Actas dermo-sifiliograficas最新文献_第10页

Unraveling the Link Between Bullous Pemphigoid and Neurological Disease: A Single-center Study of 257 Patients 揭示大疱性类天疱疮与神经系统疾病之间的联系：一项257例患者的单中心研究。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2024.10.071

L.M. Nieto-Benito , R. Suárez-Fernández

{"title":"Unraveling the Link Between Bullous Pemphigoid and Neurological Disease: A Single-center Study of 257 Patients","authors":"L.M. Nieto-Benito , R. Suárez-Fernández","doi":"10.1016/j.ad.2024.10.071","DOIUrl":"10.1016/j.ad.2024.10.071","url":null,"abstract":"<div><h3>Background</h3><div>Multiple studies have corroborated the association between bullous pemphigoid (BP) and neurological diseases; patients with both diseases (BP-N) have been associated with a worse prognosis and specific clinical and immunological characteristics, defining a different subtype of BP.</div></div><div><h3>Objectives</h3><div>We aimed to determine the prevalence and characteristics of BP cases with neurological comorbidities (BP-N) and review the related published literature.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, observational study of BP cases treated at a referral center for autoimmune blistering diseases from January 2000 through June 2020.</div></div><div><h3>Results</h3><div>We collected epidemiological, clinical, histopathological, progression and laboratory data from a total of 257 cases, 102 of which were BP-N. Senile dementia, Alzheimer's disease and vascular dementia were the most frequent neurological comorbidities. Compared with cases without neurological comorbidities, BP-N cases had more intense tissue eosinophilia (<em>p</em>  =0.000), and anti-BP180 IgG antibodies (<em>p</em>  <!-->0.007). At the time of data collection, 78 BP-N were deceased.</div></div><div><h3>Conclusions</h3><div>Our case series highlighted the relevance of neurological comorbidities in BP patients; although the pathogenesis is still to be elucidated, the neuroinflammation present in neurodegenerative diseases could explain the neurocutaneous link and the chronological relationship between these entities.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 8","pages":"Pages 807-814"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Artículo traducido] Infecciones mucocutáneas por el virus del herpes simple: estudio de 6 años en el mayor hospital universitario terciario de Portugal 在葡萄牙最大的三级教学医院进行的为期六年的粘膜单纯疱疹病毒感染研究。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.05.024

C. Brazão , D. Mancha , L. Sun , M.R. Barreto , L. Marques-Lito , J. Borges-Costa

{"title":"[Artículo traducido] Infecciones mucocutáneas por el virus del herpes simple: estudio de 6 años en el mayor hospital universitario terciario de Portugal","authors":"C. Brazão , D. Mancha , L. Sun , M.R. Barreto , L. Marques-Lito , J. Borges-Costa","doi":"10.1016/j.ad.2025.05.024","DOIUrl":"10.1016/j.ad.2025.05.024","url":null,"abstract":"<div><div>Herpes simplex virus (HSV) infections are widespread among humans. Their diagnosis is predominantly clinical, but its laboratory confirmation is increasingly encouraged. We conducted a 6-year retrospective, observational study of polymerase chain reaction (PCR) confirmed mucocutaneous HSV infections in the largest Portuguese tertiary teaching hospital. Throughout this period, a total of 947 PCR herpesvirus tests in mucocutaneous swabs were performed, 448 of which tested positive (266 for HSV). Regarding the PCR-confirmed mucocutaneous HSV infections, HSV-1 was the main cause of orolabial herpes and HSV-2 of genital herpes. A significant proportion of patients were immunocompromised, demonstrating the risk for herpesvirus infection and reactivation in this setting. HSV-1 genital herpes was more common in women, younger individuals and had a lower rate of recurrences. This study demonstrates the variable clinical spectrum of HSV infections, and the importance of their laboratory confirmation, as the recognition of the specific pathogen may determine optimal management and prognosis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 8","pages":"Pages T897-T901"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Artículo traducido] Eficacia de los medicamentos locales de uso común en el tratamiento de la rosácea: evaluación sistemática y metaanálisis 广泛使用的局部药物治疗酒渣鼻的疗效：系统回顾和荟萃分析。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.06.004

X. Gao , W. Xiang

{"title":"[Artículo traducido] Eficacia de los medicamentos locales de uso común en el tratamiento de la rosácea: evaluación sistemática y metaanálisis","authors":"X. Gao , W. Xiang","doi":"10.1016/j.ad.2025.06.004","DOIUrl":"10.1016/j.ad.2025.06.004","url":null,"abstract":"<div><div>Topical interventions for rosacea are often used to relieve local symptoms. However, currently, there are few articles to systematically analyze the efficacy profile of topical drugs for rosacea. This study aimed to investigate the efficacy profile of widely used topical drugs. To acquire appropriate information from related literature, we looked into 4 databases. Efficacy was appraised with the Investigator Global Assessment, Clinician's Erythema Assessment, Patient's Self-Assessment and Subject Self-Assessment of Rosacea Facial Redness scales. Treatment-emergent adverse events and dermal tolerability were also recorded. According to 21 randomized controlled trials included, a total of 6 topical drugs including minocycline, ivermectin, azelaic acid, metronidazole, brimonidine and oxymetazoline were reported. These drugs are well-tolerated and safe. Ivermectin is more effective than azelaic acid and metronidazole. Azelaic acid has a better efficacy profile than metronidazole according to included studies. Minocycline turned out to be effective improving the symptoms of rosacea. Brimonidine and oxymetazoline both have significant effects on reducing facial redness.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 8","pages":"Pages T863-T875"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Artículo traducido] Penfigoide ampolloso y comorbilidad neurológica: ¿causa o consecuencia? Estudio retrospectivo unicéntrico de 257 pacientes 揭示大疱性类天疱疮与神经系统疾病之间的联系：一项257例患者的单中心研究

