Actas urologicas espanolas最新文献

{"title":"Eficacia de la intervención dietética con calcio y control de oxalato en la prevención de los cálculos de oxalato cálcico: revisión integrativa","authors":"P. Vázquez Carral","doi":"10.1016/j.acuro.2025.501826","DOIUrl":"10.1016/j.acuro.2025.501826","url":null,"abstract":"<div><h3>Introduction</h3><div>Calcium oxalate kidney stones—the most common type of renal calculi—are closely associated with dietary and metabolic factors. An appropriate dietary approach can help prevent their formation and reduce the risk of recurrence.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of dietary interventions involving adequate calcium intake combined with oxalate control in preventing the formation of calcium oxalate kidney stones.</div></div><div><h3>Evidence acquisition</h3><div>An integrative review was conducted in PubMed®, Scopus®, Medline®, and Dialnet® (2014-2024), following PRISMA guidelines, focusing on calcium and oxalate dietary management in kidney stone disease.</div></div><div><h3>Evidence synthesis and conclusions</h3><div>The reviewed evidence indicates that an adequate calcium intake (800-1,200<!--> <!-->mg/day) reduces intestinal oxalate absorption and, consequently, urinary oxalate excretion. Additionally, hydration, sodium restriction, and urine alkalinization with citrate are complementary dietary strategies. Recent studies also suggest that urinary microbiota and genetic predisposition may influence individual responses to dietary interventions. Overall, a personalized dietary approach may constitute an effective and accessible strategy for the prevention of calcium oxalate kidney stones. However, the current body of evidence is limited by methodological constraints and heterogeneity across studies.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501826"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nefrectomía citorreductora diferida en adultos con carcinoma de células renales metastásico y trombo tumoral en vena cava tratados con neoadyuvancia basada en inmunoterapia: revisión sistemática","authors":"E.S. Cruz Peralta ,&nbsp;M. González Domínguez ,&nbsp;R.J. Salgueiro Ergueta ,&nbsp;M.L. Peralta Pedrero","doi":"10.1016/j.acuro.2025.501799","DOIUrl":"10.1016/j.acuro.2025.501799","url":null,"abstract":"<div><h3>Introduction</h3><div>Renal cell carcinoma (RCC) invades the inferior vena cava (IVC) in 4% to 10% of cases, increasing the risk of surgical complications that affect oncological outcomes.</div></div><div><h3>Materials and methods</h3><div>The research question was defined using the PICOST acronym. An exhaustive search, material selection, and data extraction were conducted in duplicate and independently. Original articles were included on patients with metastatic RCC (mRCC) with thrombus in the IVC, treated with immune checkpoint inhibitors with or without tyrosine kinase inhibitors (TKIs) and cytoreductive nephrectomy (CN). Studies involving patients with thrombi localized solely to the renal artery or atrium were excluded.</div></div><div><h3>Results</h3><div>A total of 17 articles were included: one retrospective cohort, five retrospective case series, and 11 retrospective case reports. In total, 32 patients were analyzed; 10 were excluded due to the absence of metastases. In most cases, the size of the primary tumor decreased. Regarding the thrombus in the IVC, based on the level, out of 22 patients, 7 remained unchanged, 13 showed a reduction (9 by one level, 3 by two levels, and 1 by three levels), and one showed an increase. In another case, the magnitude of the reduction in thrombus size or level was not specified. Tumor thrombus size decreased even in cases where the level remained unchanged.</div></div><div><h3>Conclusions</h3><div>Patients with mRCC and thrombus in the IVC may benefit from neoadjuvant treatment with immune checkpoint inhibitors, with or without TKIs, and delayed cytoreductive nephrectomy.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501799"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación de los resultados del trasplante renal pediátrico según la duración del catéter ureteral: una revisión sistemática de los Grupos de Trabajo de Urología Pediátrica y Trasplante Renal de la Sección de Jóvenes Urólogos Académicos","authors":"I.B. de Angst ,&nbsp;M. Reichert ,&nbsp;M.I. Dönmez ,&nbsp;Y. Quiroz ,&nbsp;F. O’Kelly ,&nbsp;S. Sforza ,&nbsp;W.M. Bramer ,&nbsp;B. Bañuelos ,&nbsp;E. Bindi ,&nbsp;I. Selvi ,&nbsp;F. Brandt ,&nbsp;E. Starink ,&nbsp;J. Stufken ,&nbsp;A. Territo ,&nbsp;A. López-Abad ,&nbsp;R.J.M. Lammers ,&nbsp;L.A. ‘t Hoen","doi":"10.1016/j.acuro.2025.501825","DOIUrl":"10.1016/j.acuro.2025.501825","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Urological complications are common after kidney transplantation (KTx), mostly in the form of ureterovesical obstruction or leakage. Routine ureteral stenting was previously shown to reduce these complications on the expense of other complications such as urinary tract infections. There is no consensus on optimal duration of stents, and relevant literature on this topic is lacking. The aim of this systematic review is to summarize and compare the incidences of stent-related complications using short (&lt;<!