Actas dermo-sifiliograficas最新文献

{"title":"RF-Biological Treatments in Familial Benign Pemphigus or Hailey–Hailey Disease","authors":"P. Balado-Simó , M. Mansilla-Polo , J.M. Mascaró Jr.","doi":"10.1016/j.ad.2025.104565","DOIUrl":"10.1016/j.ad.2025.104565","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104565"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Oral Minoxidil as Treatment for COVID-19-Related Telogen Effluvium: Results From a Retrospective Series of 69 Patients","authors":"C.D. Villarreal-Villarreal ,&nbsp;E. Boland-Rodriguez ,&nbsp;D. Mares-Custodio ,&nbsp;D. Asz-Sigall ,&nbsp;J.F. Molina-de la Garza ,&nbsp;D. Saceda-Corralo ,&nbsp;S. Vano-Galvan","doi":"10.1016/j.ad.2025.104569","DOIUrl":"10.1016/j.ad.2025.104569","url":null,"abstract":"<div><h3>Background and objective</h3><div>Coronavirus disease 2019 (COVID-19) associated telogen effluvium (CATE) has been observed in patients after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it is self-limiting, hair loss can be very distressing, and some patients may seek medical treatment to help promote hair regrowth. Low-dose oral minoxidil (LDOM) has emerged as a novel and very efficient therapy for different types of alopecia. However, information on its safety and efficacy profile in the management of CATE remains scarce. This study aims to evaluate the treatment response to LDOM in CATE patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective study at a single dermatology center. Adult patients diagnosed with telogen effluvium from December 2020 to October 2022, with a prior history of SARS-CoV-2 infection, and treated with LDOM were included. The efficacy of LDOM was evaluated with the hair-shedding score (HSS).</div></div><div><h3>Results</h3><div>In all, 69 patients, 50 (72.5%) women and 19 (27.5%) men were included. A total of 55 patients (79.7%) exhibited mild and moderate symptoms; 8 (11.5%), severe disease; and 6 (8.7%) remained asymptomatic. The time elapsed between COVID-19 and telogen effluvium diagnosis was 117 days (80–181). The HSS continuously decreased during the 2nd, 3rd, and 4th visits after treatment initiation. Compared with baseline, the median (interquartile range) HSS was significantly lower at the 2nd visit (5 [5–6]; <em>P</em> <!-->&lt;<!--> <!-->.001), the 3rd visit (4 [3–5]; <em>P</em> <!-->&lt;<!--> <!-->.001), and the 4th visit (2 [1–2]; <em>P</em> <!-->&lt;<!--> <!-->.001). The time for telogen effluvium resolution was 93 days (55–148).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that LDOM is a safe and effective therapy for patients with CATE.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104569"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heparin-Induced Cutaneous Necrosis","authors":"M. Mansilla-Polo ,&nbsp;M. Llavador-Ros","doi":"10.1016/j.ad.2025.104568","DOIUrl":"10.1016/j.ad.2025.104568","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104568"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation Between Gut Microbiome and Inflammatory Interleukins in Psoriasis Patients Compared to Healthy Controls: An Observational Study","authors":"L. Schneller-Pavelescu ,&nbsp;C. Mora-Martínez ,&nbsp;M.J. Sánchez-Pujol ,&nbsp;Y. Sanz ,&nbsp;E. Caparrós-Cayuela ,&nbsp;R. Francés-Guarinos ,&nbsp;J.M. Ramos-Rincón ,&nbsp;I. Belinchón-Romero","doi":"10.1016/j.ad.2025.104579","DOIUrl":"10.1016/j.ad.2025.104579","url":null,"abstract":"<div><h3>Background</h3><div>The gut microbiota interacts with the immune system and plays an important role in many inflammatory diseases such as psoriasis, although the exact mechanisms in this disease are not yet well understood.</div></div><div><h3>Objectives</h3><div>To characterize differences in the microbiota between patients with psoriasis and healthy controls, and to assess the relationship between these differences and the interleukins involved in psoriasis.