Accounts of materials research最新文献

{"title":"Pore Engineering in Metal–Organic Frameworks for Enhanced Hydrocarbon Adsorption and Separation","authors":"Xiao-Jing Xie, Min-Yi Zhou, Heng Zeng*, Weigang Lu* and Dan Li*, ","doi":"10.1021/accountsmr.4c0033610.1021/accountsmr.4c00336","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00336https://doi.org/10.1021/accountsmr.4c00336","url":null,"abstract":"<p >The separation and purification of hydrocarbons are crucially important processes in the petrochemical industry, as they are essential for producing high-quality chemicals and fuels. However, traditional thermal-driven separation practices, such as cryogenic distillation, are notoriously energy-intensive, accounting for a notable portion of the energy consumption in industrial operations. This has spurred the exploration and development of low-energy and sustainable alternative separation technologies, among which adsorption/desorption-based separation with porous materials has gained significant attention. Metal–organic frameworks (MOFs) are emerging as ideal porous materials for hydrocarbon separation due to their exceptional porosity and structural tunability. This Account delves into the latest advancements in microporous MOFs for hydrocarbon separation, categorizing them based on their pore structures: single array, tandem array, and orthogonal array. Single-array MOFs feature uniformly arranged channel-like pores along the axial direction, facilitating the incorporation of binding sites on the pore surfaces. One notable functional group used in these applications is open metal sites (OMSs), which can engage in strong metal-π interactions with unsaturated hydrocarbons such as acetylene. For example, JNU-1 demonstrates increased binding energy with the increasing pressure of acetylene due to the induce-fit effect, where framework contraction behavior is triggered by its OMSs. JNU-4 offers two binding sites per metal center for acetylene molecules, greatly improving the adsorption capacity. On the other hand, introducing low-polarity groups, as seen in JNU-6-CH<sub>3</sub>, can effectively enhance the separation performance in favor of alkanes while maintaining structural integrity under humid conditions. Another methyl group-modified MOF, JNU-5-CH<sub>3</sub>, exhibits an acetylene-triggered gate-opening effect due to the multiple supramolecular interactions with acetylene. Tandem-array MOFs provide enhanced selectivity and adsorption capacity through the interconnection of spacious cavities with narrow apertures. For instance, JNU-2 with pore-channel interconnected structure exhibits improved separation efficiency for C<sub>2</sub>H<sub>6</sub>/C<sub>2</sub>H<sub>4</sub> and hexane isomers. The slim channels connecting the large cavities act as screening sites for matching-sized molecules to pass through, while the large cavities function as storage sites for large adsorption capacity. Orthogonal-array MOFs, like JNU-3a, feature one-dimensional (1D) channels that enable rapid diffusion, complemented by molecular pockets on both sides that facilitate selective recognition. The dynamic “gourd-shaped” opening of the pocket demonstrates notable adaptability when interacting with different hydrocarbons, allowing for sieving-like behavior in the separation of propylene/propane, as well as efficient separation of ethylene from its mixtures with","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 2","pages":"195–209 195–209"},"PeriodicalIF":14.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pore Engineering in Metal–Organic Frameworks for Enhanced Hydrocarbon Adsorption and Separation","authors":"Xiao-Jing Xie, Min-Yi Zhou, Heng Zeng, Weigang Lu, Dan Li","doi":"10.1021/accountsmr.4c00336","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00336","url":null,"abstract":"The separation and purification of hydrocarbons are crucially important processes in the petrochemical industry, as they are essential for producing high-quality chemicals and fuels. However, traditional thermal-driven separation practices, such as cryogenic distillation, are notoriously energy-intensive, accounting for a notable portion of the energy consumption in industrial operations. This has spurred the exploration and development of low-energy and sustainable alternative separation technologies, among which adsorption/desorption-based separation with porous materials has gained significant attention. Metal–organic frameworks (MOFs) are emerging as ideal porous materials for hydrocarbon separation due to their exceptional porosity and structural tunability. This Account delves into the latest advancements in microporous MOFs for hydrocarbon separation, categorizing them based on their pore structures: single array, tandem array, and orthogonal array. Single-array MOFs feature uniformly arranged channel-like pores along the axial direction, facilitating the incorporation of binding sites on the pore surfaces. One notable functional group used in these applications is open metal sites (OMSs), which can engage in strong metal-π interactions with unsaturated hydrocarbons such as acetylene. For example, JNU-1 demonstrates increased binding energy with the increasing pressure of acetylene due to the induce-fit effect, where framework contraction behavior is triggered by its OMSs. JNU-4 offers two binding sites per metal center for