Acta physiologica Sinica Pub Date : 2023-12-25

Yuan Zhang, Cheng-Zhen Huang, Hou-Zao Chen, Yu Nie, Miao-Qing Hu

{"title":"[Study of senescence protein p66Shc on myocardial tissue repair in adult mice].","authors":"Yuan Zhang, Cheng-Zhen Huang, Hou-Zao Chen, Yu Nie, Miao-Qing Hu","doi":"","DOIUrl":"","url":null,"abstract":"Our previous study has shown that p66Shc plays an important role in the process of myocardial regeneration in newborn mice, and p66Shc deficiency leads to weakened myocardial regeneration in newborn mice. This study aims to explore the role of p66Shc protein in myocardial injury repair after myocardial infarction in adult mice, in order to provide a new target for the treatment of myocardial injury after myocardial infarction. Mouse myocardial infarction models of adult wild-type (WT) and p66Shc knockout (KO) were constructed by anterior descending branch ligation. The survival rate and heart-to-body weight ratio of two models were compared and analyzed. Masson's staining was used to identify scar area of injured myocardial tissue, and myocyte area was determined by wheat germ agglutinin (WGA) staining. TUNEL staining was used to detect the cardiomyocyte apoptosis. The protein expression of brain natriuretic peptide (BNP), a common marker of myocardial hypertrophy, was detected by Western blotting. The results showed that there was no significant difference in survival rate, myocardial scar area, myocyte apoptosis, and heart weight to body weight ratio between the WT and p66ShcKO mice after myocardial infarction surgery. Whereas the protein expression level of BNP in the p66ShcKO mice was significantly down-regulated compared with that in the WT mice. These results suggest that, unlike in neonatal mice, the deletion of p66Shc has no significant effect on myocardial injury repair after myocardial infarction in adult mice.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"946-952"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway]. [通过靶向红细胞核因子 2 相关因子 2 信号通路用作抗衰老剂的中药]。

Acta physiologica Sinica Pub Date : 2023-12-25

Jia-Yi Xu, Liang-Wen Yan, Shen-Kang Tang, Peng-Fei Liu

引用次数: 0

[Effects of virtual reality in phase I cardiac rehabilitation training for elderly coronary heart disease patients after percutaneous coronary intervention]. [虚拟现实技术在老年冠心病患者经皮冠状动脉介入术后第一阶段心脏康复训练中的效果]。

Acta physiologica Sinica Pub Date : 2023-12-25

Ying Wang, Sheng-Lan Yang, Su-Xin Luo, Hua Tong, Qin Fang, Yong-Zheng Guo

{"title":"[Effects of virtual reality in phase I cardiac rehabilitation training for elderly coronary heart disease patients after percutaneous coronary intervention].","authors":"Ying Wang, Sheng-Lan Yang, Su-Xin Luo, Hua Tong, Qin Fang, Yong-Zheng Guo","doi":"","DOIUrl":"","url":null,"abstract":"The study aimed to examine the effects of virtual reality (VR) technology-based phase I cardiac rehabilitation (CR) program in elderly coronary heart disease (CHD) patients after percutaneous coronary intervention (PCI). Thirty-six cases of elderly CHD patients who underwent PCI in the First Affiliated Hospital of Chongqing Medical University from June 2022 to April 2023 were recruited by convenience sampling method. The patients were randomly assigned by means of random digital table method to two study groups: control group (n = 18), which received conventional nursing intervention after PCI, and experimental group (n = 18), which received a combined program of conventional nursing intervention together with CR program based on VR technology. The 6 min walk test (6MWT), Simple Physical Performance Battery (SPPB), SF-36 scale, Hospital Anxiety and Depression Scale (HADS) and Impact of Events Scale-Revised (IES-R) were tested before and after rehabilitation. Moreover, the incidence of major adverse cardiovascular events (MACE) was recorded at 3 months after PCI. After VR-based CR, the 6MWT distance and SPPB scores of patients in the experimental group were higher than those in control group (P < 0.05). The HADS scores and IES-R scores of the patients in the experimental group were lower than those in control group (P < 0.01), and the difference in SF-36 scale scores was not statistically significant between two groups (P > 0.05). The incidence of MACE was not significantly different at 3 months after PCI (P > 0.05). These results suggest that VR-based phase I CR program mitigates the degree of PCI postoperative stress, anxiety, and depression in elderly CHD patients, however, enhances the resistance to fatigue and does not increase the risk of adverse cardiac events, suggesting it is a safe intervention.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"953-961"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neurovascular coupling responses and cognitive function: The impact of aging and the interventional effect of exercise]. [神经血管耦合反应与认知功能：衰老的影响和运动的干预效果]。

