{"title":"Isolated Digital Clubbing Due to a Rare Tumor","authors":"A.G.B.F. Andrade, C.M. Murari, T.B. Brandalize, A.O. Michalany","doi":"10.1016/j.ad.2023.11.026","DOIUrl":"10.1016/j.ad.2023.11.026","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 1026-1028"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Artículo traducido] Tumor raro como causa de acropaquia digital aislada","authors":"A.G.B.F. Andrade, C.M. Murari, T.B. Brandalize, A.O. Michalany","doi":"10.1016/j.ad.2025.07.004","DOIUrl":"10.1016/j.ad.2025.07.004","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T1026-T1028"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hiperhidrosis, anticolinérgicos y demencia","authors":"J. del Boz , J.C. Bautista Vidal","doi":"10.1016/j.ad.2024.11.026","DOIUrl":"10.1016/j.ad.2024.11.026","url":null,"abstract":"<div><div>In recent decades, the use of certain oral anticholinergics for the treatment of hyperhidrosis has become widespread, often off-label but supported by multiple studies, including clinical trials, demonstrating their effectiveness and an apparently good safety profile. Similarly, various studies published in recent years have associated the use of anticholinergics to the development of dementia, particularly in elderly patients. Additionally, other studies have suggested that hyperhidrosis itself may be an early symptom of developing dementia. However, to date, no research has specifically linked the use of oral anticholinergics for hyperhidrosis treatment with the development of dementia. We present the currently available data on this controversial topic.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 985-989"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.A. Salinas-Santander , A.A. Lima-Galindo , A.A. Marqués-Esparza , J.A. Ocampo-Garza , J. Ocampo-Candiani
{"title":"[Artículo traducido] Asociación entre Vitiligo vulgaris y el polimorfismo rs7129973 del gen TYR en la población mexicana","authors":"M.A. Salinas-Santander , A.A. Lima-Galindo , A.A. Marqués-Esparza , J.A. Ocampo-Garza , J. Ocampo-Candiani","doi":"10.1016/j.ad.2025.07.005","DOIUrl":"10.1016/j.ad.2025.07.005","url":null,"abstract":"<div><div>Vitiligo is a multifactorial disease characterized by skin depigmentation. Although there are several genetic components involved in its development, the participation of the <em>TYR</em> rs7129973 gene polymorphism has not yet been explored. Our objective was to evaluate the association between <em>Vitiligo</em> <em>vulgaris</em> and the <em>TYR</em> rs7129973 gene polymorphism in a Mexican population. Therefore, a total of 84 <em>Vitiligo</em> <em>vulgaris</em> patients and 90 control subjects from northeastern Mexico were analyzed through PCR-RFLP to determine the association between vitiligo and <em>TYR</em> rs7129973. We found that the carriers of <em>TYR</em> rs7129973 G alleles (AG and GG genotypes) were more prevalent among patients with vitiligo (<em>P</em> <!--><<!--> <!-->0.05). However, this genetic variant had no correlation with the age of onset, vitiligo activity, family history of vitiligo, and personal history of thyroid disease (<em>P</em> <!-->><!--> <!-->0.05). Thereby, we can conclude that the <em>TYR</em> rs7129973 polymorphism constitutes a risk factor for the development of <em>Vitiligo</em> <em>vulgaris</em> in the Mexican population.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T1007-T1011"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sánchez-Merino , F. Vílchez-Márquez , A. Núñez-García , C. Botella-García , S. Arias-Santiago
{"title":"Análisis de la calidad de vida en los pacientes con linfomas cutáneos","authors":"A. Sánchez-Merino , F. Vílchez-Márquez , A. Núñez-García , C. Botella-García , S. Arias-Santiago","doi":"10.1016/j.ad.2024.08.015","DOIUrl":"10.1016/j.ad.2024.08.015","url":null,"abstract":"<div><div>Primary cutaneous lymphomas are a heterogeneous group of non-Hodgkin's lymphomas, most of them chronic with multiple relapses, which can have an impact on the patient's quality of life. The main aim of the study was to assess the quality of life of patients with cutaneous lymphomas using different validated questionnaires. A total of 32 patients were included in the study (mean age, 64 years; 75%. men). A total of 68.8% of lymphomas were mycosis fungoides. Age, number of therapies administered and pruritus were associated with worse quality of life as assessed by the different questionnaires. The use of quality of life-questionnaires may be useful in the holistic evaluation of the patient.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 1001-1006"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Al-wattar-Ceballos, L. Martínez-Montalvo, M. Carmona-Rodríguez
{"title":"Safety and Efficacy Profile of Anti-IL17 Treatments in Hidradenitis Suppurativa: Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials","authors":"O. Al-wattar-Ceballos, L. Martínez-Montalvo, M. Carmona-Rodríguez","doi":"10.1016/j.ad.2024.12.027","DOIUrl":"10.1016/j.ad.2024.12.027","url":null,"abstract":"<div><h3>Background and objective</h3><div>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is difficult to manage, requiring the use of biologic drugs such as anti-TNFα and anti-interleukin 17 (anti-IL17). The aim of our review is to evaluate the safety and efficacy profile of anti-IL17 drugs in patients with HS.</div></div><div><h3>Materials and methods</h3><div>We conducted a systematic review with subsequent meta-analysis following the population, intervention, comparison, outcome and type of study (PICOS) method. We included only randomized clinical trials with placebo (S) that included individuals with HS ≥<!--> <!-->18 years old (P), and who had been on placebo (C) OR, an anti-IL17 biologic drug (I) to measure safety and efficacy outcomes (O). Search was conducted across multiple databases: PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. The risk of bias of each study, publication bias, sensitivity analysis, and certainty of evidence were determined.</div></div><div><h3>Results</h3><div>A total of 320 bibliographic references were obtained, 4 of which met the inclusion criteria. Compared to placebo, the meta-analysis showed a significantly higher percentage of patients achieving Hidradenitis Suppurativa Clinical Response (HiSCR) OR, of 1.96 [1.79–2.15], a greater decrease in DLQI, MD −1.92 [−2.68,−1.16] and an increase in adverse effects; OR, 1.21 [1.09, 1.34], particularly due to Candida infections; OR, 5.61 [2.66–11.83].</div></div><div><h3>Conclusions</h3><div>Treatment with anti-IL17 biologic drugs is effective in patients with moderate-to-severe HS. Although these drugs are safe, they should be monitored due to the risk of infections, mainly candidiasis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 945-958"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Translated article] Hyperhidrosis, Anticholinergics, and Dementia","authors":"J. del Boz , J.C. Bautista Vidal","doi":"10.1016/j.ad.2025.07.007","DOIUrl":"10.1016/j.ad.2025.07.007","url":null,"abstract":"<div><div>In recent decades, the use of certain oral anticholinergics for the treatment of hyperhidrosis has become widespread, often off-label but supported by multiple studies, including clinical trials, demonstrating their effectiveness and an apparently good safety profile. Similarly, various studies published in recent years have associated the use of anticholinergics to the development of dementia, particularly in elderly patients. Additionally, other studies have suggested that hyperhidrosis itself may be an early symptom of developing dementia. However, to date, no research has specifically linked the use of oral anticholinergics for hyperhidrosis treatment with the development of dementia. We present the currently available data on this controversial topic.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T985-T989"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}