C. García-Sánchez , I. García-Obrero , C. Muñoz-Calahorro , A.J. Rodríguez-Pérez , R.A. Medina-López
{"title":"Eficacia de los ejercicios de suelo pélvico guiados pre-prostatectomía radical robótica en la incontinencia urinaria y calidad de vida","authors":"C. García-Sánchez , I. García-Obrero , C. Muñoz-Calahorro , A.J. Rodríguez-Pérez , R.A. Medina-López","doi":"10.1016/j.acuro.2025.501702","DOIUrl":"10.1016/j.acuro.2025.501702","url":null,"abstract":"<div><h3>Introduction and objective</h3><div>Radical prostatectomy has a great impact on urinary continence, although it is a multifactorial aspect. The aim of the study was to evaluate the effect of guided Pelvic Floor Exercises (PFE) versus written information prior to robotic radical prostatectomy (RRP) on the rate of urinary incontinence, and their effect on patients’ quality of life.</div></div><div><h3>Material and method</h3><div>62 patients were randomized to an experimental (physiotherapist-guided exercises) or control (written information) group. The primary outcome was incontinence rate (measured by pad test). Secondary outcomes were incontinence severity, quality of life (measured by the 36-Item Short Form Survey Instrument (SF-36) and the King's Health Questionnaire (KHQ)), voiding dynamics, correlation between incontinence and quality of life, and other incontinence-related factors.</div></div><div><h3>Results</h3><div>We found no differences in the incontinence rate between groups in the months of follow-up (82.61% vs 84.62%, month 1; 61.54% vs 75.86%, month 3; 50% vs 53.33%, month 6; 30.77% vs 40%, month 12) nor in the severity of incontinence between groups. There were significant differences in the quality of life related to “emotional problems” and “personal relationships”, in favor of the control group. We found correlations between incontinence severity and age, severity and quality of life, urgency/frequency and quality of life.</div></div><div><h3>Conclusions</h3><div>Guided exercises prior to RRP do not seem to offer benefits over written information in either the rate or severity of incontinence. Urinary incontinence correlates with age and quality of life. Quality of life correlates with urgency and voiding frequency.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501702"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factores de riesgo y modelos predictivos de litiasis renal en la población estadounidense: estudio de cohortes emparejadas mediante puntuación de propensión","authors":"Y. Sun, F. Xu, Z. Xiao, Y. An, H. Zhao","doi":"10.1016/j.acuro.2025.501715","DOIUrl":"10.1016/j.acuro.2025.501715","url":null,"abstract":"<div><h3>Objective</h3><div>This study sought to identify risk factors and develop predictive models for kidney stone disease in the U.S. population using data from the National Health and Nutrition Examination Survey (NHANES).</div></div><div><h3>Methods</h3><div>In a propensity score–matched cohort study, we examined the association of serum α-Klotho, hemoglobin levels, serum creatinine, and the urinary albumin-to-creatinine ratio (uACR) with kidney stone disease.</div></div><div><h3>Results</h3><div>Initially, 216,560 participants were screened; following propensity matching, 28,370 adults aged 40 to 79 years were included in the final analysis. Serum α-Klotho levels were inversely associated with kidney stone disease, particularly among individuals with chronic kidney disease and those who consumed alcohol. Hemoglobin levels demonstrated an inverse association with kidney stone disease risk, whereas serum creatinine levels exhibited a U-shaped relationship. No significant trend was observed for uACR overall. Low hemoglobin and α-Klotho levels, as well as elevated serum creatinine and uACR, were significantly associated with increased all-cause mortality.</div></div><div><h3>Conclusion</h3><div>Our findings underscore the significance of serum α-Klotho, hemoglobin, serum creatinine, and uACR levels in assessing the risk of kidney stone disease and all-cause mortality, suggesting these markers as potential targets for prevention and management strategies. Further research is warranted to clarify the mechanisms underlying these associations.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501715"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L.E. Ortega Polledo , E. García Rico , A. Sánchez Pellejero , G.F.J. Bianchini Hernández , A. Sanchís Bonet , J. Gómez Rivas , I. Galante Romo , J. Moreno Sierra , B. Miñana , S. Ahyai , S. Alonso y Gregorio