acetylene molecules, greatly improving the adsorption capacity. On the other hand, introducing low-polarity groups, as seen in JNU-6-CH<sub>3</sub>, can effectively enhance the separation performance in favor of alkanes while maintaining structural integrity under humid conditions. Another methyl group-modified MOF, JNU-5-CH<sub>3</sub>, exhibits an acetylene-triggered gate-opening effect due to the multiple supramolecular interactions with acetylene. Tandem-array MOFs provide enhanced selectivity and adsorption capacity through the interconnection of spacious cavities with narrow apertures. For instance, JNU-2 with pore-channel interconnected structure exhibits improved separation efficiency for C<sub>2</sub>H<sub>6</sub>/C<sub>2</sub>H<sub>4</sub> and hexane isomers. The slim channels connecting the large cavities act as screening sites for matching-sized molecules to pass through, while the large cavities function as storage sites for large adsorption capacity. Orthogonal-array MOFs, like JNU-3a, feature one-dimensional (1D) channels that enable rapid diffusion, complemented by molecular pockets on both sides that facilitate selective recognition. The dynamic “gourd-shaped” opening of the pocket demonstrates notable adaptability when interacting with different hydrocarbons, allowing for sieving-like behavior in the separation of propylene/propane, as well as efficient separation of ethylene from its mixtures with alk","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Cathodes for Practical Lithium–Sulfur Batteries","authors":"Jang-Yeon Hwang, Hyeona Park, Hun Kim, Shivam Kansara and Yang-Kook Sun*, ","doi":"10.1021/accountsmr.4c0036810.1021/accountsmr.4c00368","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00368https://doi.org/10.1021/accountsmr.4c00368","url":null,"abstract":"<p >Sulfur, being lightweight, cost-effective, and offering a remarkably high lithium-ion storage capacity, has positioned lithium–sulfur (Li–S) batteries as promising candidates for applications that demand high energy density. These range from electric vehicles (EVs) to urban air mobility (UAM) systems. Despite this potential, Li–S batteries still face significant performance challenges, limiting their practical application. Chief among these challenges are the limited lifespan and low charge–discharge efficiency, predominantly caused by the dissolution of lithium polysulfide intermediate products formed during battery cycling in ether-based electrolytes. Moreover, sulfur and lithium sulfide, which constitute the active material in the cathode, are intrinsically insulating, complicating efforts to increase the active material content in the cathode and fabricate thick cathodes with high conductivity. These issues have long stood in the way of Li–S batteries achieving commercial viability. Overcoming these obstacles requires a multifaceted approach that focuses on modifications at the level of the cathode materials such as the active material, conductive agents, binders, and additives. This Account delves into these key challenges and presents a comprehensive overview of research strategies aimed at enhancing the performance of Li–S batteries with a particular focus on the sulfur cathode. First, the Account addresses practical challenges in Li–S batteries, such as the complex composition of the cathode, the low sulfur utilization efficiency, suboptimal electrolyte-to-sulfur ratios, and nonuniform sulfur conversion reactions. Strategies to overcome these barriers include the design of advanced cathode architectures that promote high sulfur utilization and an improved energy density. Modifications to the components of the cathode and the adjoining materials, such as the incorporation of conductive additives, help mitigate the insulating nature of sulfur.</p><p >Additionally, the Account places particular emphasis on the innovative use of pelletizing techniques in sulfur cathode fabrication, which has demonstrated notable improvements in the cathode performance. One of the Account’s highlights is the discussion of low-temperature operation strategies for Li–S batteries, which is a critical area for real-world application, especially in aerospace and cold-environment operations. There are significant performance differences when transitioning from lab-scale coin cells to larger pouch cells, underscoring the importance of considering cell geometries and their impact on the scalability and performance. Finally, the Account explores the development of all-solid-state Li–S batteries, a promising approach that could fundamentally address the issue of lithium polysulfide dissolution by eliminating the use of liquid electrolytes altogether. The inherent drawbacks of Li–S batteries, such as the insulating nature of sulfur and the challenges of high sulfur ","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 2","pages":"245–258 245–258"},"PeriodicalIF":14.