Actas urologicas espanolas最新文献

{"title":"Comentario sobre «El uso de la cirugía robótica para el tratamiento de estenosis uretrales y contracturas del cuello vesical: una revisión sistemática»","authors":"R. Mehta , S. Kumar","doi":"10.1016/j.acuro.2025.501739","DOIUrl":"10.1016/j.acuro.2025.501739","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 5","pages":"Article 501739"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota intestinal y cáncer de próstata: análisis de las comunidades bacterianas en distintos escenarios clínicos","authors":"M. Carballo Quintá ,&nbsp;S. Perez Castro ,&nbsp;A. Freire Rodriguez ,&nbsp;C. Daviña Nuñez ,&nbsp;A. Bellas Pereira ,&nbsp;J.J. Cabrera Alvargonzalez ,&nbsp;M. Perez Schoch ,&nbsp;C.A. Muller Arteaga ,&nbsp;J.F. Sanchez Garcia ,&nbsp;E. Cespón Outeda ,&nbsp;E. Lopez Diez","doi":"10.1016/j.acuro.2025.501748","DOIUrl":"10.1016/j.acuro.2025.501748","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Gut microbiota (GM) comprises a diverse community of bacteria associated with a wide range of diseases. Emerging research indicates that GM dysbiosis may affect the progression of prostate cancer (PC) and its response to treatment. This study aimed to describe GM in patients with PC at various disease stages.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional study was conducted at <em>Complejo Hospitalario Universitario de Vigo</em> between 2023 and 2024. 49 patients were classified into three groups: active surveillance (AS), disease-free post-treatment (DF) and advanced disease (AD). Faecal samples were obtained for GM analysis and DNA was used for 16S Rrna sequencing. The structure of the microbial community was examined via alpha and beta diversity analysis, and differential abundance was measured using the LinDA model.</div></div><div><h3>Results</h3><div>Alpha diversity analysis revealed diminished taxon richness in patients under AS and in those treated with androgen receptor pathway inhibitors (ARPI). Beta diversity analysis indicated substantial changes attributable to the treatment group, radiation, hormone therapy, and ARPI. The AD group had a diminished number of potentially advantageous bacteria (<em>Methanobrevibacter</em>, <em>Paraprevotella</em>, <em>Colidextribacter</em>) and an elevated abundance of Terrisporobacter and Streptococcus compared to the DF group. The AS group showed reduction in <em>Intestinibacter</em>, <em>Adlercreutzia</em>, <em>Subdoligranulum</em>, and <em>Methanobrevibacter</em>, along with an increase in <em>Fusicatenibacter</em>, <em>Lachnospiraceae</em>, and <em>Lachnoclostridium</em>.</div></div><div><h3>Conclusions</h3><div>Patients who remain disease-free after therapy have restored microbiota abundant in potential beneficial bacteria, in contrast to individuals with severe disease or those under active monitoring. This study indicates that gut microbiome characteristics could assist in risk assessment and act as possible treatment targets for prostate cancer.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 5","pages":"Article 501748"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relación de los parámetros del tracto urinario inferior y el residuo posmiccional en grupos de edad pediátrica y adolescente: estudio de cohortes en un centro terciario de referencia","authors":"Y.E. Genc ,&nbsp;C.A. Sekerci ,&nbsp;O.C. Ozkan ,&nbsp;D. Dorucu ,&nbsp;F. Arslan ,&nbsp;R. Ergun ,&nbsp;S. Yucel ,&nbsp;T. Tarcan","doi":"10.1016/j.acuro.2025.501752","DOIUrl":"10.1016/j.acuro.2025.501752","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Uroflowmetry and postvoid residual urine volume measurement remain essential in evaluating patients with lower urinary tract dysfunction. The objective was to identify patients with a high risk of infection or renal damage based on the lower urinary tract parameters.</div></div><div><h3>Materials and methods</h3><div>Over a one-year period we investigated patients who had an indication for uroflowmetry and postvoid residual urine volume measurement between 5-18 years of age. All parameters were prospectively recorded. After the initial evaluation, patients were divided into increased/normal postvoid residual urine volume groups. Lower urinary tract parameters, urinary tract infection and hydronephrosis status were analyzed.</div></div><div><h3>Results</h3><div>A total of 176 girls and 140 boys with an age of 9 (5-16) were assessed. When increased (n<!