Actas dermo-sifiliograficas最新文献

{"title":"Survival and mortality risk factors in patients aged 85 years and older attending an oncologic dermatology unit: A retrospective study of 102 patients.","authors":"Ri Fernández-de-Misa Cabrera, R Fernández-de-Misa-Sánchez, J González Rodríguez, M N Hernández Hernández","doi":"10.1016/j.ad.2026.104761","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104761","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104761"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile pyoderma gangrenosum.","authors":"I López Riquelme, E Gómez Moyano, L Martínez Pilar","doi":"10.1016/j.ad.2026.104765","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104765","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104765"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Frequency Ultrasound in High-Risk Cutaneous Squamous Cell Carcinoma.","authors":"I Ciobotariu, M Sanmartin, E Nagore, C Requena, B Llombart, C Serra, O Sanmartin","doi":"10.1016/j.ad.2026.104767","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104767","url":null,"abstract":"<p><strong>Introduction: </strong>High-frequency ultrasound (HFUS) is a valuable tool for the preoperative tumor assessment of cutaneous squamous cell carcinoma (cSCC). A subgroup of patients with cSCC is at an increased risk of tumor recurrence, metastasis, and disease-specific mortality - high-risk cSCC (HRcSCC). The use of HFUS can provide early knowledge of tumor thickness and depth of invasion, allowing for more appropriate surgical planning and staging in this subset of patients.</p><p><strong>Materials and methods: </strong>We designed a prospective observational cohort study on patients diagnosed with cSCC and surgically treated on at Instituto Valenciano de Oncología (IVO) from January 1, 2016 to January 31, 2022. Clinical, histological and imaging data necessary for patient management were used. Patients with cSCC in situ, noncutaneous SCC or located in anogenital areas, and those who did not undergo surgical treatment were excluded. HFUS was used preoperatively to assess tumor size, depth, and morphological patterns, which were then compared with histopathological findings.</p><p><strong>Results: </strong>A total of 186 patients with cSCC were included in the study, mostly men (M:F = 3:1), with a mean age of 78.4 years. The patients were followed for a mean of 35 months after surgery. Seven distinct HFUS patterns were identified among HRcSCC cases during the study. Seventy-five cases (40.3%) met high-risk clinical-pathological criteria. There was a significant association between the type of ultrasound pattern and the presence of HRcSCC: chi-square (6) = 22.84; P < .001. HFUS tumor measurements showed strong correlation with histopathology (Pearson's r > 0.85; intraclass correlation coefficient [ICC] = 0.842, P < .001; 95%CI, 0.79-0.88). While HFUS modestly improved specificity over palpation in detecting deep invasion, the difference was not statistically significant.</p><p><strong>Conclusions: </strong>HFUS is a reliable, cost-effective technique for preoperative evaluation of cSCC. It accurately estimates tumor dimensions and helps identify high-risk features based on ultrasonographic patterns. Although not superior to palpation in assessing invasion depth, HFUS enhances risk stratification and informs more precise surgical planning in HRcSCC.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104767"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective series of 40 patients treated with acitretin for hidradenitis suppurativa.","authors":"A Imbernon-Moya, M Martínez-Pérez, C Axpe-Gil, M J Barros-Eyzaguirre, A Domínguez-García, K Magaletskyy-Kharachko","doi":"10.1016/j.ad.2026.104768","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104768","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104768"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mohs micrographic surgery for dermatofibrosarcoma protuberans: our experience using frozen sections and a literature review.","authors":"Sandra Martínez-Fernández, Beatriz González-Sixto, Carlos Feal, Carlos Álvarez, M Teresa Abalde, Ángeles Flórez","doi":"10.1016/j.ad.2026.104763","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104763","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Mohs micrographic surgery (MMS) is considered the gold standard for the treatment of dermatofibrosarcoma protuberans (DFSP). Although paraffin-based MMS is the most widely accepted technique, no study has demonstrated its superiority over frozen-section MMS. We present our experience with frozen-section MMS for DFSP and review the literature.</p><p><strong>Materials and methods: </strong>We conducted a retrospective, observational, single-center study of all patients with DFSP treated with frozen-section MMS between July 2014 and July 2023. Demographic and tumor characteristics, surgical characteristics, and clinical outcomes were analyzed.</p><p><strong>Results: </strong>Twenty-nine patients were included (72.4% female; median age, 46 years). DFSP was most commonly located on the back (27.6%), upper extremities (24.1%), and lower extremities (24.1%). The median preoperative tumor size was 4.5 cm, and the median postoperative defect size was 6.3 cm. Surgical defects were repaired by direct closure in 75% of cases. Two patients experienced postoperative complications. No recurrences were recorded after a median follow-up of 74 months. The median number of MMS stages required was 2 and was significantly higher for tumors located on the extremities (P = .038).</p><p><strong>Conclusions: </strong>We present a series of 29 patients with DFSP treated with frozen-section MMS, with no recurrences after a median follow-up of 74 months. These findings provide additional evidence of the effectiveness and characteristics of this technique. We consider frozen-section MMS a suitable treatment option for DFSP.