Advances in biochemical engineering/biotechnology最新文献_第7页

Fundamentals of Cultivated Meat Technology: Cell Culture and Tissue Engineering (Essentials of Cell Culture, Know-How Transfer from the Red Biotechnology). 培养肉类技术基础：细胞培养和组织工程（细胞培养的基本要素，从红色生物技术的技术转移）。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_289

Neta Lavon, Sagit Shalel-Levanon, Ayelet Maor-Shoshani

{"title":"Fundamentals of Cultivated Meat Technology: Cell Culture and Tissue Engineering (Essentials of Cell Culture, Know-How Transfer from the Red Biotechnology).","authors":"Neta Lavon, Sagit Shalel-Levanon, Ayelet Maor-Shoshani","doi":"10.1007/10_2025_289","DOIUrl":"10.1007/10_2025_289","url":null,"abstract":"This chapter focuses on the fundamentals of animal cell culture for cultivated meat production. We will explore how cultivated meat companies approach cell cultivation to align with the industry's goals of creating food products that meet consumer expectations for taste, cost, and safety. Building on the foundations established by the \"red biotech\" industry, we have adapted many of its technologies but have also had to make significant advancements to address the unique requirements of food production. The chapter covers the current state of the art and highlights future developments in the field. We will explain the basics of cell culture, including production facilities, cell lines, cell culture growth conditions, and cell culture media. Special emphasis will be placed on growth media optimization, which remains one of the most critical areas of development. We will discuss general approaches for medium optimization including analytical methods for monitoring key quality attributes. Finally, we will present examples of optimization processes we performed in our platform using bovine embryonic stem cells for large-scale cell mass production.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145706940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Production of Cellulases to Develop a Low-Cost Sugar Platform. 纤维素酶的稳健生产，以开发低成本的糖平台。

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Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_318

Kehang Li, Yaohua Zhong

引用次数: 0

Sustainable Production of Succinic Acid from Lignocellulosic Hydrolysate. 木质纤维素水解物可持续生产琥珀酸的研究。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_323

Rui-Qi Tang, Du-Wen Zeng, Xin-Qing Zhao, Du Zhu

{"title":"Sustainable Production of Succinic Acid from Lignocellulosic Hydrolysate.","authors":"Rui-Qi Tang, Du-Wen Zeng, Xin-Qing Zhao, Du Zhu","doi":"10.1007/10_2026_323","DOIUrl":"10.1007/10_2026_323","url":null,"abstract":"Biosynthesis of succinic acid (SA) represents one of the largest sectors in industrial biotechnology for biochemical production. Currently, the markets for fossil-derived and bio-based SA are comparable in scale, with the bio-based segment expanding particularly rapidly. In response to the growing demand for sustainable and renewable production routes, diverse types of lignocellulosic biomass have been employed as feedstocks. This chapter provides an overview of the microorganisms commonly used in SA production, including native producers such as Actinobacillus succinogenes, Anaerobiospirillum succiniciproducens, Basfia succiniciproducens, Mannheimia succiniciproducens, as well as engineered producers like Corynebacterium glutamicum, Escherichia coli, Saccharomyces cerevisiae, Yarrowia lipolytica, Kluyveromyces marxianus, and Issatchenkia orientalis. Their production performance, including titer, yield, and productivity, on conventional substrates such as glucose and on mixed sugars derived from lignocellulosic biomass is reviewed. The chapter concludes with a discussion of future prospects, highlighting the importance of integrating designed enzymes, robust strains, and fermentation optimization for sustainable SA production.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"221-248"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148147911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical and Analytical Methodologies. 数值和分析方法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_297

Tomaž Urbič, Igor Plazl

引用次数: 0

Alternative Strategies to Promote Biomolecule Nucleation. 促进生物分子成核的替代策略。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_309

Jose A Gavira, Abel Moreno

{"title":"Alternative Strategies to Promote Biomolecule Nucleation.","authors":"Jose A Gavira, Abel Moreno","doi":"10.1007/10_2025_309","DOIUrl":"10.1007/10_2025_309","url":null,"abstract":"Nucleation marks the beginning of phase separation in a system driven to produce crystalline material. Therefore, to determine the final characteristics of the product, crystal density, and size, nucleation should be fine-tuned. This is a general behavior, independent of the nature of the substance. In protein crystallization, the primary goal is typically to obtain crystals of the highest quality possible for structure determination and of a size suitable for the technique to be used. Small homogeneous crystals are queried for XFEL and serial crystallography, whereas neutron diffraction requires them to be cubic millimeter-sized, and electron diffraction needs flat micrometer-sized samples. Therefore, understanding how nucleation occurs and controlling it are of paramount importance not only for crystallizing target enzymes but also for producing biomolecule crystals for pharmaceutical and industrial applications. There are numerous possibilities and strategies for inducing nucleation in protein crystallization, based on various characteristics such as chemical influences, modified surfaces, or physical methods, including the use of external fields, e.g., electric, magnetic, ultrasound, or light. In this chapter, we will cover a portion of these possibilities. We will review the influence of several chemical substances, including hydrogels, modified surfaces, nanoparticles, and ionic liquids. New trends, such as the use of the switchable water concept and crystallization under hydrophobic conditions, will also be introduced as future perspectives.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"271-302"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaerobic Digestion of Agricultural Residues for Biogas Production. 农业废弃物厌氧消化用于沼气生产。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_325