--> <!-->=<!--> <!-->135) / normal postvoid residual urine volume (n<!--> <!-->=<!--> <!-->181) groups of patients were analysed, patients with a diagnosis of dysfunctional voiding, staccato and interrupted-shaped flow pattern, decreased Qavg, increased micrution duration, decreased daytime voiding frequency, and constipation were found to be prone to increased postvoid residual urine volume. A diagnosis of overactive bladder or dysfunctional voiding and high postvoid residual urine volume were both found to be related to infections.</div></div><div><h3>Conclusions</h3><div>We contributed to the literature by evaluating different types of lower urinary tract conditions and their clinical parameters to better understand the predisposing factors to detect patients at risk of infections or renal damage such as dysfunctional voiding, staccato and interrupted-shaped flow pattern, constipation, decreased Qavg, prolonged duration of micturition and decreased daytime voiding frequency regardless of age and gender status.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 5","pages":"Article 501752"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¿Influye el tipo de anestesia en los resultados de la nefrolitotomía percutánea? Un metaanálisis de ensayos controlados aleatorizados","authors":"C. Giulioni ,&nbsp;A. Singh ,&nbsp;S.K. Yuen ,&nbsp;C. Nedbal ,&nbsp;V. de Stefano ,&nbsp;E.J. Lim ,&nbsp;M.L. Wroclawski ,&nbsp;C.A. Chai ,&nbsp;M. Maggi ,&nbsp;A. Cafarelli ,&nbsp;D. Castellani ,&nbsp;R. Tp ,&nbsp;A. Satapathy ,&nbsp;V. Gauhar","doi":"10.1016/j.acuro.2025.501755","DOIUrl":"10.1016/j.acuro.2025.501755","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review the outcomes of Percutaneous nephrolithotomy (PCNL) performed in local (LA) or regional anaesthesia (RA) as compared to general anaesthesia (GA).</div></div><div><h3>Methods</h3><div>Literature search was conducted on 12^th April 2024 including PubMed, Medline, Embase, and Scopus database. Complications were assessed using the Cochran-Mantel-Haenszel Method with the random effect model and reported as odds ratio (OR), 95% confidence interval (CI), and p-values. Analyses were two-tailed and the significance was set at <em>P</em>&lt;.05 and a 95% CI. Continuous variables were pooled using the inverse variance of the mean difference with a random effect, 95% CI, and p-values.</div></div><div><h3>Results</h3><div>Fourteen studies were included. Overall, there were 1413 patients, with 703 patients in the LA/RA group and 710 in the GA group. There was no difference in Clavien grade I-II and ≥III complications, postoperative pain, postoperative headache, Operative Time, postoperative stay, stone-free rate, and intraoperative mean heart rate between LA/RA and GA. Meta-analysis shows that the Nausea and Vomiting rate favors the LA/RA group (OR 0.10), Blood Transfusion rate is lower in LA/RA group (OR 0.40), Intraoperative Blood Loss is lower in LA/RA group (MD −59.63<!--> <!-->ml) and Intraoperative Mean Arterial Pressure is lower in LA/RA group (MD −10.80<!--> <!-->mmHg).</div></div><div><h3>Conclusions</h3><div>This meta-analysis shows no difference in stone-free and complication rates or hospital stay if PCNL is done under GA or LA/RA. LA/RA offers advantages for better intraoperative hemodynamic stability with lesser post-operative nausea and vomiting. PCNL under RA adoption in clinical practice is perhaps limited to centers where specialist anesthetist services can support this procedure.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 5","pages":"Article 501755"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enucleación prostática con láser holmium (HoLEP) En-bloc: experiencia inicial y consolidación de la técnica","authors":"J. Pineda-Murillo,&nbsp;O. Hernández-León,&nbsp;J.S. Cuéllar del Río,&nbsp;J.R. Arellano-Cuadros,&nbsp;G. Martínez-Carrillo,&nbsp;G.A. Quintero-Cortés,&nbsp;S.P. de la Paz-Martínez,&nbsp;J.C. Ávalos-Ramón,&nbsp;J.A. Lugo-García","doi":"10.1016/j.acuro.2025.501745","DOIUrl":"10.1016/j.acuro.2025.501745","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Benign prostatic enlargement has a prevalence of approximately 60% in 60-year-old men. En bloc enucleation and its variants, which emerged in 2010, are methods to enucleate the 3<!--> <!