Actas dermo-sifiliograficas最新文献

{"title":"Inflammatory Cell Immunophenotypes in Regressing Melanomas and Halo Nevi: Possible Keys to Distinguish Intensely Inflamed Tumors","authors":"A. Brugués ,&nbsp;G. Roccuzzo ,&nbsp;A. Garcia-Herrera ,&nbsp;L. Alós ,&nbsp;J. Malvehy ,&nbsp;S. Puig ,&nbsp;R. Senetta ,&nbsp;S. Ribero ,&nbsp;C. Carrera","doi":"10.1016/j.ad.2025.01.011","DOIUrl":"10.1016/j.ad.2025.01.011","url":null,"abstract":"<div><h3>Introduction</h3><div>The immunophenotypic analysis of inflammatory cells in the tumor microenvironment of regressing melanomas is object of ongoing debate. On the other hand, benign halo nevi paradigmatically show marked inflammation. Characterizing these immune profiles can provide insights into the local immune response, its pathogenesis, and differential diagnosis.</div></div><div><h3>Methodology</h3><div>A cohort of 16 clinically atypical Sutton nevi from <em>Hospital Clínic de Barcelona</em>, Spain, and 70 regressing melanomas from Turin University Hospital, Italy, were evaluated. Histological assessments analyzed inflammation density, location, fibrosis, and markers like CD3, CD4, CD8, CD25, FOXP3, and PD1.</div></div><div><h3>Results</h3><div>Sutton nevi showed higher inflammation density than regressing melanomas, but similar location and quantity of fibrosis. Sutton nevi had higher CD8/CD3 ratios and melanomas, higher CD4/CD3 and CD4/CD8 ratios. Markers such as CD25/CD4, FOXP3/CD4, and PD1/CD4 were more common in Sutton nevi.</div></div><div><h3>Conclusion</h3><div>Results indicate a stronger cytotoxic reaction and consequently a regulatory mechanism in halo nevi, characterized by increased PD1, FOXP3, and CD25. This research further characterizes halo nevi and regressing melanomas, and shows possible clues to distinguish those challenging inflamed melanocytic tumors from melanomas.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 967-973"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artículo traducido] Adición de antihistamínicos a la terapia con isotretinoína para el acné moderado a severo: resumen estructurado de revisiones sistemáticas (FRISBEE)","authors":"V. Meza ,&nbsp;A. Figueroa ,&nbsp;D. Saavedra ,&nbsp;F. Valenzuela","doi":"10.1016/j.ad.2025.07.002","DOIUrl":"10.1016/j.ad.2025.07.002","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T1040-T1042"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Translated article] New Insights on the Etiopathogenesis of Vitiligo","authors":"B. Clemente Hernández ,&nbsp;T. Gracia-Cazaña ,&nbsp;J. Ciriza ,&nbsp;Y. Gilaberte","doi":"10.1016/j.ad.2025.07.016","DOIUrl":"10.1016/j.ad.2025.07.016","url":null,"abstract":"<div><div>Vitiligo is an acquired skin disorder characterised by progressive depigmentation of the skin due to selective loss of melanocytes. Its aetiopathogenesis is complex and multifactorial, involving an interaction between genetic, immunological and environmental factors. Recent evidence leans towards an integrated model in which autoimmunity, mediated mainly by cytotoxic T lymphocytes and inflammatory cytokines, plays a central role. In addition, oxidative stress contributes significantly to melanocyte dysfunction and apoptosis. Genetic studies have identified numerous loci associated with vitiligo, most notably the involvement of genes related to adaptive and innate immunity as well as cellular metabolism. Environmental factors such as trauma, chemical exposure and psychosocial stress may also act as triggers in predisposed individuals. This review synthesises the most recent advances in the aetiopathogenesis of vitiligo, providing a comprehensive overview of the mechanisms involved and opening up new possibilities for the development of therapeutic approaches based on this knowledge.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T974-T984"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artículo traducido] Comparación entre la aplicación subcutánea vs. subcutánea e intramuscular combinada de toxina botulínica para el tratamiento de la alopecia androgenética: un ensayo clínico aleatorizado","authors":"A.A. Lima-Galindo ,&nbsp;S.S. Ocampo-Garza ,&nbsp;J. Ocampo-Candiani ,&nbsp;A. Tosti ,&nbsp;A. Sarahi Guerra-Garza ,&nbsp;J. Ocampo-Garza","doi":"10.1016/j.ad.2025.07.020","DOIUrl":"10.1016/j.ad.2025.07.020","url":null,"abstract":"<div><h3>Background</h3><div>Botulinum toxin A has emerged as an alternative treatment for patients who have contraindications to other therapies or as an adjuvant therapy in the treatment of androgenetic alopecia (AGA), although little is known about its safety and efficacy profile or the mechanism involved in this disease.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy profile of botulinum toxin as monotherapy for AGA and compare subcutaneous vs subcutaneous and intramuscular application.