3D printing in medicine最新文献

{"title":"Custom-made 3D-printed X-ray shield for tumor-specific irradiation of xenograft mice.","authors":"Markus Lechner, Anna Kolz, Kristina Herre, Dana Matzek, Adrian Schomburg, Bastian Popper","doi":"10.1186/s41205-025-00264-z","DOIUrl":"10.1186/s41205-025-00264-z","url":null,"abstract":"<p><strong>Background: </strong>Xenograft mouse models play an important role in preclinical cancer research, particularly in the development of new therapeutics. To test the efficacy of a combination therapy consisting of radiation and new drug candidates, it is crucial that only the tumor area is irradiated, while other parts of the body are shielded. In this study, a 3D-printed radiopaque back shield was designed for tumor-specific irradiation and evaluated in a xenograft mouse model.</p><p><strong>Methods: </strong>Different radiopaque materials were initially tested for their shielding properties using the Multirad 225 X-ray irradiator and the most suitable material was used for printing a back shield with a tumor site-specific opening of the cover. Tumor bearing mice were irradiated four times with a dose of 3.5 Gy. To evaluate proper body shielding, blood samples, spleens and bone marrow were examined at the end of the experiment.</p><p><strong>Results: </strong>A tungsten filament was identified to be most efficient for shielding and used to 3D print a pie-slice-shaped back shield with a tumor-site specific opening, while polylactic acid was used to print a scaffold that ensured proper positioning of the shield. The simple design allowed cost-efficient and fast 3D printing, easy handling and individual modifications of the tumor site openings. In terms of animal safety, the product provided sufficient shielding in the low-dose irradiation protocols of xenograft mice.</p><p><strong>Conclusion: </strong>The custom-designed 3D-printed tungsten back shields provide proper shielding of the animals body and allow for subcutaneous tumor irradiation under standardized conditions.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"17"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed skull model for enhancing training in external ventricular drainage within medical education.","authors":"Katharina Scheidt, Fabian Kropla, Dirk Winkler, Robert Möbius, Martin Vychopen, Johannes Wach, Erdem Güresir, Ronny Grunert","doi":"10.1186/s41205-025-00263-0","DOIUrl":"10.1186/s41205-025-00263-0","url":null,"abstract":"<p><strong>Background: </strong>The importance of reducing error rates in invasive procedures has led to the development of teaching phantoms. In collaboration with surgeons and engineers at the University Hospital of Leipzig, a new 3D-printed simulation model for external ventricular drainage was created. This model includes system-relevant components such as the ventricular system, the surrounding brain tissue and the skull bone to be trephined. The methodology for developing the simulation model is described in detail. Additionally, the system was initially evaluated by neurosurgeons using a Likert scale. Future studies are planned to assess the system's accuracy and perform comparative analyses.</p><p><strong>Methods: </strong>The data required for analysis were extracted from medical images. The phantom consists of three components: the ventricular system, the brain mass, and the skull bone. The bone component was fabricated via 3D printing using a realistic hard polyamide, PA12. The ventricular system was also 3D printed as a hollow structure using a flexible material, Elastic Resin 50 A from Formlabs. The brain tissue was modeled via a cast gelatin mold. The cerebrospinal fluid was a water solution.</p><p><strong>Results: </strong>The system's initial tests successfully simulated cerebrospinal fluid flow through the tube into the ventricular system. The skull can be trepanned. Additional materials are required at the drilling sites because of chip formation. A more pointed cannula than usual can puncture the ventricular system. With a concentration of 30 g/l, gelatin is a realistic imitation of brain tissue.</p><p><strong>Conclusion: </strong>All essential components of the skull, brain and ventricle exhibit a degree of realism that has never been achieved before. In terms of its design and reproducibility, the model is exceptionally well suited for training and consolidating methods and procedures as part of a realistic training program for the placement of external ventricular drainage.