-->lobes of the prostatic capsule completely, maintaining the capsular plane and the urethral sphincter while removing the prostate. The aim of the present study is to analyze the implementation of the surgical technique, considering the learning curve and the experience accumulated in a group of patients before and after its development.</div></div><div><h3>Material and methods</h3><div>Retrospective study from July 2022 to November 2024, in which 136 patients with lower urinary tract symptoms due to prostate growth with indication for surgical treatment were included. Bleeding, surgical time, hospital stay, enucleated prostate volume, as well as enucleation, morcellation, time and laser energy efficiencies were analyzed.</div></div><div><h3>Results</h3><div>The efficacy of the procedure was higher in the post-curve group with a <em>P</em> <!-->&lt;<!--> <!-->0.0001 compared to the pre-curve group with a coefficient of determination R² <!-->=<!--> <!-->0.8091. Enucleation efficiencies, laser time and energy showed a statistically significant difference (<em>P</em> <!--> <!-->0.05) in favor of the post-curve group.</div></div><div><h3>Conclusions</h3><div>Holmium laser enucleation of the prostate has proven to be an effective and safe surgical treatment, even during the learning curve. The turning point of the procedure depends on proper mentoring and the appropriate selection of cases during the training process.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501745"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precisión de Bladder EpiCheck en el diagnóstico del carcinoma urotelial del tracto urinario superior: un metaanálisis","authors":"S. Artero Fullana ,&nbsp;J. Caño Velasco ,&nbsp;A. Lafuente Puentedura ,&nbsp;L. Polanco Pujol ,&nbsp;V. Bataller Monfort ,&nbsp;M. Moralejo Gárate ,&nbsp;J.D. Subiela ,&nbsp;A. Gallioli ,&nbsp;M. Moschini ,&nbsp;R. Pichler ,&nbsp;F. del Giudice ,&nbsp;G. Marcq ,&nbsp;J. Teoh ,&nbsp;F. Soria ,&nbsp;L. Mertens ,&nbsp;W. Krajewski ,&nbsp;E. Laukhtina ,&nbsp;K. Mori ,&nbsp;B. Pradere ,&nbsp;L. Afferi ,&nbsp;C. Hernández Fernández","doi":"10.1016/j.acuro.2025.501720","DOIUrl":"10.1016/j.acuro.2025.501720","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Current upper tract urothelial carcinoma (UTUC) diagnosis and disease management rely on the combination of CT Urography (CTU), cytology and ureteroscopy (URS). The limited accuracy and complications associated with these tools have led to the search for non-invasive and reliable biomarkers. Our aim was to review and analyse the existing data on the use of Bladder EpiCheck® to assess its performance as a diagnostic tool for UTUC.</div></div><div><h3>Material and methods</h3><div>A literature search on the diagnostic value of Bladder EpiCheck® as a urinary biomarker in UTUC was conducted through PubMed, Web of Science and Scopus until February 2024. Pooled sensitivity (Se), specificity (Sp), negative predictive value (NPV) and positive predictive value (PPV) of the biomarker were calculated. Diagnostic performance was assessed through the area under the curve (AUC).</div></div><div><h3>Results</h3><div>Four studies, including 334 patients, were included in the quantitative analysis. Bladder EpiCheck® showed promising pooled diagnostic values with Se of 0.85 (95%<!--> <!-->CI: 0.55-0.96), Sp of 0.93 (95%<!--> <!-->CI: 0.56-0.99), PPV of 0.74 (95%<!--> <!-->CI: 0.54-0.87) and NPV of 0.84 (95%<!--> <!-->CI: 0.77-0.89). The exact AUC obtained was 0.912.</div></div><div><h3>Conclusions</h3><div>Bladder EpiCheck® is an effective diagnostic tool in UTUC, showing a promising diagnostic accuracy, with a Se and NPV of 85% and 84%, respectively. Its use in UTUC diagnosis and follow-up could reduce or postpone the need for more invasive procedures, such as URS, thereby reducing the procedure-associated risks and improving patients’ quality of life. Although further research and large prospective studies are needed, the current results indicate that Bladder EpiCheck® is a promising tool in UTUC diagnosis, treatment decision-making, and follow-up.