Actas dermo-sifiliograficas最新文献_第2页

Pilomatricomas: Differential Characteristics Based on the Age of Presentation. 毛囊间质瘤：基于表现年龄的不同特征。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.12.016

J Clavijo Herrera, J M Morón Ocaña, I M Coronel Pérez, C V Almeida González

引用次数: 0

Anifrolumab for of refractory cutaneous lupus erythematosus: a Spanish clinical practice-based multicenter study. 治疗难治性皮肤红斑狼疮的Anifrolumab：一项基于西班牙临床实践的多中心研究。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.09.023

D Martín-Torregrosa, M Mansilla-Polo, A Grau-Echavarría, V Zaragoza-Ninet, N Jara-Rico, R Alcalá-García, I Torres-Navarro, R Botella-Estrada

引用次数: 0

ICHTHYOSIS: clinical and molecular update. Part 1: introduction and non-syndromic ichthyoses. 鱼鳞病：临床和分子更新。第1部分：介绍和非综合征性鱼病。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.09.025

C Gutiérrez-Cerrajero, R González Sarmiento, Á Hernández Martín

{"title":"ICHTHYOSIS: clinical and molecular update. Part 1: introduction and non-syndromic ichthyoses.","authors":"C Gutiérrez-Cerrajero, R González Sarmiento, Á Hernández Martín","doi":"10.1016/j.ad.2024.09.025","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.025","url":null,"abstract":"Ichthyoses are a heterogeneous group of diseases sharing symptoms and a common etiopathogenic mechanism. Clinically, these diseases are characterized by the presence of erythema and variable degrees of skin thickening and desquamation. Although the affected area, severity, and molecular substrate are very variable, they are all signs of a disruption of the barrier formed during epidermal differentiation. Ichthyoses follow patterns of Mendelian inheritance and present symptoms since birth or shortly thereafter. Clinically, they can be categorized into non-syndromic (when symptoms are caused exclusively by the epidermal barrier dysfunction) and syndromic ichthyoses (when the causal gene has extracutaneous functions impacting other organs).Knowledge of molecular mechanisms has improved dramatically over the past few years, and we currently know not only most causal genes, but also the functions of the encoded proteins and their impact on skin barrier formation. In the first part of this review, we'll be introducing ichthyosis physiopathology, along with a clinical and genetic update of non-syndromic entities (those included in the consensus classification and those clinically and/or molecularly characterized since then).","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laboratory changes during dupilumab treatment for atopic dermatitis. 杜匹单抗治疗特应性皮炎期间的实验室变化。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.10.059

D Flor, C Montero-Vilchez, T Montero-Vilchez, S Arias-Santiago, M Gonçalo

{"title":"Laboratory changes during dupilumab treatment for atopic dermatitis.","authors":"D Flor, C Montero-Vilchez, T Montero-Vilchez, S Arias-Santiago, M Gonçalo","doi":"10.1016/j.ad.2024.10.059","DOIUrl":"https://doi.org/10.1016/j.ad.2024.10.059","url":null,"abstract":"Introduction: Dupilumab is an IL-4 / IL-13 inhibitor monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (AD) with remarkable safety and efficacy profiles. However, former studies have reported an increase in serum eosinophils during treatment, with undetermined clinical significance.The objective: of this study is to evaluate changes in blood eosinophils and other laboratory parameters while on dupilumab.Methods: We conducted a multicenter, prospective, observational study from 2018 through 2022 with adolescent and adult patients with moderate-to-severe atopic dermatitis treated with dupilumab from Hospital Universitario Virgen de las Nieves, Spain, and Coimbra University Hospital, Portugal. Clinical scoring of the dermatitis, complete blood count, total serum IgE and LDH levels were collected at baseline and on weeks 8, 16, 24 and 48.Results: We included a total of 81 patients (41 women/40 men; mean age of 30.86 ± 12.26 years). Clinical and demographic characteristics were similar across centres. AD severity scales (EASI, SCORAD, ItchVAS and SleepVAS) showed sustained improvement from week 8 of treatment onwards. Eosinophil levels were significantly higher on week 16 (0.69 x103/μL) vs baseline (0.41 x103/μL) (p = 0.018) and returned to baseline levels on week 48 (0.59 x103/μL, p > 0.05). LDH and IgE levels decreased during the study.Conclusion: Our study showed a significant clinical improvement of AD but a mild and self-limited increase in eosinophil levels on week 16, not associated with any clinical signs. Therefore, elevated serum eosinophil levels in AD patients on dupilumab does not seem clinically relevant and should not condition treatment withdrawal.","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary Intention Healing After Mohs Micrographic Surgery: An Updated Review of Classic and Novel Applications, Benefits and Complications. 莫氏显微摄影手术后的二次意向愈合：经典和新应用的最新回顾，益处和并发症。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.09.024