Acta physiologica Sinica Pub Date : 2023-12-25

Yi-Min He, Chun-Li Wu, Yu-Mo Dong, Hua-Duo Wu, Qian Wang, Ning Jiang

{"title":"[Neurovascular coupling responses and cognitive function: The impact of aging and the interventional effect of exercise].","authors":"Yi-Min He, Chun-Li Wu, Yu-Mo Dong, Hua-Duo Wu, Qian Wang, Ning Jiang","doi":"","DOIUrl":"","url":null,"abstract":"Aging is a natural process accompanied with a progressive deterioration of cognitive functions. With an aging population, more and more elderly people are suffering from cognitive impairment. Previous studies have paid more attention to the impact of inflammation and oxidative stress on cognitive function during aging. Recently, it has been discovered that neurovascular coupling (NVC), a mechanism regulating cerebral blood flow, may play a significant role in aging-related cognitive impairment. NVC responses regulate the supply of energy substances and oxygen during brain activity, which in turn enhances cognitive function. However, as people grow older, NVC responses gradually weaken, which may be one of the mechanisms underlying aging-induced cognitive impairment. Given the important role of NVC responses in the brain, it is necessary to search for intervention methods that can improve NVC responses and promote cognitive function. Exercise is an effective means to delay aging and improve cognitive function. It also has a certain promoting effect on NVC responses. This article reviews the regulatory mechanisms of NVC responses, the relationship between NVC responses and cognitive function, and explores the effects of aging and exercise intervention on NVC responses, hoping to provide new research ideas for exercise intervention to improve NVC responses and promote cognitive function in the elderly.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"903-917"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Research advances in the role of Rab GTPases in Alzheimer's disease]. [Rab GTPases 在阿尔茨海默病中作用的研究进展]。

Acta physiologica Sinica Pub Date : 2023-12-25

Jing Zhang, Hai-Tian Jiang, Dao-Bin Han, Hui Yu, Lu-Wen Wang, Bo Su

引用次数: 0

[Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention]. [NLRP3炎症小体在糖尿病和运动干预中的作用]。

Acta physiologica Sinica Pub Date : 2023-12-25

Rui-Ming Wen, Hong-Yan Lyu, Bo Chang, Xue-Jie Yi

引用次数: 0

[Development of comprehensive vitality scale for the elderly based on classical test theory and analytic hierarchy process]. [基于经典测试理论和层次分析法编制老年人综合活力量表]。

Acta physiologica Sinica Pub Date : 2023-12-25

Ruo-Ling Zhu, Sheng-Nan Wang, Li Li, Xue-Ting Lin, Xiao-Li Tian, Lei Wu

{"title":"[Development of comprehensive vitality scale for the elderly based on classical test theory and analytic hierarchy process].","authors":"Ruo-Ling Zhu, Sheng-Nan Wang, Li Li, Xue-Ting Lin, Xiao-Li Tian, Lei Wu","doi":"","DOIUrl":"","url":null,"abstract":"The present study aims to construct an elderly vitality index evaluation system and develop a comprehensive vitality evaluation scale for the elderly to reasonably evaluate the vitality level of the elderly in China, so as to provide a reference for promoting the realization of \"active aging\" and \"healthy aging\". Literature research and in-depth interview were used to collect the senile vitality sensitive indexes. The indexes were screened and corrected by Delphi expert consultation method, item analysis method based on classical test theory, factor analysis method, and reliability and validity analysis method. The analytic hierarchy process was used to calculate the weight of each level of indexes. An elderly vitality evaluation system including 4 first-level indexes and 24 second-level indexes was constructed. The consistency test results of all levels of indicators showed that the consistency index (CI) and consistent ratio (CR) were both less than 0.1, which met the requirements and showed satisfactory consistency. The weights of exercise vitality, nutritional vitality, psychological vitality and social vitality were 0.263, 0.141, 0.455 and 0.141, respectively. In conclusion, the comprehensive vitality scale constructed for the Chinese elderly is reliable and scientific, and can be used to evaluate the vitality of the elderly.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"927-936"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly]. [老年人心房颤动的代谢机制和干预策略]。