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501720"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsia dinámica de ganglio centinela en cáncer de pene: 25 años de experiencia en un centro oncológico terciario","authors":"C. Rodríguez ,&nbsp;M. Hassi ,&nbsp;Á. García ,&nbsp;A. Calatrava ,&nbsp;P. De Pablos-Rodríguez ,&nbsp;J. Casanova ,&nbsp;Á. Gómez-Ferrer","doi":"10.1016/j.acuro.2025.501721","DOIUrl":"10.1016/j.acuro.2025.501721","url":null,"abstract":"<div><h3>Introduction</h3><div>Penile cancer lymph node (LN) metastases are critical prognostic factors. The European Association of Urology (EAU) guidelines recommend dynamic sentinel node biopsy (DSNB) as a less invasive alternative for cN0 patients with intermediate- to high-risk tumors. Due to the rarity of penile cancer, lymph node staging tends to be underutilized, and few centers have a significant number of patients to develop the DSNB technique and observe its evolution over time. Previously, our series reported a sensitivity of 66%, and our aim is to contribute to the available evidence, based on 25 years of real-world experience.</div></div><div><h3>Materials and methods</h3><div>Retrospective single-center study involving 95 groins of 51 patients with intermediate or high-risk penile squamous carcinoma, who underwent DSNB between November 1999 and July 2024. Clinical data, including histology, surgical treatment, and complications, were analyzed. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Complications were registered using the Clavien-Dindo system.</div></div><div><h3>Results</h3><div>The median age of patients was 60 (range 30 – 84) years. 10/51 patients (21%) had metastatic sentinel node. DSNB successfully identified sentinel nodes in 95.7% for right and 89.5% for left groins. The false-negative rate was 8.1%, with a sensitivity of 77%, specificity of 100%, PPV of 100%, and NPV of 92%. 18% (9/51) of patients suffered complications being most of them minor (6/9), 3 patients experimented major complications.</div></div><div><h3>Discussion and conclusion</h3><div>The updated DSNB outcomes show improved diagnostic accuracy compared to previous reports, reflecting enhanced techniques and learning curves. The study highlights the accuracy and the low morbidity of DSNB.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501721"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valor de HCY, c-sdLDL, creatinina, IL-6 y PSA en el diagnóstico de la hiperplasia prostática benigna en el anciano","authors":"W. Qin,&nbsp;S. Liu,&nbsp;L. Liu,&nbsp;M. Liu,&nbsp;J. Chen,&nbsp;P. Dai","doi":"10.1016/j.acuro.2025.501744","DOIUrl":"10.1016/j.acuro.2025.501744","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the diagnostic value of serum metabolic markers such as HCY, sdLDL-C, Crea, inflammatory factor IL-6 and prostate-specific antigen in elderly patients with prostatic hyperplasia (BPH).</div></div><div><h3>Methods</h3><div>150 senile patients with hyperplasia of prostate were selected as observation group and 169 healthy senile patients were selected as control group. The tPSA, fPSA, fPSA/tPSA and prostate size data of the two groups were collected, and serum samples of the subjects were collected for the detection of HCY, sdLDL, Crea, IL-6 and other indicators. Univariate analysis, correlation analysis and logistic regression analysis were conducted to analyze the relationship between each index and senility prostatic hyperplasia. The diagnostic efficiency of each serum metabolite was analyzed by receiver operating characteristic curve (ROC).</div></div><div><h3>Results</h3><div>Serum levels of tPSA, fPSA, Crea, HCY, sdLDL-C and IL-6 were significantly increased, fPSA/tPSA ratio and HDL were significantly decreased, and TCHO, TG and LDL had no statistical significance. Serum tPSA and fPSA levels were positively correlated with prostate size, serum IL-6, Crea and HCY levels were positively correlated with tPSA and fPSA levels, and serum sdLDL-C levels were negatively correlated with fPSA levels. Logistic regression analysis showed that tPSA, fPSA, prostate size, HCY, Crea and IL-6 were risk factors for prostate hyperplasia. HDL and fPSA/tPSA are protective factors for benign prostatic hyperplasia. ROC curve analysis showed that the sensitivity and specificity of fPSA/tPSA and IL-6 were 82.7% and 72%, 83.4% and 80.5%, and the area under ROC curve were 0.840 and 0.825, respectively. tPSA and fPSA combined with HCY, IL-6 and Crea had the best diagnostic efficiency, with the area under ROC curve reaching 0.881, specificity and sensitivity reaching 84% and 77.3%, respectively.</div></div><div><h3>Conclusion</h3><div>The combined detection of prostate-specific antigen, HCY, Crea and IL-6 can significantly improve the diagnostic efficiency of senile prostatic hyperplasia, and optimize the diagnosis and treatment scheme can even be used as a major screening index to evaluate and predict the incidence of BPH in senile prostatic hyperplasia.