[Research progress on the mechanism of autophagy flow injury caused by lysosomal dysfunction after cerebral ischemia].

Q3 Medicine
生理学报 Pub Date : 2024-10-25
Jia-Qian Wang, Hong-Yun He, Yi-Hao Deng
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引用次数: 0

Abstract

Ischemic stroke is an acute cerebrovascular disease caused by cerebral vascular obstruction, which is the third leading cause of human death and disability. Multiple studies have demonstrated that autophagy plays a positive role in neurons after ischemic stroke. Autophagy is the main intracellular mechanism that mediates the degradation and recycling of various substrates in lysosomes, so it is very important to maintain normal function of lysosomes. However, cerebral ischemia can result in significant impairment of lysosomal function, subsequently leading to disruption in autophagy flow and exacerbation of neuronal injury. This review elucidates the mechanism of autophagic flux injury resulting from lysosomal dysfunction induced by impaired fusion between autophagosomes and lysosomes, alterations in the acidic environment within lysosomes, and diminished biosynthesis of lysosomes following ischemic stroke. The lysosome is regarded as the primary focal point for investigating the mechanism of autophagic flux injury, with the aim of modulating neuronal autophagic flux to improve cerebral ischemia-induced brain injury. This approach holds potential for exerting a neuroprotective effect and providing a novel avenue for stroke treatment.

[脑缺血后溶酶体功能障碍导致自噬流损伤机制的研究进展]。
缺血性中风是一种由脑血管阻塞引起的急性脑血管疾病,是导致人类死亡和残疾的第三大原因。多项研究表明,自噬在缺血性中风后的神经元中发挥着积极作用。自噬是细胞内介导溶酶体中各种底物降解和再循环的主要机制,因此维持溶酶体的正常功能非常重要。然而,脑缺血可导致溶酶体功能严重受损,继而导致自噬流中断,加重神经元损伤。本综述阐明了缺血性脑卒中后自噬体与溶酶体融合障碍、溶酶体内酸性环境改变以及溶酶体生物合成减少所引起的溶酶体功能障碍导致的自噬通量损伤的机制。溶酶体被认为是研究自噬通量损伤机制的主要焦点,目的是调节神经元自噬通量以改善脑缺血诱发的脑损伤。这种方法有望发挥神经保护作用,为中风治疗提供一条新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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