Advances in biochemical engineering/biotechnology最新文献_第6页

Correction to: Perspectives Towards AI and ML. 更正：对AI和ML的看法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_331

Guoquan Wu, Zhe Wu

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Mathematical Modeling. 数学建模。

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Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_296

Botond Szilágyi

{"title":"Mathematical Modeling.","authors":"Botond Szilágyi","doi":"10.1007/10_2025_296","DOIUrl":"10.1007/10_2025_296","url":null,"abstract":"Solution crystallization is becoming increasingly important as separation, purification, and controlled particle formation of biomolecules in pharmaceutical applications, with high potential as a green and scalable method at an industrial level. As this book's previous chapters discussed already, a large amount of attention is paid to the fundamental aspects of nucleation and growth, as triggering the crystallization of macromolecules is often challenging. Once the suitable ranges of the key thermodynamic conditions are identified, such as the solvent system, precipitating agent, concentration, pH, and temperature, the toolsets of the crystallization process engineering, relying on mathematical modeling, can support the process understanding, design, optimization, and control/operation.As a primer to this chapter, one must keep in mind that the results drawn from the relatively small number of proteins and other biomolecular systems studied in detail in the past indicate that a strong correspondence exists between the growth behavior and mechanisms of the biomolecule crystals with theories accumulated into the crystallization of inorganic small-molecule crystals. Although there is no guarantee that all protein and other biomolecular systems analyzed in the future will obey the same or similar fundamental rules, given the available evidence, a generic crystallization modeling and control overview will be given here. This chapter is divided into two main sections. Firstly, the mathematical modeling and simulation aspects will be described, which can help to understand, analyze, and optimize the processes on a manufacturing level. Secondly, control solutions will be presented for crystallizers that enable the realization of the desired products.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"323-353"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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From Muscle Fibers to Functional Foods: Bridging Conventional and Cultivated Approaches. 从肌肉纤维到功能性食品：连接传统和人工方法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_290

Martin Krøyer Rasmussen, Rebekka Rinder Thøgersen, Jette Feveile Young, Margrethe Therkildsen

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Consumer and Social Perspectives to Cultivated Meat. 消费者和社会对养殖肉类的看法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_332

Liisa Lähteenmäki, Angelica Rossi

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Phase Diagrams as a DOE Tool in Biomolecular Crystallization. 相图在生物分子结晶研究中的应用。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_305

Dorota Antos, Michał Kołodziej, Bartłomiej Filip, Wojciech Piątkowski

{"title":"Phase Diagrams as a DOE Tool in Biomolecular Crystallization.","authors":"Dorota Antos, Michał Kołodziej, Bartłomiej Filip, Wojciech Piątkowski","doi":"10.1007/10_2025_305","DOIUrl":"10.1007/10_2025_305","url":null,"abstract":"This chapter describes the methodology and theoretical background for establishing crystallization phase diagrams of biomolecules with a focus on proteins whose crystallization involves specific problems which are not met in the case of small molecules. These problems arise from the effects triggered by the heterogeneity of the protein crystals as a result of water uptake, the drift of pH in the crystallization medium, and the hydrodynamic conditions occurring in stirring devices. Each of them can affect the shape of the phase diagram and hence the location of the crystallization window on the plane of operating variables. Water uptake in protein crystals influences the equilibrium concentration of the constituents of the crystallization medium and, thereby, alters the boundary of the phase diagram. pH drift occurs in the course of the phase transition as a result of protein dissociation in aqueous solutions, which disturbs the crystallization equilibrium. The method of stirring the crystallization medium used to establish the phase diagram has an impact on the formation of the crystalline phase and thus also on the boundaries of the phase diagram. This chapter aims to elucidate the mechanism underlying these effects and provides hints for their quantification and the establishment of crystallization phase diagrams by adequate experimental procedures.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"117-138"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microfluidic Devices for High-Throughput In Situ Serial Crystallography. 用于高通量原位连续晶体学的微流控装置。

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Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_294

Sofia Jaho, Samuel John Hjorth-Jensen, Monika Budayova-Spano

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Bioprocess Engineering for Cultivated Meat. 养殖肉类的生物工艺工程。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_292

Julia Bernfeld, Simon Zschieschang, Marline Kirsch, Jordi Morales-Dalmau, Jasper Liedtke, Antonina Lavrentieva

{"title":"Bioprocess Engineering for Cultivated Meat.","authors":"Julia Bernfeld, Simon Zschieschang, Marline Kirsch, Jordi Morales-Dalmau, Jasper Liedtke, Antonina Lavrentieva","doi":"10.1007/10_2025_292","DOIUrl":"10.1007/10_2025_292","url":null,"abstract":"Cultivated meat (CM) has emerged as a promising solution to the environmental, ethical, and food security concerns associated with conventional meat production. However, realising its full potential depends on developing robust, scalable, and cost-effective bioprocessing strategies. This chapter explores the entire CM bioprocessing pipeline, from upstream challenges such as the development of robust cell lines, scaling up cell cultures, and evaluating different operating modes like batch, fed-batch, and perfusion to downstream processes such as biomass harvesting, purification, and product structuring. Key considerations include ensuring sterility, monitoring critical process parameters, and supporting effective cell proliferation and differentiation. Economically, the high cost of media and capital expenditures remain a major barrier to scale. Strategies such as media recycling, bulk ingredient sourcing, and in-house production are being explored to reduce costs. Emerging technologies like artificial intelligence, machine learning, and digital twins offer new tools for optimising operations, though adoption is still in early stages. As the industry progresses toward commercialisation, continued innovation in bioprocess engineering, guided by techno-economic modelling, will be crucial to achieving scalable and sustainable meat alternatives.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"17-62"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Processes and Products Derived from Lignocellulosic Feedstock: A Biorefinery Approach. 从木质纤维素原料衍生的工艺和产品：生物精炼方法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_334