</div></div><div><h3>Methods</h3><div>We conducted a 6-month, randomized, controlled trial to compare the efficacy of subcutaneous vs combined intramuscular and subcutaneous botulinum toxin application in men with AGA at a dermatology clinic in northeastern Mexico.</div></div><div><h3>Results</h3><div>A total of 15 men, aged 27–63 years, diagnosed with androgenetic alopecia (AGA) classified as stages III to V on the Hamilton-Norwood scale, and with no prior treatment for, at least, 6 months prior to being included in the study, were randomly allocated following a computer-generated sequence created prior to the start of the study. The sequence was blinded to both patients and investigators. Participants received a single session of botulinum toxin, administered either subcutaneously and intramuscularly (Group A) or subcutaneously as monotherapy (Group B). Each patient received 100 units of botulinum toxin. When comparing the initial and follow-up trichoscopic photographs of the frontal and vertex regions 6 months after botulinum toxin application using Fotofinder Trichoscale®, no significant changes were observed in hair density or the vellus/terminal hair ratio in either Group A or Group B (<em>p</em> <!-->&gt;<!--> <!-->0.05), and a significant reduction in hair thickness was detected in the frontal region of both groups. Terminal hair count in the frontal region decreased significantly in Group A (<em>p</em> <!-->=<!--> <!-->0.035), whereas the reduction in Group B was not statistically significant. In the occipital region, none of the evaluated parameters showed significant changes (<em>p</em> <!-->&gt;<!--> <!-->0.05). Additionally, no significant differences were seen between the 2 treatment modalities 6 months after application (<em>p</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>Based on our study, we did not find any supportive results for the use of botulinum toxin in the treatment of AGA.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T959-T966"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actualización de la tricodinia, un reto para los dermatólogos","authors":"G. Rodriguez-Tamez ,&nbsp;A. Imbernon-Moya ,&nbsp;D. Saceda-Corralo ,&nbsp;S. Vano-Galvan","doi":"10.1016/j.ad.2024.08.007","DOIUrl":"10.1016/j.ad.2024.08.007","url":null,"abstract":"<div><div>Trichodynia is the sensation of pain in the scalp, which, in most cases, is associated with certain types of alopecia. Despite being a term coined by Rebora back in 1996 to described patients with diffuse alopecia consistent with telogen effluvium, this symptom has currently been reported in other entities. Androgenic alopecia, scarring alopecia, alopecia areata, trichotillomania, and chemotherapy-induced alopecia are common causes of trichodynia. Similarly, its association with psychiatric comorbidities, including depression, anxiety, obsessive-compulsive disorder and somatoform disorders has been reported with a higher prevalence among women. Although its pathogenesis is still to be elucidate, some factors involved are substance<!--> <!-->P, psychiatric comorbidities and perifollicular inflammation. Clinically it exhibits pain or discomfort of the scalp, almost always in association with hair los. The sensation of pain can occur throughout the scalp or locally in some specific areas. Diagnosis is clinical and one of exclusion. Regarding treatment, there are no specific therapies for trichodynia. However, the use of botulinum toxin<!--> <!-->A, antidepressants, neuromodulators, propranolol, topical corticosteroids, oral corticosteroids and topical cannabinoids are therapeutic alternatives that should be taken into consideration. Since treatment of trichodynia is still therapeutically challenging for dermatologists more prospective studies are needed to evaluate new therapies.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 990-994"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FR- Terapia de células T con receptores quiméricos de antígenos (CAR-T) en dermatología","authors":"E.L. Pinto-Pulido ,&nbsp;G. López de Hontanar-Torres","doi":"10.1016/j.ad.2024.10.073","DOIUrl":"10.1016/j.ad.2024.10.073","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages 1021-1022"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudohernia postherpética","authors":"P. López Sanz,&nbsp;A. García Vázquez,&nbsp;M.E. Alfaro Martínez","doi":"10.1016/j.ad.2024.01.028","DOIUrl":"10.1016/j.ad.2024.01.028","url":null,"abstract":"","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Page 1025"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Artículo traducido] Eficacia y seguridad de los tratamientos anti-IL17 en la hidradenitis supurativa: revisión sistemática y metaanálisis de ensayos aleatorizados controlados con placebo","authors":"O. Al-wattar-Ceballos,&nbsp;L. Martínez-Montalvo,&nbsp;M. Carmona-Rodríguez","doi":"10.1016/j.ad.2025.07.019","DOIUrl":"10.1016/j.ad.2025.07.019","url":null,"abstract":"<div><h3>Background and objective</h3><div>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that is difficult to manage, requiring the use of biologic drugs such as anti-TNFα and anti-interleukin 17 (anti-IL17). The aim of our review is to evaluate the safety and efficacy profile of anti-IL17 drugs in patients with HS.