{"title":"Análisis prospectivo de la curva de aprendizaje en enucleación prostática con láser de holmio: serie de 125 casos","authors":"L.E. Ortega Polledo , E. García Rico , A. Sánchez Pellejero , G.F.J. Bianchini Hernández , A. Sanchís Bonet , J. Gómez Rivas , I. Galante Romo , J. Moreno Sierra , B. Miñana , S. Ahyai , S. Alonso y Gregorio","doi":"10.1016/j.acuro.2025.501705","DOIUrl":"10.1016/j.acuro.2025.501705","url":null,"abstract":"<div><h3>Objective</h3><div>The objective is to evaluate the effectiveness and safety of a surgeon's learning curve for holmium laser enucleation of the prostate in 125 consecutive cases.</div></div><div><h3>Materials and methods</h3><div>Preoperative baseline characteristics, functional outcomes, surgical times, and complications of the first 125 patients treated by holmium laser enucleation of the prostate were recorded. The sample was divided into quintiles (25 cases/group), and statistical analysis was carried out using the ANOVA test, Kruskal-Wallis H test, Chi-squared test, and likelihood-ratio test.</div></div><div><h3>Results</h3><div>Surgical time decreased progressively: 92<!--> <!-->min (Q1), 65<!--> <!-->min (Q2), 54<!--> <!-->min (Q3), 45<!--> <!-->min (Q4) and 50<!--> <!-->min (Q5) (p<!--> <!--><<!--> <!-->0.001). Enucleation rate gradually increased: 1.08<!--> <!-->g/min (Q1), 1.65<!--> <!-->g/min (Q2), 1.82<!--> <!-->g/min (Q3), 1.96<!--> <!-->g/min (Q4) and 2.74<!--> <!-->g/min (Q5) (p<!--> <!--><<!--> <!-->0.001). There were no differences in enucleated weight (Q1: 51<!--> <!-->g, Q2: 57<!--> <!-->g, Q3: 51<!--> <!-->g, Q4: 53<!--> <!-->g, Q5: 65<!--> <!-->g) (p<!--> <!-->=<!--> <!-->0.21), length of hospital stay (median 1.12 days), bladder catheterization (mean 1.51 days), intra- and postoperative complications or urethral stricture (5.6%) (p<!--> <!-->><!--> <!-->0.05). Time to continence recovery was similar in quintiles 1 to 4 (23, 27, 21 and 20 days, respectively) and shorter in quintile 5 (3.5 days) (p<!--> <!--><<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>The initiation of a holmium laser enucleation of the prostate program following the completion of training demonstrates a low morbidity rate and highly favorable functional outcomes. The efficiency of the technique demonstrates a linear and consistent increase from the outset of the learning curve, with significantly reduced surgical times achieved after 25 cases.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501705"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"El drenaje de las venas varicosas (vein milking) durante la varicocelectomía microscópica subinguinal: efectos sobre el dolor, el resultado estético y el espermiograma","authors":"B. Kati , E. Ordek , I. Demir , E. Sabri Pelit","doi":"10.1016/j.acuro.2025.501706","DOIUrl":"10.1016/j.acuro.2025.501706","url":null,"abstract":"<div><h3>Introduction</h3><div>Varicocele, defined as abnormal convoluted enlargement of the pampiniform plexus veins, is the most common cause of correctable male infertility. This study aimed to investigate the effect of blood drainage in varicose veins on spermiogram parameters, postoperative pain, cosmetic appearance, and patient satisfaction in patients undergoing subinguinal microscopic varicocelectomy.</div></div><div><h3>Methods</h3><div>Patients diagnosed with clinical varicocele and admitted to our urology outpatient clinic between January 2020 and January 2024 were evaluated. Those with a venous vessel diameter<!--> <!-->≥<!--> <!-->2.5<!--> <!-->mm underwent subinguinal microscopic varicocelectomy. In 75 patients, a small incision was made in the thickest varicose vein, and the veins were ligated after venous blood was drained by hand patting. In another 75 patients, vessels were cut and ligated by the classical method without venous blood drainage. Exclusion criteria included patients younger than 18, those with secondary varicocelectomy history, undescended testis, testicular trauma or tumors, and prior infertility treatment. Preoperative and postoperative spermiogram values, pain scores, cosmetic appearance, and patient satisfaction were recorded and compared.</div></div><div><h3>Results</h3><div>The pain rate was significantly lower (p<!--> <!--><<!--> <!-->0.05) in the blood-milking varicocelectomy group during postoperative controls (7-10 days) compared to the classical method group. The blood-milking group also showed significantly higher (p<!--> <!--><<!--> <!-->0.05) sperm count and motility at the 3rd postoperative month. Cosmetic satisfaction was significantly higher (p<!--> <!--><<!--> <!-->0.05) in the blood-milking group.</div></div><div><h3>Conclusions</h3><div>Blood drainage during subinguinal microscopic varicocelectomy significantly reduces postoperative pain and enhances sperm values, cosmetic outcomes, and patient satisfaction. These findings reveal that vein-milking techniques during varicocelectomy can optimize postoperative outcomes.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 3","pages":"Article 501706"},"PeriodicalIF":1.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M.Á. Arrabal-Polo , L. Gómez-Morón , F. Gutiérrez-Tejero , A. Zambudio-Munuera , I. Millán-Ramos , M. Arrabal-Martín