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"16"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of distal radius giant cell tumor with 3D-printed metal prosthesis combined with mesh patch.","authors":"Tianwen Zhang, Xiaoning Tan, Zhenchao Yuan, Bin Liu, Jiachang Tan","doi":"10.1186/s41205-025-00261-2","DOIUrl":"10.1186/s41205-025-00261-2","url":null,"abstract":"<p><strong>Objective: </strong>This study introduces a surgical technique involving the use of 3D-printed all-metal prostheses combined with mesh patches for the treatment of distal radial giant cell tumors, analyzing and evaluating the midterm outcomes for patients undergoing this treatment. The experience provides insights into the application of prosthesis replacement for reconstructing distal radial defects.</p><p><strong>Methods: </strong>From January 2018 to January 2021, our center treated five cases of distal radial giant cell tumors using 3D-printed all-metal prostheses combined with mesh patches. Postoperative pain, range of motion, and grip strength were evaluated for all patients. Oncological outcomes, complications, and degenerative changes in the wrist joint were also assessed. Functional outcomes were evaluated based on the Mayo wrist score system.</p><p><strong>Results: </strong>The average follow-up period was 40.8 months (range: 32-66months). At the last follow-up, the mean range of motion (ROM) in the affected wrists was 20° extension, 21.6° flexion, 71.2° pronation, and 50° supination. The mean grip strength on the affected side was 64.2% compared to the unaffected side, with a Mayo score of 70. There were no incidences of aseptic loosening, wrist subluxation, or infections post-prosthesis replacement, although two cases presented with distal radioulnar joint dislocation. Of these, one case demonstrated ulnar impaction syndrome with positive ulnar variance and lunate bone degenerative changes on the 12-month postoperative radiographs. No recurrences or metastases were observed.</p><p><strong>Conclusion: </strong>Utilizing 3D-printed metal prostheses and mesh grafts for the treatment of Campanacci Grade III or recurrent giant cell tumors of the distal radius is an effective approach. This strategy provides favorable functional outcomes during the early to mid stages of treatment, while also maintaining a low risk of complications. The concurrent use of mesh grafts facilitates early postoperative exercise, thereby accelerating functional recovery. Moreover, the intraoperative protection or reconstruction of joint ligaments, along with precise matching of the prostheses, contributes to a reduction in the risk of complications.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"15"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional vs. 3D printed band and loop space maintainers: a fracture strength analysis.","authors":"Sakshi Metkar, Bhagyashree Thakur, Dian Agustin Wahjuningrum, Ali A Assiry, Khalid Alshamrani, Sudhir Rama Varma, Ajinkya M Pawar, Mohmed Isaqali Karobari","doi":"10.1186/s41205-025-00262-1","DOIUrl":"10.1186/s41205-025-00262-1","url":null,"abstract":"<p><p>Premature loss of primary teeth is a common occurrence in pediatric dentistry and often necessitates the use of space maintainers to prevent complications. Traditional space maintainers, such as band and loop space maintainers (BLSM), have been widely used, but are fabricated using conventional methods. With advancements in technology, three-dimensional (3D) printing has emerged as a promising alternative for fabricating dental appliances including space maintainers. This study aimed to evaluate and compare the fracture strengths of conventional band and loop space maintainers (C-BLSMs) fabricated using stainless steel with that of 3D printed BLSMs manufactured using additive manufacturing techniques. Fifteen C-BLSM and fifteen 3D printed BLSMs were fabricated and subjected to fracture-strength testing using a universal testing machine. The maximum occlusal bite force in the mixed dentition was determined based on established literature. Statistical analysis was performed to compare the mean fracture resistance between the two groups. The mean fracture resistance of the 3D printed BLSMs was significantly higher (308.53 N) than that of C-BLSMs (130.85 N). This difference was statistically significant (p < 0.05), highlighting the superior mechanical properties of 3D printed BLSMs. Three-dimensional printing technology offers significant advantages in terms of fracture strength compared with conventional fabrication methods for BLSMs.