J Gil-Lianes, I Marti-Marti, D Morgado-Carrasco

引用次数: 0

Glossy, Pale White Plaque on the Thigh. 大腿上有光滑的白斑。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.11.024

I R Camardella, M V Marin, S Rodríguez Saa

引用次数: 0

ICHTHYOSIS: clinical and molecular update. Part 2: syndromic ichthyosis. Diagnostic and therapeutic approach of ichthyosis. 鱼鳞病：临床和分子更新。第二部分：综合征性鱼鳞病。鱼鳞病的诊断和治疗方法。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-02 DOI: 10.1016/j.ad.2024.09.026

C Gutiérrez-Cerrajero, R González Sarmiento, Á Hernández Martín

{"title":"ICHTHYOSIS: clinical and molecular update. Part 2: syndromic ichthyosis. Diagnostic and therapeutic approach of ichthyosis.","authors":"C Gutiérrez-Cerrajero, R González Sarmiento, Á Hernández Martín","doi":"10.1016/j.ad.2024.09.026","DOIUrl":"https://doi.org/10.1016/j.ad.2024.09.026","url":null,"abstract":"Syndromic ichthyoses are a group of disorders whose genetic alterations impact both epidermal and non-epidermal tissues. Therefore, patients present symptoms in other organs. Most are extraordinary and, in some, ichthyosiform desquamation has been poorly described. Their patterns of inheritance are diverse; their extracutaneous clinical signs, heterogeneous; and the skin symptoms, highly variable, which hinders a proper clinical classification. Ichthyosis diagnosis starts with proper anamnesis, detailed physical examination, and detection of associated analytic and/or histologic findings. Genetic testing is indispensable, not only for diagnostic certainty, but also because understanding the molecular substrate for each patient is the first step towards finding an individualized therapeutic regimen. While it will almost invariably involve facilitating desquamation and maintaining skin hydration using topical exfoliants and emollients, recently, replacement therapies aiming at substituting the proteins and lipids specifically altered in each patient are being developed and gene therapy approaches with the ultimate goal of curing the disease are being assessed. In part 2 of this review, we'll be updating the clinical and genetic findings of syndromic entities, ichthyosis diagnosis and treatment.","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Translated article] RF- Relationship Between Porokeratosis and Skin Cancer. [RF-角化病与皮肤癌之间的关系。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1016/j.ad.2024.10.011

M Luque-Luna, L Corbella-Bagot, J M Mascaró

引用次数: 0

[Translated article] Diagnosis of Onychomycosis: Utility of an Immunochromatography Strip Test Compared with Conventional Culture. 甲癣的诊断。与培养法相比，快速抗原检测试验更有用。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-01 Epub Date: 2024-10-10 DOI: 10.1016/j.ad.2024.10.013

L Fernández-Fuente, S Herrero-Ruiz, B Echeverría-García, J García-Martínez, J Borbujo

