Actas dermo-sifiliograficas最新文献

{"title":"Recent developments in the histopathology of non-scarring alopecias.","authors":"A Fernandez-Flores","doi":"10.1016/j.ad.2025.02.030","DOIUrl":"https://doi.org/10.1016/j.ad.2025.02.030","url":null,"abstract":"<p><p>The diagnosis of alopecia has traditionally relied on distinguishing between scarring and non-scarring forms, a differentiation that is not always straightforward from either a clinical or histopathological perspective. While the histopathological features of various types of alopecia are well established, recent reports have introduced new variants of non-scarring alopecia and identified histological features to achieve diagnosis. Some of these findings have therapeutic implications, while others provide novel pathogenic insights that enhance our understanding of alopecia. This article highlights recent advancements in the histopathology of non-scarring alopecia as reported in the literature.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous versus combined subcutaneous and intramuscular botulinum toxin for androgenetic alopecia: a randomized clinical trial.","authors":"A A Lima-Galindo, S S Ocampo-Garza, J Ocampo-Candiani, A Tosti, A Sarahi Guerra-Garza, J Ocampo-Garza","doi":"10.1016/j.ad.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.ad.2025.01.012","url":null,"abstract":"<p><strong>Background: </strong>Botulinum toxin A has emerged as an alternative treatment for patients who have contraindications to other therapies or as an adjuvant therapy in the treatment of androgenetic alopecia (AGA), although little is known about its safety and efficacy profile or the mechanism involved in this disease.</p><p><strong>Objective: </strong>To evaluate the efficacy profile of botulinum toxin as monotherapy for AGA and compare subcutaneous vs subcutaneous and intramuscular application.</p><p><strong>Methods: </strong>We conducted a 6-month, randomized, controlled trial to compare the efficacy of subcutaneous vs combined intramuscular and subcutaneous botulinum toxin application in men with AGA at a dermatology clinic in northeastern Mexico.</p><p><strong>Results: </strong>A total of 15 men, aged 27 to 63 years, diagnosed with androgenetic alopecia (AGA) classified as stages III to V on the Hamilton-Norwood scale, and with no prior treatment for, at least, 6 months prior to being included in the study, were randomly allocated following a computer-generated sequence created prior to the start of the study. The sequence was blinded to both patients and investigators. Participants received a single session of botulinum toxin, administered either subcutaneously and intramuscularly (Group A) or subcutaneously as monotherapy (Group B). Each patient received 100 units of botulinum toxin. When comparing the initial and follow-up trichoscopic photographs of the frontal and vertex regions 6 months after botulinum toxin application using Fotofinder Trichoscale®, no significant changes were observed in hair density or the vellus/terminal hair ratio in either Group A or Group B (p > 0.05), and a significant reduction in hair thickness was detected in the frontal region of both groups. Terminal hair count in the frontal region decreased significantly in Group A (p = 0.035), whereas the reduction in Group B was not statistically significant. In the occipital region, none of the evaluated parameters showed significant changes (p > 0.05). Additionally, no significant differences were seen between the 2 treatment modalities 6 months after application (p > 0.05).</p><p><strong>Conclusion: </strong>Based on our study, we did not find any supportive results for the use of botulinum toxin in the treatment of AGA.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title: Addition of Antihistamines to Therapy with Isotretinoin for Moderate to Severe Acne: A Friendly Summary of the Body of Evidence (FRISBEE).","authors":"V Meza, A Figueroa, D Saavedra, F Valenzuela","doi":"10.1016/j.ad.2025.02.028","DOIUrl":"https://doi.org/10.1016/j.ad.2025.02.028","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish dermatologists' publications in top-tier journals: a bibliometric analysis (1950-2024).","authors":"W Hassan, A E Duarte","doi":"10.1016/j.ad.2025.02.029","DOIUrl":"https://doi.org/10.1016/j.ad.2025.02.029","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing nipple adenoma: the utility of dermoscopy.","authors":"M Colmenero Sendra, P Gutiérrez Hernández, J B Repiso Jiménez","doi":"10.1016/j.ad.2023.12.011","DOIUrl":"https://doi.org/10.1016/j.ad.2023.12.011","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated digital clubbing due to a rare tumor.","authors":"Agbf Andrade, C M Murari, T B Brandalize, A O Michalany","doi":"10.1016/j.ad.2023.11.026","DOIUrl":"https://doi.org/10.1016/j.ad.2023.11.026","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy profile of anti-IL17 treatments in hidradenitis suppurativa: systematic review and meta-analysis of randomized placebo-controlled trials.","authors":"O Al-Wattar-Ceballos, L Martínez-Montalvo, M Carmona-Rodríguez","doi":"10.1016/j.ad.2024.12.027","DOIUrl":"https://doi.org/10.1016/j.ad.2024.12.027","url":null,"abstract":"<p><strong>Background and objective: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is difficult to manage, requiring the use of biologic drugs such as anti-TNFα and anti-interleukin 17 (anti-IL17). The aim of our review is to evaluate the safety and efficacy profile of anti-IL17 drugs in patients with HS.