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"14"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsoft HoloLens 2 vs. tablet-based augmented reality and 3D printing for fronto-orbital reconstruction of craniosynostosis: a case study.","authors":"Alicia Pose-Díez-de-la-Lastra, Mónica García-Sevilla, Austin Tapp, Manuel Tousidonis, Juan-Vicente Darriba-Alles, Marius George Linguraru, Javier Pascau, Santiago Ochandiano","doi":"10.1186/s41205-025-00251-4","DOIUrl":"10.1186/s41205-025-00251-4","url":null,"abstract":"<p><strong>Background: </strong>Craniosynostosis is a congenital condition characterized by the premature fusion of cranial sutures, leading to potential complications such as abnormal skull growth, increased intracranial pressure, and cognitive delays. Traditionally, open cranial vault reconstruction (OCVR) has been used to treat this condition. However, it is highly subjective and greatly dependent on the surgeon's expertise, which can lead to residual deformities and the need for reoperation. Effective preoperative planning can greatly improve surgical outcomes, although the major challenge is accurately translating this plan into the clinical setting. Recently, augmented reality (AR) and 3D printing have emerged as promising technologies to facilitate this endeavor. In this work, we propose three alternatives, leveraging these technologies, to guide the precise repositioning of remodeled bone fragments in the patient.</p><p><strong>Methods: </strong>The three guidance methods are AR on a tablet, AR with Microsoft HoloLens 2, and 3D-printed spacers. The accuracy of each method was assessed by measuring the deviation of each bone fragment from the virtual surgical plan (VSP) in a simulated environment using 3D-printed phantoms based on a 14-month-old boy with trigonocephaly. The same assessment was also performed during his actual surgery.</p><p><strong>Results: </strong>All three guidance methods demonstrated similar levels of accuracy, with mean placement errors below 1 mm in all cases. The AR systems allowed for real-time adjustments, enhancing precision. Statistical analysis showed no significant differences in error rates between the different methods or attempts.</p><p><strong>Conclusions: </strong>Integrating AR and 3D printing into craniosynostosis surgery holds great potential for improving OCVR. While 3D-printed spacers are useful when digital technologies are unavailable, AR-based methods provide more comprehensive guidance. Nevertheless, our study suggests that the choice may depend more on the specific clinical context, user-specific skills, and available resources rather than on a clear superiority of one method over the others.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trabecular-bone mimicking osteoconductive collagen scaffolds: an optimized 3D printing approach using freeform reversible embedding of suspended hydrogels.","authors":"Michael G Kontakis, Marie Moulin, Brittmarie Andersson, Norein Norein, Ayan Samanta, Christina Stelzl, Adam Engberg, Anna Diez-Escudero, Johan Kreuger, Nils P Hailer","doi":"10.1186/s41205-025-00255-0","DOIUrl":"10.1186/s41205-025-00255-0","url":null,"abstract":"<p><strong>Background: </strong>Technological constraints limit 3D printing of collagen structures with complex trabecular shapes. However, the Freeform Reversible Embedding of Suspended Hydrogels (FRESH) method may allow for precise 3D printing of porous collagen scaffolds that carry the potential for repairing critical size bone defects.</p><p><strong>Methods: </strong>Collagen type I scaffolds mimicking trabecular bone were fabricated through FRESH 3D printing and compared either with 2D collagen coatings or with 3D-printed polyethylene glycol diacrylate (PEGDA) scaffolds. The porosity of the printed scaffolds was visualized by confocal microscopy, the surface geometry of the scaffolds was investigated by scanning electron microscopy (SEM), and their mechanical properties were assessed with a rheometer. The osteoconductive properties of the different scaffolds were evaluated for up to four weeks by seeding and propagation of primary human osteoblasts (hOBs) or SaOS-2 cells. Intracellular alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) activities were measured, and cells colonizing scaffolds were stained for osteocalcin (OCN).</p><p><strong>Results: </strong>The FRESH technique enables printing of constructs at the millimetre scale using highly concentrated collagen, and the creation of stable trabecular structures that can support the growth osteogenic cells. FRESH-printed collagen scaffolds displayed an intricate and fibrous 3D network, as visualized by SEM, whereas the PEGDA scaffolds had a smooth surface. Amplitude sweep analyses revealed that the collagen scaffolds exhibited predominantly elastic behaviour, as indicated by higher storage modulus values relative to loss modulus values, while the degradation rate of collagen scaffolds was greater than PEGDA. The osteoconductive properties of collagen scaffolds were similar to those of PEGDA scaffolds but superior to 2D collagen, as verified by cell culture followed by analysis of ALP/LDH activity and OCN immunostaining.