与膀胱尿道反流史妇女妊娠并发症相关的因素：欧洲泌尿学协会(EAU) -欧洲泌尿学协会青年泌尿科（YAU）儿科泌尿学工作组的系统综述

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY

Actas urologicas espanolas Pub Date : 2025-10-01 DOI:10.1016/j.acuro.2025.501821

I. Selvi , M.İ. Dönmez , N. Baydilli , Y. Quirroz Madarriaga , R. Lammers , E. Bindi , S. Sforza , F. O’Kelly , B. Haid , B. Banuelos Marco , L.A. t’Hoen

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引用次数: 0

摘要

膀胱输尿管反流（VUR）可能对受影响的个体，特别是女性有长期的影响。它与尿路感染（UTI）的关系错综复杂，在怀孕期间存在进一步的风险，因为尿路感染更成问题。目的分析已有文献资料，探讨儿童期有VUR病史妇女妊娠相关并发症的相关因素。方法检索spubmed， MEDLINE， Embase和Cochrane Library数据库，以确定截至2024年1月（PROSPERO注册ID: CRD42024550470）的所有已发表的儿童期有VUR病史的妇女妊娠结局的报告。选择标准包括所有报道儿童期有VUR病史的孕妇妊娠结局（母体和胎儿发病率）的英文原创文章。经过筛选和资格评估，17篇文章符合PICO纳入标准。结果共纳入文献1060篇（排除后保留17篇），共纳入2349例儿童期有VUR病史的妇女、1167例孕妇和2206例妊娠。与一般产科人群相比，结果显示存在肾瘢痕的妊娠相关并发症（特别是发热性尿路感染、妊娠期高血压、先兆子痫）的发生率增加，即使妇女在儿童时期接受过抗反流手术，但没有持续的低级别VUR。尽管缺乏长期随访的大型前瞻性随机对照试验，但基于本系统综述的结果，我们得出结论，即使VUR已经消退，也应建议在妊娠期间密切监测持续存在的高级别VUR或有肾瘢痕的妇女。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Factores asociados con complicaciones en el embarazo de mujeres con antecedente de reflujo vesicoureteral: una revisión sistemática del Grupo de Trabajo de Urología Pediátrica de la Sección de Jóvenes Urólogos Académicos (YAU) - Asociación Europea de Urología (EAU)

Introduction

Vesicoureteral reflux (VUR) may have long lasting effects on affected individuals, especially in females. Its intertwined relationship with urinary tract infection (UTI) has been well documented and there is a further risk during pregnancy where UTIs are more problematic.

Objective

To analyze existing data within the literature to identify factors associated with pregnancy-related complications in women with a history of VUR in childhood.

Methods

PubMed, MEDLINE, Embase, and the Cochrane Library databases were searched to identify all published reports of pregnancy outcomes in women with a history of VUR in childhood up to January 2024 (PROSPERO Registration ID: CRD42024550470). Selection criteria included all English-language original articles reporting pregnancy outcomes (maternal and fetal morbidities) in pregnant patients with a history of VUR in childhood. After screening and eligibility assessment, 17 articles met the PICO inclusion criteria.

Results

The search yielded 1060 papers, of which 17 remained after exclusions, and assessed 2349 women with a history of VUR in childhood, 1167 pregnant women and a total of 2206 pregnancies. Compared with the general obstetric population, the results showed an increased rate of pregnancy-related complications (particularly febrile urinary tract infection, gestational hypertension, pre-eclampsia) in the presence of renal scarring, even if the women had undergone anti-reflux surgery in childhood, but not persistent low-grade VUR.

Conclusion

Despite the lack of larger prospective randomized controlled trials with long-term follow-up, based on the findings of this systematic review, we conclude that close monitoring during pregnancy should be recommended in the presence of persistent high-grade VUR or in women with renal scarring, even if VUR has resolved.

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来源期刊

Actas urologicas espanolas UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

46 days

期刊介绍： Actas Urológicas Españolas is an international journal dedicated to urological diseases and renal transplant. It has been the official publication of the Spanish Urology Association since 1974 and of the American Urology Confederation since 2008. Its articles cover all aspects related to urology. Actas Urológicas Españolas, governed by the peer review system (double blinded), is published online in Spanish and English. Consequently, manuscripts may be sent in Spanish or English and bidirectional free cost translation will be provided.