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Cathodes for Practical Lithium–Sulfur Batteries","authors":"Jang-Yeon Hwang, Hyeona Park, Hun Kim, Shivam Kansara, Yang-Kook Sun","doi":"10.1021/accountsmr.4c00368","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00368","url":null,"abstract":"Sulfur, being lightweight, cost-effective, and offering a remarkably high lithium-ion storage capacity, has positioned lithium–sulfur (Li–S) batteries as promising candidates for applications that demand high energy density. These range from electric vehicles (EVs) to urban air mobility (UAM) systems. Despite this potential, Li–S batteries still face significant performance challenges, limiting their practical application. Chief among these challenges are the limited lifespan and low charge–discharge efficiency, predominantly caused by the dissolution of lithium polysulfide intermediate products formed during battery cycling in ether-based electrolytes. Moreover, sulfur and lithium sulfide, which constitute the active material in the cathode, are intrinsically insulating, complicating efforts to increase the active material content in the cathode and fabricate thick cathodes with high conductivity. These issues have long stood in the way of Li–S batteries achieving commercial viability. Overcoming these obstacles requires a multifaceted approach that focuses on modifications at the level of the cathode materials such as the active material, conductive agents, binders, and additives. This Account delves into these key challenges and presents a comprehensive overview of research strategies aimed at enhancing the performance of Li–S batteries with a particular focus on the sulfur cathode. First, the Account addresses practical challenges in Li–S batteries, such as the complex composition of the cathode, the low sulfur utilization efficiency, suboptimal electrolyte-to-sulfur ratios, and nonuniform sulfur conversion reactions. Strategies to overcome these barriers include the design of advanced cathode architectures that promote high sulfur utilization and an improved energy density. Modifications to the components of the cathode and the adjoining materials, such as the incorporation of conductive additives, help mitigate the insulating nature of sulfur.","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable Batteries for Bioelectronics","authors":"Yiding Jiao, Er He, Tingting Ye, Yuanzhen Wang, Haotian Yin and Ye Zhang*, ","doi":"10.1021/accountsmr.4c0034210.1021/accountsmr.4c00342","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00342https://doi.org/10.1021/accountsmr.4c00342","url":null,"abstract":"<p >Implantable bioelectronics that interface directly with biological tissues have been widely used to alleviate symptoms of chronic diseases, restore lost or degraded body functions, and monitor health conditions in real-time. These devices have revolutionized medicine by providing continuous therapeutic interventions and diagnostics. Energy sources are the most critical components in implantable bioelectronics, as they determine operational lifetime and reliability. Compared with other energy storage and harvesting devices and wireless charging methods, batteries provide high energy density and stable power output, making them the preferred choice for many implantable applications. The advent of implantable bioelectronic devices has been significantly propelled by the high energy densities offered by lithium battery technology, which has led to a profound transformation in our daily lives.</p><p >To advance the field of implantable bioelectronics, the development of next-generation implantable batteries is essential. These batteries must be soft to match the mechanical properties of biological tissues, minimizing tissue damage and immune responses. Additionally, they must be biocompatible, particularly when in proximity to vital organs like the heart and brain, to prevent toxicity and adverse reactions. Beyond biocompatibility, these batteries need to exhibit excellent electrochemical performance, thermomechanical resilience, and structural integrity for reliable operation in body fluids over extended periods. Enhancing the energy and power density of these batteries can lead to device miniaturization, extend their service life, improve operating efficiency, and meet a broader range of high-power applications. Achieving these advancements not only enables cableless and shape-conformal integration with multifunctionality but also underscores the significant research efforts dedicated to understanding and optimizing the performance of next-generation implantable batteries. To this end, numerous research efforts have been devoted in recent years to developing next-generation implantable batteries from material development, structural design, and performance optimization perspectives.</p><p >In this Account, we first outline the development history of current implantable batteries from their inception to the present day. We then delineate the requirements for the next generation of implantable batteries, considering emerging application scenarios. Subsequently, we review the recent advancements in the development of soft, biocompatible, long-term stable, high-energy, and high-power-density implantable batteries. Additionally, we explore the efficient integration of these batteries into biomedical devices. We conclude with the development routes and future perspectives for implantable batteries. This Account promotes the development of new implantable batteries through the collaboration of multiple disciplines, including energy, materials, chemistr","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 2","pages":"221–232 221–232"},"PeriodicalIF":14.