Actas dermo-sifiliograficas最新文献

{"title":"[Translated article] Clinical–Epidemiological Profile, and Treatment Response in Relation to Associated Atopic Comorbidity in Atopic Dermatitis. Experience From the BIOBADATOP Registry","authors":"V. Peris-Espino ,&nbsp;M. Munera-Campos ,&nbsp;P. Chicharro ,&nbsp;A. González Quesada ,&nbsp;Á. Flórez Menéndez ,&nbsp;P. de la Cueva Dobao ,&nbsp;A.M. Giménez Arnau ,&nbsp;Y. Gilaberte Calzada ,&nbsp;M. Rodríguez Serna ,&nbsp;T. Montero-Vilchez ,&nbsp;J.F. Silvestre Salvador ,&nbsp;R. Ruiz-Villaverde ,&nbsp;M. Elosua-González ,&nbsp;E. del Alcázar-Viladomiu ,&nbsp;J. Sánchez-Pérez ,&nbsp;G. Carretero Hernández ,&nbsp;A. Batalla ,&nbsp;H.J. Suh Oh ,&nbsp;C. Couselo-Rodríguez ,&nbsp;C. Mauleón Fernández ,&nbsp;J.M. Carrascosa Carrillo","doi":"10.1016/j.ad.2025.02.014","DOIUrl":"10.1016/j.ad.2025.02.014","url":null,"abstract":"<div><h3>Background</h3><div>Despite advances made in treatments for atopic dermatitis (AD), information on its impact and interaction with atopic comorbidities, such as asthma, rhinoconjunctivitis, and ocular disease is limited. This study aims to assess the clinical–epidemiological characteristics of patients with AD – treatment response included – while taking into consideration atopic comorbidities like these.</div></div><div><h3>Materials and methods</h3><div>Data were analyzed from the multicenter BIOBADATOP registry (a prospective cohort of AD patients initiating systemic treatment). We conducted a descriptive analysis of the main characteristics collected in the registry in relation to atopic comorbidity.</div></div><div><h3>Results</h3><div>We included a total of 509 patients, mostly adults (81.9%) with severe AD (73.7%). Patients with personal atopic comorbidity (64%) more frequently exhibited flexural dermatitis (89.7% vs. 81.5%), a higher mean of previous systemic treatments (1.6 vs. 1.3), and higher baseline values on the POEM scale (19.6 vs. 17.9). Patients with familial atopic comorbidity (40.7%) had a higher incidence of pediatric/adolescent patients (24.2% vs. 13.9%) and a history of allergic rhinoconjunctivitis (61.1% vs. 47.1%). No differences regarding treatment response were observed at the 6- and 12-month follow-ups based on the presence or absence of atopic comorbidities.</div></div><div><h3>Conclusions</h3><div>Results suggest that a history of atopic comorbidity is associated with an early onset and persistent course of AD. Although no differences were reported in the short-term treatment response, further follow-up is required to better understand the impact of comorbidities on AD.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T337-T348"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Rainbow Pattern: Key Potential or Distraction in the Diagnostic Dermoscopy","authors":"M.E. Alfaro Martínez,&nbsp;P. López Sanz,&nbsp;A. García Vázquez","doi":"10.1016/j.ad.2025.02.013","DOIUrl":"10.1016/j.ad.2025.02.013","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T418-T420"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FR – Actualización en el tratamiento farmacológico de alopecia androgenética en pacientes transgénero","authors":"O. Al-wattar-Ceballos,&nbsp;L. Martínez-Montalvo,&nbsp;M. Montero-García","doi":"10.1016/j.ad.2023.12.008","DOIUrl":"10.1016/j.ad.2023.12.008","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 421-422"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artículo traducido] Evaluación parental de los resultados estéticos de los hemangiomas infantiles: resultados de la cohorte prospectiva española de hemangiomas infantiles","authors":"M. Colmenero-Sendra ,&nbsp;J. del Boz-González ,&nbsp;E. Baselga Torres ,&nbsp;J. Bernabéu-Wittel ,&nbsp;E. Roé-Crespo ,&nbsp;A. Vicente ,&nbsp;M. Valdivieso-Ramos ,&nbsp;A. Martín-Santiago ,&nbsp;S.I. Palencia-Pérez ,&nbsp;M.T. Montserrat-García ,&nbsp;A. Azón-Masoliver ,&nbsp;M. Dañino ,&nbsp;C. Tubau Prims ,&nbsp;C. Prat ,&nbsp;A. Giacaman ,&nbsp;J.J. Domínguez-Cruz ,&nbsp;A. Bauzá Alonso ,&nbsp;M. Grau-Pérez ,&nbsp;M.