{"title":"[Translated article] Diagnosis of Onychomycosis: Utility of an Immunochromatography Strip Test Compared with Conventional Culture.","authors":"L Fernández-Fuente, S Herrero-Ruiz, B Echeverría-García, J García-Martínez, J Borbujo","doi":"10.1016/j.ad.2024.10.013","DOIUrl":"10.1016/j.ad.2024.10.013","url":null,"abstract":"Background: Ringworm is highly prevalent in our setting and is frequently observed in our routine clinical practice. Diagnostic confirmation depends on techniques that are not always accessible (PCR), with highly variable sensitivity depending on the observer (direct microscopy) or delayed results (culture, histopathology). Recently, an immunochromatography-based rapid test (Diafactory®) for the antigenic detection of dermatophytes has been developed. This diagnostic tool can help diagnose ringworm, allowing early initiation of treatment and fewer consultation visits.Objective: To determine the sensitivity and specificity of the rapid antigen detection test compared to conventional culture.Material and methods: For a full year, 333 nail samples were collected from patients with suspected onychomycosis. The rapid test and the conventional culture were simultaneously performed on each sample. Those with a positive antigenic test result began treatment early. The remaining patients had appointments for serial cultures and subsequent medical consultation to evaluate the results.Results: Compared to conventional culture, the sensitivity and specificity rates of the rapid antigen detection test are 97.2% and 80.7%, respectively.Conclusion: The effectiveness of the rapid antigen detection test is similar to that of conventional culture for the detection of dermatophytes in nail samples. It is a quick and simple diagnostic technique that reduces the number of patient visits to the hospital, and allows early treatment start.","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"T15-T20"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Translated article] Measurement Assessment of Minimal Disease Activity in Psoriasis in Spain: A National Cross-Sectional Study. 西班牙银屑病最低疾病活动度评估：一项全国横断面研究。

IF 3.8

Actas dermo-sifiliograficas Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1016/j.ad.2024.10.009

G Carretero Hernández, M Ara Martín, S Armesto Alonso, I Belinchón Romero, N Eiris Salvado, M Ferrán Farrés, C Galache Osuna, M García Bustínduy, J García Latasa de Araníbar, M Juliá Manresa, M Llamas Velasco, A López Ferrer, M Roncero Riesco, D Ruiz Genao, R Ruíz-Villaverde, L Salgado Boquete, C Soria Martínez, E Vilarrasa Rull, M A Descalzo

{"title":"[Translated article] Measurement Assessment of Minimal Disease Activity in Psoriasis in Spain: A National Cross-Sectional Study.","authors":"G Carretero Hernández, M Ara Martín, S Armesto Alonso, I Belinchón Romero, N Eiris Salvado, M Ferrán Farrés, C Galache Osuna, M García Bustínduy, J García Latasa de Araníbar, M Juliá Manresa, M Llamas Velasco, A López Ferrer, M Roncero Riesco, D Ruiz Genao, R Ruíz-Villaverde, L Salgado Boquete, C Soria Martínez, E Vilarrasa Rull, M A Descalzo","doi":"10.1016/j.ad.2024.10.009","DOIUrl":"10.1016/j.ad.2024.10.009","url":null,"abstract":"Introduction: In 2017, the Spanish Academy of Dermatology and Venereology Psoriasis Working Group (PWG) designed the Minimal Disease Activity (MDA) criteria to determine the level of disease activity. We hereby present the results of an observational, cross-sectional, multicenter study of the nationwide application of these criteria.Material and methods: We conducted a non-randomized sampling, stratified to achieve autonomic and provincial representation of consecutive patients with psoriasis (Ps) vulgaris without active arthritis. A total of 830 patients were included: 493 men (59.5%), with a mean age of 51.4 years (SD, 14.2), from all autonomous regions of Spain (except for Ceuta and Melilla) and 44 (88%) out of the 50 provinces. A questionnaire was obtained with demographic data, DLQI, subjective assessment-on a scale from 0 to 10-of itching, erythema, desquamation, visibility, and the patients' PASI and BSA.Results: More than 50% failed to meet the MDA criteria (491; 59.2%), with significant differences being reported by region, sex, and age. Additionally, significant differences were reported based on the therapy used (P<.001). The use of biological therapies was associated with higher MDA compliance compared to other therapies (59.4% vs 23.3%). No differences were reported among various biological therapies.Conclusions: The overall rate of MDA compliance is low, with differences being based on geographic location, sex, age, and drug used, yet none of these factors separately justify them.","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":"T21-T30"},"PeriodicalIF":3.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0