Actas dermo-sifiliograficas最新文献

{"title":"Pollution, a Relevant Exposome Factor in Skin Aging and the Role of Multi-benefit Photoprotection.","authors":"J Santamaria, Y Gilaberte, L Prudkin, J Piquero-Casals","doi":"10.1016/j.ad.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.ad.2025.04.005","url":null,"abstract":"<p><p>Skin aging is a complex, continuous, multifactorial process resulting from cumulative morphological and functional changes in the skin over time. This happens because of 2 processes: intrinsic and extrinsic skin aging. Intrinsic skin aging occurs naturally over time and reflects each person's genetic makeup, or heredity. Extrinsic skin aging, on the other hand, is due to exposomal factors, such as solar radiation, air pollution, tobacco or nutrition, being the first 2 the most important of all. Exposure to air pollutants, primarily gases such as ground-level ozone and particulate matter, can accelerate the process via 4 key mechanisms: reactive oxygen species generation, inflammation, skin microbiome disruption, and aryl hydrocarbon receptor activation. Regarding solar radiation, all wavelengths reaching the Earth's surface have an impact on the skin, having a synergistic effect with air pollution (\"photo-pollution\"). Here, we discuss this phenomenon and mitigation strategies, including sunscreens, cosmetics with film-forming plus antioxidant ingredients, and oral supplementation.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver Variability in the Histopathological Evaluation of Melanoma: Analysis of 60 Cases.","authors":"V Sanz-Motilva, A Martorell, E Manrique-Silva, L Terradez-Mas, C Requena, V Traves, O Sanmartín, J L Rodríguez-Peralto, E Nagore","doi":"10.1016/j.ad.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.ad.2025.04.004","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving Landscape of Melanoma in Portugal, Spain, Italy, and Greece: Trends and Insights.","authors":"L Cayuela, J J Pereyra-Rodríguez, J C Hernández-Rodríguez, R C Bueno-Molina, A Cayuela","doi":"10.1016/j.ad.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.ad.2025.04.002","url":null,"abstract":"<p><strong>Objective: </strong>To study melanoma incidence trends from 1990 through 2021 in Southern European countries-Portugal, Spain, Italy, Greece-and explore regional and age-period-cohort (A-P-C) patterns.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease Study 2021 were used to calculate age-standardized incidence rates (ASIRs). Joinpoint regression and age-period cohort (A-P-C) models were applied to identify trends and patterns.</p><p><strong>Results: </strong>A substantial increase in melanoma ASIRs was observed across all Southern European countries from 1990 through 2021. Joinpoint analysis revealed a potential turning point in the 2010s, with ASIRs stabilizing or declining in younger age groups across all countries. For instance, rates among younger women in Italy, Portugal, and Spain have shown signs of stabilization or decline, while Greek women experienced a continued but slower increase. Men exhibited a similar trend, except for Greece, where the increase rate persisted albeit at a slower pace. Gender differences were evident, with younger women generally facing higher risks vs men but exhibiting a slower rise in incidence with age. The A-P-C analysis confirmed a pronounced cohort effect, indicating a higher risk for melanoma among earlier birth cohorts. Among younger generations, there is evidence of stabilization or even a decline in incidence rates.</p><p><strong>Conclusion: </strong>Melanoma rates are rising in Southern Europe, especially among men. While younger populations show promising declines, likely due to sun protection efforts, older generations continue to be affected. Addressing regional disparities and sustaining these positive trends requires ongoing efforts and comprehensive prevention strategies.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Approach to Hidradenitis Suppurativa.","authors":"L Mateu-Arrom, L Puig, E Vilarrasa","doi":"10.1016/j.ad.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.ad.2025.04.003","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review on Dietary Supplements in the Prevention and/or Treatment of Actinic Keratosis and Field Cancerization.","authors":"A Rodríguez-Luna, A Zamarrón, C Longo, G Pellacani, K Peris, P Calzavara-Pinton, M V de Galvez, Y Gilaberte, M de Troya, Á Juarranz, Salvador González","doi":"10.1016/j.ad.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.ad.2025.04.001","url":null,"abstract":"<p><strong>Background: </strong>Actinic keratoses (AKs) are chronic, recurrent precancerous lesions primarily induced by long-term sun exposure, commonly found on sun-exposed areas such as the face, neck, hands, forearms, and lower legs. AKs are prevalent, affecting millions worldwide, and pose a significant risk of transforming into invasive squamous cell carcinomas (SCCs).