Jing-Wang Cui, Si-Hua Liu, Liang-Xiao Tan and Jian-Ke Sun*,
{"title":"","authors":"Jing-Wang Cui, Si-Hua Liu, Liang-Xiao Tan and Jian-Ke Sun*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 4","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":14.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/accountsmr.4c00402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144420384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell–Material Interactions in Vascular Tissue Engineering","authors":"Connor D Amelung, Sharon Gerecht","doi":"10.1021/accountsmr.4c00390","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00390","url":null,"abstract":"The vascular system, encompassing blood and lymphatic vessels, is essential for nutrient transport, waste elimination, and homeostasis regulation. Composed of endothelial cells and mural cells, such as smooth muscle cells and pericytes, the vasculature is critical for various physiological processes, including development, organogenesis, wound healing, and tumor metastasis. The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity. However, studying these complex interactions <i>in vivo</i> presents considerable challenges, underscoring the need for innovative research methodologies. For example, traditional 2D cell culture fails to account for the complex, multifaceted environment that cells are exposed to <i>in vivo</i>. Vascular tissue engineering has emerged as a promising approach, aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology. A central facet of vascular tissue engineering is biomaterial design, in which natural or synthetic polymers are assembled into water-swollen networks, or hydrogels, for 3D cell cultures that can last days or weeks. By utilizing hydrogel biomaterials, researchers can create tunable model systems that closely mimic the natural vascular environment, such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel. These customizable microenvironments facilitate critical cell–matrix interactions, enabling investigations into key vascular mechanisms such as adhesion, migration, proliferation, and differentiation. This Account explores key aspects of cell–matrix interactions in vascular tissue engineering and the biomaterials designed to study them. We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues: matrix stiffness can be tuned to mimic the stiffness of <i>in vivo</i> tissues, viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues, spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix, and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling. We then examine how the biochemical properties of materials influence vascular function: matrix composition can replicate the factors expected in the vascular extracellular matrix, bioactive cues are presented to match the complex gradients formed by paracrine signaling, and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks. Finally, we identify major challenges in the field, highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue const","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell–Material Interactions in Vascular Tissue Engineering","authors":"Connor D Amelung, and , Sharon Gerecht*, ","doi":"10.1021/accountsmr.4c0039010.1021/accountsmr.4c00390","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00390https://doi.org/10.1021/accountsmr.4c00390","url":null,"abstract":"<p >The vascular system, encompassing blood and lymphatic vessels, is essential for nutrient transport, waste elimination, and homeostasis regulation. Composed of endothelial cells and mural cells, such as smooth muscle cells and pericytes, the vasculature is critical for various physiological processes, including development, organogenesis, wound healing, and tumor metastasis. The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity. However, studying these complex interactions <i>in vivo</i> presents considerable challenges, underscoring the need for innovative research methodologies. For example, traditional 2D cell culture fails to account for the complex, multifaceted environment that cells are exposed to <i>in vivo</i>. Vascular tissue engineering has emerged as a promising approach, aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology. A central facet of vascular tissue engineering is biomaterial design, in which natural or synthetic polymers are assembled into water-swollen networks, or hydrogels, for 3D cell cultures that can last days or weeks. By utilizing hydrogel biomaterials, researchers can create tunable model systems that closely mimic the natural vascular environment, such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel. These customizable microenvironments facilitate critical cell–matrix interactions, enabling investigations into key vascular mechanisms such as adhesion, migration, proliferation, and differentiation. This Account explores key aspects of cell–matrix interactions in vascular tissue engineering and the biomaterials designed to study them. We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues: matrix stiffness can be tuned to mimic the stiffness of <i>in vivo</i> tissues, viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues, spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix, and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling. We then examine how the biochemical properties of materials influence vascular function: matrix composition can replicate the factors expected in the vascular extracellular matrix, bioactive cues are presented to match the complex gradients formed by paracrine signaling, and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks. Finally, we identify major challenges in the field, highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue c","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 5","pages":"577–588 577–588"},"PeriodicalIF":14.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lattice Energy Reservoir in Metal Halide Perovskites","authors":"Xiaoming Wen*, and , Baohua Jia, ","doi":"10.1021/accountsmr.5c00047","DOIUrl":"10.1021/accountsmr.5c00047","url":null,"abstract":"","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 6","pages":"672–677"},"PeriodicalIF":14.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Perspective on the Rational Design of Spinel Catalysts for Polysulfide Conversion","authors":"Wen Xie, Qian Wu and Zhichuan J. Xu*, ","doi":"10.1021/accountsmr.5c00092","DOIUrl":"10.1021/accountsmr.5c00092","url":null,"abstract":"","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 6","pages":"678–684"},"PeriodicalIF":14.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Man Li, Suixuan Li, Zhihan Zhang, Chuanjin Su, Bryce Wong, Yongjie Hu
{"title":"Advancing Thermal Management Technology for Power Semiconductors through Materials and Interface Engineering","authors":"Man Li, Suixuan Li, Zhihan Zhang, Chuanjin Su, Bryce Wong, Yongjie Hu","doi":"10.1021/accountsmr.4c00349","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00349","url":null,"abstract":"Power semiconductors and chips are essential in modern electronics, driving applications from personal devices and data centers to energy technologies, vehicles, and Internet infrastructure. However, efficient heat dissipation remains a critical challenge, directly affecting their performance, reliability, and lifespan. High-power electronics based on wide- and ultrawide-bandgap semiconductors can exhibit power densities exceeding 10 kW/cm<sup>2</sup>, hundreds of times higher than digital electronics, posing significant thermal management challenges. Addressing this issue requires advanced materials and interface engineering, alongside a comprehensive understanding of materials physics, chemistry, transport dynamics, and various electronic, thermal, and mechanical properties.","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143798531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