</div></div><div><h3>Materials and methods</h3><div>We conducted a systematic review with subsequent meta-analysis following the population, intervention, comparison, outcome and type of study (PICOS) method. We included only randomized clinical trials with placebo (S) that included individuals with HS<!--> <!-->≥<!--> <!-->18 years old (P), and who had been on placebo (C) OR, an anti-IL17 biologic drug (I) to measure safety and efficacy outcomes (O). Search was conducted across multiple databases: PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. The risk of bias of each study, publication bias, sensitivity analysis, and certainty of evidence were determined.</div></div><div><h3>Results</h3><div>A total of 320 bibliographic references were obtained, 4 of which met the inclusion criteria. Compared to placebo, the meta-analysis showed a significantly higher percentage of patients achieving Hidradenitis Suppurativa Clinical Response (HiSCR) OR, of 1.96 [1.79-2.15], a greater decrease in DLQI, MD −1.92 [−2.68, −1.16] and an increase in adverse effects; OR: 1.21 [1.09-1.34], particularly due to <em>Candida</em> infections; OR, 5.61 [2.66-11.83].</div></div><div><h3>Conclusions</h3><div>Treatment with anti-IL17 biologic drugs is effective in patients with moderate-to-severe HS. Although these drugs are safe, they should be monitored due to the risk of infections, mainly candidiasis.</div></div>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":"116 9","pages":"Pages T945-T958"},"PeriodicalIF":2.8,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Extracellular Trap (NET) Markers in Psoriasis: Linking With Disease Severity and Comorbidities.","authors":"J Arroyo-Andrés, A Gotor Rivera, B Díaz-Benito, A Moraga, I Lizasoain Hernández, R Rivera-Díaz","doi":"10.1016/j.ad.2025.09.006","DOIUrl":"10.1016/j.ad.2025.09.006","url":null,"abstract":"<p><p>Psoriatic patients have shown higher levels of neutrophil extracellular traps (NETs) vs healthy controls. Psoriasis is often associated with other comorbidities such as cardiovascular disease. An increase in indirect markers of NETs has been found in patients with increased cardiovascular events in patients without psoriasis. We conducted a prospective observational study with psoriatic patients. A total of 39 of patients were included. Myeloperoxidase, neutrophil elastase and double-stranded DNA were significantly higher in patients with severe-to-moderate vs mild psoriasis. Myeloperoxidase was also significantly higher in patients of moderate high vs low cardiovascular risk (p=.01) in patients with mild psoriasis. Patients with psoriatic arthritis show higher myeloperoxidase levels higher vs those without arthritis (p=.048). Myeloperoxidase was also significantly correlated (p=.0375) with the patients' BMI. The detection of NETs through indirect markers (myeloperoxidase, neutrophil elastase and double-stranded DNA) is associated with the severity of psoriasis. In addition, myeloperoxidase can be useful in psoriatic patients as biomarkers of comorbidities.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanoma Diagnosis With 3D Total-Body Photography.","authors":"A Ferreirinha, V Farricha, A L João","doi":"10.1016/j.ad.2025.09.005","DOIUrl":"10.1016/j.ad.2025.09.005","url":null,"abstract":"<p><p>Skin cancer is a growing global health challenge, emphasizing the need for early detection. In recent years, 3D total-body photography has emerged as a promising tool in dermatology. This non-invasive imaging technique provides a comprehensive visual representation of a patient's skin, enabling the early detection of suspicious lesions and the surveillance of existing nevi. Despite its promising role in early melanoma detection, ongoing research is essential to validate its real-world impact and address its current limitations. Although it enhances diagnostic accuracy, this technique currently does not replace the need for a thorough examination by a dermatologist. This review provides a comprehensive overview of the most recent findings on the application of 3D total-body photography in melanoma diagnosis.</p>","PeriodicalId":7173,"journal":{"name":"Actas dermo-sifiliograficas","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}