{"title":"Tratamiento adyuvante en el cáncer renal de células claras de riesgo intermedio-alto. Revisión sistemática","authors":"M.Á. Arrabal-Polo , L. Gómez-Morón , F. Gutiérrez-Tejero , A. Zambudio-Munuera , I. Millán-Ramos , M. Arrabal-Martín","doi":"10.1016/j.acuro.2025.501685","DOIUrl":"10.1016/j.acuro.2025.501685","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the lack of comparative studies on adjuvant treatment for clear cell renal cell carcinoma, we present an updated systematic review, exploring the various options for adjuvant therapy. This review is conducted in accordance with the PRISMA guidelines.</div></div><div><h3>Material and method</h3><div>A systematic review was conducted, and 13 clinical trials were included after applying the pre-specified inclusion criteria. The risk of bias and the level of evidence were assessed. Subsequently, the requisite data were extracted in order to present the findings of the studies.</div></div><div><h3>Results and discussion</h3><div>The present systematic review establishes that pembrolizumab can be used as adjuvant therapy in patients with advanced renal cancer at high risk after nephrectomy. This is supported by the KEYNOTE-564 study, which concluded that it increased disease-free survival (DFS) and overall survival. The use of sunitinib is discussed, since the study published in NEJM shows a modest benefit in terms of DFS, but only in an independent and blinded central review. According to the PROTECT study, pazopanib has no overall benefit. The EVEREST study showed no significant benefit over everolimus. Further studies are needed to confirm the use of axitinib, as the ATLAS trial showed statistically significant results in DFS in higher-risk population based on investigator assessment, but not based on independent central review. Therapy with 5-FU, α-IFN and IL-2, atezolizumab, sorafenib, thalidomide, nivolumab<!--> <!-->+<!--> <!-->ipilimumab should not be used in the adjuvant setting.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501685"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"¿Qué saben los varones españoles sobre el cáncer de próstata?","authors":"C. Vargas-Blasco , J. Arimany-Manso","doi":"10.1016/j.acuro.2025.501698","DOIUrl":"10.1016/j.acuro.2025.501698","url":null,"abstract":"","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501698"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B.M. Ljubetic , S.L. Thorogood , E.F. Becher , I. Alvarez de Toledo , R. Carrion , A. Carvajal , E. Fernández-Pascual , J.I. Martinez-Salamanca , C. Nelson , J. Quesada , C.A. Salter , J. Torremade , M. d’Anna , R. Valenzuela , J.P. Mulhall , J.M. Flores
{"title":"Validación inicial lingüística y cultural de una encuesta de satisfacción sobre el uso de la prótesis inflable de pene en español","authors":"B.M. Ljubetic , S.L. Thorogood , E.F. Becher , I. Alvarez de Toledo , R. Carrion , A. Carvajal , E. Fernández-Pascual , J.I. Martinez-Salamanca , C. Nelson , J. Quesada , C.A. Salter , J. Torremade , M. d’Anna , R. Valenzuela , J.P. Mulhall , J.M. Flores","doi":"10.1016/j.acuro.2025.501700","DOIUrl":"10.1016/j.acuro.2025.501700","url":null,"abstract":"<div><h3>Introduction</h3><div>The Satisfaction Survey for Inflatable Penile Implant (SSIPI) is useful tool to assess patient outcomes after inflatable penile prosthesis implant (PPI) surgery. However, this survey is not validated in Spanish. This work aims to report the initial steps carried out for the linguistic validation of the SSIPI translation into Spanish.</div></div><div><h3>Method</h3><div>The linguistic validation process had the following steps: (i)<!--> <!-->SSIPI forward translation; (ii)<!--> <!-->reconciliation; (iii)<!--> <!-->back translation; (iv)<!--> <!-->harmonization, review, and correction of the translation, and (v)<!--> <!-->cognitive interviewing and testing the new translated version. Urologists from Spain, South America, and the United States participated in these steps. The last step was performed in 3 centers: Medellín, Colombia; Florida, United States; and Madrid, Spain.</div></div><div><h3>Results</h3><div>19 Spanish-speaking patients tested the initial translated version of SSIPI. Most patients found the translated SSIPI questionnaire easy to understand; however, of the 16 questions, patients most frequently commented that questions 3, 5, and 7 should be modified. The median number of observations or comments per question was 1 (1, 3). Based on these suggestions, the research group adapted the questionnaire to obtain the final version in Spanish.</div></div><div><h3>Conclusion</h3><div>This study evaluates the initial steps for the translation and linguistic validation of the SSIPI questionnaire into Spanish. The results indicate a remarkable level of readability and comprehension, while some challenges were observed in certain questions. This work demonstrates that a standardized and protocolized process is needed to translate and validate surveys into Spanish.