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Advances in biochemical engineering/biotechnology最新文献

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Aerobic Utilization of Methanol for Microbial Growth and Production. 甲醇在微生物生长和生产中的好氧利用。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2021_177
Volker F Wendisch, Gregor Kosec, Stéphanie Heux, Trygve Brautaset
{"title":"Aerobic Utilization of Methanol for Microbial Growth and Production.","authors":"Volker F Wendisch,&nbsp;Gregor Kosec,&nbsp;Stéphanie Heux,&nbsp;Trygve Brautaset","doi":"10.1007/10_2021_177","DOIUrl":"https://doi.org/10.1007/10_2021_177","url":null,"abstract":"<p><p>Methanol is a reduced one-carbon (C1) compound. It supports growth of aerobic methylotrophs that gain ATP from reduced redox equivalents by respiratory phosphorylation in their electron transport chains. Notably, linear oxidation of methanol to carbon dioxide may yield three reduced redox equivalents if methanol oxidation is NAD-dependent as, e.g., in Bacillus methanolicus. Methanol has a higher degree of reduction per carbon than glucose (6 vs. 4), and thus, lends itself as an ideal carbon source for microbial production of reduced target compounds. However, C-C bond formation in the RuMP or serine cycle, a prerequisite for production of larger molecules, requires ATP and/or reduced redox equivalents. Moreover, heat dissipation and a high demand for oxygen during catabolic oxidation of methanol may pose challenges for fermentation processes. In this chapter, we summarize metabolic pathways for aerobic methanol utilization, aerobic methylotrophs as industrial production hosts, strain engineering, and methanol bioreactor processes. In addition, we provide technological and market outlooks.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"180 ","pages":"169-212"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Primer on Microfluidics: From Basic Principles to Microfabrication. 微流体入门:从基本原理到微加工。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2020_156
Ann-Kathrin Klein, Andreas Dietzel
{"title":"A Primer on Microfluidics: From Basic Principles to Microfabrication.","authors":"Ann-Kathrin Klein,&nbsp;Andreas Dietzel","doi":"10.1007/10_2020_156","DOIUrl":"https://doi.org/10.1007/10_2020_156","url":null,"abstract":"<p><p>Microfluidic systems enable manipulating fluids in different functional units which are integrated on a microchip. This chapter describes the basics of microfluidics, where physical effects have a different impact compared to macroscopic systems. Furthermore, an overwiew is given on the microfabrication of these systems. The focus lies on clean-room fabrication methods based on photolithography and soft lithography. Finally, an outlook on advanced maskless micro- and nanofabrication methods is given. Special attention is paid to laser structuring processes.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"179 ","pages":"17-35"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/10_2020_156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39122147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Biosensor Trends in Organ-on-a-Chip. 芯片上器官生物传感器的发展趋势。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2020_129
Mario Rothbauer, Peter Ertl
{"title":"Emerging Biosensor Trends in Organ-on-a-Chip.","authors":"Mario Rothbauer,&nbsp;Peter Ertl","doi":"10.1007/10_2020_129","DOIUrl":"https://doi.org/10.1007/10_2020_129","url":null,"abstract":"<p><p>Organ-on-a-chip technology is ideally suited to cultivate and analyze 2D/3D cell cultures, organoids, and other tissue analogues in vitro, because these microphysiological systems have been shown to generate architectures, structural organization, and functions that closely resemble their respective human tissues and organs. Although great efforts have been undertaken to demonstrate organotypic cell behavior, proper cell-to-cell communication, and tissue interactions in recent years, the integration of biosensing strategies into organ-on-a-chip platforms is still in its infancy. While a multitude of micro-, nano-, and biosensors are well established and could be easily adapted for organ-on-a-chip models, to date only a handful of analytical approaches (aside from microscopical techniques) have been combined with organ-on-a-chip technology. This chapter aims to summarize current efforts and survey the progress that has been made in integrating analytical techniques that are being implemented for organ-, multi-organ-, and body-on-a-chip systems based on electrochemical and optical sensors.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"179 ","pages":"343-354"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/10_2020_129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38201578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Microfluidics in Biotechnology: Quo Vadis. 微流体技术在生物技术中的应用。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2020_162