Tian Yuan, Yue-Qin Tang

{"title":"Anaerobic Digestion of Agricultural Residues for Biogas Production.","authors":"Tian Yuan, Yue-Qin Tang","doi":"10.1007/10_2026_325","DOIUrl":"10.1007/10_2026_325","url":null,"abstract":"Anaerobic digestion (AD) is a promising method for treating organic waste while producing bioenergy and nutrient-rich fertilizer. Since the biogas generated from organic waste could replace fossil fuel use and the nutrients could be more efficiently recovered compared to composting, the AD process is essential for the development of a sustainable and circular economy. Agricultural residue is generated in large amounts worldwide and shows enormous potential for bioenergy generation. However, the high lignocellulose content restrains its biodegradability and limits its methane productivity during AD. Therefore, optimization of operating parameters and development of enhancement methods have been widely studied to enhance methane production from agricultural residue. In addition, the efficient utilization of anaerobic digestate has also been extensively studied to maximize nutrient recovery efficiency and prevent environmental and economic impacts of the AD process. This chapter summarizes the important factors, microbial mechanisms, and enhancement strategies for AD of agricultural residue and the potential utilization of anaerobic digestate, aiming to provide a comprehensive understanding and future perspectives of sustainable AD practices.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"301-335"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148012592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composting of Agricultural Residues into Organic Fertilizers for Sustainable Agriculture. 农业残留物堆肥成有机肥的可持续农业研究

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_324

Sun Zhaoyong, Iwabuchi Kazunori, Xu Yang, Zhang Wenshuai, Li Xiaoxing

{"title":"Composting of Agricultural Residues into Organic Fertilizers for Sustainable Agriculture.","authors":"Sun Zhaoyong, Iwabuchi Kazunori, Xu Yang, Zhang Wenshuai, Li Xiaoxing","doi":"10.1007/10_2026_324","DOIUrl":"10.1007/10_2026_324","url":null,"abstract":"The global generation of vast quantities of agricultural residues poses a significant environmental and logistical challenge. Composting offers an economically feasible and environmentally sustainable solution by efficiently transforming these waste materials into high-value organic fertilizers, thereby enhancing soil fertility and crop productivity. This chapter presents a comprehensive review of recent advances in the composting of agricultural residues, covering the entire process - from fundamental principles and microbial mechanisms to process optimization strategies and agricultural applications of the final compost product. It begins by addressing the challenges associated with the structural complexity and compositional heterogeneity of agricultural residues. Key composting principles, critical physicochemical parameters influencing process efficiency, and successional dynamics of microbial communities are then examined in detail. This chapter further evaluates various strategies to enhance composting performance, including pretreatment methods, co-composting, and integration of emerging additives such as biochar, metal oxides, and microbial inoculants. Special emphasis is placed on the agronomic benefits of mature compost, including its role in improving soil health, ensuring effective inactivation of pathogens and weed seeds, and supporting sustainable, long-term crop production. In summary, this review provides a robust theoretical and technological foundation for the effective valorization of agricultural residues into safe, nutrient-rich organic fertilizers, contributing to the advancement of circular agriculture and more sustainable agroecosystems.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"249-282"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical Scale in Biomolecular Crystallization. 生物分子结晶的技术规模。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2025_301

Wenqing Tian, Wenqian Chen, Huaiyu Yang

{"title":"Technical Scale in Biomolecular Crystallization.","authors":"Wenqing Tian, Wenqian Chen, Huaiyu Yang","doi":"10.1007/10_2025_301","DOIUrl":"10.1007/10_2025_301","url":null,"abstract":"In recent years, the scalability of biomolecular crystallization processes has garnered significant attention due to its advantages in enhancing product quality and reducing manufacturing costs compared to the traditional purification methods. Unlike the crystallization process of small molecules, biomolecular crystallization lacks a comprehensive theory or guidelines, often relying on modified crystallization theories and empirical approaches. It is challenging to guide protein molecules assembling into ordered crystal lattice due to the huge molecular size and complexity of the structure, and protein crystals are more delicate and fragile than conventional small organic molecular crystals. Furthermore, proteins often exhibit limited stability within specific environmental conditions, such as varying pH and temperature ranges. Consequently, many standard methods employed for small-molecule crystallization are not applicable to biomolecular crystallization. Most of the bimolecular crystallization research are focused on tiny scale, while more research on biomolecular crystallization at various larger technical scales has emerged over time. The scaling up mechenism from the tiny scale to the large scale is critical to widely apply the biomolecular crystallization. This chapter begins by summarizing the different methods used in biomolecular crystallization. Then, biomolecular crystallization is reviewed from nL to μL scale (e.g., hanging drop or sitting drop) to mL scale, such as in small batch or microfluidic crystallizer till hundred mL or L scale, such as standard stirred crystallizer. Finally, it explores different crystallization scales with corresponding process monitoring and analytical methods for the crystallization kinetics.","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":" ","pages":"123-147"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Numerical and Analytical Methodologies. 修正：数值和分析方法。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2026-01-01 DOI: 10.1007/10_2026_330

Tomaž Urbič, Igor Plazl

引用次数: 0

Correction to: The Human Gut Microbiota: A Dynamic Biologic Factory. 更正：人类肠道微生物群：动态生物工厂。

4区工程技术

Advances in biochemical engineering/biotechnology Pub Date : 2025-01-01 DOI: 10.1007/10_2024_253

Alireza Minagar, Rabih Jabbour

引用次数: 0