</p><p><strong>Conclusions: </strong>Our findings suggest that FRESH-printed collagen scaffolds exhibit favourable mechanical, degradation and osteoconductive properties, potentially outperforming synthetic polymers such as PEGDA in bone tissue engineering applications.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"11"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel algorithm for streamlined surgeon-dominated patient-specific implant design in computer-assisted jaw reconstruction.","authors":"Ankit Nayak, Jane Jingya Pu, Xingna Yu, Yu-Xiong Su","doi":"10.1186/s41205-025-00260-3","DOIUrl":"10.1186/s41205-025-00260-3","url":null,"abstract":"<p><strong>Background: </strong>Computer-assisted surgery has transformed the approach to jaw resection and reconstruction in recent years. However, the extensive time and technical expertise needed for the planning and creation of patient-specific implants and guides have posed significant challenges for many surgeons in the field. This study introduces a novel algorithm designed to streamline the traditionally intricate and time-consuming Computer-Aided Design (CAD) process for developing patient-specific implants (PSIs).</p><p><strong>Methods: </strong>The algorithm requires a three-dimensional (3D) model of the reconstructed part. A set of points is selected along the planned location of the plate by the surgeon, defining both the geometry and the positions of the screw holes. These points are then connected to create trace lines, followed by smoothing using cubic-spline data interpolation. Subsequently, a rectangle is swept along the trace line to form the skeleton of the PSI's surface model. Screw holes are incorporated into the surface model, which is then converted into 3D printable file format. Finite element analysis is conducted to evaluate the functionality of the designed PSI.</p><p><strong>Results: </strong>Implant design time exhibits significant reductions with the proposed algorithm, which optimizes the model files for printing. Finite Element Analysis is successfully applied to demonstrate the stress levels in the implant plate, which are within safe limits for titanium 3D-printed implants.</p><p><strong>Conclusions: </strong>This algorithm offers a faster, more efficient, and accurate alternative to traditional CAD methods, with the potential to revolutionize the field of patient-specific implant design. Furthermore, the study demonstrates the utility of a mechanistic model for correlating patient bite force with muscle forces in the literature.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"12"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalizable deep learning framework for 3D medical image segmentation using limited training data.","authors":"Tobias Ekman, Arthur Barakat, Einar Heiberg","doi":"10.1186/s41205-025-00254-1","DOIUrl":"10.1186/s41205-025-00254-1","url":null,"abstract":"<p><p>Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective, leading to inter-observer variability. Machine learning algorithms, particularly deep learning models, have gained traction for automating the process and are now considered state-of-the-art. However, deep-learning methods typically demand large datasets for fine-tuning and powerful graphics cards, limiting their applicability in resource-constrained settings. In this paper we introduce a robust deep learning framework for 3D medical segmentation that achieves high performance across a range of medical segmentation tasks, even when trained on a small number of subjects. This approach overcomes the need for extensive data and heavy GPU resources, facilitating adoption within healthcare systems. The potential is exemplified through six different clinical applications involving orthopedics, orbital segmentation, mandible CT, cardiac CT, fetal MRI and lung CT. Notably, a small set of hyper-parameters and augmentation settings produced segmentations with an average Dice score of 92% (SD = ±0.06) across a diverse range of organs and tissues.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"9"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Site evaluation of a novel point-of-care 3D printing quality assurance protocol for a material jetting 3D printer.","authors":"Matthew D Marquardt, Nicholas Beemster, William Corcuera, Dylan T Beckler, Kyle VanKoevering, Megan Malara, Teri Snyder, Zachary C Thumser","doi":"10.1186/s41205-025-00259-w","DOIUrl":"10.1186/s41205-025-00259-w","url":null,"abstract":"<p><strong>Background: </strong>The maturation of 3D printing technologies has opened up a new space for patient advancements in healthcare from trainee education to patient specific medical devices. Point-of-care (POC) manufacturing, where model production is done on-site, includes multiple benefits such as enhanced communication, reduced lead time, and lower costs. However, the small scale of many POC manufacturing operations complicates their ability to establish quality assurance practices. This study presents a novel low-cost quality assurance protocol for POC 3D printing.