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104763"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor budding in cutaneous melanoma: An emerging prognostic biomarker associated with metastasis and survival.","authors":"V Allendes-Alvarez, F Villanueva-Andrade, P Vargas-Mora","doi":"10.1016/j.ad.2026.104755","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104755","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104755"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of injectable dermal fillers in aesthetic dermatology: Design and baseline findings from the prospective multicenter SIDE-AEDV registry.","authors":"J C Hernández-Rodríguez, J García-Gavín, M Romero-Rodríguez, S Rodríguez-Marcos, Javier Arnaiz-Campuzano, M Casado-Carreto, B Porto-Hormaza, L Peña-Merino, G Braceras, S Mateo-Suárez, L Pérez-Naranjo, J María-Ricart, M-Á Descalzo, I García-Doval, S Carrasco Sánchez","doi":"10.1016/j.ad.2026.104758","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104758","url":null,"abstract":"<p><strong>Background: </strong> Injectable dermal fillers are widely used in aesthetic dermatology, but systematic safety surveillance remains limited. The SIDE-AEDV registry was established to characterize injectable filler procedures and support future evaluation of adverse events and associated risk factors in Spain.</p><p><strong>Methods: </strong> SIDE-AEDV is a prospective, multicenter observational registry involving dermatologist members of the Spanish Academy of Dermatology and Venereology. Consecutive adult patients receiving dermal fillers were enrolled, and pseudonymized demographic, clinical, and procedural data were collected using REDCap. The protocol includes adverse event surveillance and follow-up at 180 days. This initial analysis describes baseline findings.</p><p><strong>Results: </strong> A total of 571 patients from five centers were enrolled; 96.3% were women, and the mean age was 51.2 years. Previous injectable treatments were reported by 46.2% of participants, with hyaluronic acid being the most frequently used filler. Previous moderate-to-severe complications were documented in 10.7% of patients with available data. Cannulas were used in 58.1% of procedures, and fanning was the most common injection technique (47.7%). Most injections were performed in the subdermal plane (70.4%). The preauricular region, jawline, and mandibular angle were the most frequently treated anatomical sites.</p><p><strong>Conclusions: </strong> The SIDE-AEDV registry provides a prospective framework for monitoring the safety of injectable dermal fillers in routine aesthetic dermatology practice. Its initial findings characterize participating patients and injection techniques, establishing a foundation for future analyses of adverse events, potentially modifiable risk factors, and evidence-based safety recommendations.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104758"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folliculotropic mycosis fungoides presenting with acneiform lesions, comedones, and alopecia: A diagnostic challenge.","authors":"J F Orts Paco, S Mallo García, B Rebollo Caballero","doi":"10.1016/j.ad.2026.104752","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104752","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104752"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schnitzler syndrome vs VEXAS syndrome: Differential diagnosis and response to IL-1 inhibitors in three cases.","authors":"L Taboada Paz, R Román Cheuque, D Jiménez Gallo, M Linares Barrios","doi":"10.1016/j.ad.2026.104750","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104750","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104750"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitors and cardiovascular outcomes in patients with moderate-to-severe psoriasis receiving biologic therapy: A propensity score-matched cohort study.","authors":"A Gotor-Rivera, J Hernández Sánchez, E Chamorro Jiménez, E García Rivera, P L Ortiz Romero, R Rivera-Diaz","doi":"10.1016/j.ad.2026.104756","DOIUrl":"https://doi.org/10.1016/j.ad.2026.104756","url":null,"abstract":"<p><strong>Background: </strong>Patients with moderate-to-severe psoriasis have an increased risk of cardiovascular disease. Sodium-glucose cotransporter 2 (SGLT2) inhibitors provide cardiovascular benefits, but their association with cardiovascular outcomes in patients with psoriasis remains insufficiently studied.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the global TriNetX research network. Patients older than 40 years with plaque psoriasis receiving biologic therapy were categorized according to SGLT2 inhibitor use. Propensity score matching was performed to balance demographic characteristics, cardiovascular risk factors, kidney disease, and concomitant antidiabetic medications.</p><p><strong>Results: </strong>After matching, 2,016 patients were included in each cohort. SGLT2 inhibitor use was associated with a significantly lower incidence of acute myocardial infarction (HR, 0.601; 95%CI, 0.426-0.849), stroke (HR, 0.553; 95%CI, 0.381-0.804), heart failure (HR, 0.751; 95%CI, 0.581-0.970), peripheral artery disease (HR, 0.648; 95%CI, 0.470-0.894), and angina pectoris (HR, 0.601; 95%CI, 0.404-0.894). No significant association was observed for transient ischemic attack.</p><p><strong>Conclusions: </strong>SGLT2 inhibitor use was associated with favorable cardiovascular outcomes in patients with moderate-to-severe psoriasis receiving biologic therapy. These findings support further prospective investigation of SGLT2 inhibitors as a potential strategy for cardiovascular risk reduction in this population.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"104756"},"PeriodicalIF":2.9,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}