Jing-Wang Cui, Si-Hua Liu, Liang-Xiao Tan and Jian-Ke Sun*,
{"title":"","authors":"Jing-Wang Cui, Si-Hua Liu, Liang-Xiao Tan and Jian-Ke Sun*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 4","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":14.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/accountsmr.4c00402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144420384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell–Material Interactions in Vascular Tissue Engineering","authors":"Connor D Amelung, Sharon Gerecht","doi":"10.1021/accountsmr.4c00390","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00390","url":null,"abstract":"The vascular system, encompassing blood and lymphatic vessels, is essential for nutrient transport, waste elimination, and homeostasis regulation. Composed of endothelial cells and mural cells, such as smooth muscle cells and pericytes, the vasculature is critical for various physiological processes, including development, organogenesis, wound healing, and tumor metastasis. The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity. However, studying these complex interactions <i>in vivo</i> presents considerable challenges, underscoring the need for innovative research methodologies. For example, traditional 2D cell culture fails to account for the complex, multifaceted environment that cells are exposed to <i>in vivo</i>. Vascular tissue engineering has emerged as a promising approach, aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology. A central facet of vascular tissue engineering is biomaterial design, in which natural or synthetic polymers are assembled into water-swollen networks, or hydrogels, for 3D cell cultures that can last days or weeks. By utilizing hydrogel biomaterials, researchers can create tunable model systems that closely mimic the natural vascular environment, such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel. These customizable microenvironments facilitate critical cell–matrix interactions, enabling investigations into key vascular mechanisms such as adhesion, migration, proliferation, and differentiation. This Account explores key aspects of cell–matrix interactions in vascular tissue engineering and the biomaterials designed to study them. We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues: matrix stiffness can be tuned to mimic the stiffness of <i>in vivo</i> tissues, viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues, spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix, and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling. We then examine how the biochemical properties of materials influence vascular function: matrix composition can replicate the factors expected in the vascular extracellular matrix, bioactive cues are presented to match the complex gradients formed by paracrine signaling, and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks. Finally, we identify major challenges in the field, highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue const","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cell–Material Interactions in Vascular Tissue Engineering","authors":"Connor D Amelung, and , Sharon Gerecht*, ","doi":"10.1021/accountsmr.4c0039010.1021/accountsmr.4c00390","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00390https://doi.org/10.1021/accountsmr.4c00390","url":null,"abstract":"<p >The vascular system, encompassing blood and lymphatic vessels, is essential for nutrient transport, waste elimination, and homeostasis regulation. Composed of endothelial cells and mural cells, such as smooth muscle cells and pericytes, the vasculature is critical for various physiological processes, including development, organogenesis, wound healing, and tumor metastasis. The interplay between the biophysical properties of the extracellular matrix and its biochemical composition significantly influences vascular function and integrity. However, studying these complex interactions <i>in vivo</i> presents considerable challenges, underscoring the need for innovative research methodologies. For example, traditional 2D cell culture fails to account for the complex, multifaceted environment that cells are exposed to <i>in vivo</i>. Vascular tissue engineering has emerged as a promising approach, aiming to replicate the architecture and functionality of blood vessels to enhance understanding of vascular development and pathology. A central facet of vascular tissue engineering is biomaterial design, in which natural or synthetic polymers are assembled into water-swollen networks, or hydrogels, for 3D cell cultures that can last days or weeks. By utilizing hydrogel biomaterials, researchers can create tunable model systems that closely mimic the natural vascular environment, such as by modifying polymer backbone functionalization and the local biochemical environment or altering the resultant physical properties of the hydrogel. These customizable microenvironments facilitate critical cell–matrix interactions, enabling investigations into key vascular mechanisms such as adhesion, migration, proliferation, and differentiation. This Account explores key aspects of cell–matrix interactions in vascular tissue engineering and the biomaterials designed to study them. We begin with advancements in material design that replicate the spatial and mechanical properties of vascular tissues: matrix stiffness can be tuned to mimic the stiffness of <i>in vivo</i> tissues, viscoelasticity is introduced to replicate the time-dependent strain associated with biologic fluids and tissues, spatial orientation is designed to mimic the architecture common to naturally occurring extracellular matrix, and degradation is an inherent feature of these materials to facilitate cell-caused microenvironment remodeling. We then examine how the biochemical properties of materials influence vascular function: matrix composition can replicate the factors expected in the vascular extracellular matrix, bioactive cues are presented to match the complex gradients formed by paracrine signaling, and hypoxia can be introduced via material design to understand how angiogenesis occurs at the edges of existing vascular networks. Finally, we identify major challenges in the field, highlighting current obstacles and proposing future strategies to enhance the characterization of vascular tissue c","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 5","pages":"577–588 577–588"},"PeriodicalIF":14.