--> <!-->2 weeks) and long (≥<!--> <!-->2 weeks) stent duration after pediatric KTx.</div></div><div><h3>Material and methods</h3><div>A systematic search in Embase, MEDLINE, Cochrane, and ClinicalTrial.gov was performed. Studies reporting on children (0-18 years) undergoing KTx with intraoperative ureteral stenting with at least one month follow up were included. Data on surgical and outcome characteristics were extracted.</div></div><div><h3>Results</h3><div>From a total of 322 articles, 14 studies were included, reporting on 971 pediatric KTx of whom 411 were female (42%). Sample sizes ranged from 32 to 146 patients. Mean or median age at time of transplantation ranged from 3.36 to 14.7 years. A systematic synthesis approach was used to summarize results. Of the 4 comparative studies, only one showed significantly more post-transplant urinary tract infections in the long duration group, without a significant difference in other urological complications.</div></div><div><h3>Conclusions</h3><div>Due to lack of good quality studies, it remains uncertain whether a short stent duration is safer and more feasible for reducing the incidence of stent-related complications in pediatric KTx, while also preventing stenosis or leakage at the ureterovesical anastomosis.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501825"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfil e interacción de los usuarios con una app de salud digital para urolitiasis: estudio descriptivo de los primeros 699 usuarios","authors":"J.A. Mainez ,&nbsp;J.A. Galán ,&nbsp;J.M. López ,&nbsp;B. Isern-Amengual ,&nbsp;P. Sanchís-Cortés","doi":"10.1016/j.acuro.2025.501819","DOIUrl":"10.1016/j.acuro.2025.501819","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Urolithiasis is a prevalent urological condition that requires continuous monitoring and management to prevent recurrence. The myLit-Control® App is a digital health tool designed to support self-management by tracking urinary pH, water intake, and medication adherence. This study aimed to describe the demographic and clinical characteristics of myLit-Control® App users in Spain, analyze their engagement patterns, and evaluate adherence to health goals.</div></div><div><h3>Patients and methods</h3><div>This retrospective observational study included users who downloaded the app between May 2022 and June 2024. Data on demographics, urinary pH tracking, water intake, and medication adherence were extracted and analyzed to explore correlations, group comparisons, and identify factors influencing adherence and outcomes.</div></div><div><h3>Results</h3><div>The study included 699 users, with a median age of 50 years (IQR: 40-59) and 57.1% male. A total of 217 users (31.0%) were taking urolithiasis-specific treatment. Urine pH monitoring was used by 52.9% of participants, with a rate of 53% (±<!--> <!-->37) within target pH levels. Water intake tracking was the most frequently used feature, yet adherence to hydration goals remained low (15<!--> <!-->±<!--> <!-->30%). A negative correlation was observed between age and treatment adherence (r<!--> <!-->=<!--> <!-->−0.456, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The myLit-Control® App facilitates urinary pH monitoring and medication adherence, supporting self-management in urolithiasis patients. However, engagement with key features, particularly water intake tracking, remains suboptimal. Future research should explore long-term outcomes and strategies to enhance patient adherence, ensuring effective integration of mHealth tools in routine clinical practice.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501819"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación de la litotricia con láser de fibra de tulio y láser Holmium:YAG en la cirugía retrógrada intrarrenal para el tratamiento de cálculos renales: estudio prospectivo aleatorizado","authors":"B. Kozubaev ,&nbsp;S. Oguz Demirdogen ,&nbsp;T. Aksakalli ,&nbsp;F. Ozkaya ,&nbsp;S. Adanur","doi":"10.1016/j.acuro.2025.501808","DOIUrl":"10.1016/j.acuro.2025.501808","url":null,"abstract":"<div><h3>Objective</h3><div>This study compares the clinical outcomes of Holmium:YAG (Ho:YAG) laser lithotripsy and Thulium Fiber Laser (TFL) lithotripsy in retrograde intrarenal surgery (RIRS) for kidney stones &lt;<!