</div></div><div><h3>Methods</h3><div>A cross-sectional observational study was conducted in which sociodemographic data, blood samples, and stool samples were collected from patients with psoriasis and healthy controls attending our center between June 2019 and May 2020. Cytokines (interleukin (IL) 17, 22, 23, 31, 33, 36, interferon (IFN) γ, and transforming growth factor (TGF) β) were analyzed using ELISA, and microbiota was analyzed through 16S amplicon sequencing.</div></div><div><h3>Results</h3><div>Thirty-six patients and 24 controls were included. Absolute abundance analysis found a higher abundance of the phylum Synergistota in the control group (<em>p</em> <!-->&lt;<!--> <!-->0.05). Differential abundance analysis found higher abundance of the genus <em>Subdoligranulum</em> and <em>Lactobacillus</em>, and the species <em>Bacteroides plebeius</em> (<em>p</em> <!-->&lt;<!--> <!-->0.05), and lower abundance of the species <em>Senegalimassilia anaerobia</em> and the genus <em>Ruminococcus</em> (<em>p</em> <!-->&lt;<!--> <!-->0.05) in the psoriasis group. A relationship was observed between <em>Subdoligranulum</em> and TNFα, IL17, IL22, IL23, IL31, IL33, IL36, IFNγ, and TGFβ (<em>p</em> <!-->&lt;<!--> <!-->0.05), as well as between <em>Lactobacillus</em> and IL17, IL23, IL36, TNFα, and TGFβ (<em>p</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>Significant alterations in the gut microbiota of patients with psoriasis were detected and a relationship with inflammatory interleukins, suggesting their involvement in the disease. These findings could aid in the development of future probiotic treatments for psoriasis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104579"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Erythema and Thickening of the Nasal Skin","authors":"B. Rebollo Caballero ,&nbsp;S. Mallo García ,&nbsp;B. Ocaña Castillo","doi":"10.1016/j.ad.2025.104580","DOIUrl":"10.1016/j.ad.2025.104580","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104580"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade of Biologic Therapy for Hidradenitis Suppurativa: What Have We Achieved?","authors":"J. Romaní","doi":"10.1016/j.ad.2025.104574","DOIUrl":"10.1016/j.ad.2025.104574","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104574"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linezolid, an Alternative to Ertapenem in Recalcitrant Hidradenitis Suppurativa: A Series of 6 Cases","authors":"T.L. Vega López ,&nbsp;L. Aguilar González ,&nbsp;R.P. Román Cheuque ,&nbsp;D. Jiménez Gallo","doi":"10.1016/j.ad.2025.104575","DOIUrl":"10.1016/j.ad.2025.104575","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104575"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adnexal Tumours: The Unconditional Help of Dermoscopy","authors":"L.M. Nieto-Benito ,&nbsp;M. Garrido-Ruiz ,&nbsp;M. Huerta-Brogeras ,&nbsp;A. Tomás-Velázquez ,&nbsp;P. Redondo-Bellón","doi":"10.1016/j.ad.2025.104576","DOIUrl":"10.1016/j.ad.2025.104576","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104576"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Morphea Induced by Simvastatin","authors":"M. Álvarez-Salafranca ,&nbsp;A. Lapeña-Casado ,&nbsp;M. García-García ,&nbsp;A. Montes-Torres","doi":"10.1016/j.ad.2025.104571","DOIUrl":"10.1016/j.ad.2025.104571","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104571"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Hand Swelling as a Sign of Systemic Amyloidosis","authors":"M.A. Sirvent-Sáez,&nbsp;A.I. Sánchez-Del-Campo,&nbsp;D. Moreno-Ramírez","doi":"10.1016/j.ad.2025.104577","DOIUrl":"10.1016/j.ad.2025.104577","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 5","pages":"Article 104577"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}