Actas dermo-sifiliograficas最新文献

{"title":"Clinical Lessons in Dermatology: Insights into Diagnosis, Management, and Professional Practice","authors":"J.R. Estela Cubells , W.D. James","doi":"10.1016/j.ad.2025.104554","DOIUrl":"10.1016/j.ad.2025.104554","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104554"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained Efficacy of a Short Course of Upadacitinib in Atopic Dermatitis","authors":"S. Córdoba, A. Martínez-Lauwers Dolz, A.A. Garrido-Ríos, J. Borbujo","doi":"10.1016/j.ad.2025.104548","DOIUrl":"10.1016/j.ad.2025.104548","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104548"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Perspectives on the Atopic March: Results of a Cross-Sectional Multicenter National Survey and Brief Review of the Literature","authors":"M. Mansilla-Polo , R. Botella-Estrada , A. Martín-Santiago","doi":"10.1016/j.ad.2025.104545","DOIUrl":"10.1016/j.ad.2025.104545","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104545"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postimplantation Breasts Erythema, Advancing in the Knowledge of Telangiectatic Reticular Erythema","authors":"C. Llamas-Segura, F.J. De La Torre-Gomar, F.J. Navarro Triviño, R. Ruiz-Villaverde","doi":"10.1016/j.ad.2025.104546","DOIUrl":"10.1016/j.ad.2025.104546","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104546"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stretch Marks: Systematic Review of its Therapeutic Approach","authors":"J. Algarra Sahuquillo ,&nbsp;A. Martín-Gorgojo","doi":"10.1016/j.ad.2025.104553","DOIUrl":"10.1016/j.ad.2025.104553","url":null,"abstract":"<div><h3>Introduction</h3><div>Stretch marks are common lesions that affect areas under stress, especially common in pregnant women and adolescents. Despite its prevalence, its treatment and prevention are a challenge in Dermatology.</div></div><div><h3>Material and methods</h3><div>Systematic review of the literature published in PubMed and LILACS (1976–2024). The articles were classified according to their scientific evidence (level 1, randomized controlled studies; level 5, clinical cases).</div></div><div><h3>Results</h3><div>A total of 69 articles were evaluated: 20 on topical treatments, 35 on lasers and energy devices, and 14 on other therapies. Tretinoin at 0.1% and glycolic acid at different concentrations demonstrated clinical improvement, especially in recent stretch marks. Ablative and non-ablative lasers and radiofrequency with microneedles presented good results. Other treatments, such as PRP, are useful in combination.</div></div><div><h3>Conclusions</h3><div>Current evidence does not allow defining a single treatment; some works are of low quality and with small samples. The combination of treatments helps to improve results.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104553"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milia-Like Papules and Ulcerated Nodules in a Man With Bartter Syndrome","authors":"E. Carmona-Rocha ,&nbsp;E. Subiela ,&nbsp;L. Puig ,&nbsp;C.E. Morales-Munera","doi":"10.1016/j.ad.2025.104557","DOIUrl":"10.1016/j.ad.2025.104557","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104557"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Eczematous Reaction to Imiquimod 5% Cream","authors":"C. Fidanzi,&nbsp;N. Mori,&nbsp;V. Dini,&nbsp;E. Manni","doi":"10.1016/j.ad.2025.104558","DOIUrl":"10.1016/j.ad.2025.104558","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104558"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study","authors":"A. Martorell ,&nbsp;E. Vilarrasa-Rull ,&nbsp;P. Fernandez-Crehuet ,&nbsp;A. Molina-Leyva ,&nbsp;M. Mansilla ,&nbsp;R. Garcia-Ruiz ,&nbsp;P. Garbayo-Salmons ,&nbsp;J.M. Ortiz-Salvador ,&nbsp;F. Alfageme-Roldan ,&nbsp;J. Garcias-Ladaria ,&nbsp;J. Bassas-Vila ,&nbsp;I. Fuertes-de-Vega ,&nbsp;L. Carnero-Gonzalez ,&nbsp;M. Almenara-Blasco ,&nbsp;I. Torres-Navarro ,&nbsp;R. Aguayo-Ortiz ,&nbsp;P. Gil Pallares ,&nbsp;R. Fornons-Servent ,&nbsp;I. Gracia-Darder ,&nbsp;V. Mora-Fernández ,&nbsp;J. Melgosa","doi":"10.1016/j.ad.2025.104562","DOIUrl":"10.1016/j.ad.2025.104562","url":null,"abstract":"<div><h3>Background/objective</h3><div>There is no consensus on the response rates of secukinumab, as findings from phase III trials differ from those reported in clinical-practice studies. This study aimed to assess the mid-term safety and efficacy profile of secukinumab in patients with moderate-to-severe Hidradenitis suppurativa (HS).