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable Batteries for Bioelectronics","authors":"Yiding Jiao, Er He, Tingting Ye, Yuanzhen Wang, Haotian Yin, Ye Zhang","doi":"10.1021/accountsmr.4c00342","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00342","url":null,"abstract":"Implantable bioelectronics that interface directly with biological tissues have been widely used to alleviate symptoms of chronic diseases, restore lost or degraded body functions, and monitor health conditions in real-time. These devices have revolutionized medicine by providing continuous therapeutic interventions and diagnostics. Energy sources are the most critical components in implantable bioelectronics, as they determine operational lifetime and reliability. Compared with other energy storage and harvesting devices and wireless charging methods, batteries provide high energy density and stable power output, making them the preferred choice for many implantable applications. The advent of implantable bioelectronic devices has been significantly propelled by the high energy densities offered by lithium battery technology, which has led to a profound transformation in our daily lives.","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational Design and Controlled Synthesis of MOF-Derived Single-Atom Catalysts","authors":"Weibin Chen, Bingbing Ma and Ruqiang Zou*, ","doi":"10.1021/accountsmr.4c0033010.1021/accountsmr.4c00330","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00330https://doi.org/10.1021/accountsmr.4c00330","url":null,"abstract":"<p >Single-atom catalysts (SACs) represent a transformative advancement in heterogeneous catalysis, offering unparalleled opportunities for maximizing atomic efficiency and enhancing performance. SACs are characterized by isolated metal atoms uniformly dispersed on suitable supports, ensuring each metal atom serves as an independent catalytic site. This dispersion mitigates metal atom aggregation, a common issue in conventional nanocatalysts, thus enabling superior activity, selectivity, and stability. Metal–organic frameworks (MOFs) have emerged as an ideal platform for SAC synthesis due to their structural diversity, tunable coordination environments, and high surface areas. MOFs provide well-defined coordination sites that facilitate the precise stabilization of single metal atoms, presenting significant advantages over traditional supports like metal oxides and metal materials. Carbonization of MOFs yields MOF-derived carbon materials that retain key structural characteristics while offering enhanced electrical conductivity and stability, making them suitable for various catalytic applications.</p><p >Recent advances in the rational design and controlled synthesis of MOF-derived SACs have significantly improved their performance in electrocatalytic processes such as the oxygen reduction reaction (ORR) and carbon dioxide reduction reaction (CO<sub>2</sub>RR). However, challenges remain, including maintaining structural integrity during high-temperature carbonization, enhancing mass and electron transport and ensuring the stability of isolated metal atoms under reaction conditions. To address these challenges, strategies such as using structure-directing agents to stabilize MOF frameworks, forming high-energy porous carbon networks, and optimizing support morphologies have been developed to maximize active site exposure and accessibility. On the other hand, the interplay between active metal sites and their coordination environments is crucial in determining the catalytic activity and selectivity of SACs. Advanced computational modeling, coupled with experimental validation, has provided insights into the electronic structure of SACs and the interactions between metal atoms and supports. These insights have enabled researchers to fine-tune local atomic coordination, leading to significant enhancements in performance. For instance, modifying the coordination environment of metal atoms optimizes the binding strength of reaction intermediates, thereby improving both activity and selectivity. This account highlights our group’s contributions to MOF-derived SACs, focusing on innovative design, functionalization, and synthesis approaches that enhance catalytic activity. Notable strategies include using structure-directing agents to maintain pore connectivity during carbonization, preserving high surface areas, and enhancing mass transport. We also discuss the design of high-energy MOF-derived porous carbon networks that facilitate continuous electron","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 2","pages":"210–220 210–220"},"PeriodicalIF":14.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational Design and Controlled Synthesis of MOF-Derived Single-Atom Catalysts","authors":"Weibin Chen, Bingbing Ma, Ruqiang Zou","doi":"10.1021/accountsmr.4c00330","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00330","url":null,"abstract":"Single-atom catalysts (SACs) represent a transformative advancement in heterogeneous catalysis, offering unparalleled opportunities for maximizing atomic efficiency and enhancing performance. SACs are characterized by isolated metal atoms uniformly dispersed on suitable supports, ensuring each metal atom serves as an independent catalytic site. This dispersion mitigates metal atom aggregation, a common issue in conventional nanocatalysts, thus enabling superior activity, selectivity, and stability. Metal–organic frameworks (MOFs) have emerged as an ideal platform