Romit Mitra, Aritro Sanjib Sen, Supratit Ghosh, Goldy De Bhowmick, Ankita Debnath, Ramkrishna Sen

{"title":"Processes and Products Derived from Lignocellulosic Feedstock: A Biorefinery Approach.","authors":"Romit Mitra, Aritro Sanjib Sen, Supratit Ghosh, Goldy De Bhowmick, Ankita Debnath, Ramkrishna Sen","doi":"10.1007/10_2026_334","DOIUrl":"10.1007/10_2026_334","url":null,"abstract":"The global imperative to transition from fossil-dependent industries toward sustainable, circular production models has positioned lignocellulosic biomass as a cornerstone feedstock for the modern bioeconomy. This chapter provides a critical synthesis of lignocellulosic biorefineries, evaluating the integrated processes and diverse value chains required to transform complex plant matter into high-value commodities. While the tripartite structure of cellulose, hemicellulose, and lignin offers immense potential for the production of biofuels, bioenergy, and platform chemicals, its inherent recalcitrance poses a formidable barrier to commercial viability. To address this, the chapter systematically examines various pretreatment approaches, including physical, chemical, physicochemical, and biological methods, highlighting their mechanisms, advantages, and limitations. Emerging green and sustainable technologies, such as deep eutectic solvents, ionic liquids, and supercritical fluid-based processes, are also critically discussed in the context of improving biomass fractionation and process sustainability. Subsequently, key conversion pathways such as thermal, thermochemical, and biochemical are explored for the valorization of lignocellulosic biomass into fuels, platform chemicals, and other value-added products. It highlights recent breakthroughs in enzymatic saccharification and microbial fermentation, with a focus on how metabolic engineering and process optimization are currently overcoming traditional yield limitations. The chapter further addresses integrated and hybrid biorefinery concepts, such as consolidated bioprocessing and process intensification, which aim to maximize resource utilization and economic feasibility. Overall, this chapter provides critical insights into current advancements, challenges, and future prospects of lignocellulosic biorefineries in advancing a sustainable and carbon-neutral bioeconomy.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"33-77"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Engineering of Microbial Strains for 1,2,4-Butanetriol Production: Progress and Future Perspectives. 1,2,4-丁三醇生产微生物菌株代谢工程研究进展及展望

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_322

Wei-Bin Wang, Meng-Rui Tao, Kai Li, Takahiro Bamba, Cheng Cheng, Tomohisa Hasunuma, Akihiko Kondo, Nuttha Thongchul, Shuai Zhao, Jia-Xun Feng, Xin-Qing Zhao, Feng-Wu Bai

{"title":"Metabolic Engineering of Microbial Strains for 1,2,4-Butanetriol Production: Progress and Future Perspectives.","authors":"Wei-Bin Wang, Meng-Rui Tao, Kai Li, Takahiro Bamba, Cheng Cheng, Tomohisa Hasunuma, Akihiko Kondo, Nuttha Thongchul, Shuai Zhao, Jia-Xun Feng, Xin-Qing Zhao, Feng-Wu Bai","doi":"10.1007/10_2026_322","DOIUrl":"10.1007/10_2026_322","url":null,"abstract":"Sustainable production of biofuels and biochemicals from renewable biomass represents a promising alternative to fossil-based feedstocks, offering significant benefits for low-carbon economies and environmental protection. The biochemical 1,2,4-butanetriol (BT) is an important short-chain chiral triol, which is widely used as pharmaceuticals, industrial foam, anticorrosion additives, and plasticizers. Although biosynthesis of BT has been achieved in various engineered microbes, achieving cost-competitive production remains a significant challenge. This chapter focuses on research progress in metabolic engineering of BT production, which mainly includes (1) design of BT biosynthetic pathways for expression in bacterial and yeast cell factories, (2) current metabolic engineering and process optimization strategies to optimize BT production, and (3) utilizing lignocellulosic biomass as a sustainable feedstock for BT production. In addition, future prospects on enhancing BT production efficiency through advanced metabolic engineering and synthetic biology approaches integrating with artificial intelligence (AI)-based technologies are also presented.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"203-219"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Edible Scaffolds for Cultivated Meat Production. 用于养殖肉类生产的可食用支架。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_291

Mariana P Hanga, Simona Fehlmann, Nicole Kleger, Maria Laura Vieri, Travis Callue, Alice Millbank, Eirini Theodosiou

引用次数: 0