</p><p><strong>Objective: </strong>This systematic review aims to update the scientific evidence on the role of oral bioactives, nutraceuticals, or dietary supplements in the treatment of AKs and field cancerization, while evaluating their safety and efficacy profile.</p><p><strong>Methods: </strong>A review plan was pre-registered in the PROSPERO database (CRD42023485985). Following the PRISMA guidelines, we identified, selected, and included relevant studies. We screened a total of 234 articles, thoroughly reviewed 38 full texts, and ultimately included 21 articles published from 2013 through 2023 for analysis.</p><p><strong>Results: </strong>The selected studies were categorized into 3 groups based on the chemical nature of the supplements: polyphenols (11 studies), vitamins (8 studies), and others (2 studies). The studies included preclinical (9) and clinical (12) studies. Clinical trials have demonstrated the efficacy profile of polyphenolic supplements, such as Polypodium leucotomos extract (PLE) and others in improving skin health and reducing the risk of skin cancers. Preclinical studies highlighted the protective effects of polyphenols against UV-induced damage and neoplastic transformation. Vitamin supplementation studies revealed mixed results, with clear data showing benefits in reducing the risk of precancerous lesions and skin cancers after nicotinamide (NAM) treatment, while others did not demonstrate significant protective effects.</p><p><strong>Conclusions: </strong>The review confirms the efficacy of polyphenols in preventing and treating AKs and related skin conditions. However, the role of vitamins and other supplements requires further investigation due to inconsistent and/or scarce findings. Future clinical trials should focus on diverse populations at higher risk of skin cancer and explore new ingredients as well as combinations of various ingredients to optimize therapeutic applications.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Assessment of Infantile Hemangioma Cosmetic Clinical Outcomes: Results of the Spanish Hemangioma Nationwide Prospective Cohort","authors":"M. Colmenero-Sendra ,&nbsp;J. del Boz-González ,&nbsp;E. Baselga Torres ,&nbsp;J. Bernabéu-Wittel ,&nbsp;E. Roé-Crespo ,&nbsp;A. Vicente ,&nbsp;M. Valdivieso-Ramos ,&nbsp;A. Martín-Santiago ,&nbsp;S.I. Palencia-Pérez ,&nbsp;M.T. Montserrat-García ,&nbsp;A. Azón-Masoliver ,&nbsp;M. Dañino ,&nbsp;C. Tubau Prims ,&nbsp;C. Prat ,&nbsp;A. Giacaman ,&nbsp;J.J. Domínguez-Cruz ,&nbsp;A. Bauzá Alonso ,&nbsp;M. Grau-Pérez ,&nbsp;M.Á. Descalzo ,&nbsp;I. García-Doval","doi":"10.1016/j.ad.2024.06.010","DOIUrl":"10.1016/j.ad.2024.06.010","url":null,"abstract":"<div><h3>Background</h3><div>Functional impairment is the main consideration when it comes to choosing therapy for infantile hemangiomas (IH). However, since most hemangiomas are treated for cosmetic reasons, it is important to know the cosmetic outcome assessed by the parents.</div></div><div><h3>Objective</h3><div>To evaluate the aesthetic outcomes of IH, considering the characteristics of the lesions and the treatments used.</div></div><div><h3>Patients and methods</h3><div>The Spanish Infantile Hemangioma Nationwide Prospective Cohort (2016–2022) recruited all consecutive patients diagnosed with IH in 12 Spanish hospitals. The children included had two photos of the IH lesion (at both baseline and at the end of the study). A panel of parents blindly assessed all available photos using a scale from 0 (worst cosmetic outcomes) to 10 (best cosmetic outcomes). The different scores – both before and after treatment – as well as the outcomes percent considered excellent (<u>&gt;</u>9) were described and compared. We analyzed the effect of receiving different therapies and performed causal model analyses estimating the mean treatment effect of parents’ assessments.</div></div><div><h3>Results</h3><div>The median follow-up was 3.1 years. A total of 824 photos were evaluated. Baseline aesthetic impact was higher in the propranolol group vs the topical timolol and observation treatment groups (1.85 vs 3.14 vs 3.66 respectively; <em>p</em> <!-->&lt;<!--> <!-->0.001). After treatment, the aesthetic impact was similar between both treatment groups (7.59 vs 7.93 vs 7.90; <em>p</em> <!-->&gt;<!--> <!-->0.2). The causal model could only be applied to the comparison between topical timolol and observation, revealing no differences whatsoever.</div></div><div><h3>Conclusion</h3><div>This is the first prospective cohort to analyze the aesthetic outcome of IH. The final aesthetic results of the three therapies were similar, with nearly 40% of patients achieving excellent aesthetic outcomes.