Steffen Winkler, Alexander Grünberger, Janina Bahnemann
{"title":"Microfluidics in Biotechnology: Quo Vadis.","authors":"Steffen Winkler,&nbsp;Alexander Grünberger,&nbsp;Janina Bahnemann","doi":"10.1007/10_2020_162","DOIUrl":"https://doi.org/10.1007/10_2020_162","url":null,"abstract":"<p><p>The emerging technique of microfluidics offers new approaches for precisely controlling fluidic conditions on a small scale, while simultaneously facilitating data collection in both high-throughput and quantitative manners. As such, the so-called lab-on-a-chip (LOC) systems have the potential to revolutionize the field of biotechnology. But what needs to happen in order to truly integrate them into routine biotechnological applications? In this chapter, some of the most promising applications of microfluidic technology within the field of biotechnology are surveyed, and a few strategies for overcoming current challenges posed by microfluidic LOC systems are examined. In addition, we also discuss the intensifying trend (across all biotechnology fields) of using point-of-use applications which is being facilitated by new technological achievements.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"179 ","pages":"355-380"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/10_2020_162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38860400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Microfluidics in Biotechnology 生物技术中的微流体
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/978-3-031-04188-4
{"title":"Microfluidics in Biotechnology","authors":"","doi":"10.1007/978-3-031-04188-4","DOIUrl":"https://doi.org/10.1007/978-3-031-04188-4","url":null,"abstract":"","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"59 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50986203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Process Engineering Aspects for the Microbial Conversion of C1 Gases. C1气体微生物转化的工艺工程方面。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2021_172
Dirk Weuster-Botz
{"title":"Process Engineering Aspects for the Microbial Conversion of C1 Gases.","authors":"Dirk Weuster-Botz","doi":"10.1007/10_2021_172","DOIUrl":"https://doi.org/10.1007/10_2021_172","url":null,"abstract":"<p><p>Industrially applied bioprocesses for the reduction of C1 gases (CO<sub>2</sub> and/or CO) are based in particular on (syn)gas fermentation with acetogenic bacteria and on photobioprocesses with microalgae. In each case, process engineering characteristics of the autotrophic microorganisms are specified and process engineering aspects for improving gas and electron supply are summarized before suitable bioreactor configurations are discussed for the production of organic products under given economic constraints. Additionally, requirements for the purity of C1 gases are summarized briefly. Finally, similarities and differences in microbial CO<sub>2</sub> valorization are depicted comparing gas fermentations with acetogenic bacteria and photobioprocesses with microalgae.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"180 ","pages":"33-56"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Human-Device Interaction in the Life Science Laboratory. 生命科学实验室中的人机交互。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2021_183
Robert Söldner, Sophia Rheinländer, Tim Meyer, Michael Olszowy, Jonas Austerjost
{"title":"Human-Device Interaction in the Life Science Laboratory.","authors":"Robert Söldner,&nbsp;Sophia Rheinländer,&nbsp;Tim Meyer,&nbsp;Michael Olszowy,&nbsp;Jonas Austerjost","doi":"10.1007/10_2021_183","DOIUrl":"https://doi.org/10.1007/10_2021_183","url":null,"abstract":"<p><p>The interaction of the human user with equipment and software is a central aspect of the work in the life science laboratory. The enhancement of the usability and intuition of software and hardware products, as well as holistic interaction solutions are a demand from all stakeholders in the scientific laboratory who desire more efficient workflows. Shorter training periods, parallelization of workflows, improved data integrity, and enhanced safety are only a few advantages innovative intuitive human-device-interfaces can bring. With recent advances in artificial intelligence (AI), the availability of smart devices, as well as unified communication protocols, holistic interaction solutions are on the rise. Future interaction in the laboratory will not be limited to pushing mechanical buttons on equipment. Instead, the interplay between voice, gestures, and innovative hard- and software components will drive interactions in the laboratory into a more streamlined future.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"182 ","pages":"83-113"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39958796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Organ-on-a-Chip. Organ-on-a-Chip。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2020_135