</p><p><strong>Materials and methods: </strong>We conducted a systematic review with subsequent meta-analysis following the population, intervention, comparison, outcome and type of study (PICOS) method. We included only randomized clinical trials with placebo (S) that included individuals with HS > 18 years old (P), and who had been on placebo (C) OR, an anti-IL17 biologic drug (I) to measure safety and efficacy outcomes (O). Search was conducted across multiple databases: PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. The risk of bias of each study, publication bias, sensitivity analysis, and certainty of evidence were determined.</p><p><strong>Results: </strong>A total of 320 bibliographic references were obtained, 4 of which met the inclusion criteria. Compared to placebo, the meta-analysis showed a significantly higher percentage of patients achieving Hidradenitis Suppurativa Clinical Response (HiSCR) OR, of 1.96 [1.79-2.15], a greater decrease in DLQI, MD -1.92 [-2.68,-1.16] and an increase in adverse effects; OR, 1.21 [1.09, 1.34], particularly due to Candida infections; OR, 5.61 [2.66-11.83].</p><p><strong>Conclusions: </strong>Treatment with anti-IL17 biologic drugs is effective in patients with moderate-to-severe HS. Although these drugs are safe, they should be monitored due to the risk of infections, mainly candidiasis.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic association of TYR rs7129973 with Vitiligo vulgaris in Mexicans.","authors":"M A Salinas-Santander, A A Lima-Galindo, A A Marques-Esparza, J A Ocampo-Garza, J Ocampo-Candiani","doi":"10.1016/j.ad.2024.09.032","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.032","url":null,"abstract":"<p><p>Vitiligo is a multifactorial disease characterized by skin depigmentation. Although there are several genetic components involved in its development, the participation of the TYR rs7129973 gene polymorphism has not yet been explored. Our objective was to evaluate the association between vitiligo vulgaris and the TYR rs7129973 gene polymorphism in a Mexican population. Therefore, a total of 84 vitiligo vulgaris patients and 90 control subjects from northeastern Mexico were analyzed through PCR-RFLP to determine the association between vitiligo and TYR rs7129973. We found that the carriers of TYR rs7129973 G alleles (AG and GG genotypes) were more prevalent among patients with vitiligo (P < 0.05). However, this genetic variant had no correlation with the age of onset, vitiligo activity, family history of vitiligo, and personal history of thyroid disease (P > 0.05). Thereby, we can conclude that the TYR rs7129973 polymorphism constitutes a risk factor for the development of vitiligo vulgaris in the Mexican population.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory cell immunophenotypes in regressing melanomas and halo nevi: possible keys to distinguish intensely inflamed tumors.","authors":"A Brugués, G Roccuzzo, A Garcia-Herrera, L Alós, J Malvehy, S Puig, R Senetta, S Ribero, C Carrera","doi":"10.1016/j.ad.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.ad.2025.01.011","url":null,"abstract":"<p><strong>Introduction: </strong>The immunophenotypic analysis of inflammatory cells in the tumor microenvironment of regressing melanomas is object of ongoing debate. On the other hand, benign halo nevi paradigmatically show marked inflammation. Characterizing these immune profiles can provide insights into the local immune response, its pathogenesis, and differential diagnosis.</p><p><strong>Methodology: </strong>A cohort of 16 clinically atypical Sutton nevi from Hospital Clínic de Barcelona, Spain, and 70 regressing melanomas from Turin University Hospital, Italy, were evaluated. Histological assessments analyzed inflammation density, location, fibrosis, and markers like CD3, CD4, CD8, CD25, FOXP3, and PD1.</p><p><strong>Results: </strong>Sutton nevi showed higher inflammation density than regressing melanomas, but similar location and quantity of fibrosis. Sutton nevi had higher CD8/CD3 ratios and melanomas, higher CD4/CD3 and CD4/CD8 ratios. Markers such as CD25/CD4, FOXP3/CD4, and PD1/CD4 were more common in Sutton nevi.</p><p><strong>Conclusion: </strong>Results indicate a stronger cytotoxic reaction and consequently a regulatory mechanism in halo nevi, characterized by increased PD1, FOXP3, and CD25. This research further characterizes halo nevi and regressing melanomas, and shows possible clues to distinguish those challenging inflamed melanocytic tumors from melanomas.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postherpetic pseudohernia: a case report.","authors":"P López Sanz, A García Vázquez, M E Alfaro Martínez","doi":"10.1016/j.ad.2024.01.028","DOIUrl":"https://doi.org/10.1016/j.ad.2024.01.028","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}