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501744"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADN tumoral circulante en el cáncer de vejiga músculo invasivo: una revisión sistemática","authors":"A.A. Grosso ,&nbsp;A. Cadenar ,&nbsp;S. Pillozzi ,&nbsp;G. Carli ,&nbsp;F. Lipparini ,&nbsp;F. Di Maida ,&nbsp;R. Pichler ,&nbsp;W. Krajewski ,&nbsp;S. Albisinni ,&nbsp;E. Laukhtina ,&nbsp;S. Mancon ,&nbsp;F. del Giudice ,&nbsp;M.C. Mir ,&nbsp;F. Soria ,&nbsp;M. Moschini ,&nbsp;S.F. Shariat ,&nbsp;M. Roupret ,&nbsp;J. Yuen-Chun Teoh ,&nbsp;L. Antonuzzo ,&nbsp;A. Breda ,&nbsp;A. Mari","doi":"10.1016/j.acuro.2025.501717","DOIUrl":"10.1016/j.acuro.2025.501717","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the role of circulating tumor DNA (ctDNA) as a prognostic and predictive biomarker in the perioperative management of muscle-invasive bladder cancer (MIBC).</div></div><div><h3>Methods</h3><div>We conducted a systematic literature review using PubMed, Medline, and Embase, following PRISMA guidelines. Studies from January 2013 to March 2024 were included if they examined ctDNA in MIBC patients undergoing radical cystectomy (RC) and perioperative chemotherapy or immunotherapy.</div></div><div><h3>Results</h3><div>Eight studies were included. ctDNA detected before RC was associated with poor recurrence-free survival and higher risk of nodal and locally advanced disease. Postoperative ctDNA levels correlated with shorter disease-free survival and higher recurrence rates. ctDNA clearance during neoadjuvant chemotherapy was predictive of treatment response. ctDNA status post-neoadjuvant immunotherapy correlated with pathological outcomes and recurrence rates.</div></div><div><h3>Conclusions</h3><div>ctDNA is a promising biomarker for predicting oncological outcomes in MIBC, with potential to guide perioperative treatment decisions. Further randomized controlled trials are needed to validate these findings.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501717"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percepción real de los informes de anatomía patológica en urología","authors":"A. Cimadamore ,&nbsp;M. Moschini ,&nbsp;J. Teoh ,&nbsp;S. Albisinni ,&nbsp;Z. Adwin ,&nbsp;W. Shen Tan ,&nbsp;K. Mori ,&nbsp;M. Wroclawski ,&nbsp;F. Soria ,&nbsp;A. Aziz ,&nbsp;E. Laukhtina ,&nbsp;D.M. Carrión ,&nbsp;W. Krajewski ,&nbsp;M. Karavitakis ,&nbsp;M. Abufaraj ,&nbsp;A. Uleri ,&nbsp;A. Gallioli ,&nbsp;B. Pradere ,&nbsp;en representación del Grupo de Trabajo de Carcinoma Urotelial de la Sección de Jóvenes Urólogos Académicos - Asociación Europea de Urología (EAU-YAU)","doi":"10.1016/j.acuro.2025.501751","DOIUrl":"10.1016/j.acuro.2025.501751","url":null,"abstract":"<div><h3>Introduction</h3><div>Collaboration between pathologists and urologists is crucial for accurate diagnostic reporting and patient management, particularly in urology. This study aims to evaluate international practices regarding pathology reporting of bladder specimens to identify areas for improvement.</div></div><div><h3>Materials and methods</h3><div>A web-based survey with 32 questions was developed in collaboration with the EAU Young Academic Urologists Urothelial Cancer Working Party. It was sent to urologists with more than 5<!--> <!-->years of experience across different institutions globally. Descriptive statistics were used to evaluate the responses.</div></div><div><h3>Results</h3><div>A total of 157 responses were received from urologists, representing a response rate of 65%. Most respondents (64.3%) found pathological reports comprehensive, although 36% reported unclear reports in some cases. Pathologists were contacted for clarification in less than 20% of cases. Notably, the reporting of pathological subtypes and depth of invasion was inconsistent among institutions.</div></div><div><h3>Conclusion</h3><div>The survey highlights variability in pathology report quality across centers. Standardized reporting, increased pathologist involvement in multidisciplinary teams, and adherence to international guidelines are necessary to improve the accuracy and clarity of pathology reports in urology.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 4","pages":"Article 501751"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}