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501700"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluación de la percepción de la imagen corporal y los niveles de dolor, fatiga y ansiedad de pacientes en hemodiálisis a la espera de trasplante renal y de pacientes trasplantados","authors":"F. Hassan , N. Doğan","doi":"10.1016/j.acuro.2025.501707","DOIUrl":"10.1016/j.acuro.2025.501707","url":null,"abstract":"<div><h3>Objective</h3><div>This study was conducted to evaluate the body image perception, pain, fatigue and anxiety levels of individuals with kidney transplantation and undergoing hemodialysis and waiting for kidney transplantation.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study was conducted with 240 individuals who applied to the nephrology outpatient clinic and dialysis unit between 29 August 2021 and 20 May 2022. Data in the study were collected using Patient Information Form, LANSS Pain Scale, Visual Similarity Scale for Fatigue, Beck Anxiety Scale and Body Image Scale.</div></div><div><h3>Results</h3><div>The Body Image Scale total score average of individuals undergoing hemodialysis is 104.8<!--> <!-->±<!--> <!-->15.4, the LANSS Pain Scale total score average is 18.7<!--> <!-->±<!--> <!-->5.4, the Visual Similarity Scale total score average for Fatigue is 29.5<!--> <!-->±<!--> <!-->1.2, and the Beck Anxiety Scale total score average is 104.8<!--> <!-->±<!--> <!-->15.4. The total score average is 47.6<!--> <!-->±<!--> <!-->6.8.</div><div>The LANSS Pain Scale total mean score of individuals with kidney transplantation is 8.2<!--> <!-->±<!--> <!-->2.0, the Body Image Scale total score mean is 75.6<!--> <!-->±<!--> <!-->3.5, the Visual Similarity Scale total score mean for Fatigue is 24.3<!--> <!-->±<!--> <!-->1, and the Beck Anxiety Scale total score mean is 24.3<!--> <!-->±<!--> <!-->1. The mean total score of the scale was found to be 25.6<!--> <!-->±<!--> <!-->4.1.</div></div><div><h3>Conclusions</h3><div>It has been determined that hemodialysis patients waiting for a kidney transplant are not satisfied with their body image, experience more pain, and have higher levels of fatigue and anxiety than patients who have had a kidney transplant.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501707"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I.P. Tobia, C. Pedergrana, A.G. Alfieri, J.C. Tejerizo, M.I. González, G.A. Favre
{"title":"Relación entre los cultivos intestinales intraoperatorios y la infección urinaria postoperatoria en pacientes sometidos a cistectomía radical y derivación urinaria con conducto ileal","authors":"I.P. Tobia, C. Pedergrana, A.G. Alfieri, J.C. Tejerizo, M.I. González, G.A. Favre","doi":"10.1016/j.acuro.2025.501703","DOIUrl":"10.1016/j.acuro.2025.501703","url":null,"abstract":"<div><h3>Introduction</h3><div>Radical cystectomy (RC) is a preferred treatment for muscle-invasive bladder cancer (T2-T4) and certain non-muscle-invasive tumors. Post-cystectomy, urinary diversions often utilize intestinal segments, which are prone to complications, notably urinary tract infections (UTIs).</div></div><div><h3>Objective</h3><div>To estimate the association between intraoperative cultures of the isolated intestinal loop and urine cultures during UTI episodes in RC patients with urinary diversion. Additionally, to compare urinary cultures from catheters at discharge with UTI cultures and calculate UTI prevalence and readmission rates within three months postoperatively.</div></div><div><h3>Materials and Methods</h3><div>This prospective, observational cohort study included patients who underwent RC with ileal segment diversion our center between April 2021 and January 2024. Intraoperative cultures were obtained by washing the isolated ileal loop, and urine cultures were taken during postoperative UTI episodes. Patients were followed for 90 days post-surgery, and new cultures were performed if UTI symptoms appeared.</div></div><div><h3>Results</h3><div>Among 118 cystectomies, 82 patients were included, with a mean age of 67.8 years. UTI prevalence within the first three months was 43.9%. The kappa concordance index for bacteria between intraoperative and UTI cultures was 0.033 (poor), and for cultures from discharge catheters and UTI episodes, it was 0.251 (fair). UTI readmission rate was 28.9%, with no significant predictors identified.</div></div><div><h3>Conclusion</h3><div>There is no significant association between germs in intraoperative intestinal cultures or discharge catheters and those in UTI cultures in RC patients with urinary diversion. The three-month UTI prevalence is 43.9%, with a 28.9% readmission rate. Continuous epidemiological surveillance is recommended for appropriate antibiotic therapy.</div></div>","PeriodicalId":7145,"journal":{"name":"Actas urologicas espanolas","volume":"49 2","pages":"Article 501703"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}