Á. Descalzo ,&nbsp;I. García-Doval","doi":"10.1016/j.ad.2024.11.023","DOIUrl":"10.1016/j.ad.2024.11.023","url":null,"abstract":"<div><h3>Background</h3><div>Functional impairment is the main consideration when it comes to choosing therapy for infantile hemangiomas (IH). However, since most hemangiomas are treated for cosmetic reasons, it is important to know the cosmetic outcome assessed by the parents.</div></div><div><h3>Objective</h3><div>To evaluate the aesthetic outcomes of IH, considering the characteristics of the lesions and the treatments used.</div></div><div><h3>Patients and methods</h3><div>The Spanish Infantile Hemangioma Nationwide Prospective Cohort (2016-2022) recruited all consecutive patients diagnosed with IH in 12 Spanish hospitals. The children included had two photos of the IH lesion (at both baseline and at the end of the study). A panel of parents blindly assessed all available photos using a scale from 0 (worst cosmetic outcomes) to 10 (best cosmetic outcomes). The different scores — both before and after treatment — as well as the outcomes percent considered excellent (≥<!--> <!-->9) were described and compared. We analyzed the effect of receiving different therapies and performed causal model analyses estimating the mean treatment effect of parents’ assessments.</div></div><div><h3>Results</h3><div>The median follow-up was 3.1<!--> <!-->years. A total of 824 photos were evaluated. Baseline aesthetic impact was higher in the propranolol group vs the topical timolol and observation treatment groups (1.85 vs 3.14 vs 3.66 respectively; <em>P</em> <!-->&lt;<!--> <!-->.001). After treatment, the aesthetic impact was similar between both treatment groups (7.59 vs 7.93 vs 7.90; <em>P</em> <!-->&gt;<!--> <!-->.2). The causal model could only be applied to the comparison between topical timolol and observation, revealing no differences whatsoever.</div></div><div><h3>Conclusion</h3><div>This is the first prospective cohort to analyze the aesthetic outcome of IH. The final aesthetic results of the three therapies were similar, with nearly 40% of patients achieving excellent aesthetic outcomes.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T327-T336"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] An Update on EBV-related Cutaneous Lymphoproliferative Disorders: a Systematic Review","authors":"S. García-González ,&nbsp;L. Prieto-Torres ,&nbsp;M. García-García","doi":"10.1016/j.ad.2025.02.009","DOIUrl":"10.1016/j.ad.2025.02.009","url":null,"abstract":"<div><div>Epstein Barr virus (EBV) positive lymphoproliferative disorders (LPD) with cutaneous involvement include a series of rare entities that go from indolent processes to aggressive lymphomas. B-cell EBV+ LPD mainly affect immunocompromised patients while T-cell EBV+ LPD are more prevalent in specific geographic regions such as Asia, Central America, and South America. Since the latest WHO-EORTC classification of cutaneous lymphomas in 2018, significant changes have been included in the new classifications of hematological malignancies. This systematic review summarizes the main clinical, histological, immunophenotypic and molecular characteristics of B- and T-cell EBV+ LPD that may compromise the skin at diagnosis. B-cell EBV+ LPD include primary cutaneous lymphomas such as EBV-Mucocutaneous Ulcer, as well as systemic lymphomas affecting the skin at diagnosis that may present such as lymphomatoid granulomatosis (LG), EBV diffuse large B cell lymphoma, NOS, plasmablastic lymphoma (PBL), extracavitary primary effusion