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.06.002

L.M. Nieto-Benito , R. Suárez-Fernández

{"title":"[Artículo traducido] Penfigoide ampolloso y comorbilidad neurológica: ¿causa o consecuencia? Estudio retrospectivo unicéntrico de 257 pacientes","authors":"L.M. Nieto-Benito , R. Suárez-Fernández","doi":"10.1016/j.ad.2025.06.002","DOIUrl":"10.1016/j.ad.2025.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Multiple studies have corroborated the association between bullous pemphigoid (BP) and neurological diseases; patients with both diseases (BP-N) have been associated with a worse prognosis and specific clinical and immunological characteristics, defining a different subtype of BP.</div></div><div><h3>Objectives</h3><div>We aimed to determine the prevalence and characteristics of BP cases with neurological comorbidities (BP-N) and review the related published literature.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, observational study of BP cases treated at a referral center for autoimmune blistering diseases from January 2000 through June 2020.</div></div><div><h3>Results</h3><div>We collected epidemiological, clinical, histopathological, progression and laboratory data from a total of 257 cases, 102 of which were BP-N. Senile dementia, Alzheimer's disease and vascular dementia were the most frequent neurological comorbidities. Compared with cases without neurological comorbidities, BP-N cases had more intense tissue eosinophilia (<em>P</em>=.012) and higher concentrations of circulating eosinophils (<em>P</em>=.000), and anti-BP180 IgG antibodies (<em>P</em>=.007). At the time of data collection, 78 BP-N were deceased.</div></div><div><h3>Conclusions</h3><div>Our case series highlighted the relevance of neurological comorbidities in BP patients; although the pathogenesis is still to be elucidated, the neuroinflammation present in neurodegenerative diseases could explain the neurocutaneous link and the chronological relationship between these entities.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 8","pages":"Pages T807-T814"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Translated article] Bullous Lesions After Total Knee Arthroplasty 膝关节成形术后的水泡病变。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.06.007

G.G. Dradi, E. Gómez de la Fuente, E. García Zamora

引用次数: 0

Dermatología y videojuegos 皮肤病学和电子游戏。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.02.027

A. López Valle, I. Macías Martín

引用次数: 0

Nuevas medidas de prevención en venereología: revisión de la evidencia existente sobre DoxiPrEP/PEP y vacuna 4CMenB 性病预防新措施：DoxiPrEP/PEP抗生素和4CMenB疫苗的证据综述

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2024.11.028

A. Català , J. Riera , I. Fuertes de Vega

引用次数: 0

Actualización del documento de consenso español sobre el hemangioma infantil 更新西班牙关于婴儿血管瘤的共识文件。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2024.12.025

E. Baselga , J. Bernabeu-Wittel , I. Betlloch Mas , M. Campos Domínguez , A. Carrasco Sanz , J. del Boz , R. de Lucas Laguna , J. del Pozo Losada , A. Hernández Martín , L. Jiménez Montañés , J.C. López Gutiérrez , A. Martín-Santiago , P. Redondo , A. Torrelo Fernández , A. Vicente Villa

引用次数: 0

Efficacy of Widely Used Topical Drugs for Rosacea: A Systematic Review and Meta-Analysis 广泛使用的局部药物治疗酒渣鼻的疗效：系统回顾和荟萃分析。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2024.12.026

X. Gao , W. Xiang

{"title":"Efficacy of Widely Used Topical Drugs for Rosacea: A Systematic Review and Meta-Analysis","authors":"X. Gao , W. Xiang","doi":"10.1016/j.ad.2024.12.026","DOIUrl":"10.1016/j.ad.2024.12.026","url":null,"abstract":"<div><div>Topical interventions for rosacea are often used to relieve local symptoms. However, currently, there are few articles to systematically analyze the efficacy profile of topical drugs for rosacea. This study aimed to investigate the efficacy profile of widely used topical drugs. To acquire appropriate information from related literature, we looked into 4 databases. Efficacy was appraised with the Investigator Global Assessment, Clinician's Erythema Assessment, Patient's Self-Assessment and Subject Self-Assessment of Rosacea Facial Redness scales. Treatment-emergent adverse events and dermal tolerability were also recorded. According to 21 randomized controlled trials included, a total of 6 topical drugs including minocycline, ivermectin, azelaic acid, metronidazole, brimonidine and oxymetazoline were reported. These drugs are well-tolerated and safe. Ivermectin is more effective than azelaic acid and metronidazole. Azelaic acid has a better efficacy profile than metronidazole according to included studies. Minocycline turned out to be effective improving the symptoms of rosacea. Brimonidine and oxymetazoline both have significant effects on reducing facial redness.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 8","pages":"Pages 863-875"},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Artículo traducido] Los patrones de detección del melanoma se relacionan con el espesor de Breslow: el papel del dermatólogo 黑色素瘤检测模式及其与乳腺厚度的关系：皮肤科医生的角色。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2025-09-01 DOI: 10.1016/j.ad.2025.05.021

M. López-Pardo Rico , D. Soto-García , C. Peña Penabad , M.D. Sánchez-Aguilar Rojas , Grupo Gallego del melanoma

引用次数: 0