--> <!-->20<!--> <!-->mm.</div></div><div><h3>Materials and Methods</h3><div>Patients who underwent RIRS for renal stones &lt;<!--> <!-->20<!--> <!-->mm between September 2022 and November 2023 were prospectively analyzed. They were randomly assigned to either the TFL or Ho:YAG laser group using a sealed-envelope method. Preoperative demographics, stone characteristics, kidney-ureter-bladder x-ray (KUB), ultrasound and noncontrast computer tomography (NCCT) scan findings were recorded. Operative time, laser usage time, postoperative stone-free rate (SFR), and complications were assessed and statistically analyzed.</div></div><div><h3>Results</h3><div>A total of 126 patients (mean age: 49.16<!--> <!-->±<!--> <!-->15.18 years; 64.3% male, 35.7% female) were included. The TFL group (n<!--> <!-->=<!--> <!-->64, 50.8%) had significantly shorter operative and laser usage times than the Ho:YAG laser group (n<!--> <!-->=<!--> <!-->62, 49.2%) (operative time: 45.77<!--> <!-->±<!--> <!-->15.67<!--> <!-->min vs. 52.79<!--> <!-->±<!--> <!-->18.11<!--> <!-->min, p<!--> <!-->=<!--> <!-->0.031; laser usage: 29.84<!--> <!-->±<!--> <!-->13.32<!--> <!-->min vs. 36.39<!--> <!-->±<!--> <!-->15.75<!--> <!-->min, p<!--> <!-->=<!--> <!-->0.024). No significant SFR difference was found between groups (TFL group: n<!--> <!-->=<!--> <!-->57, 91.8% vs. Ho:YAG laser group: n<!--> <!-->=<!--> <!-->60, 93.8%; p<!--> <!-->=<!--> <!-->0.488).</div></div><div><h3>Conclusion</h3><div>In the treatment of kidney stones smaller than 20<!--> <!-->mm using laser lithotripsy, both TFL and Ho:YAG laser are effective, safe, and associated with low complication rates. However, the use of TFL significantly reduces operative time and lithotripsy time, potentially improving surgical efficiency. Further studies with larger patient cohorts are necessary to validate these findings and provide additional insights into the advantages and limitations of each laser type.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501808"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación del pronóstico entre carcinoma vesical musculoinvasivo primario y progresivo: análisis prospectivo de resultados a largo plazo tras cistectomía radical","authors":"S. Juste-Álvarez,&nbsp;C. García-Rayo Encina,&nbsp;C. Gómez del Cañizo,&nbsp;M. Hernández-Arroyo,&nbsp;N.R. Miranda Utrera,&nbsp;A. Rodríguez-Antolín,&nbsp;F. Guerrero-Ramos","doi":"10.1016/j.acuro.2025.501815","DOIUrl":"10.1016/j.acuro.2025.501815","url":null,"abstract":"<div><h3>Introduction</h3><div>Up to 15% of muscle-invasive bladder cancers (MIBC) arise from the progression of a non-muscle-invasive neoplasm. Despite sharing similar treatment strategies, the literature reports differences in survival rates between these 2<!--> <!-->groups. This study aims to identify differences in recurrence and survival that may influence individualized treatment approaches.</div></div><div><h3>Material and methods</h3><div>Prospective study of cystectomies performed for MIBC between 2011 and 2023, collecting demographic, diagnostic, treatment, and recurrence data (local, urothelial, or distant). A comparative and multivariate analysis was conducted.</div></div><div><h3>Results</h3><div>We did not observe significant differences in recurrence rates between primary and progressive MIBC. However, the group with progression showed better overall survival (OS) rates at 2, 5 and 10 years (100%, 90%, 55%) compared to the primary (80%, 55%, 35%; <em>P</em> = 0.012), as well as better cancer-specific survival (CSS) (100%, 100%, 95% vs. 85%, 77%, 65%; <em>P</em> = 0.033). Independent risk factors for recurrence include pN<!--> <!-->+<!--> <!-->(OR: 3.72) and lymphovascular invasion (LVI) (OR: 5.53). Predictors of lower OS include age, nodal involvement, LVI and relapse at any level. For CSS, predictors include nodal involvement, LVI and relapse at any level.</div></div><div><h3>Conclusions</h3><div>In our series, patients with progressive MIBC have better OS and CSS. For both groups, pN<!--> <!-->+<!--> <!-->and LVI are independent risk factors for recurrence. Nodal involvement, LVI and relapse at any level are predictors of poorer OS and CSS.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501815"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factores asociados con complicaciones en el embarazo de mujeres con antecedente de reflujo vesicoureteral: una revisión sistemática del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos (YAU) - Asociación Europea de Urología (EAU)","authors":"I. Selvi ,&nbsp;M.