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lattice Energy Reservoir in Metal Halide Perovskites","authors":"Xiaoming Wen, Baohua Jia","doi":"10.1021/accountsmr.5c00047","DOIUrl":"https://doi.org/10.1021/accountsmr.5c00047","url":null,"abstract":"Figure 1. Scheme of lattice energy reservoir as dynamic nanodomain in halide perovskites. Blue LER: before energy storage, red LER: energy accumulation by phonon-lattice coupling, higher potential energy is established over the surrounding. (ph-phonon) Figure 2. (a) Scheme for LER suppress hot carrier cooling. The homojunction with strain of different lattice suppress thermal transport to the surrounding lattice and then induces acoustic-optical phonon upconversion. (b) Proposed phonon dynamics in Perovskites. The labeled phonon dynamic processes are (1) Fröhlich interaction of carriers primarily on the lead-halide framework; (2) relaxation of lead-halide LO phonon, organic sublattice can be excited by phonon–phonon scattering; (3) propagation of acoustic phonon is blocked due to anharmonic phonon–phonon scatterings; (4) upconversion of acoustic phonons; and (5) carrier reheating. (3) Reproduced with permission from ref (3). Copyright 2017 The Authors. Figure 3. PL enhancement in halide perovskites with continuous illumination at the time scale of seconds. PL Intensity (a) and PL decay curves (b) in MAPbI<sub>3</sub> nanoplatelet under continuous illumination (405 nm 200 mW/cm<sup>2</sup>). Figure 4. Schematic photobrightening by LER induced subgap carrier upconversion. (a) Without LER effect before illumination and (c) display a short carrier lifetime. (b) Upon illumination hot LERs form (red regions) and the subgap carrier can be upconverted back to the CB, (d) resulting in a significantly prolonged carrier lifetime. (TS: trapping/metastable states, ph: phonon, e: electron.) Figure 5. Schematic subgap electron upconversion driven by hot LERs under illumination. Figure 6. (a) Time-dependent PL spectra in MAPbBr<sub>3</sub> single crystal under 405 nm excitation at a fluence of 350 mW/cm<sup>2</sup>. (b) Fluorescence intermittency in MAPbBr<sub>3</sub> single grain as a function of time under the continuous excitation of 405 nm. Dr Wen Xiaoming was awarded bachelor’s and master’s degrees from Zhejiang University, and a PhD from Swinburne University, Australia in 2007. From 1989 to 2003, he worked at Yunnan University as full professor and deputy head of department. He has performed research at the University of Melbourne, University of New South Wales, Swinburne University of Technology in Australia and Academia Sinica in Taiwan on ultrafast spectroscopy and photophysics of materials. He is currently a senior researcher and theme leader at RMIT University, focusing on the photophysics of perovskites and photovoltaic applications. Prof Baohua Jia was awarded a PhD from Swinburne University. She is a Fellow of Australian Academy of Technological Sciences and Technologies (FTSE), a Future Fellow of Australian Research Council and Founding Director of Centre for Atomaterials and Nanomanufacturing (CAN) at RMIT University, Australia. Professor Jia serves as Editor-in-Chief for NPJ Nanophotonics. Prof Jia is a Fellow of Optica, and a Fellow of the Inst","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Perspective on the Rational Design of Spinel Catalysts for Polysulfide Conversion","authors":"Wen Xie, Qian Wu, Zhichuan J. Xu","doi":"10.1021/accountsmr.5c00092","DOIUrl":"https://doi.org/10.1021/accountsmr.5c00092","url":null,"abstract":"Figure 1. Illustration of normal spinel, inverse spinel, and defected inverse spinel structures. Figure 2. Illustration of d-orbitals splitting in (a) octahedral field and (b) tetrahedral field. Figure 3. Schematic illustration of the role of spin state and M-O covalency in regulating the polysulfide conversion activity of spinel oxides. (a) The role of spin state in regulating the bonding and antibonding states of molecular orbitals between metal cations and sulfur species. (b) The optimized structures of the (111) plane of spinel oxides. The right box shows that one oxygen atom is connected to one tetrahedral cation and two octahedral cations. (c) Illustration of different M<sub>Oct</sub>–O–M<sub>Td</sub> covalencies and their corresponding active sites in spinel oxides. The top box indicates that the M<sub>Td</sub>- active sites are more likely to be generated when the covalency of M<sub>Td</sub>–O is weaker than that of M<sub>Oct</sub>–O. Otherwise, M<sub>Oct</sub>– active sites are more likely to be generated, as shown in the bottom box. [Reproduced with permission from ref (14). Copyright 2020, Springer Nature.] (d) Illustration of the role of M–O covalency in regulating the electron distribution after bond breakage. A weak M–O covalency leads to an unequal distribution of electrons after bond breakage and the generation of two partially ionic parts. In contrast, a strong M–O covalency makes bond breakage more difficult. Only intermediate M–O covalency contributes to the equal distribution of electrons after bond breakage and the exposure of active sites. [Reproduced with permission from ref (14). Copyright 2020, Springer Nature.] Figure 4. Schematic illustration of the design strategies of spinel catalysts. (a) Illustration of site occupancy switch in spinel structures by adjusting the annealing temperature. X indicates anions (e.g., O, S). [Reproduced with permission from ref (3). Copyright 2025, American Chemical Society, Washington, DC.] (b) The role of doping in regulating the valence electrons of metal and lattice sulfur sites of spinel sulfides. [Reproduced with permission from ref (23). Copyright 2025, Wiley-VCH.] (c) The evolution of Co<sup>3+</sup> spin state and the construction of Co–O–Co spin channel. [Reproduced with permission from ref (24). Copyright 2021, Wiley-VCH.] (d) Illustration of the adsorption–conversion process of polysulfides on the surface of CoFeMnO YSNCs. [Reproduced with permission from ref (18). Copyright 2022, Wiley-VCH.] Figure 5. Outlook and perspectives on the rational design of spinel catalysts for polysulfide conversion. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/accountsmr.5c00092. Additional discussion on spinel structure, cation coordination environment and spin state, and M–O covalency (PDF) A Perspective\u0000on the Rational Design of Spinel Catalysts\u0000for Polysulfide Conversion <span> 2 </span><span> views </span> <span> 0 </span><span> shares </span> <spa","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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