{"title":"CO2 Laser Ablation for Multiple Miliary Osteoma Cutis: Diagnostic and Procedural Role of the “Spark Sign”","authors":"P. López Sanz , D. Barco","doi":"10.1016/j.ad.2025.104502","DOIUrl":"10.1016/j.ad.2025.104502","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104502"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J.M. Villa-Gonzalez , M.R. Gonzalez-Hermosa , M. Ardigò , S. Gonzalez
{"title":"Monitoring the Effectiveness of Noninvasive or Minimally Invasive Therapies for Nonmelanocytic Lesions Using Reflectance Confocal Microscopy: A Systematic Review","authors":"J.M. Villa-Gonzalez , M.R. Gonzalez-Hermosa , M. Ardigò , S. Gonzalez","doi":"10.1016/j.ad.2025.104492","DOIUrl":"10.1016/j.ad.2025.104492","url":null,"abstract":"<div><div>In vivo reflectance confocal microscopy (RCM) enables monitoring of non-melanocytic skin cancers (NMSC) treated with non-invasive or minimally invasive therapies. This systematic review analyzed studies on NMSC treated with these therapies and monitored by RCM. A total of 56 articles were included, with 40 focusing on squamous conditions, such as actinic keratosis and squamous cell carcinoma, 15 on basal cell carcinoma (BCC), and 1 on extramammary Paget's disease. Evaluated therapies included ablative laser, cryosurgery, photodynamic therapy, 5-fluorouracil, imiquimod, and tirbanibulin, among others. RCM demonstrated complete response in squamous conditions with normalization of the honeycomb pattern and reduction of scaling and parakeratosis, frequently allowing for detection of subclinical malignancy. In BCC, RCM showed complete response as disappearance of tumor islands. RCM allows treatment optimization and early monitoring, even when inflammation hinders clinical assessment. It is recommended that RCM evaluations be performed starting at least 1 month after treatment for squamous conditions and 3 months for BCC.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104492"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Cotarelo Hernández , T. Puerta López , J.A. Pérez-García
{"title":"Facial Lesions Transmission in the Context of Sexual Relations","authors":"M. Cotarelo Hernández , T. Puerta López , J.A. Pérez-García","doi":"10.1016/j.ad.2025.104501","DOIUrl":"10.1016/j.ad.2025.104501","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104501"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Barrutia-Etxebarria, R.M. Escribano De La Torre, J. Gimeno Castillo
{"title":"Arborizing Vessels and Whitish Shiny Structures on a Salmon-colored Background: A Diagnostic Framework","authors":"A. Barrutia-Etxebarria, R.M. Escribano De La Torre, J. Gimeno Castillo","doi":"10.1016/j.ad.2025.104506","DOIUrl":"10.1016/j.ad.2025.104506","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104506"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Balado-Simó , S. Gomez-Martinez , D. Morgado-Carrasco
{"title":"Tranexamic Acid in Cutaneous Oncologic and Cosmetic Surgery: A Comprehensive Narrative Review","authors":"P. Balado-Simó , S. Gomez-Martinez , D. Morgado-Carrasco","doi":"10.1016/j.ad.2025.104485","DOIUrl":"10.1016/j.ad.2025.104485","url":null,"abstract":"<div><div>Tranexamic acid (TXA) is a synthetic lysine analog with antifibrinolytic properties used to reduce bleeding during various surgical procedures. In dermatologic surgery, it is often applied topically (soaked gauze), subcutaneously (intralesional with local anesthesia), and intravenously. We conducted a narrative review on the utility of TXA in dermatologic surgery, both oncologic and esthetic. Therefore, we conducted a literature search across PubMed and Google Scholar during March 2025, including retrospective and prospective studies, and systematic reviews. We eventually found multiple randomized clinical trials demonstrating a reduction in intra- and postoperative bleeding, ecchymosis, and minor hematomas, especially in Mohs surgery, blepharoplasty, and facial rhytidectomy (facelift), and reduced surgical duration during blepharoplasty and rhytidectomy. The safety profile of TXA is highly favorable, with no observed increase in thromboembolic events. However, optimal dosing and routes of administration have yet to be established.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104485"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rivera-Diaz , B. Joven , G. Hernandez-Ibarburu , C. García-Donoso , J.L. Pablos , P.L. Ortiz-Romero
{"title":"Evaluation of the Risk of Psoriatic Arthritis in Patients With Psoriasis Undergoing Biological Treatment. Global Population Study (TRINETX)","authors":"R. Rivera-Diaz , B. Joven , G. Hernandez-Ibarburu , C. García-Donoso , J.L. Pablos , P.L. Ortiz-Romero","doi":"10.1016/j.ad.2025.104488","DOIUrl":"10.1016/j.ad.2025.104488","url":null,"abstract":"<div><h3>Introduction</h3><div>Psoriatic arthritis (PsA) is an inflammatory condition associated with psoriasis (PsO), with variable prevalence ranging from 6% to 42%. Despite the known link between PsO and PsA, reliable biomarkers for predicting PsA onset remain elusive. Recent research has identified risk determinants including obesity, onychopathy, PsO severity, and familial predisposition. Detecting PsO patients at risk of developing PsA is crucial given the disparity in treatment efficacy post-PsA establishment.</div></div><div><h3>Objective</h3><div>This study evaluates the rate of PsA among PsO patients undergoing targeted biologic therapy as first- or second-line therapy.</div></div><div><h3>Material and methods</h3><div>We conducted a retrospective cohort study utilizing TriNetX database and identified PsO patients receiving biologic therapy. Propensity score matching was applied to adjust for potential confounders. Patients were followed for 5 years, and the incidence rate of PsA was determined. Statistical analyses were performed to estimate relative risks and hazard ratios.</div></div><div><h3>Results</h3><div>Among 1,175,000 PsO patients, 41,990 received first-line biologic therapy. Following matching, patients initiating IL12/23i or IL23i exhibited a lower PsA incidence rate vs TNFi. Second-line IL12/23i and IL23i treatment also showed a lower PsA risk vs TNFi. IL17i did not significantly differ from TNFi in PsA risk.</div></div><div><h3>Conclusion</h3><div>This study highlights differential PsA risk among PsO patients on biologic therapy, suggesting potential benefits of IL12/23i and IL23i in PsA prevention. Prospective studies are needed to confirm these findings and optimize PsA prevention strategies.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 1","pages":"Article 104488"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145686755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}