Actas dermo-sifiliograficas最新文献

Response: Wood's lamp in inflammatory, autoimmune, and infectious dermatoses and skin cancer. 反应：伍德灯在炎症、自身免疫、感染性皮肤病和皮肤癌中的作用。

IF 2.9

Actas dermo-sifiliograficas Pub Date : 2026-09-05 DOI: 10.1016/j.ad.2026.104718

M Torrent García, J Pardo Sánchez, F Alarcón Soldevilla

引用次数: 0

New treatments for adult female acne. 成年女性痤疮的新疗法。

IF 2.9

Actas dermo-sifiliograficas Pub Date : 2026-06-24 DOI: 10.1016/j.ad.2026.104703

M Zalve-Vicedo, T Montero-Vilchez, A Buendía-Eisman, S Arias Santiago

{"title":"New treatments for adult female acne.","authors":"M Zalve-Vicedo, T Montero-Vilchez, A Buendía-Eisman, S Arias Santiago","doi":"10.1016/j.ad.2026.104703","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104703","url":null,"abstract":"<p><strong>Introduction: </strong>Adult female acne is a common dermatological condition whose management is challenging because of its tendency toward chronicity, recurrence, and resistance to available treatments. The aim of this systematic review is to study the effectiveness, safety, and use profile of antiandrogenic treatments used as an alternative in women who present alterations in androgen hormones or receptors or who have a state of hyperandrogenism.</p><p><strong>Material and methods: </strong>A search was conducted in the PubMed database including all types of epidemiological studies-clinical trials, retrospective, prospective, cohort, and case-series studies-published in the last 10 years and performed in humans that evaluated the effectiveness and safety of antiandrogenic treatments-spironolactone, metformin, and bicalutamide-in patients with acne.</p><p><strong>Results: </strong>Thirteen articles met the inclusion criteria, evaluating a total of 1335 patients. Of these 13 articles, 4 (30.8%) addressed spironolactone and 9 (69.2%) addressed metformin. No studies were found evaluating the effectiveness and tolerability of bicalutamide for acne. Both drugs showed good results in reducing acne lesions, measured with different scales, and in terms of safety and tolerability. The most frequent adverse effects were menstrual irregularities in the case of spironolactone and gastrointestinal discomfort with the use of metformin. The latter also showed good results in improving the lipid profile, insulin resistance, and BMI, which should be taken into consideration in the management of acne associated with polycystic ovary syndrome.</p><p><strong>Conclusion: </strong>Although antiandrogenic treatments such as spironolactone and metformin have shown promise as options for the management of acne in adult women, more controlled and randomized studies comparing these drugs with each other and with placebo are needed to evaluate their efficacy and tolerability with a higher level of evidence.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104703"},"PeriodicalIF":2.9,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Botulinum Toxin for Pachyonychia Congenita: A Case Report on the Management of Loss of Therapeutic Response. 肉毒杆菌毒素治疗先天性厚甲：1例治疗反应丧失的处理报告。

IF 2.9

Actas dermo-sifiliograficas Pub Date : 2026-06-24 DOI: 10.1016/j.ad.2026.104712

L Mateu-Arrom, H Iznardo, E Roé, E Baselga, L Puig, C Morales-Munera

引用次数: 0

Specific autoantibody profile in a case series of mucous membrane pemphigoid. 粘膜类天疱疮病例系列的特异性自身抗体谱。

IF 2.9

Actas dermo-sifiliograficas Pub Date : 2026-06-22 DOI: 10.1016/j.ad.2026.104695

M Viedma-Martinez, R Roman-Cheuque, R de la Varga-Martínez, D Jimenez-Gallo, T Hashimoto, M Linares-Barrios

引用次数: 0

Refractory Dermatomyositis Treated With Anifrolumab: Clinical Response and Dynamics of Type-I Interferon Signature. 用Anifrolumab治疗难治性皮肌炎：临床反应和i型干扰素信号的动态。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-15 DOI: 10.1016/j.ad.2026.104679

M E Gimeno-Ribes, A Mensa-Vilaro, J I Aróstegui, S Prieto-González, J C Milisenda, X Bosch-Amate, J M Mascaró

{"title":"Refractory Dermatomyositis Treated With Anifrolumab: Clinical Response and Dynamics of Type-I Interferon Signature.","authors":"M E Gimeno-Ribes, A Mensa-Vilaro, J I Aróstegui, S Prieto-González, J C Milisenda, X Bosch-Amate, J M Mascaró","doi":"10.1016/j.ad.2026.104679","DOIUrl":"10.1016/j.ad.2026.104679","url":null,"abstract":"<p><p>Dermatomyositis (DM) is a systemic inflammatory disease predominantly affecting the skin and muscles, with potential involvement of internal organs. Despite multiple therapeutic options, treatment response may be unsatisfactory. Type-I interferon (IFN) signaling pathways have been proposed as key drivers of disease pathogenesis. Consequently, treatment with anifrolumab, a monoclonal antibody targeting IFN receptor-1, may offer therapeutic benefit. To date, only a few cases of refractory DM successfully treated with anifrolumab have been reported. We present two cases of refractory DM treated with anifrolumab achieving an almost complete cutaneous response. Longitudinal evaluation of the type-I IFN signature revealed a decrease during treatment. These findings support the hypothesis that type-I IFN plays a pathogenic role in DM, especially in patients with refractory disease. In this context, we aim to highlight the importance of considering anifrolumab as a therapeutic option and underscore the potential of the IFN signature as a biomarker of treatment response.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104679"},"PeriodicalIF":2.8,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acne Vulgaris and Quality of Life: A Study of 100 Cases. 寻常性痤疮与生活质量：100例研究。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-15 DOI: 10.1016/j.ad.2026.104680