for SAC synthesis due to their structural diversity, tunable coordination environments, and high surface areas. MOFs provide well-defined coordination sites that facilitate the precise stabilization of single metal atoms, presenting significant advantages over traditional supports like metal oxides and metal materials. Carbonization of MOFs yields MOF-derived carbon materials that retain key structural characteristics while offering enhanced electrical conductivity and stability, making them suitable for various catalytic applications.","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-Functionalized Solid-State Nanochannels with Enhanced Sensing","authors":"Xiaojin Zhang,&nbsp;Haowen Cai,&nbsp;Tiantian Hu,&nbsp;Meihua Lin,&nbsp;Yu Dai* and Fan Xia,&nbsp;","doi":"10.1021/accountsmr.4c0032310.1021/accountsmr.4c00323","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00323https://doi.org/10.1021/accountsmr.4c00323","url":null,"abstract":"<p >After billions of years of evolution, organisms in nature have almost completed the intelligent manipulation of all life processes. Biological nanopores embedded in the cell membrane of organisms are representatives with intelligent manipulation capabilities. Biological nanopores can achieve controllable transmembrane transport of various ions and molecules, playing an important role in molecular biology processes such as substance exchange, signal transmission, energy conversion, and system function regulation in cells. Scientists have utilized biological nanopores for sensing analysis, such as gene sequencing and single-molecule detection. However, due to the characteristic that proteins (components of biological nanopores) cannot exist stably for a long time, scientists have developed solid-state nanopores/nanochannels with high mechanical strength, strong plasticity, and easy surface modification.</p><p >The sensing technology based on solid-state nanopores/nanochannels has attracted widespread attention in research fields such as biology, chemistry, and physics due to its advantages of fast speed, high throughput, and label free. Specific target capture can be achieved by probe modification at the inner walls of solid-state nanopores/nanochannels. When the target binds to the probe, the spatial hindrance, charge distribution, and hydrophilicity/hydrophobicity inside the channel change, thereby affecting the ion current output signal. At present, the sensing technology based on solid-state nanopores/nanochannels has achieved in situ detection of targets with sizes ranging from 100 pm-100 nm. It is worth noting that due to the inability of targets larger than 1 μm, such as cells, to pass through the channel, inner wall functionalized nanopores/nanochannels cannot achieve direct in situ detection of cells.</p><p >In fact, the surfaces of nanopores/nanochannels that can be used for functionalization include an inner wall and outer surface. Our group has first conducted a series of experiments to distinguish the probes at the inner wall and outer surface of nanochannels and proved that the probes on the outer surface can also be helpful for detection. In recent years, our research has focused on the outer surface of solid-state nanochannels, which presents a highly controllable model to study the ability to independently regulate ion transport. In addition, our work is followed by many groups in a short period. Here, we mainly summarize the DNA functionalization that distinguishes the inner wall and outer surface of nanochannels to enhance the sensitivity, specificity, and accuracy of nanochannel sensing. The challenges and future development opportunities faced by nanochannels in the field of sensing are explored. We believe that the content of this Account has certain guiding significance for the DNA functionalization of nanochannels and their applications in sensing.</p>","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"6 3","pages":"285–293 285–293"},"PeriodicalIF":14.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-Functionalized Solid-State Nanochannels with Enhanced Sensing","authors":"Xiaojin Zhang, Haowen Cai, Tiantian Hu, Meihua Lin, Yu Dai, Fan Xia","doi":"10.1021/accountsmr.4c00323","DOIUrl":"https://doi.org/10.1021/accountsmr.4c00323","url":null,"abstract":"After billions of years of evolution, organisms in nature have almost completed the intelligent manipulation of all life processes. Biological nanopores embedded in the cell membrane of organisms are representatives with intelligent manipulation capabilities. Biological nanopores can achieve controllable transmembrane transport of various ions and molecules, playing an important role in molecular biology processes such as substance exchange, signal transmission, energy conversion, and system function regulation in cells. Scientists have utilized biological nanopores for sensing analysis, such as gene sequencing and single-molecule detection. However, due to the characteristic that proteins (components of biological nanopores) cannot exist stably for a long time, scientists have developed solid-state nanopores/nanochannels with high mechanical strength, strong plasticity, and easy surface modification.","PeriodicalId":72040,"journal":{"name":"Accounts of materials research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142905533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}