İ. Dönmez ,&nbsp;N. Baydilli ,&nbsp;Y. Quirroz Madarriaga ,&nbsp;R. Lammers ,&nbsp;E. Bindi ,&nbsp;S. Sforza ,&nbsp;F. O’Kelly ,&nbsp;B. Haid ,&nbsp;B. Banuelos Marco ,&nbsp;L.A. t’Hoen","doi":"10.1016/j.acuro.2025.501821","DOIUrl":"10.1016/j.acuro.2025.501821","url":null,"abstract":"<div><h3>Introduction</h3><div>Vesicoureteral reflux (VUR) may have long lasting effects on affected individuals, especially in females. Its intertwined relationship with urinary tract infection (UTI) has been well documented and there is a further risk during pregnancy where UTIs are more problematic.</div></div><div><h3>Objective</h3><div>To analyze existing data within the literature to identify factors associated with pregnancy-related complications in women with a history of VUR in childhood.</div></div><div><h3>Methods</h3><div>PubMed, MEDLINE, Embase, and the Cochrane Library databases were searched to identify all published reports of pregnancy outcomes in women with a history of VUR in childhood up to January 2024 (PROSPERO Registration ID: CRD42024550470). Selection criteria included all English-language original articles reporting pregnancy outcomes (maternal and fetal morbidities) in pregnant patients with a history of VUR in childhood. After screening and eligibility assessment, 17 articles met the PICO inclusion criteria.</div></div><div><h3>Results</h3><div>The search yielded 1060 papers, of which 17 remained after exclusions, and assessed 2349 women with a history of VUR in childhood, 1167 pregnant women and a total of 2206 pregnancies. Compared with the general obstetric population, the results showed an increased rate of pregnancy-related complications (particularly febrile urinary tract infection, gestational hypertension, pre-eclampsia) in the presence of renal scarring, even if the women had undergone anti-reflux surgery in childhood, but not persistent low-grade VUR.</div></div><div><h3>Conclusion</h3><div>Despite the lack of larger prospective randomized controlled trials with long-term follow-up, based on the findings of this systematic review, we conclude that close monitoring during pregnancy should be recommended in the presence of persistent high-grade VUR or in women with renal scarring, even if VUR has resolved.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501821"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Técnicas de uretero-ureterostomía en la duplicación ureteral: una revisión narrativa de la literatura","authors":"M. Keleş ,&nbsp;A. Harun Kinik ,&nbsp;M. Selçuk Silay","doi":"10.1016/j.acuro.2025.501817","DOIUrl":"10.1016/j.acuro.2025.501817","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this narrative review is to evaluate the uretero-ureteral anastomosis (UUA) methods applied as a surgical option in duplicated renal systems.</div></div><div><h3>Material and methods</h3><div>Studies evaluating pediatric patients under 18<!--> <!-->years of age who underwent any type of uretero-ureteral anastomosis due to double collecting system were included in the review. The other surgical methods to treat duplex systems such as heminephrectomy, ureteral reimplantation and ureteral clipping were excluded. The studies found by searching the keywords «double collecting system ureter ureteral anastomosis», «double collecting system ureteroureterostomy», «duplex kidney ureter ureteral anastomosis», «duplex kidney ureteroureterostomy» in PubMed. Study design, operative measures, technique of surgery, follow-up time, key results and complications were recorded.</div></div><div><h3>Results</h3><div>A total of 29 studies from 1967 to 2024 (including 2024) were included in the review. When the studies were analysed, there were no studies comparing the three main UUA procedures (open, laparoscopic and robot-assisted laparoscopic). In studies comparing open and robot-assisted UUA, and laparoscopic versus open techniques, minimally invasive approaches demonstrated shorter hospital stays and comparable outcomes, while operation times were similar across groups.</div></div><div><h3>Discussion</h3><div>According to the available literature, all of the operative approaches are feasible with high success and low complication rates. However, it is not sufficient to determine the superiority of open, laparoscopic and robot-assisted laparoscopic UUA methods. Prospective comparative studies are required to elucidate the effectivity of different methods to treat duplex systems in children.