Fatima-Zahra Agharbi, Bouchra Elghouti, Soumiya Chiheb

引用次数: 0

Hair Graying Update and Review 头发变白的更新和回顾。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-01 Epub Date: 2025-12-17 DOI: 10.1016/j.ad.2025.104564

K.M. Ramirez-Gomez , A. Imbernon-Moya , M.F. Villegas-Calzada , S. Vano-Galvan , D. Saceda-Corralo

引用次数: 0

Human Amniotic Membrane Grafting for the Management of Toxic Epidermal Necrolysis 人羊膜移植治疗中毒性表皮坏死松解症。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-01 Epub Date: 2025-12-17 DOI: 10.1016/j.ad.2025.104567

M. Mansilla-Polo , P. Alvedro-Ruiz , M.D. Pérez-Del Caz , R. Botella-Estrada

引用次数: 0

Evaluation of the Efficacy of Photoprotective Formulations Applied in Conjunction With Topical Active Ingredients in Patients With Photodermatoses 评价光防护制剂与外用活性成分联合应用于光性皮肤病患者的疗效。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-01 Epub Date: 2025-12-30 DOI: 10.1016/j.ad.2025.104581

R. Castillo-Muñoz , J. Aguilera , E. Navarrete-De Gálvez , E. Herrera-Acosta , J.A. Suárez-Pérez , M. Rodríguez-Ruiz , C. Sánchez-Roldán , L. Martínez-Pilar , D.J. Godoy-Díaz , M. Aguilar-Bernier , M. De Troya-Martín , M.V. De Gálvez

{"title":"Evaluation of the Efficacy of Photoprotective Formulations Applied in Conjunction With Topical Active Ingredients in Patients With Photodermatoses","authors":"R. Castillo-Muñoz , J. Aguilera , E. Navarrete-De Gálvez , E. Herrera-Acosta , J.A. Suárez-Pérez , M. Rodríguez-Ruiz , C. Sánchez-Roldán , L. Martínez-Pilar , D.J. Godoy-Díaz , M. Aguilar-Bernier , M. De Troya-Martín , M.V. De Gálvez","doi":"10.1016/j.ad.2025.104581","DOIUrl":"10.1016/j.ad.2025.104581","url":null,"abstract":"<div><h3>Background</h3><div>One of the main strategies in the prevention of photodermatoses is the use of topical sunscreens, which sometimes must be applied together with topical drugs specific for the dermatosis with the possibility that the efficacy of the sunscreen may be altered.</div></div><div><h3>Objectives</h3><div>The aim of this study was to analyse whether the efficacy of the sunscreen could be affected when applied together with topical drugs routinely used in patients with photodermatoses and whether there is any variation when they are applied before or after the drug.</div></div><div><h3>Methods</h3><div>Ninety-three volunteer patients with photodermatoses participated. Very high SPF sunscreens were used with corticosteroids, antibiotics and topical antifungals as active ingredients. Paravertebral areas were delimited in each individual and the sunscreen was applied alone and in association with a drug in different sequential order. Ultraviolet reflectance photography and image analysis were used to compare the level of UV absorption by the sunscreen/drug combinations in the different areas.</div></div><div><h3>Results</h3><div>UV reflectance analysis showed no difference in the efficacy of the sunscreen applied before or after the various drugs used. In the antifungal group, a significant increase in the effect of the sunscreen was observed when the antifungal was applied first.</div></div><div><h3>Conclusions</h3><div>The efficacy of sunscreens was not altered by combined use with corticosteroids, antibiotics or topical antifungals. These results are of great relevance for patients with photodermatosis who often have to combine these active ingredients with photoprotection.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104581"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Ultrasound in Digital Fibrokeratomas: Series of 4 Cases 手指纤维性角化瘤的皮肤超声诊断（附4例分析）。

IF 2.8

Actas dermo-sifiliograficas Pub Date : 2026-05-01 Epub Date: 2025-12-17 DOI: 10.1016/j.ad.2025.104572

C. Sobrino García-Yanes, C. Carrión-García, A. Garrido-Ríos, B. Echeverría-García, H. Álvarez-Garrido, J. Borbujo-Martínez

引用次数: 0