Ilka Maschmeyer, Sofia Kakava
{"title":"Organ-on-a-Chip.","authors":"Ilka Maschmeyer,&nbsp;Sofia Kakava","doi":"10.1007/10_2020_135","DOIUrl":"https://doi.org/10.1007/10_2020_135","url":null,"abstract":"<p><p>Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made the realization of this tool closer than ever. Organ-on-a-chip platforms have been the first step forward, leading to the combination and integration of multiple organ models in the same platform with human-on-a-chip being the ultimate goal. Despite the current progress and technological developments, there are still several unmet engineering and biological challenges curtailing their development and widespread application in the biomedical field. The potentials, challenges, and current work on this unprecedented tool are being discussed in this chapter.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"179 ","pages":"311-342"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/10_2020_135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38396832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conversion of Carbon Monoxide to Chemicals Using Microbial Consortia. 利用微生物群将一氧化碳转化为化学品。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2021_180
Ivette Parera Olm, Diana Z Sousa
{"title":"Conversion of Carbon Monoxide to Chemicals Using Microbial Consortia.","authors":"Ivette Parera Olm,&nbsp;Diana Z Sousa","doi":"10.1007/10_2021_180","DOIUrl":"https://doi.org/10.1007/10_2021_180","url":null,"abstract":"<p><p>Syngas, a gaseous mixture of CO, H<sub>2</sub> and CO<sub>2</sub>, can be produced by gasification of carbon-containing materials, including organic waste materials or lignocellulosic biomass. The conversion of bio-based syngas to chemicals is foreseen as an important process in circular bioeconomy. Carbon monoxide is also produced as a waste gas in many industrial sectors (e.g., chemical, energy, steel). Often, the purity level of bio-based syngas and waste gases is low and/or the ratios of syngas components are not adequate for chemical conversion (e.g., by Fischer-Tropsch). Microbes are robust catalysts to transform impure syngas into a broad spectrum of products. Fermentation of CO-rich waste gases to ethanol has reached commercial scale (by axenic cultures of Clostridium species), but production of other chemical building blocks is underexplored. Currently, genetic engineering of carboxydotrophic acetogens is applied to increase the portfolio of products from syngas/CO, but the limited energy metabolism of these microbes limits product yields and applications (for example, only products requiring low levels of ATP for synthesis can be produced). An alternative approach is to explore microbial consortia, including open mixed cultures and synthetic co-cultures, to create a metabolic network based on CO conversion that can yield products such as medium-chain carboxylic acids, higher alcohols and other added-value chemicals.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"180 ","pages":"373-407"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
FAIR Data Infrastructure. 公平数据基础设施。
4区 工程技术
Advances in biochemical engineering/biotechnology Pub Date : 2022-01-01 DOI: 10.1007/10_2021_193
Janna Neumann
{"title":"FAIR Data Infrastructure.","authors":"Janna Neumann","doi":"10.1007/10_2021_193","DOIUrl":"https://doi.org/10.1007/10_2021_193","url":null,"abstract":"<p><p>In this chapter the concept of research data management is highlighted in the context of the data publication and data infrastructures. One focus of this contribution lies on the topics of metadata and the FAIR data principles associated with data sharing and data infrastructures such as data repositories. The challenges for researchers and research communities towards open science are discussed and the first steps towards FAIR data infrastructures are illustrated.</p>","PeriodicalId":7198,"journal":{"name":"Advances in biochemical engineering/biotechnology","volume":"182 ","pages":"195-207"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39869036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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