Acta physiologica Sinica Pub Date : 2023-12-25

Yuan-Qing Yang, Ling-Yan Jin, Zi-Wei Chen, Qiang-Sun Zheng, Xing-Hua Qin

{"title":"[Metabolic mechanism and intervention strategy of atrial fibrillation in the elderly].","authors":"Yuan-Qing Yang, Ling-Yan Jin, Zi-Wei Chen, Qiang-Sun Zheng, Xing-Hua Qin","doi":"","DOIUrl":"","url":null,"abstract":"Atrial fibrillation (AF) is a cardiovascular epidemic that occurs primarily in the elderly with primary cardiovascular diseases, leading to severe consequences such as stroke and heart failure. The heart is an energy-consuming organ, which requires a high degree of metabolic flexibility to ensure a quick switch of metabolic substrates to meet its energy needs in response to physiological and pathological stimulation. Metabolism is closely related to the occurrence of AF, and AF patients manifest metabolic inflexibility, such as insulin resistance and the metabolic shift from aerobic metabolism to anaerobic glycolysis. Moreover, our research group and the others have shown that metabolic inflexibility is a crucial pathologic mechanism for AF. Energy metabolism is closely linked to the aging process and aging-related diseases, and impaired metabolic flexibility is considered as an essential driver of aging. Therefore, this review focuses on the alteration of metabolic flexibility in the elderly and reveals that impaired metabolic flexibility may be an important driver for the high prevalence of AF in the elderly, hoping to provide intervention strategies for the prevention and treatment of AF in the elderly.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"779-787"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Exercise promotes healthy cardiovascular aging]. [运动促进心血管健康老化]。

Acta physiologica Sinica Pub Date : 2023-12-25

Min Li, Meng-Ya Feng, Zi-Hang Feng, Jia Li, Xing Zhang, Feng Gao

{"title":"[Exercise promotes healthy cardiovascular aging].","authors":"Min Li, Meng-Ya Feng, Zi-Hang Feng, Jia Li, Xing Zhang, Feng Gao","doi":"","DOIUrl":"","url":null,"abstract":"Cardiovascular disease (CVD) is an important factor threatening the health of the elderly. Aging leads to changes in the structure and function of the cardiovascular system, which increases the risk of CVD in the elderly. Cardiac aging is characterized by increased left ventricular wall thickness, increased degree of myocardial fibrosis, increased cardiac hardness, and decreased cardiac function, while vascular aging is characterized by enlarged lumen, thickened wall, and endothelial dysfunction. Promoting healthy cardiovascular aging means reducing the age-related cardiovascular dysfunction and the risks of CVD. Exercise is a crucial means for the treatment and rehabilitation of CVD. Exercise reduces the risk factors of CVD, remodels the cardiovascular structure, and increases the resistance of heart to detrimental stimulus, which promotes healthy cardiovascular aging. The improved mitochondrial function via exercise plays a key role in the health effects of exercise. In addition, exercise promotes the secretion of exerkines in various tissues and organs, which plays a role in reducing inflammation, improving metabolism, inhibiting apoptosis, etc., thus benefiting cardiovascular health. This review discusses the mechanism and potential application of exercise in promoting healthy cardiovascular aging. Exploring the specific mechanisms underlying exercise-induced cardiovascular health and formulating accurate exercise prescriptions for different populations is an important direction to promote healthy cardiovascular aging and prevent CVD.","PeriodicalId":7134,"journal":{"name":"Acta physiologica Sinica","volume":"75 6","pages":"887-902"},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Research progress in drugs targeting 5-lipoxygenase for age-related diseases]. [针对老年相关疾病的 5-脂氧合酶药物研究进展]。

Acta physiologica Sinica Pub Date : 2023-12-25

Zhi-Jun Li, Yan-Hui Ma, Xi-Xi Hou, Tuan-Li Yao, Xiang-Yang Qin

引用次数: 0

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