</div></div><div><h3>Methods</h3><div>This retrospective, multicenter study included patients with moderate-to-severe HS treated with secukinumab (300<!--> <!-->mg every four weeks) between 2020 and 2024. Eligible patients were aged ≥18 years, with a clinical diagnosis of moderate-to-severe HS, and a minimum follow-up of 24 weeks. Key exclusions included patients treated with nonstandard secukinumab dosing regimens or those with insufficient clinical data. The primary endpoints were achievement of HiSCR50 (≥50% reduction in the combined count of nodules and abscesses) at weeks 16 and 24). Secondary endpoints included achieving a ≥55% reduction in the International HS Severity Score (IHS4-55) and adverse events.</div></div><div><h3>Results</h3><div>A total of 263 patients (49.4%, women; 50.6%, men; mean age, 41.8<!--> <!-->±<!--> <!-->13.2 years) were included. The most common HS phenotype was mixed (49.4%), and 55.1% had Hurley stage III disease. At weeks 16 and 24, a total of 57.4% and 63.6% of patients achieved HiSCR50, respectively. The mean IHS4 score dropped significantly from 16.7<!--> <!-->±<!--> <!-->10.0 at baseline to 7.6<!--> <!-->±<!--> <!-->5.6 at week 24 (<em>p</em> <!-->&lt;<!--> <!-->0.0001). At weeks 16 and 24, 52% and 56% of patients achieved an IHS4-55 response. Secukinumab was discontinued in 14.5% of patients because of lack of efficacy or adverse events.</div></div><div><h3>Conclusions</h3><div>Secukinumab demonstrated a significant safety and efficacy profile for patients with moderate-to-severe in a real-world setting, with better outcomes than those reported in earlier clinical trials. Response evaluation at both week 16 and 24 is crucial due to variations in treatment effectiveness.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 4","pages":"Article 104562"},"PeriodicalIF":2.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruxolitinib in the Treatment of Vitiligo. The Importance of the JAK STAT Pathway","authors":"J.L. López Estebaranz ,&nbsp;G. Segurado Miravalles ,&nbsp;S. Ros Abarca","doi":"10.1016/j.ad.2025.104543","DOIUrl":"10.1016/j.ad.2025.104543","url":null,"abstract":"<div><div>Vitiligo is a chronic autoimmune disease of multifactorial nature that causes skin depigmentation as a consequence of melanocyte loss. Although sometimes it is said to be untreatable, there are therapies that have succeeded in halting its progression and promoting repigmentation. One of these are inhibitors of the JAK-STAT pathway, which plays a prominent role in the immunopathogenesis of the disease. Ruxolitinib, a JAK 1/2 inhibitor, has been the first topical drug approved for the treatment of vitiligo. This narrative review addresses the immunopathologic processes involved in vitiligo, the role of the JAK-STAT pathway, and the efficacy and safety results of ruxolitinib in the treatment of nonsegmental vitiligo in adult and adolescent patients older than 12 years with facial involvement. In addition, the psychological repercussions and the impact on the quality of life suffered by patients with vitiligo are described.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 3","pages":"Article 104543"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145720011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subungual Involvement in Perforating Granuloma Annulare","authors":"E. Prat-Colilles ,&nbsp;M. Martinez-Molina ,&nbsp;C. Alcoverro Godoy ,&nbsp;A. Quer Pi-Sunyer ,&nbsp;V. Morillas Lahuerta ,&nbsp;J.M. Carrascosa-Carrillo","doi":"10.1016/j.ad.2025.104530","DOIUrl":"10.1016/j.ad.2025.104530","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"117 3","pages":"Article 104530"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}