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501817"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicidad aguda de la SBRT en cáncer de próstata localizado: estudio multicéntrico español","authors":"S.E. Romero Zoghbi ,&nbsp;F. López Campos ,&nbsp;D. Sanz-Rosa ,&nbsp;J. Fernández Ibiza ,&nbsp;I.J. Thuissard-Vasallo ,&nbsp;C. Andreu-Vázquez ,&nbsp;C. Laria ,&nbsp;J. Andreescu Yagüe ,&nbsp;E. Krumina ,&nbsp;A. Ocanto ,&nbsp;M. Mateos ,&nbsp;L.A. Glaría ,&nbsp;J.A. García Cuesta ,&nbsp;D. Gonsalves ,&nbsp;C. Fernández ,&nbsp;D. Esteban ,&nbsp;J. Begara de la Fuente ,&nbsp;D. Rivas ,&nbsp;E. López Ramírez ,&nbsp;L. Aakki ,&nbsp;F. Couñago","doi":"10.1016/j.acuro.2025.501798","DOIUrl":"10.1016/j.acuro.2025.501798","url":null,"abstract":"<div><h3>Introduction</h3><div>Stereotactic body radiation therapy (SBRT) has emerged as an effective option for the treatment of localized prostate cancer; however, data from real-world clinical practice remain limited.</div></div><div><h3>Material and Methods</h3><div>Between January 2020 and December 2023, 251 patients with localized prostate cancer treated with SBRT were included in 12 centers in Spain. The treatment volume included prostate<!--> <!-->+<!--> <!-->/- seminal vesicles, without prophylactic pelvic radiotherapy. A dose of 35-40<!--> <!-->Gy was prescribed in 5 fractions, every other day. Acute genitourinary (GU), gastrointestinal (GI) and sexual toxicity was assessed up to 6 months post-treatment using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0.</div></div><div><h3>Results</h3><div>A total of 251 patients were classified based on the National Comprehensive Cancer Network (NCCN®) classification. Four percent of patients had very low-risk disease, 26.3% low-risk, and 66.5% intermediate-risk (27.1% favorable intermediate and 39.4% unfavorable intermediate). Additionally, 2.8% were classified as high-risk and 0.4% as very high-risk. The median patient age was 72 years (range: 65–76), and the baseline PSA was 6.7<!--> <!-->ng/mL (range: 5.3–8.7). The median SBRT dose was 40<!--> <!-->Gy (range: 35–40<!--> <!-->Gy). Grade 2 acute GU toxicity occurred in 6.4% of patients, and grade 3 in 0.4%. Grade 2 GI toxicity was observed in 0.8%, with no cases of grade 3 GI toxicity. Regarding sexual toxicity, 11.2% of patients experienced grade 2, and 1.2% grade 3 toxicity.</div></div><div><h3>Conclusions</h3><div>Five-fraction SBRT is a feasible and safe treatment with a low incidence of acute toxicity.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 8","pages":"Article 501798"},"PeriodicalIF":1.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis de la composición de cálculos urinarios mediante espectroscopia infrarroja","authors":"X. Han ,&nbsp;Z. Zhang ,&nbsp;P. Yao ,&nbsp;X. Yang","doi":"10.1016/j.acuro.2025.501810","DOIUrl":"10.1016/j.acuro.2025.501810","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the composition of urinary stones in Lanzhou area and provide a reference basis for its clinical prevention and treatment.</div></div><div><h3>Methods</h3><div>A total of 1284 patients with urinary stones were included in the study. The differences in the distribution of stone components among different genders and ages were then analyzed.</div></div><div><h3>Results</h3><div>The overall male-to-female ratio of the cases was 3.2:1. The average age of the patients was 45.1<!--> <!-->±<!--> <!-->14.0 years old. The ratio between upper and lower urinary tract stones was 7.13:1. Mixed stone composition accounted for the majority, 79.0% (1014/1284), with calcium oxalate monohydrate<!--> <!-->+<!--> <!-->calcium oxalate dihydrate<!--> <!-->+<!--> <!-->carbonate apatite being the most prevalent at 35% (449/1284), and calcium oxalate monohydrate stones being the most prevalent of the single components at 17.8% (228/1284). Apatite carbonate 62.2% (191/307) and magnesium ammonium phosphate hexahydrate 9.8% (30/307) were significantly higher in female patients compared to apatite carbonate 55.2% (539/977) and 2.8% (27/977) in male patients. Calcium oxalate was significantly more prevalent in patients aged 18-60 years than in patients &lt;<!--> <!-->18 and ≥<!--> <!-->60 years. The proportion of patients over the age of 60 with urinary stones (10.4%) was significantly higher than patients in other age groups.</div></div><div><h3>Conclusion</h3><div>Urological stones in Lanzhou area are mainly of mixed type, calcium oxalate monohydrate<!--> <!-->+<!--> <!-->calcium oxalate dihydrate<!--> <!-->+<!--> <!-->carbonate apatite is the most; with the increase of patient's age, the proportion of uric acid stones increases; the distribution of urinary stone components has significant differences with different genders of patients and different age groups, which is of great significance for clinical prevention and treatment.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 7","pages":"Article 501810"},"PeriodicalIF":1.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}