lymphoma (EC-PEL) EBV+, EBV-positive polymorphic B cell LPD, and post-transplant lymphoproliferative disorders (PTLD). Regarding T-cell EBV+ LPD, most of these entities are categorized within T/NK-cell lymphoproliferative processes and lymphomas of childhood, including extranodal T/NK lymphoma, and even more exceptional forms such as EBV-positive T-cell centrofollicular lymphoma and intravascular T/NK-cell lymphoma. Diagnosis is based on integrating the clinical, histological, immunohistochemical, and genetic criteria discussed throughout this article. Differential diagnosis is a challenge for dermatologists and pathologists, so having scientific evidence available in this field is of paramount importance because overtreatment must be carefully avoided.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T378-T393"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] “Butterfly” or Malar Rash: Not Everything Is Lupus","authors":"M.D. Pegalajar-García ,&nbsp;A. Sevilla-Linares ,&nbsp;A. Santos-Briz","doi":"10.1016/j.ad.2025.02.003","DOIUrl":"10.1016/j.ad.2025.02.003","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T425-T426"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humanistic and Economic Burden of Atopic Dermatitis in Pediatric Patients in Spain: A Systematic Review","authors":"A. Torrelo Fernández ,&nbsp;A. Vicente ,&nbsp;A. Martin-Santiago ,&nbsp;R. de Lucas Laguna ,&nbsp;J.C. Armario-Hita ,&nbsp;R. Moro ,&nbsp;S. Díaz-Cerezo ,&nbsp;L. Lizán ,&nbsp;M. Núñez","doi":"10.1016/j.ad.2024.06.011","DOIUrl":"10.1016/j.ad.2024.06.011","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is a chronic, inflammatory skin disease affecting all age groups, particularly children. This systematic review provides an overview of the humanistic and economic disease burden in the pediatric population with AD in Spain. The evidence, collected from 11 observational studies published over the past 10 years, exhibits the most common characteristics of the patients, disease burden, patient-reported outcomes, use of resources, and treatment patterns. The burden of AD extends beyond physical symptoms, with associated comorbidities such as asthma and impaired health-related quality of life and mental health disorders, particularly in severe cases. Traditional therapies, primarily topical corticosteroids, face adherence and efficacy challenges. Despite promising innovative treatments and available biological therapies, their use is still limited in the pediatric population. The findings of the present review highlight the scarce scientific evidence on the economic burden of pediatric AD, as well as the most updated humanistic evidence on this disease. At the same time, the need for individualized care and innovative therapeutic interventions to address the multifaceted challenges of pediatric AD in Spain is evident.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages 365-377"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Erythema, Localized Edema and Heat vs Forearm Perimeter Increase. Time to Revise the Consensus Recommendations on the Vortex Provocation Test in Vibratory Urticaria–Angioedema?","authors":"M.E. Gatica-Ortega ,&nbsp;B. Sánchez-Albisua ,&nbsp;D.M. Arranz-Sánchez ,&nbsp;B. Pérez-Tato ,&nbsp;A. Sánchez-Gilo ,&nbsp;S. Córdoba-Guijarro ,&nbsp;F.J. Ortiz-Frutos ,&nbsp;N. Hernández-Cano ,&nbsp;E. Gómez de la Fuente ,&nbsp;M. Elosua-González ,&nbsp;M. Bergón-Sendín ,&nbsp;C. García-Martín ,&nbsp;T. Sanz-Sánchez ,&nbsp;O. Mazuela-Díez ,&nbsp;R. Torres-Aranda ,&nbsp;L. Vergara-de-la-Campa ,&nbsp;S. Marinero-Escobedo ,&nbsp;A. Alegre-Bailo ,&nbsp;A. Garrido-Ríos ,&nbsp;F. Tous-Romero ,&nbsp;M.A. Pastor-Nieto","doi":"10.1016/j.ad.2025.02.010","DOIUrl":"10.1016/j.ad.2025.02.010","url":null,"abstract":"<div><h3>Background and objective</h3><div>Diagnosis of vibratory urticaria/angioedema is established after performing the vortex provocation test. There is current consensus on measuring the forearm perimeter after running such test to define a positive response to it.