</p><p><strong>Methods: </strong>Four hundred specially designed quality assurance cubes were printed across four material jetting printers (J5 Medijet, Stratasys, Eden Prairie, Minnesota, USA) at two large medical centers. Three inner dimension and three outer dimension measurements as well as edge angles were measured for every cube by trained research personnel. The delta and absolute error was calculated for each cube and then compared across variables (axis, material, inner vs. outer dimension, swath and machine/site/personnel) using ANOVA analysis.</p><p><strong>Results: </strong>Print axis and inner vs. outer dimension of the model produced statistically significant differences in error while there was no statistically significant difference in the error for material, print swath, or machine/site/personnel. For the print axes, the printers produced an average error of 26, 53, and 57 μm and the error at three sigma was found to be 100, 158, and 198 μm for the Z, R, and Theta axes, respectively.</p><p><strong>Conclusion: </strong>This study demonstrates that this novel protocol is both feasible and reliable for quality assurance in POC 3D printing across multiple sites. This protocol offers an adaptable framework that allows users to tailor the QA process to their specific needs. Through the comprehensive method, users can measure and identify all relevant factors that might introduce error into their printed product and then follow the most critical aspects for their situation across every print. The QA cubes produced via this protocol can provide guidance on print quality and alert users to unsatisfactory machine operation which could cause prints to fall outside of engineering and clinical tolerances.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"10"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of three-dimensional printing technology in laparoscopic right hemicolectomy for colon cancer: a pilot study and video demonstration.","authors":"Zongxian Zhao, Rundong Yao, Yuan Yao, Zongju Hu, Shu Zhu, Fusheng Wang","doi":"10.1186/s41205-025-00258-x","DOIUrl":"10.1186/s41205-025-00258-x","url":null,"abstract":"<p><strong>Background: </strong>Patients who undergo laparoscopic right hemicolectomy often have vascular anomalies, creating challenges for surgeons. Preoperative identification of vascular anomalies and intraoperative precise navigation can enhance surgical safety and reduce the difficulty of the procedure. Accordingly, this study aimed to explore and evaluate the application of three-dimensional (3D) reconstruction and printing technology in laparoscopic right hemicolectomy and its assistance in preoperative planning and intraoperative navigation.</p><p><strong>Method: </strong>11 3D-reconstructed images and printed models of right hemicolectomy vasculature were preoperatively created to assist in developing individualized surgical plans. Intraoperatively, essential vessels (gastrocolic trunk of Henle, GTH) were identified and located with the help of the 3D printed models. Additionally, 36 cases without the assistance of 3D printing were retrospectively collected for the control group. Statistical analysis was performed to evaluate the impact of the 3D printed models on surgery-related characteristics.</p><p><strong>Results: </strong>The 3D-printed models accurately depicted anatomical structures, particularly the positions and adjacent relationships of essential vessels, including the superior mesenteric artery (SMA), superior mesenteric vein (SMV), GTH and related arterial/venous branches. The operation time was significantly lower in the 3D printing group (198.6 ± 8.8 min in 3D printing group vs. 230.7 ± 47.5 min in control group, P = 0.025).</p><p><strong>Conclusions: </strong>In conclusion, this study represents a novel vascular 3D printed modelfor surgical planning and intraoperative navigation in laparoscopic right hemicolectomy. It underscores the potential clinical applications of 3D printing in this context. Preoperative identification of vascular anomalies and precise intraoperative navigation can feasibly reduce surgical difficulty and enhance safety.</p>","PeriodicalId":72036,"journal":{"name":"3D printing in medicine","volume":"11 1","pages":"8"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}