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 327-336"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comedones perianales: ¿una variante de hidradenitis supurativa o una entidad per se? Serie de 5 casos","authors":"M. Fabregat-Pratdepadua,&nbsp;V. Mora Fernández,&nbsp;J. Verdaguer-Faja,&nbsp;J. Bassas Vila","doi":"10.1016/j.ad.2023.10.054","DOIUrl":"10.1016/j.ad.2023.10.054","url":null,"abstract":"<div><div>Although comedones are a prevalent entity in multiple skin diseases, their perianal location as a cluster is a rare finding. We describe 5 patients with grouped perianal comedones who developed the lesions in adulthood and were treatment-naïve in the perianal area. Four of them had had inflammatory lesions in armpits and groins. In 2, the anatomopathological examination revealed the presence of follicular infundibulum dilatation, cystification, and fibrotic and inflammatory changes in the underlying dermis—findings consistent with hidradenitis suppurativa—which is why we wonder whether grouped perianal comedones are a mild form of hidradenitis suppurativa or an isolated entity.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 403-406"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FR - Actualización en el tratamiento de la alopecia areata","authors":"E.L. Pinto-Pulido ,&nbsp;E. García-Verdú ,&nbsp;D. Vega-Díez","doi":"10.1016/j.ad.2024.04.029","DOIUrl":"10.1016/j.ad.2024.04.029","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 423-424"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terapia compresiva en las heridas de pierna por aumento del espacio de difusión","authors":"B. Gonzalez Rodriguez ,&nbsp;L. Calderon Lozano ,&nbsp;J. Fulgencio Barbarin ,&nbsp;E. Conde Montero","doi":"10.1016/j.ad.2024.05.030","DOIUrl":"10.1016/j.ad.2024.05.030","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 442-443"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eritema, edema localizado y calor versus aumento del perímetro del antebrazo. ¿Ha llegado el momento de revisar las recomendaciones de consenso de la prueba de provocación del vórtice en urticaria-angioedema vibratorios?","authors":"M.E. Gatica-Ortega ,&nbsp;B. Sánchez-Albisua ,&nbsp;D.M. Arranz-Sánchez ,&nbsp;B. Pérez-Tato ,&nbsp;A. Sánchez-Gilo ,&nbsp;S. Córdoba-Guijarro ,&nbsp;F.J. Ortiz-Frutos ,&nbsp;N. Hernández-Cano ,&nbsp;E. Gómez de la Fuente ,&nbsp;M. Elosua-González ,&nbsp;M. Bergón-Sendín ,&nbsp;C. García-Martín ,&nbsp;T. Sanz-Sánchez ,&nbsp;O. Mazuela-Díez ,&nbsp;R. Torres-Aranda ,&nbsp;L. Vergara-de-la-Campa ,&nbsp;S. Marinero-Escobedo ,&nbsp;A. Alegre-Bailo ,&nbsp;A. Garrido-Ríos ,&nbsp;F. Tous-Romero ,&nbsp;M.A. Pastor-Nieto","doi":"10.1016/j.ad.2024.10.058","DOIUrl":"10.1016/j.ad.2024.10.058","url":null,"abstract":"<div><h3>Background and objective</h3><div>Diagnosis of vibratory urticaria/angioedema is established after performing the vortex provocation test. There is current consensus on measuring the forearm perimeter after running such test to define a positive response to it.</div></div><div><h3>Material and method</h3><div>We evaluated the frequency of prior symptoms following vibratory stimuli in volunteers using a questionnaire, response to the vortex provocation test in the same volunteers (increase in forearm perimeter, erythema, localized edema, heat, and pruritus), interrater reliability, and correlation between the scores obtained in the questionnaire and response to the test.</div></div><div><h3>Results</h3><div>A total of 40 volunteers participated in this survey, 17 of whom were excluded due to dermographism. A total of 59% out of 123 without dermographism responded positively to ≥1 items of the questionnaire. Localized erythema, heat or localized edema were reported in 58.5%, 38.2%, and 32.5%, respectively. A total of 73.6% of volunteers presented with itch. The mean intensity of itch was 3.44, 95%CI: 2.94-3.94). Interrater agreement was low regarding the increase in forearm circumference at 3 levels (intraclass correlation coefficient, 0.477, 95%CI: 0.253-0.634; 0.496, 95%CI: 0.280-0.647; and 0.370, 95%CI: 0.100-0.559, respectively) and optimal regarding erythema, heat and localized edema (Kappa index, 0.868; 0.756; and 0.757, respectively). A significant correlation was identified between the questionnaire score and the altered response to the test in its different variables.</div></div><div><h3>Conclusions</h3><div>We propose the following variables: erythema; localized edema; heat; and the intensity/speed of onset/duration of pruritus to define a positive response to the vortex provocation test given their ease of execution and optimal inter-observer agreement.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 357-364"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}