</div></div><div><h3>Material and method</h3><div>We evaluated the frequency of prior symptoms following vibratory stimuli in volunteers using a questionnaire, response to the vortex provocation test in the same volunteers (increase in forearm perimeter, erythema, localized edema, heat, and pruritus), inter-rater reliability, and correlation between the scores obtained in the questionnaire and response to the test.</div></div><div><h3>Results</h3><div>A total of 40 volunteers participated in this survey, 17 of whom were excluded due to dermographism. A total of 59% out of 123 without dermographism responded positively to ≥1 items of the questionnaire. Localized erythema, heat or localized edema were reported in 58.5%, 38.2%, and 32.5%, respectively. A total of 73.6% of volunteers presented with itch. The mean intensity of itch was 3.44, 95% CI, 2.94–3.94. Inter-rater agreement was low regarding the increase in forearm circumference at three levels (intraclass correlation coefficient, 0.477, 95% CI: 0.253–0.634; 0.496, 95% CI: 0.280–0.647; and 0.370, 95% CI: 0.100–0.559, respectively) and optimal regarding erythema, heat and localized edema (kappa index, 0.868; 0.756; and 0.757, respectively). A significant correlation was identified between the questionnaire score and the altered response to the test in its different variables.</div></div><div><h3>Conclusions</h3><div>We propose the following variables: erythema; localized edema; heat; and the intensity/speed of onset/duration of pruritus to define a positive response to the vortex provocation test given their ease of execution and optimal inter-observer agreement.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T357-T364"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] Low-dose Oral Minoxidil for Frontal Fibrosing Alopecia: A 122-patient Case Series","authors":"C. Pindado-Ortega ,&nbsp;R. Pirmez ,&nbsp;D.F. Melo ,&nbsp;L.J.F. Binato ,&nbsp;M.L. Porriño-Bustamante ,&nbsp;J.B. Carpi ,&nbsp;R. Gil-Redondo ,&nbsp;Á. Hermosa-Gelbard ,&nbsp;J. Jiménez-Cauhé ,&nbsp;D. Saceda-Corralo ,&nbsp;S. Vaño-Galván","doi":"10.1016/j.ad.2025.02.008","DOIUrl":"10.1016/j.ad.2025.02.008","url":null,"abstract":"<div><div>The objective of our study was to analyze the effectiveness of oral minoxidil on the frontotemporal hairline in patients with FFA. We conducted a retrospective, descriptive, multicenter study in 2 Brazilian and 1 Spanish centers. Responses were graded on a scale of 3 positive points. A total of 122 patients were included. Subjective improvement in the density of the frontotemporal hairline was observed in 45.1% patients, which was categorized as mild (34.4%), moderate (9.0%), and excellent (1.6%). Hair density improved in 57.4% of the patients’ interparietal. Additionally, 25.4% and 3.3% of the patients experienced eyebrow and eyelash growth, respectively. Adverse effects were detected in 33.6% patients, with hypertrichosis being the most common (23.8%). In this study, oral minoxidil proved to be an additional therapy for FFA that not only improved the patients’ overall hair and eyebrow growth, but also the density of the frontotemporal hairline.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 4","pages":"Pages T407-T411"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FR - Actualización en el tratamiento del fenómeno de Raynaud.","authors":"P Merlo-Gómez, I Polo Rodríguez, E Lucía Pinto-Pulido","doi":"10.1016/j.ad.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.ad.2025.03.026","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}