydrogen bonding) that govern NA adsorption. Subsequently,we systematically discuss our research studies in modern electrochemicalNA biosensing applications enabled by NA base affinity interactions.Specifically, we focus on our NA adsorption-based electrochemicalstrategies to overcome the unique biosensing differences of diverseDNA methylation, miRNA, mRNA, and lncRNA biomarker types to addresschallenges of cancer mutations and invasive pathogens in healthcareand agricultural settings. Finally, we summarize the future developmentsof this field of NA adsorption-based electrochemical biosensors basedon the present seminal studies investigating NA affinity interactionsof high-dimensional NA structures and different electrode materials.&lt;/p&gt;&lt;p&gt;We envision our Account which highlights the use of fundamentalNA-electrode material adsorption knowledge in driving innovative NAbiosensor technologies for diverse human an","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"431–445"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle–Nanofiber Superstructures","authors":"Bin Zhao,&nbsp;Luiz G. Greca,&nbsp;Bruno D. Mattos","doi":"10.1021/accountsmr.5c00308","DOIUrl":"10.1021/accountsmr.5c00308","url":null,"abstract":"<p>Superstructured particle assembliesare sought as efficient platformsfor transferring properties from the nano- to macroscale while combiningmodularity and versatility with facile and scalable fabrication processes.Such assemblies are achieved by structuring primary particle usingvarious assembly techniques, which enables the control and customizationof morphological features across length scales. Ensuring high cohesionwithin these assemblies is crucial for practical applications, bothto mitigate nanotoxicity and bioaccumulation and to prevent the lossof performance resulting from subunit detachment. In this Account,the integration of biobased nanofibers into particle constructs isdiscussed in terms of their ability to act as universal binders thatoffer several advantages over case-specific strategies to developstrength in superstructures. Cellulose nanofibers, among others, havea remarkable capacity to confer cohesion to virtually any particulatesystem, thereby improving strength and toughness and opening severalopportunities to manipulate their nano- to macrostructures. At thenano- and microscale, nanofibers can disrupt particle lattices, therebyenhancing access to surface functionalities. At the macroscale, nanofibersenable control over the viscoelastic properties of particle suspensionsand govern their consolidation into dried particle–nanofiberconstructs. Cellulose nanofibers are the most widely used in supraparticlefabrication, but several other fibrillar nanomaterials from chitin,amyloid, and aramid show promise for a broad range of particle–nanofiberassemblies. This Account presents a detailed review of the abilityof nanofibers to enhance cohesion and manipulate supraparticle structures.First, cellulose nanofibers are introduced, and aspects like extraction,surface chemistry, modification, and colloidal properties are discussed,as they play important roles in transferring cohesion from the nanofibrillarnetwork onto the particle–nanofiber assembly. Then, nanofiber–particleinteractions in dilute and concentrated regimes are discussed andrelated to the forces and phenomena that drive the consolidation ofthese robust constructs. Analyses of mesh size and crowding of associatednanofiber networks are put into perspective and discussed in termsof particle entrapment and particle–nanofiber interactionsprior to consolidation. Methods currently employed to fabricate superstructuredmaterials are presented, including casting on superhydrophobic surfaces,templates and hydrophilic substrates, foaming for particle–nanofibernetworks at air–liquid interfaces, 3D printing, and spray drying.Finally, practical applications for particle–nanofiber superstructuresare introduced and discussed in terms of the gains obtained by usingwell-defined nanostructured materials and supraparticles.</p>","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 5","pages":"461–472"},"PeriodicalIF":14.1,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}